02103nas a2200241 4500008004100000022001400041245011200055210006900167260010600236300001400342490000700356520122600363653001001589653000801599653000701607653002001614653001901634100002001653700002101673700001901694700002201713856012601735 2005 eng d a0009-250900aGas-liquid flow generated by a Rushton turbine in stirred vessel: CARPT/CT measurements and CFD simulations0 aGasliquid flow generated by a Rushton turbine in stirred vessel  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR a2215-22290 v603 a

In this work, computer-automated radioactive particle tracking (CARPT), computed tomography (CT) and computational fluid dynamic (CFD) based models were used to investigate gas-liquid flow generated by a Rushton turbine. CARPT and CT measurements were carried out in a gas-liquid stirred vessel operating in two different flow regimes and captured the quantitative Eulerian information of gas-liquid flow. The CARPT data was then used to extract the circulation tune distribution in a vessel. A two-fluid model along with the standard k-epsilon turbulence model was used to simulate the dispersed gas-liquid flow in a stirred vessel. Appropriate drag corrections to account for bulk turbulence (along the lines proposed by Brucato et al. (Chem. Eng. Sci. 45(1998) 3295)) were developed to correctly simulate different flow regimes. The computational snapshot approach was used to simulate impeller rotation and was implemented in the commercial CFD code, FLUENT4.5 (of Fluent. Inc., USA). Most model predictions compared favourably with CARPT and CT measurements. Validated CFD models as attempted in this paper are promising to simulation of industrial stirred vessels. (c) 2005 Elsevier Ltd. All rights reserved.

10aCARPT10aCFD10aCT10agas-liquid flow10astirred vessel1 aKhopkar, A., R.1 aRammohan, A., R.1 aRanade, V., V.1 aDudukovic, M., P. uhttp://library.ncl.res.in/content/gas-liquid-flow-generated-rushton-turbine-stirred-vessel-carptct-measurements-and-cfd-002158nas a2200241 4500008004100000022001400041245006700055210006700122260010600189300001200295490000700307520131200314653001501626653002001641653002501661653002601686653001101712100002801723700002001751700002401771700002101795856010001816 2005 eng d a0965-174800aGene expression patterns of helicoverpa armigera gut proteases0 aGene expression patterns of helicoverpa armigera gut proteases aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR a355-3670 v353 a

Relative quantification of reported gut proteinase cDNAs from Helicoverpa armigera larvae fed on various host plants (cotton, chickpea, pigeonpea, tomato and okra), non-host plant Pis (winged bean, bitter gourd, ground nut, and capsicum) and during larval development has been carried out using semi-quantitative RT-PCR. Five trypsin-like and three chymotrypsin-like proteinases were categorized as insensitive or sensitive to most of the proteinase inhibitors (Pis) and insensitive/sensitive to specific Pis based on their expression analysis. These results were supported by amino acid sequence analysis, where diverged amino acids were observed in the regions, which are reported to be involved in typical trypsin trypsin inhibitor interactions and critical for proteinase inhibitor resistance. Among exopeptidases (five aminopeptidase and three carboxypeptidase), HaAmi4 and HaAmi5 of aminopeptidase and HaCar1 of carboxypeptidase exhibited considerable differential expression. Elastase and cathepsin B-like proteinases were expressed at negligible levels. The proteases identified in the study would be ideal candidates for further interactions studies with protease inhibitors to understand the structural reasons of protease inhibitor insensitivity (c) 2005 Elsevier Ltd. All rights reserved.

10aexpression10agut proteinases10aHelicoverpa armigera10aProteinase inhibitors10aRT-PCR1 aChougule, Nanasaheb, P.1 aGiri, Ashok, P.1 aSainani, Mohini, N.1 aGupta, Vidya, S. uhttp://library.ncl.res.in/content/gene-expression-patterns-helicoverpa-armigera-gut-proteases-001220nas a2200181 4500008004100000022001400041245012800055210006900183260009200252300001400344490000800358520043700366653002600803653005300829100001400882700001100896856013100907 2005 eng d a0026-897600aGeneral formalism of the Fock space multireference coupled cluster method for investigating molecular electronic resonances0 aGeneral formalism of the Fock space multireference coupled clust a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcAUG a2267-22750 v1033 a

Electron correlation and relaxation effects play a substantial role in the formation and decay of resonance states. In this paper we formulate a complex absorbing potential combined with the Fock space multireference coupled cluster method for the correlated calculations of resonance energy and width. This can describe the dynamic and non-dynamic electron correlation efficiently in the ionized or electron attached states.

10aelectronic resonances10aFock space multireference coupled cluster method1 aSajeev, Y1 aPal, S uhttp://library.ncl.res.in/content/general-formalism-fock-space-multireference-coupled-cluster-method-investigating-molecular-002493nas a2200205 4500008004100000022001400041245009400055210006900149260006900218300001000287490000800297520166700305653004101972653002102013653006202034653002502096653002202121100002502143856011902168 2005 eng d a1385-894700aGeneral kinetic model framework for the interpretation of adiabatic calorimeter rate data0 aGeneral kinetic model framework for the interpretation of adiaba aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcJUN a67-780 v1103 a

Notwithstanding the variety and complexity of the reactions studied by adiabatic calorimeters like ARC, the data interpretation techniques are not general enough. Traditional thermokinetic analysis primarily lumps a complex multi-step reaction into a single overall reaction and ignores possible thermal effects in some of the possible side reactions. With detailed chromatographic/mass spectrometric analysis of the headspace gases and the condensed phase residues, the pressure profile becomes an additional source of identification of the mechanism and the kinetics of the overall reaction. Finally, in the context of new multiphase catalytic processes of greater efficiency and environment friendliness and with reference to the storage of potentially incompatible fluid mixtures in metallic containers, ARC studies of heterogeneous reaction systems are becoming part of the mandatory safety evaluations. With a few additional measurements a proper kinetic interpretation of the ARC data on such systems seems possible. The paper presents a general model that was shown to be easily adaptable to a number of published reactions of various complexities referred to above. Standard thermal hazard characteristics like the onset temperature, adiabatic temperature rise, self-heat rate, time-to-maximum rate, pressure-temperature profile, etc. could be accurately calculated by the model and these compared closely with the experimental data. It is hoped that the model would be useful as a general-purpose tool for the interpretation of adiabatic calorimetric data for the purpose of process hazard assessment. (c) 2005 Elsevier B.V. All rights reserved.

10aaccelerating rate calorimeters (ARC)10aKinetic modeling10aMOC (material of construction) incompatibility in storage10amulti-step reactions10arunaway reactions1 aBhattacharya, Arijit uhttp://library.ncl.res.in/content/general-kinetic-model-framework-interpretation-adiabatic-calorimeter-rate-data-002831nas a2200169 4500008004100000022001400041245010500055210006900160260007100229300001200300490000700312520214500319100003302464700001702497700002002514856012702534 2005 eng d a1549-959600aGeneral melting point prediction based on a diverse compound data set and artificial neural networks0 aGeneral melting point prediction based on a diverse compound dat a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY a581-5900 v453 a

We report the development of a robust and general model for the prediction of melting points. It is based on a diverse data set of 4173 compounds and employs a large number of 2D and 3D descriptors to capture molecular physicochemical and other graph-based properties. Dimensionality reduction is performed by principal component analysis, while a fully connected feed-forward back-propagation artificial neural network is employed for model generation. The melting point is a fundamental physicochemical property of a molecule that is controlled by both single-molecule properties and intermolecular interactions due to packing in the solid state. Thus, it is difficult to predict, and previously only melting point models for clearly defined and smaller compound sets have been developed. Here we derive the first general model that covers a comparatively large and relevant part of organic chemical space. The final model is based on 2D descriptors, which are found to contain more relevant information than the 3D descriptors calculated. Internal random validation of the model achieves a correlation coefficient of R-2 = 0.661 with an average absolute error of 37.6 degrees C. The model is internally consistent with a correlation coefficient of the test set of Q(2) = 0.658 (average absolute error 38.2 degrees C) and a correlation coefficient of the internal validation set of Q(2) = 0.645 (average absolute error 39.8 degrees C). Additional validation was performed on an external drug data set consisting of 277 compounds. On this external data set a correlation coefficient of Q(2) = 0.662 (average absolute error 32.6 degrees C) was achieved, showing ability of the model to generalize. Compared to an earlier model for the prediction of melting points of druglike compounds our model exhibits slightly improved performance, despite the much larger chemical space covered. The remaining model error is due to molecular properties that are not captured using single-molecule based descriptors, namely both inter- and intramolecular interactions and crystal packing, for which examples of and reasons for outliers are given.

