TY - JOUR T1 - CuCN-Mediated cascade cyclization of 4-(2-bromophenyl)-2-butenoates: a high-yield synthesis of substituted naphthalene amino esters JF - Journal of Organic Chemistry Y1 - 2013 A1 - Reddy, R. Santhosh A1 - Prasad, Pragati K. A1 - Ahuja, Brij Bhushan A1 - Sudalai, Arumugam AB -

A new method of CuCN-mediated one-pot cyclization of 4-(2-bromophenyl)-2-butenoates leading to efficient synthesis of substituted naphthalene amino esters including phenanthrene aromatic structural units is described. Deuterium labeling studies establish that this one-pot cascade cyclization proceeds through isomerization of olefin, intramolecular C-C bond cyclization, and aromatization as the key intermediates, all occurring in a single step.

PB - AMER CHEMICAL SOC CY - 1155 16TH ST, NW, WASHINGTON, DC 20036 USA VL - 78 IS - 10 U3 - Foreign U4 - 4.638 ER -