TY - JOUR T1 - Characterization of biocompatible NiCo2O4 nanoparticles for applications in hyperthermia and drug delivery JF - Nanomedicine-Nanotechnology Biology and Medicine Y1 - 2012 A1 - Kale, Sangeeta N. A1 - Jadhav, Anil D. A1 - Verma, Seema A1 - Koppikar, Soumya J. A1 - Kaul-Ghanekar, Ruchika A1 - Dhole, Sanjay D. A1 - Ogale, Satishchandra B. KW - Cytotoxicity KW - drug delivery KW - Magnetic hyperthermia KW - Magnetic nanoparticles AB -

Monodispersed, superparamagnetic nickel cobaltite (NCO) nanoparticles were functionalized using mercaptopropionic acid (MPA). MPA conjugates with NCO forming a metal-carboxylate linkage, with the MPA-MPA interaction occurring via formation of disulfide bonds, leaving another carboxyl end free for additional conjugation. The cytotoxicity studies on NCO-MPA show cell viability of similar to 100% up to a dosage of 40 mu g/mL on SiHa, MCF7, and B16F10 cell lines, and on mouse primary fibroblasts. Time-dependent cell viability studies done for a duration of 72 hours showed the cell lines' viability up to 80% for dosages as high as 80 mu g/mL. Negligible leaching (<5 ppm) of ionic Co or Ni was noted into the delivery medium. Upon subjecting the NCO-MPA dispersion (0.1 mg/mL) to radiofrequency absorption, the nanoparticles were heated to 75 degrees C within 2 minutes, suggesting its promise as a magnetic hyperthermia agent. Furthermore, the amino acid lysine and the drug cephalexin were successfully adducted to the NCO system, suggesting its potential for drug delivery. From the Clinical Editor: NCO-MPA nanopartciles were found to be promising magnetic hyperthermia agents, suggesting potential future clinical applications. (C) 2012 Elsevier Inc. All rights reserved.

PB - ELSEVIER SCIENCE BV CY - PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS VL - 8 IS - 4 U3 - Foreign U4 - 6.93 ER -