1 aKarthikeyan, Muthukumarasamy1 aGlen, R., C.1 aBender, Andreas uhttp://library.ncl.res.in/content/general-melting-point-prediction-based-diverse-compound-data-set-and-artificial-neural-001615nas a2200193 4500008004100000022001400041245007500055210006900130260007100199300001400270490000700284520091900291100002001210700002001230700001501250700002001265700003001285856010601315 2005 eng d a0743-746300aGold nanoparticle networks with photoresponsive interparticle spacings0 aGold nanoparticle networks with photoresponsive interparticle sp a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAUG a7979-79840 v213 a

Photoresponsive gold nanoparticle networks were prepared by functionalizing them with azobenzene derivatives. A network can be formed when a linker molecule constituting the azobenzene moiety suitably derivatized on either side with gold surface sensitive groups such as thiols and amines is added to the nanoparticle solution. It is shown that the interparticle spacing in the networks could be controlled by the reversible trans-cis isomerization of the azobenzene moiety induced by UV and visible light, respectively. The photoinduced variation in the interparticle spacings is inferred by the changes in the optical spectra of the gold nanoparticles which display a red or blue shift in the surface plasmon resonance peak depending on a decrease or increase in the interparticle spacing, respectively. Transmission electron microscopy images are in consonance with the evidence from the optical spectra.

1 aSidhaye, D., S.1 aKashyap, Sudhir1 aSastry, M.1 aHotha, Srinivas1 aPrasad, Bhagavatula L. V. uhttp://library.ncl.res.in/content/gold-nanoparticle-networks-photoresponsive-interparticle-spacings-002038nas a2200217 4500008004100000022001400041245011900055210006900174260008600243300001000329490000700339520121600346653001701562653002301579653001801602653001801620100002501638700001701663700001401680856012601694 2005 eng d a1553-317400aGold nanotriangles biologically synthesized using tamarind leaf extract and potential application in vapor sensing0 aGold nanotriangles biologically synthesized using tamarind leaf  a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcFEB a19-260 v353 a

The size and shape dependent electronic and chemical properties of metal nanoparticles has drawn the attention of chemists, physicists, biologists, and engineers who wish to use them for the development of new generation nanodevices. In this article, we report the synthesis of gold nanotriangles using tamarind leaf extract as the reducing agent. On treating aqueous chloroauric acid solution with tamarind leaf extract, rapid reduction of the chloroaurate ions is observed leading to the formation of flat and thin single crystalline gold nanotriangles. Atomic force microscopy analysis of the gold nanotriangles indicated that they ranged in thickness from 20 to 40 nm. These gold nanotriangles with unique and highly anisotropic planer shapes might find application in photonics, optoelectronics, and optical sensing. We investigated the effect of different organic solvent vapors like methanol, benzene and acetone on the conductivity of tamarind leaf extract reduced gold nanotriangles. I-V characteristics measurement of these nanotriangles was done in presence of these organic solvent vapors. The observed characteristics suggest the application of gold nanotriangles to future chemical sensors.

10aBiosynthesis10agold nanotriangles10atamarind leaf10avapor sensing1 aAnkamwar, Balaprasad1 aChaudhary, M1 aSastry, M uhttp://library.ncl.res.in/content/gold-nanotriangles-biologically-synthesized-using-tamarind-leaf-extract-and-potential-002405nas a2200265 4500008004100000022001400041245016100055210006900216260006900285300001200354490000700366520141600373653001701789653002101806653002701827653001301854100002301867700002301890700001801913700001701931700002001948700002001968700002401988856012702012 2005 eng d a0925-963500aGradual transitions in morphology of diamond films grown by using N-2 admixtures of CH4+H-2 gas in a hot filament assisted chemical vapour deposition system0 aGradual transitions in morphology of diamond films grown by usin aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcFEB a232-2420 v143 a

A study of the evolution of morphology of diamond films grown as a function of N-2 gas additions to the CH4+H-2 precursor in an HF-CVD system is presented. With the increase of admixture of N2 fraction, in contrast to earlier studies, the morphology was observed first to gradually change from {111}-faceted crystallites texture to that of an intermediate cubo-octahedral crystallite texture and then gradually but finally to transform completely into that of {100}-faceted crystallites. The threshold nitrogen concentration, [N-2](thr), required to bring about the said transition in morphology was much larger than it was reported previously. Moreover, the morphology transition required a larger [N-2](thr) when a large fraction of methane was employed. Further additions of nitrogen, that just exceeded the [N-2](thr), resulted in growth of films containing slightly bigger {100}-multi-layered grains or isolated planar {100}-platelets. For extremely large nitrogen additions, the growth of nanocrystalline or amorphous carbon films was observed. The N-2 additions more than 50 vol.% did not yield any deposition. Raman scattering and photoluminescence measurements were used respectively for characterizing the quality and nitrogen doping in the films. These results are attributed to the possible catalytic role of atomic nitrogen at the growing surface. (C) 2005 Elsevier B.V. All rights reserved.

10adiamond film10ahot filament CVD10amorphology transitions10anitrogen1 aKshirsagar, S., T.1 aKshirsagar, R., B.1 aPatil, P., S.1 aKulkarni, A.1 aMandate, A., B.1 aGaikwad, A., B.1 aGokhale, Suresh, P. uhttp://library.ncl.res.in/content/gradual-transitions-morphology-diamond-films-grown-using-n-2-admixtures-ch4h-2-gas-hot-101970nas a2200205 4500008004100000022001400041245013600055210006900191260007700260300000900337490000700346520118200353653002301535653002601558653001901584653000901603100001501612700001401627856012301641 2005 eng d a0038-905600aGreen nanocomposites from renewable resources: effect of plasticizer on the structure and material properties of clay-filled starch0 aGreen nanocomposites from renewable resources effect of plastici aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJAN a8-150 v573 a

Nanocomposites of starch were prepared via different addition sequences of plasticizer and clay by the solution method. The extent of dispersion of the filler was evaluated by wide angle X-ray diffractometry (WAXD) in the resulting composites. Thermal stability, mechanical properties and water absorption studies were conducted to measure the material properties whereas FT-IR spectroscopy was used to study the microdomain structure of composites. The sequence of addition of components (starch/plasticizer (glycerol)/clay) had a significant effect on the nature of composites formed and accordingly properties were altered. Glycerol and starch both have the tendency to penetrate into the silicate layers but penetration of glycerol is favored owing to its smaller molecule size. The filler dispersion becomes highly heterogeneous and the product becomes more brittle when starch was plasticized before filling with clay due to the formation of a bulky structure resulting from electrostatic attractions between starch and plasticizer. It was concluded that best mechanical properties can be obtained if plasticizer is added after mixing of clay in the starch matrix.

