TY - JOUR T1 - Clare: cracking the language of regulatory elements JF - Bioinformatics Y1 - 2012 A1 - Taher, Leila A1 - Narlikar, Leelavati A1 - Ovcharenko, Ivan AB -

CLARE is a computational method designed to reveal sequence encryption of tissue- specific regulatory elements. Starting with a set of regulatory elements known to be active in a particular tissue/process, it learns the sequence code of the input set and builds a predictive model from features specific to those elements. The resulting model can then be applied to user-supplied genomic regions to identify novel candidate regulatory elements. CLARE's model also provides a detailed analysis of transcription factors that most likely bind to the elements, making it an invaluable tool for understanding mechanisms of tissue- specific gene regulation.

PB - OXFORD UNIV PRESS CY - GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND VL - 28 IS - 4 U3 - Foreign U4 - 5.323 ER -