TY - JOUR T1 - Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents JF - Bioorganic & Medicinal Chemistry Letters Y1 - 2016 A1 - Subhedar, Dnyaneshwar D. A1 - Shaikh, Mubarak H. A1 - Arkile, Manisha A. A1 - Yeware, Amar A1 - Sarkar, Dhiman A1 - Shingate, Bapurao B. KW - Antitubercular KW - Cytotoxicity KW - Green protocol KW - Multicomponent reaction AB -

We have developed, highly efficient, one-pot, solvent-free, [Et3NH][HSO4] catalyzed multicomponent reaction protocol for the synthesis of 1,3-thiazolidin-4-ones in excellent yields. For the first time, the 1,3-thiazolidin-4-ones were evaluated in vitro for their antimycobacterial activity against Mycobacterium tuberculosis dormant MTB H37Ra and Mycobacterium bovis BCG strains. Among the synthesized basic 1,3-thiazolidin-4-ones, particularly the compounds 4c, 4d, 4e, 4f, 4h, 4i and 4j displays promising antitubercular activity along with no significant cytotoxicity against the cell lines MCF-7, A549 and HCT-116. (C) 2016 Elsevier Ltd. All rights reserved.

PB - PERGAMON-ELSEVIER SCIENCE LTD CY - THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND VL - 26 IS - 7 U3 -

Foreign

U4 - 2.486 ER -