10aclay-filled starch10aeffect of plasticizer10aNanocomposites10aWAXD1 aPandey, JK1 aSingh, RP uhttp://library.ncl.res.in/content/green-nanocomposites-renewable-resources-effect-plasticizer-structure-and-material-001082nas a2200193 4500008004100000022001400041245016200055210006900217260011000286300001200396490000600408520025500414100002600669700001300695700001800708700001400726700001900740856012900759 2005 eng d a1463-926200aGreen process for chlorine-free benzaldehyde from the solvent-free oxidation of benzyl alcohol with molecular oxygen over a supported nano-size gold catalyst0 aGreen process for chlorinefree benzaldehyde from the solventfree aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT a768-7700 v73 a

Benzyl alcohol is oxidized selectively to benzaldehyde with high yield, with a little formation of benzylbenzoate, by molecular oxygen over a reusable nano-size gold catalyst supported on U3O8, MgO, Al2O3 or ZrO2 in the absence of any solvent.

1 aChoudhary, Vasant, R.1 aDhar, A.1 aJana, Prabhas1 aJha, Rani1 aUphade, B., S. uhttp://library.ncl.res.in/content/green-process-chlorine-free-benzaldehyde-solvent-free-oxidation-benzyl-alcohol-molecular-002160nas a2200253 4500008004100000022001400041245012300055210006900178260007300247300001400320490000700334520120100341653002901542653002001571653003501591653003701626653001601663100002101679700001801700700002001718700001801738700002601756856012401782 2005 eng d a0167-577X00aGrowth kinetics and thermodynamic stability of octadecyltrichlorosilane self-assembled monolayer on Si (100) substrate0 aGrowth kinetics and thermodynamic stability of octadecyltrichlor aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcDEC a3890-38950 v593 a

We have studied the growth kinetics and thermodynamic stability of octadecyltrichlorosilane (OTS) self-assembled monolayers on Si (100) substrate in order to understand its role in controlling the adhesion and surface hydrophobicity. Time-dependent contact angle measurements, using water as a function of OTS concentration, show rapid monolayer formation in the initial stage followed by a slow attainment of full coverage and the overall kinetics approximately follows the Langmuir adsorption isotherm. The adsorption rate constant (k(a) = 150 M-1 s(-1)) is found to be significantly greater than the desorption rate constant (k(d) = 0.156 s(-1)) while the Gibbs free energy (Delta G(ads)) change amounts to -4.2 kcal/mol suggesting thermodynamic stability of OTS monolayer on a silicon surface. Partial monolayer formation by a `uniform' growth mechanism, even at low coverage, is revealed by atomic force microscopy (AFM) in conjunction with grazing angle FTIR spectroscopy. Analysis of the interfacial adhesion properties using Zisman plot suggests a critical surface tension (gamma(c)) of 20.7 dyn/cm for OTS monolayer on Si (100) surface. (C) 2005 Elsevier B.V. All rights reserved.

10aGibbs's free energy (AG)10agrowth kinetics10aoctadecyltrichlorosilane (OTS)10aself-assembled monolayers (SAMs)10aZisman plot1 aKulkarni, S., A.1 aMirji, S., A.1 aMandale, A., B.1 aGupta, R., P.1 aVijayamohanan, K., P. uhttp://library.ncl.res.in/content/growth-kinetics-and-thermodynamic-stability-octadecyltrichlorosilane-self-assembled-002011nas a2200277 4500008004100000022001400041245012300055210006900178260010600247300001400353490000700367520099000374653002801364653002301392653002401415653001901439653002301458100002501481700002101506700001401527700001701541700001601558700001401574700002701588856011801615 2005 eng d a0025-540800aGrowth of PbS nanopyramidal particulate films for potential applications in quantum-dot photovoltaics and nanoantennas0 aGrowth of PbS nanopyramidal particulate films for potential appl aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG a1353-13600 v403 a

We report a simple interfacial process called the liquid-liquid interface reaction technique (LLIRT) that leads to the formation of nanosized PbS particulate films with hitherto unreported pyramidal morphology. The resultant PbS films were characterized by transmission electron microscopy (TEM) with selected area electron diffraction (SAED), X-ray diffractometery (XRD), atomic force microscopy (AFM), near field scanning optical microscopy (NSOM) and UV-vis spectroscopy. The pyramidal morphology is speculated to originate from the preferred orientation of the 2 2 0 plane of cubic PbS. Our nanopyramidal PbS particulate films display remarkably sharp excitonic peak centered around 656 nm that accounts for a band gap of 1.8 eV suggesting, in turn, their potential application in QD photovoltaics. Interestingly, the feasibility of such nanopyramids to potentially act as nanoantennas (as revealed by the NSOM) is also suggested. (c) 2005 Elsevier Ltd. All rights reserved.

10aAtomic force microscopy10aChemical synthesis10aElectron microscopy10aNanostructures10aOptical properties1 aHawaldar, Ranjit, R.1 aMulik, Uttam, P.1 aPatil, K.1 aPasricha, R.1 aSathaye, S.1 aLewis, A.1 aAmalnerkar, Dinesh, P. uhttp://library.ncl.res.in/content/growth-pbs-nanopyramidal-particulate-films-potential-applications-quantum-dot-001239nas a2200217 4500008004100000022001400041245010800055210006900163260010600232300001400338490000700352520037500359653001100734653002400745653003000769653001700799100002200816700002600838700002700864856013000891 2006 eng d a0040-403900aGamma-heteroatom directed stereocontrolled staudinger cycloaddition reaction of vinylketenes and imines0 aGammaheteroatom directed stereocontrolled staudinger cycloadditi aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAUG a5993-59960 v473 a

Vinylketenes possessing a gamma-heteroatom, on Staudinger cycloaddition reaction with imines gave trans-3-vinyl-beta-lactams in very good yields. The vinyl side chain stereoselectively adopts the Z-configuration in the transition state to stabilize the vinylketene and produces, exclusively, trans-3-vinyl-beta-lactams. (c) 2006 Elsevier Ltd. All rights reserved.

10aimines10aStaudinger reaction10astereoselective synthesis10avinylketenes1 aShaikh, Aarif, L.1 aPuranik, Vedavati, G.1 aDeshmukh, A., R. A. S. uhttp://library.ncl.res.in/content/gamma-heteroatom-directed-stereocontrolled-staudinger-cycloaddition-reaction-vinylketenes-001392nas a2200253 4500008004100000022001400041245009300055210006900148260010600217300001400323490000700337520043000344653000600774653002800780653002900808653002200837653003400859653002800893100002800921700002200949700002600971700002300997856011801020 2006 eng d a0040-403900aGeneral strategy for a short and efficient synthesis of 3-hydroxy-4-methylprolines (HMP)0 aGeneral strategy for a short and efficient synthesis of 3hydroxy aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcDEC a9215-92190 v473 a

The non-proteinogenic amino acid 3-hydroxy-4-methylproline (HMP) is an active constituent of some potent antimicrobials including echinocandins, nostopeptins, pneumocandins, sporiofungin and mulundocandins. A synthesis has been achieved in 10 steps with 29% overall yield; the Evans' aldol reaction using Crimmins' modified method was pivotal to the success of the strategy. (c) 2006 Elsevier Ltd. All rights reserved.

