TY - JOUR T1 - Continuous flow nitration in miniaturized devices JF - Beilstein Journal of Organic Chemistry Y1 - 2014 A1 - Kulkarni, Amol A. KW - continuous flow KW - flow chemistry KW - microreactors KW - nitration KW - nitric acid KW - Tubular reactor AB -

This review highlights the state of the art in the field of continuous flow nitration with miniaturized devices. Although nitration has been one of the oldest and most important unit reactions, the advent of miniaturized devices has paved the way for new opportunities to reconsider the conventional approach for exothermic and selectivity sensitive nitration reactions. Four different approaches to flow nitration with microreactors are presented herein and discussed in view of their advantages, limitations and applicability of the information towards scale-up. Selected recent patents that disclose scale-up methodologies for continuous flow nitration are also briefly reviewed.

PB - BEILSTEIN-INSTITUT CY - TRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANY VL - 10 U2 -

Council of Scientific & Industrial Research (CSIR) - India

U3 - Foreign U4 - 2.697 ER -