TY - JOUR T1 - Enhancing cubosome functionality by coating with a single layer of poly-epsilon-lysine JF - ACS Applied Materials & Interfaces Y1 - 2014 A1 - Deshpande, Sonal A1 - Venugopal, Edakkal A1 - Ramagiri, Shobha A1 - Bellare, Jayesh R. A1 - Kumaraswamy, Guruswamy A1 - Singh, Neetu KW - bioconjugation KW - cubosomes KW - drug delivery vehicle KW - dual loading KW - theranostics AB -

We report the preparation and characterization of monoolein cubosomes that can be easily surface modified through adsorption of a single layer of cationic poly-epsilon-lysine. Poly-epsilon-lysine coated cubosomes show remarkable stability in serum solution, are nontoxic and, are readily internalized by HeLa cells. The poly-epsilon-lysine coating provides chemical handles for further bioconjugation of the cubosome surface. We also demonstrate that the initial release rate of a hydrophilic drug, Naproxen sodium, from the cubosomes is retarded with just a single layer of polymer. Interestingly, cubosomes loaded with Naproxen sodium, recently shown to have anticancer properties, cause more apoptosis in HeLa cells when compared to free unencapsulated drug.

PB - AMER CHEMICAL SOC CY - 1155 16TH ST, NW, WASHINGTON, DC 20036 USA VL - 6 IS - 19 U3 -

Foreign
 

U4 -

5.76
 

ER -