10a310a4-disubstituted proline10aCrimmins' aldol reaction10aGarner's aldehyde10anon-proteinogenic amino acids10aRUO4 mediated oxidation1 aMohapatra, Debendra, K.1 aMondal, Dhananjoy1 aChorghade, Mukund, S.1 aGurjar, Mukund, K. uhttp://library.ncl.res.in/content/general-strategy-short-and-efficient-synthesis-3-hydroxy-4-methylprolines-hmp-001884nas a2200277 4500008004100000022001400041245014100055210006900196260008700265300001400352490000700366520086300373653003001236653002201266653001901288653001701307100001701324700002201341700002101363700002001384700002101404700001901425700001901444700001801463856012501481 2006 eng d a0011-389100aGenetic diversity analysis in Gaultheria fragrantissima wall. (Ericaceae) from the two biodiversity hotspots in India using ISSR markers0 aGenetic diversity analysis in Gaultheria fragrantissima wall Eri aC V RAMAN AVENUE, PO BOX 8005, BANGALORE 560 080, INDIAbCURRENT SCIENCE ASSNcDEC a1634-16400 v913 a

Our study involves Inter Simple Sequence Repeat markers to analyse genetic diversity of an undershrub, Gaultheria fragrantissima Wall. (Ericaceae) from two plant diversity hotspots in India, namely Western Ghats and Northeastern Himalayas. The plants from these two regions show no morphological differences but the total heterozygosity (H-T = 0.505) is high. Furthermore, the average heterozygosity of G. fragrantissima at WG (H-s = 0.433) is higher than that at NE region (H-s, = 0.231). Within population variance is higher (15.56 %) than among population variance (8.31 %) as seen in outcrossing plant species. Mantel's test shows a strong positive correlation between the genetic and geographic distances. The plants within WG show high gene flow, which may be enough to prevent genetic drift, however, the gene flow in NE population is very low.

10aGaultheria fragrantissima10aGenetic diversity10aheterozygosity10aISSR markers1 aApte, G., S.1 aBahulikar, R., A.1 aKulkarni, R., S.1 aLagu, Meena, D.1 aKulkarni, B., G.1 aSuresh, H., S.1 aRao, P., S. N.1 aGupta, V., S. uhttp://library.ncl.res.in/content/genetic-diversity-analysis-gaultheria-fragrantissima-wall-ericaceae-two-biodiversity-001530nas a2200229 4500008004100000022001400041245009700055210006900152260008600221300001000307490000700317520071300324653000601037653002301043653001401066653002701080653001301107100002401120700001501144700001601159856012501175 2006 eng d a0039-791100aGrapevine DNA polymorphisms revealed by microsatellite-derived markers from soybean and rice0 aGrapevine DNA polymorphisms revealed by microsatellitederived ma a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcJAN a81-840 v453 a

We report detection of DNA polymorphisms in grapevine by the use of microsatellite-flanking primer pairs from soybean and rice. These "cross species" microsatellite-derived markers were checked for their inheritance patterns in controlled grapevine crosses. They produced multiple bands that segregated and can be scored as individual genetic markers of dominant type. Employed in genetic mapping studies they offer advantages such as improved reproducibility in comparison to commonly used multi-locus marker systems like RAPDs and AFLPs.

10a110a3-dipolar addition10apyrazoles10aregiospecific reaction10asydnones1 aAgrawal, Dinesh, C.1 aTopfer, R.1 aZyprian, E. uhttp://library.ncl.res.in/content/grapevine-dna-polymorphisms-revealed-microsatellite-derived-markers-soybean-and-rice-101271nas a2200229 4500008004100000022001400041245012000055210006900175260007400244300001200318490000800330520044000338653002700778653002200805653001200827653000900839653001200848100001500860700001900875700001600894856013100910 2006 eng d a1381-116900aGreen protocol for the synthesis of N-oxides from secondary amines using vanadium silicate molecular sieve catalyst0 aGreen protocol for the synthesis of Noxides from secondary amine aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR  a109-1120 v2483 a

Vanadium silicate molecular sieve catalyst VS-I was found to promote efficiently the oxidation of alpha alpha,alpha'alpha'-tetrasubstituted secondary amines with 30% aqueous hydrogen peroxide as oxidant. In comparison to other catalysts reported to date, this heterogeneous catalyst offers a remarkably simple workup procedure and is reusable without any appreciable loss of activity. (c) 2005 Elsevier B.V. All rights reserved.

10aheterogeneous catalyst10aHydrogen peroxide10aN-oxide10aVS-110azeolite1 aPhukan, P.1 aKhisti, R., S.1 aSudalai, A. uhttp://library.ncl.res.in/content/green-protocol-synthesis-n-oxides-secondary-amines-using-vanadium-silicate-molecular-sieve-002637nas a2200205 4500008004100000022001400041245017900055210006900234260007300303300001000376490000800386520175900394653002602153653003002179653002802209653002502237100002602262700001402288856012902302 2007 eng d a0926-860X00aGaClx- or GaAlClx-grafted Si-MCM-41: highly active and moisture insensitive/stable catalyst for the acylation and benzylation of benzene, naphthalene and substituted benzenes0 aGaClx or GaAlClxgrafted SiMCM41 highly active and moisture insen aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcDEC a42-480 v3333 a

GaClx- and GaAlClx-grafted Si-MCM-41 catalysts were prepared by reacting anhydrous GaCl3 and mixed anhydrous GaCl3 and AlCl3, respectively, with the terminal hydroxyl groups of Si-MCM-41 (pore size: 2.5 nm) in a dry non-aqueous reaction medium (CCl4) under reflux. The catalysts showed high activity for both the acylation and benzylation (with benzoyl chloride and benzyl chloride, respectively) of benzene, toluene, p-xylene, cumene, mesitylene, anisole and naphthalene. Both the catalysts are moisture insensitive or less moisture sensitive; the presence of moisture has a beneficial effect in the acylation over both the catalysts. The catalytically active sites of the GaClx-grafted Si-MCM-41 are (-O-)(2)GaCl (i.e. partially chlorided Ga anchored to Si through -O- linkage) species and the equivalent sites of the GaAlClx-grafted Si-MCM-41 are (-O-)(2)Ga(or Al)Cl and (-O-)(3)Ga(or Al) species. The high acylation/benzylation activities of both the catalysts even in the presence of moisture are attributed to their redox properties (Ga3+ -> Ga1+) rather than to their Lewis acid properties. After the grafting/chemical bonding, the grafted gallium chloride catalyst showed much higher acylation activity but lower benzylation activity than the physically deposited (on Si-MCM-41) or unsupported GaCl3. The GaAlClx-grafted Si-MCM-41 showed higher acylation activity than the GaClx-grafted Si-MCM-41, due to a synergetic effect of the Ga and Al species. However, the relative benzylation activity of the two catalysts showed strong dependence upon the presence or absence of electron donating group(s) and also upon the electron donating ability of the group(s) attached to the aromatic nucleus. (c) 2007 Elsevier B.V. All rights reserved.

10aacylation benzylation10aGaAlClx-grafted Si-MCM-4110aGaClx-grafted Si-MCM-4110amoisture insensitive1 aChoudhary, Vasant, R.1 aJha, Rani uhttp://library.ncl.res.in/content/gaclx-or-gaalclx-grafted-si-mcm-41-highly-active-and-moisture-insensitivestable-catalyst-002692nas a2200229 4500008004100000022001400041245006800055210006800123260007300191300001200264490000700276520188700283653001902170653001902189653001902208653003302227100002702260700002202287700002702309700002502336856010102361 2007 eng d a1383-586600aGas permeation in amine functionalized silicon rubber membranes0 aGas permeation in amine functionalized silicon rubber membranes aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT a304-3130 v573 a

Silicon rubber (SR) based thin film composite (TFC) membranes find increasing applicability in various industrial separations owing to its excellent thermal and chemical stability. The functionalization of SR would provide enhanced separation characteristics for certain separation applications. The present research focuses on gas permeation properties of dense and thin film composite membranes based on amine substituted silicon rubber (ASR) and unsubstituted silicon rubber (SR). The dense membrane sorption analysis indicated that presence of amine functionality in ASR increased pressure dependant CO2 sorption capacity. Owing to this, an elevation Of CO2 permeability by 15% and CO2 based selectivities by 22-34% in comparison to that of unsubstituted SR was observed. The TFC membranes with SR and ASR as the selective layer on the top of different ultrafiltration (UF) supports with varying properties based on polyacrylonitrile and polysulfone were prepared. The effects of crucial parameters that affected TFC membrane performance, viz., coating solution concentration, UF support membrane porosity and nature of materials were investigated. The preparation of ASR based TFC membranes was demonstrated with a simple crosslinking agent-glutaraldehyde while analyzing effects of crosslinking time on their permeation properties. Polyacrylonitrile (PAN) was found to be better support layer material for ASR based TFC formation than polysulfone (PSF). Thin defect free coating layer can be obtained by appropriate combination of coating solution concentration and support UF membrane porosity. The analysis of effective skin layer thickness of TFC membranes indicated that careful optimization of these parameters is necessary to achieve defect free TFC membranes possessing a good combination of permeance and selectivity. (C) 2007 Elsevier B.V. All rights reserved.

