TY - JOUR T1 - Antimicrobial activity of plant extracts against sexually transmitted pathogens JF - Natural Product Research Y1 - 2015 A1 - Jadhav, Nutan A1 - Kulkarni, Sangeeta A1 - Mane, Arati A1 - Kulkarni, Roshan A1 - Palshetker, Aparna A1 - Singh, Kamalinder A1 - Joshi, Swati P. A1 - Risbud, Arun A1 - Kulkarni, Smita KW - anti-STI activity KW - Candida albicans KW - fractions KW - Haemophilus ducreyi KW - microbicide KW - Neisseria gonorrhoeae KW - plant extracts AB -

Comprehensive management of sexually transmitted infections (STIs) using vaginal or rectal microbicide-based intervention is one of the strategies for prevention of HIV infection. Herbal products have been used for treating STIs traditionally. Herein, we present in vitro activity of 10 plant extracts and their 34 fractions against three sexually transmitted/reproductive tract pathogens - Neisseria gonorrhoeae, Haemophilus ducreyi and Candida albicans. The plant parts were selected; the extracts/fractions were prepared and screened by disc diffusion method. The minimum inhibitory and minimum cidal concentrations were determined. The qualitative phytochemical analysis of selected extracts/fractions showing activity was performed. Of the extracts/fractions tested, three inhibited C. albicans, ten inhibited N. gonorrhoeae and five inhibited H. ducreyi growth. Our study demonstrated that Terminalia paniculata Roth. extracts/fractions inhibited growth of all three organisms. The ethyl acetate fraction of Syzygium cumini Linn. and Bridelia retusa (L.) Spreng. extracts was found to inhibit N. gonorrhoeae at lowest concentrations.

PB - TAYLOR & FRANCIS LTD CY - 4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND VL - 29 IS - 16 U3 -

Foreign

U4 - 1.057 ER -