10aCarbon dioxide10aGas permeation10asilicon rubber10athin film composite membrane1 aAchalpurkar, Manoj, P.1 aKharul, Ulhas, K.1 aLohokare, Harshada, R.1 aKaradkar, Prasad, B. uhttp://library.ncl.res.in/content/gas-permeation-amine-functionalized-silicon-rubber-membranes-002612nas a2200265 4500008004100000022001400041245009200055210006900147260007300216300001200289490000800301520170400309653001402013653001302027653001502040653001702055653001302072100002502085700002202110700002202132700002202154700002302176700002602199856012102225 2007 eng d a0376-738800aGas sorption and transport in polyarylates: effect of substituent symmetry and polarity0 aGas sorption and transport in polyarylates effect of substituent aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcOCT a244-2510 v3033 a

The gas sorption properties of polyarylates based on bisphenol-A possessing symmetric/asymmetric substitution by nonpolar -CH3 group and symmetrically linked terephthalic acid were examined. The effects of substitution of polar bromine on terephalic acid moiety of polyarylate based on asymmetrically substituted bisphenol were also studied for physical, sorption and transport properties. The estimation of dual mode sorption parameters, solubility and diffusion coefficient revealed that nature of the substituent and substitution type plays a crucial role in depicting permeation properties. An asymmetric substitution by -CH3 group increased solubility coefficient of pure gases (N-2, O-2, CH4 and CO2) up to 27% and symmetric substitution increased the same up to 106%. This was coupled with 7-35% increase in solubility selectivity in both cases of substitution, which ascertained the usefulness of methyl group substitution in polyarylates based on terephalic acid. The pressure dependency of solubility coefficients and solubility selectivity was also investigated for these polyarylates. The sorption and transport properties of these polyarylates correlated well with physical properties of polyarylates and gases studied. The sorption/desorption kinetics of symmetrically substituted TMBisA-T was performed in order to deduce time dependent sorption behavior and to evaluate diffusivity coefficient. The apparent diffusion coefficients from sorption kinetics, desorption kinetics and from steady-states permeation-sorption were compared. The diffusion coefficients of CH4 and N-2 deduced by these methods correlated well with each other. (C) 2007 Elsevier B.V. All rights reserved.

10aDiffusion10akinetics10apermeation10apolyarylates10aSorption1 aKaradkar, Prasad, B.1 aKharul, Ulhas, K.1 aBhole, Yogesh, S.1 aBadhe, Yogesh, P.1 aTambe, Sanjeev, S.1 aKulkarni, Bhaskar, D. uhttp://library.ncl.res.in/content/gas-sorption-and-transport-polyarylates-effect-substituent-symmetry-and-polarity-001125nas a2200157 4500008004100000022001400041245014200055210006900197260010600266300001200372490000700384520040300391100002600794700002000820856012700840 2007 eng d a0040-402000aGeneral and efficient route to 3 `-deoxy-3 `-N-, S-, and C-substituted altropyranosyl thymines from 2',3'-O-anhydro-mannopyranosylthymine0 aGeneral and efficient route to 3 deoxy3 N S and Csubstituted alt aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN a602-6080 v633 a

An efficient route to 1-(2,3-O-anhydro-4,6-O-phenylmethylene–D-mannopyranosyl) thymine from 1,2,4,6-tetra-O-acetyl-3-O-tosyl-beta-D-glucopyranose has been devised. This newly synthesized epoxide is opened up regioselectively at the C-3'-position by N-, S-, and C-nucleophiles to afford a wide range of new 3-deoxy-3'-substituted altropyranosyl thymines. (c) 2006 Published by Elsevier Ltd.

1 aDeshpande, Sachin, G.1 aPathak, Tanmaya uhttp://library.ncl.res.in/content/general-and-efficient-route-3-deoxy-3-n-s-and-c-substituted-altropyranosyl-thymines-23-o02228nas a2200241 4500008004100000022001400041245017300055210006900228260007300297300001200370490000800382520125300390653003301643653002201676653002201698653002801720653002101748653002201769100002601791700001801817700002201835856012901857 2007 eng d a0926-860X00aGeneration of hydrogen peroxide via the selective reduction of oxygen by hydrazine sulfate over Br-promoted Pd/Al2O3 catalyst in an aqueous medium at ambient conditions0 aGeneration of hydrogen peroxide via the selective reduction of o aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR a202-2090 v3233 a

The in situ generation of H2O2 via the selective reduction of OZ by hydrazine sulfate (in an aqueous medium) has been thoroughly investigated over the Br-promoted Pd(or PdO)/Al2O3 catalyst. The influence of the following factors have been addressed in this study: (a) Br concentration (in the reaction medium or incorporated in the catalyst); (b) reaction conditions (viz. reaction time, temperature); (c) concentrations of reducing agent and phosphoric acid in the reaction medium. Decomposition of N2H4 (from NH4-H2SO4) and its reaction with H2O2 under similar reaction conditions (in the absence of O-2) have also been studied. H2O2, which is an intermediate product of the O-2 reduction, is involved in further consecutive reactions. It can be converted to water via its decomposition and/or reaction with the unconverted NZH(4). In the presence of Br promoter, the later (reaction with unconverted N2H4) is more dominant. Both the consecutive reactions are drastically retarded in the presence of protons and Br promoter. A plausible reaction mechanism has been proposed for illustrating the role of the protons and Br promoter in the selective formation of H2O2 in the O-2 reduction process. (C) 2007 Elsevier B.V. All rights reserved.

10abrominated Pd/Al2O3 catalyst10ahydrazine sulfate10aHydrogen peroxide10ain situ H2O2 generation10aoxygen reduction10aPd/Al2O3 catalyst1 aChoudhary, Vasant, R.1 aJana, Prabhas1 aSamanta, Chanchal uhttp://library.ncl.res.in/content/generation-hydrogen-peroxide-selective-reduction-oxygen-hydrazine-sulfate-over-br-promoted01772nas a2200265 4500008004100000022001400041245009300055210006900148260008800217300001400305490000700319520078000326653002401106653003301130653002101163653003401184100002201218700002601240700002001266700002301286700002401309700002601333700002101359856012601380 2007 eng d a0011-389100aGenetic diversity analysis of mango cultivars using inter simple sequence repeat markers0 aGenetic diversity analysis of mango cultivars using inter simple aC V RAMAN AVENUE, PO BOX 8005, BANGALORE 560 080, INDIAbCURRENT SCIENCE ASSOCcOCT a1135-11410 v933 a

With 33 polymorphic Inter Simple Sequence Repeat (ISSR) markers, genetic diversity among 70 mango cultivars and a distant outgroup was analysed. Clustering was done using Dice and Jaccard coefficients with bootstrapping. Multivariate analysis was conducted using the Euclidean distances. Among the total 420 bands, 408 were polymorphic. Probability that any ISSR fragment is shared by two different cultivars was calculated to be 2.54 x 10(-1). Non-Indian mango cultivars were found genetically diverged from Indian mango germ pool. No separation was observed between North Indian and South Indian cultivars. Twelve different cultivar-specific bands were detected for six cultivars, which approved the effectiveness of ISSR markers in mango genetic diversity analysis.

10aDNA finger printing10ainter simple sequence repeat10aMangifera indica10aprinciple coordinate analysis1 aPandit, Sagar, S.1 aMitra, Sirsha, Sribas1 aGiri, Ashok, P.1 aPujari, Keshav, H.1 aPatil, Bhimarao, P.1 aJambhale, Narayan, D.1 aGupta, Vidya, S. uhttp://library.ncl.res.in/content/genetic-diversity-analysis-mango-cultivars-using-inter-simple-sequence-repeat-markers-001560nas a2200193 4500008004100000022001400041245005400055210005400109260007100163300001400234490000700248520090200255100002701157700002201184700002601206700002101232700003201253856008101285 2007 eng d a0888-588500aGeometrical solution to the sharkskin instability0 aGeometrical solution to the sharkskin instability a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY a3048-30560 v463 a

We study the effect of die exit divergence on the sharkskin behavior, both experimentally as well as through the use of computational fluid dynamics (CFD) simulations. Sharkskin or surface fracture is known to occur immediately after the die exit, because of the large elongational deformation that a polymer melt experiences as it exits the die. We show that the diverging taper at the die exit postpones or completely removes the occurrence of sharkskin. The corresponding CFD simulations of an equivalent K-BKZ fluid show that the taper at the die exit significantly reduces the severity of the elongational flow, thereby reducing the normal stresses as the polymer melt leaves the die. We believe that, in an extrusion operation, the provision of a diverging taper at the die exit is one of the potential measures by which sharkskin instability can be eliminated on an industrial scale.

1 aPol, Harshawardhan, V.1 aJoshi, Yogesh, M.1 aTapadia, Prashant, S.1 aLele, Ashish, K.1 aMashelkar, Raghunath, Anant uhttp://library.ncl.res.in/content/geometrical-solution-sharkskin-instability01495nas a2200217 4500008004100000022001400041245011700055210006900172260007900241300001000320490000800330520068300338653002101021653000901042653002401051653001301075100002501088700001901113700001401132856013101146 2007 eng d a1431-673000aGlycine-assisted enhancement of 1,4-beta-D-xylan xylanohydrolase activity at alkaline pH with a pH optimum shift0 aGlycineassisted enhancement of 14betaDxylan xylanohydrolase acti aGENTHINER STRASSE 13, D-10785 BERLIN, GERMANYbWALTER DE GRUYTER GMBHcJAN a61-650 v3883 a

This is the first report describing the enhancement of xylanase activity by the neutral amino acid glycine. Xylanase activity is increased seven-fold at alkaline pH in the presence of glycine and its pH optimum is shifted from pH 7 to 8 without using any protein engineering techniques. Analysis of the steady-state kinetics revealed that glycine in the reaction mixture increases the K-m and k(cat) values of the enzyme. Chemoaffinity labeling and studies using glycine esters indicate an involvement of the carboxylate ion of glycine in enhancing xylanase catalytic activity. A novel possible mechanism for the glycine-assisted catalytic action of xylanase is proposed.

10aEnzyme catalysis10aOPTA10aThermomonospora sp.10aXylanase1 aVathipadiekal, Vinod1 aVerma, Anamika1 aRao, Mala uhttp://library.ncl.res.in/content/glycine-assisted-enhancement-14-beta-d-xylan-xylanohydrolase-activity-alkaline-ph-ph-optimum01870nas a2200229 4500008004100000022001400041245008000055210006900135260009500204300001400299490000600313520101500319653002701334653003101361653001301392653003401405100002301439700002601462700002001488700002601508856010601534 2007 eng d a1533-488000aGrafting reactions of living macroanions with multi-walled carbon nanotubes0 aGrafting reactions of living macroanions with multiwalled carbon a25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USAbAMER SCIENTIFIC PUBLISHERScAPR a1560-15670 v73 a

Grafting reactions of living polystyryllithium (PSLi) with acid chloride containing multi-walled carbon nanotubes (MWNTs-COCl) were performed under vacuum in benzene at room temperature. Covalent grafting of polystyrene (PS) was characterized using spectroscopic, microscopic, and thermogravimetric analyses. Grafting at different ratios of macroanion to acylchloride of the carbon nanotubes showed that the grafting efficiency was not dependent on the concentration of the macroanions. The mole percent of PS present in the MWNTs-g-PS samples was inversely proportional to the precursor molecular weight of PSLi. Direct reactions of PSLi, polybutadienyllithium and n-butyllithium with pristine MWNTs without any functional groups were also performed in the presence and in the absence of tetrahydrofuran in benzene. The grafting reactions of living macroanions either with MWNTs-COCl or with pristine MWNTs indicated a partial grafting of polymer on the carbon nanotubes in benzene at room temperature.

10aAnionic polymerization10acovalent functionalization10agrafting10amulti-walled carbon nanotubes1 aBaskaran, Durairaj1 aSakellariou, Georgios1 aMays, Jimmy, W.1 aBratcher, Matthew, S. uhttp://library.ncl.res.in/content/grafting-reactions-living-macroanions-multi-walled-carbon-nanotubes01713nas a2200217 4500008004100000020002200041022001400063245012800077210006900205260024700274300001200521490000900533520071200542100001801254700002601272700002101298700001401319700001501333700001601348856013101364 2007 eng d a978-3-540-77045-9 a0302-974300aGranular support vector machine based method for prediction of solubility of proteins on overexpression in Escherichia coli0 aGranular support vector machine based method for prediction of s aHeidelberger Platz 3, D-14197 Berlin, GermanybIndian Stat Inst, Machine Intelligence Univ; ISI Ctr Soft Comp Res; Int Assoc Pattern Recognit; Int Ctr Pure & Appl Math; Web Intelligence Consortium; Yahoo India Res & Dev; Philips Res AsiacDEC a406-4150 v48153 a

We employed a granular support vector Machines(GSVM) for prediction of soluble proteins on over expression in Escherichia coli. Granular computing splits the feature space into a set of subspaces (or information granules) such as classes, subsets, clusters and intervals [14]. By the principle of divide and conquer it decomposes a. bigger complex problem into smaller and computationally simpler problems. Each of the granules is then solved independently and all the results are aggregated to form the final solution. For the purpose of granulation association rules was employed. The results indicate that a difficult imbalanced classification problem can be successfully solved by employing GSVM.

1 aKumar, Pankaj1 aJayaraman, Valadi, K.1 aKulkarni, B., D.1 aGhosh, A.1 aDe, R., K.1 aPal, S., K. uhttp://library.ncl.res.in/content/granular-support-vector-machine-based-method-prediction-solubility-proteins-overexpression-102665nas a2200145 4500008004100000245008200041210006900123260000800192300001400200520212500214100002002339700002002359700003102379856010902410 2007 eng d00aGroup 11 metal complexes of mesocyclic thioether-aminophosphonites, (-OC10H6)0 aGroup 11 metal complexes of mesocyclic thioetheraminophosphonite cFEB a720–7313 a

Group 11 metal complexes of the mesocyclic thioether aminophosphonites [-OC10H6(μ-S)C10H6O-]PNC4H8E {2a: E = O; 2b: E = NMe; IUPAC names: 4-(dinaphtho[2,1-d:1′,2′-g][1,3,6,2]dioxathiaphosphocin-4-yl)morpholine (2a), 1-(dinaphtho[2,1-d:1′,2′-g][1,3,6,2]dioxathiaphosphocin-4-yl)-4-methylpiperazine (2b)} are reported. Thioether aminophosphonites 2a and 2b react with CuX (X = Cl, Br, and I) in a 1:1 molar ratio to give the tricoordinate, dimeric complexes [{[{-OC10H6(μ-S)C10H6O-}PNC4H8E-κP]Cu(μ-X)}2] (4a: E = O, X = Cl; 4b: E = NMe, X = Cl; 5a: E = O, X = Br; 5b: E = NMe, X = Br; 6a: E = O, X = I; 6b: E = NMe, X = I), whereas with 2:1 molar ratios monomeric complexes of the type[{[-OC10H6(μ-S)C10H6O-]PNC4H8O-κP}2CuX] (7a: E = O, X = Cl; 7b: E = NMe, X = Cl; 8a: E = O, X = Br; 8b: E = NMe, X = Br; 9a: E = O, X = I; 9b: E = NMe, X = I) are obtained in excellent yield. The P,S-chelated cationic complexes[{[-OC10H6(μ-S)C10H6O-]PNC4H8E-κP,κS}2Cu]BF4 (10a: E = O; 10b: E = NMe) are obtained when 2a and 2b are treated with half an equivalent of [(MeCN)4Cu]BF4. Similarly, thesilver complexes [{[{-OC10H6(μ-S)C10H6O-}PNC4H8E-κP,κS]AgCF3SO3}2] (11a: E = O: 11b: E = NMe) and [{[-OC10H6(μ-S)C10H6O-]PNC4H8E-κP,κS}Ag(PPh3)]CF3SO3 (12a: E = O; 12b: E = NMe) are synthesized by the treatment of thioether aminophosphonites 2a and 2b with AgOTf and [Ag(PPh3)][OTf], respectively. Reactions of 2a and 2b with [AuCl(SMe2)] produce the simple monomeric gold(I) complexes [{[-OC10H6(μ-S)C10H6O-]PNC4H8E-κP}AuCl] (13a: E = O; 13b: E = NMe). The iodo derivatives [{[-OC10H6(μ-S)C10H6O-]PNC4H8E-κP}AuI] (14a: E = O; 14b: E = NMe) are obtained by the halide-exchange reaction of 13a and 13b with CuI at room temperature. The structures of complexes 5a, 7a, 8a, 13a, 13b, and 14a are confirmed by single-crystal X-ray diffraction studies. In all of these complexes, the sulfur atom in the mesocyclic ring shows coordinative interaction towards the phosphorus atom, and in 5a, 7a, 8a, and 14a towards the metal center as well. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

1 aPunji, Benudhar1 aMague, Joel, T.1 aBalakrishna, Maravanji, S. uhttp://library.ncl.res.in/content/group-11-metal-complexes-mesocyclic-thioether-aminophosphonites-oc10h601615nas a2200193 4500008004100000022001400041245014200055210006900197260007300266300001400339490000600353520080100359653003001160653002901190653003201219100002601251700001401277856013001291 2008 eng d a1566-736700aGaAlCl(x)-grafted Mont.K-10 clay: highly active and stable solid catalyst for the friedel-crafts type benzylation and acylation reactions0 aGaAlClxgrafted MontK10 clay highly active and stable solid catal aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAR a1101-11050 v93 a

A liquid phase reaction of anhydrous GaCl(3) and AlCl(3) with the surface hydroxyl groups (with HCl evolution) of Mont. K-10 clay in dry CCL(4) under reflux resulted in a novel GaAlCl(x),-grafted Mont.K-10 catalyst [with Cl/(Ga + Al) = 1]. The catalyst showed high activity and stability in the Freidel-Crafts type benzylation and benzoylation (by benzyl chloride and benzoyl chloride, respectively) of benzene, naphthalene and substituted benzenes, even in the presence of moisture. It also showed good activity for the benzoylation of nitrobenzene (i.e. even in the presence of strong electron withdrawing group, like nitro group, attached to the benzene ring). The catalytically active surface species in the catalyst are -(O)(2)-Ga(or Al)Cl. (c) 2007 Elsevier B.V. All rights reserved.

10abenzoylation of aromatics10abenzylation of aromatics10aGaAlCl(x)-grafted Mont.K-101 aChoudhary, Vasant, R.1 aJha, Rani uhttp://library.ncl.res.in/content/gaalclx-grafted-montk-10-clay-highly-active-and-stable-solid-catalyst-friedel-crafts-type-001388nas a2200181 4500008004100000022001400041245009400055210006900149260008100218300001400299490000700313520066500320100002500985700002501010700002901035700002201064856012001086 2008 eng d a0002-782000aGas-sensing properties of zinc ferrite nanoparticles synthesized by the molten-salt route0 aGassensing properties of zinc ferrite nanoparticles synthesized  a9600 GARSINGTON RD, OXFORD OX4 2DQ, OXON, ENGLANDbBLACKWELL PUBLISHINGcAUG a2724-27260 v913 a

Zinc ferrite (ZnFe2O4) nanoparticles have been synthesized at 700 degrees C using sodium chloride as a growth inhibitor. Single-phase formation of spinel zinc ferrite having crystallite size in the range of 15-20 nm was observed by XRD and confirmed by TEM. In the present work, the gas-sensing properties of these zinc ferrite nanoparticles toward ethanol, LPG, H-2, NOx. SOx, and H2S have been studied. It was found that they exhibit excellent selective sensitivity toward 200 ppm of H2S at the operating temperature of 250 degrees C, and thus this nanosized ferrite is expected to be useful in an industrial application as a potential H2S gas sensor.

1 aDarshane, Sonali, L.1 aDeshmukh, Rupali, G.1 aSuryavanshi, Shankar, S.1 aMulla, Imtiaz, S. uhttp://library.ncl.res.in/content/gas-sensing-properties-zinc-ferrite-nanoparticles-synthesized-molten-salt-route-002133nas a2200145 4500008004100000022001400041245008200055210006900137260007400206300001400280490000700294520154800301100002201849856011601871 2008 eng d a0957-453000aGelatin hydrogels: enhanced biocompatibility, drug release and cell viability0 aGelatin hydrogels enhanced biocompatibility drug release and cel aVAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDSbSPRINGERcJUN a2351-23580 v193 a

Biodegradability and enhanced biocompatibility with pH-sensitivity of hydrogels are becoming very important issues for biomaterials applications so as to minimize the host-body reactions such as, inflammatory, antigenic, and immunogenic problems. This study involves development of hydrogel matrices of gelatin conjugated/modified with highly hydrophilic, pH-sensitive and biocompatible polymer, poly (2-ethyl-2-oxazoline) and glyoxylic acid respectively. Various compositions of gelatin conjugated/modified with poly (2-ethyl-2-oxazoline) (gp) and glyoxylic acid (gg) were synthesized. The swelling kinetics, cell viability and drug release capability from the gels at pH 4.5 and 7.4 were investigated. The results of swelling kinetics showed that, both the degree of swelling (DS) and the maximum degree of swelling (MDS) increased as function of modification (increase in modification) and pH with an increase of time, which is due to increase in ionic groups. The drug-release (1% chlorhexidine) studies at pH 7.4 and 4.5 confirmed a proportional drug release with an increase in degree of swelling. The results of in-vitro cytotoxicity tests using mouse embryonic 3T3 fibroblast cells indicated, an improved cell viability for gelatin gels conjugated/modified with poly (2-ethyl-2-oxazoline) (gp) and glyoxylic acid (gg) gels, when compared with 1% glutaraldehyde cross-linked gelatin gels (gx). Hence, cross-linked gelatin gels can be replaced with gp/gg for potential use in biomedical applications as a matrix for drug delivery.

1 aRathna, G., V. N. uhttp://library.ncl.res.in/content/gelatin-hydrogels-enhanced-biocompatibility-drug-release-and-cell-viability-002385nas a2200205 4500008004100000022001400041245011200055210006900167260007100236300001400307490000800321520157900329100002101908700001801929700003201947700002401979700001902003700002702022856013002049 2008 eng d a1520-610600aGelation of covalently edge-modified laponites in aqueous media. 1. rheology and nuclear magnetic resonance0 aGelation of covalently edgemodified laponites in aqueous media 1 a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAPR a4536-45440 v1123 a

We describe the covalent modification of the edges of laponite with organic groups and the influence of this modification on gelation behavior. We compare three materials: an unmodified laponite, a laponite edge modified with a trimethyl moiety (MLap), and an octyldimethyl moiety (OLap). Gelation is investigated using rheology and NMR T-1 relaxation measurements and nuclear Overhauser enhancement spectroscopy (NOESY). MLap and OLap show qualitatively different gelation. Gelation of MLap is very similar to laponite: MLap gels over the same time scale as laponite and has about the same solid modulus, and the MLap gel is almost as transparent as laponite. In contrast, OLap gels rapidly relative to laponite and forms a weak, turbid gel. We believe that gelation in laponite and MLap results from the formation of a network of well-dispersed platelets (or a few platelets), while in OLap, gelation results from a network of stacks of several platelets. NMR relaxation measurements indicate that gelation does not affect the average relaxation of water protons. However, T, increases marginally for the protons in the organic moieties in MLap and decreases for protons in the organic moieties in OLap. Relaxation measurements, analyses of line width, and NOESY taken together suggest that, in OLap, gelation is a consequence of association of the organic moieties on the laponite edges, and that this association strengthens with time. Thus, the time-dependent changes in NMR suggest a structural origin for the time-dependent changes in the rheological behavior.

1 aPatil, Suhas, P.1 aMathew, Renny1 aAjithkumar, Thalasseril, G.1 aRajamohanan, P., R.1 aMahesh, T., S.1 aKumaraswamy, Guruswamy uhttp://library.ncl.res.in/content/gelation-covalently-edge-modified-laponites-aqueous-media-1-rheology-and-nuclear-magnetic-001588nas a2200289 4500008004100000020002200041022001400063245004500077210004500122260010600167300001200273490000900285520068300294653002900977653001301006653002101019100002401040700002101064700002801085700001801113700002201131700001101153700001701164700001801181700002101199856007801220 2008 eng d a978-0-7354-0549-3 a0094-243X00aGelation of regenerated fibroin solution0 aGelation of regenerated fibroin solution aMonterey, CA.bAmer Inst Physics, 2 Huntington Quadrangle, STE 1NO1, Melville, NY 11747-4501 USAcAUG a573-5750 v10273 a

Silk fibroin is a high molecular weight multiblock ampiphillic protein known for its ability to form high strength fibers. It is also biocompatible; silk sutures have been traditionally used for many centuries. Recently, there has been much interest in making silk hydrogels for applications ranging from tissue engineering to controlled delivery. Fibroin gels can be formed from aqueous solutions by changing one or more state variables such as pH, temperature and ionic strength. In this work we present our investigations on the gelation of aqueous fibroin solutions derived from Bombyx Mori silk using light scattering, confocal microscopy and rheological techniques.

10adynamic light scattering10aRheology10asilk fibroin gel1 aNagarkara, Shailesh1 aLele, Ashish, K.1 aChassenieux, Christophe1 aNicolai, Taco1 aDurand, Dominique1 aCo, A.1 aLeal, L., G.1 aColby, R., H.1 aGiacomin, A., J. uhttp://library.ncl.res.in/content/gelation-regenerated-fibroin-solution-102242nas a2200217 4500008004100000022001400041245010900055210006900164260006900233300001200302490000800314520138400322653001801706653003101724653003301755653002501788653002801813653003001841100002501871856012801896 2008 eng d a1385-894700aGeneral model for analyzing data on the rate of reactive dissolution of poly-disperse particulate solids0 aGeneral model for analyzing data on the rate of reactive dissolu aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcAPR a347-3600 v1373 a

A model has been presented which successfully simulates the experimentally observed integral batch reactive dissolution rate data while accounting for the poly-dispersity of the solid particulate charge. This allowed avoiding arbitrary assumptions about the particulate inventory and size independence of the mass transfer coefficient. There is also no need for a priori identification of the controlling regime, which can change from kinetic to mass transfer during the process, apart from the possibility of the shift with the specified process and operating conditions. The model was applied with equal ease to a simple isothermal reaction, an exothermic reaction with runaway potential and to a phase-transfer catalysis reaction with a complex mechanism. The model was shown to predict the time required for a specified extent of conversion of the particulate reactant or the rate of consumption of a key liquid reactant under a variety of process and operating conditions, like temperature, liquid reactant and the catalyst concentration, particle size, poly-dispersity of the charge and agitation speed. Such information is useful in reactor design and scale-up. Where dissolution is accompanied with a runaway reaction, the model can predict quantities of interest in hazard assessment and should aid safe reactor design. (c) 2007 Elsevier B.V. All rights reserved.

10akinetic model10aparticle size distribution10apoly-disperse solid reactant10areactive dissolution10areactive thermal hazard10asolid-liquid PTC reaction1 aBhattacharya, Arijit uhttp://library.ncl.res.in/content/general-model-analyzing-data-rate-reactive-dissolution-poly-disperse-particulate-solids-000855nas a2200157 4500008004100000022001400041245008900055210006900144260007100213300001400284490000700298520023700305100002200542700001900564856011400583 2008 eng d a0022-326300aGeneral strategy for the synthesis of natural and unnatural dialkylmaleic anhydrides0 aGeneral strategy for the synthesis of natural and unnatural dial a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcSEP a6936-69380 v733 a

Starting from alkylidenesuccinimides, a wide range of dialkylmaleic anhydrides have been synthesized via the generation of a carbanion on a succinimide unit and its condensation with various alkyl halides as the key reaction.

1 aHaval, Kishan, P.1 aArgade, N., P. uhttp://library.ncl.res.in/content/general-strategy-synthesis-natural-and-unnatural-dialkylmaleic-anhydrides-001091nas a2200145 4500008004100000022001400041245014300055210006900198260011000267300001400377520038300391100002700774700002000801856012400821 2008 eng d a1359-734500aGold mediated glycosylations: selective activation of propargyl 1,2-orthoesters in the presence of aglycones containing a propargyl moiety0 aGold mediated glycosylations selective activation of propargyl 1 aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUL a4282-42843 a

Selective activation of propargyl 1,2-orthoesters in the presence of propargyl glycosides and propargyl ethers was studied; a catalytic amount of AuBr(3) activated the propargyloxy, group of the 1,2-orthoester thereby giving access to disaccharides with the propargyl group at the reducing end; furthermore, propargyl ethers were unaffected under the reaction conditions.

1 aSureshkumar, Gopalsamy1 aHotha, Srinivas uhttp://library.ncl.res.in/content/gold-mediated-glycosylations-selective-activation-propargyl-12-orthoesters-presence-001229nas a2200169 4500008004100000022001400041245003600055210003600091260011000127300001400237490000700251520065200258100003000910700002100940700002600961856007200987 2008 eng d a0306-001200aGold nanoparticle superlattices0 aGold nanoparticle superlattices aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a1871-18830 v373 a

Ordered metal nanoparticle assemblies-superlattices-have captivated and stirred the imagination of scientists and engineers alike and promise great prospect for future technologies. This potential though will greatly be determined by the understanding and control that can be exerted on the assembling processes. This tutorial review presents a brief account of the factors that govern the formation of superlattices and then presents several examples of gold nanoparticle superlattices that are distinguished by the size of participating particles, chain length/functional group of the capping agent, the substrates on which they form etc.

1 aPrasad, Bhagavatula L. V.1 aSorensen, C., M.1 aKlabunde, Kenneth, J. uhttp://library.ncl.res.in/content/gold-nanoparticle-superlattices-000510nas a2200145 4500008004100000022001400041245005000055210004900105260006800154300001000222490000600232100002200238700001900260856008500279 2008 eng d a1932-214300aGuest editorial: computational fluid dynamics0 aGuest editorial computational fluid dynamics a111 RIVER ST, HOBOKEN, NJ 07030 USAbJOHN WILEY & SONS INCcMAR a95-960 v31 aRanade, Vivek, V.1 aPareek, Vishnu uhttp://library.ncl.res.in/content/guest-editorial-computational-fluid-dynamics-001966nas a2200241 4500008004100000022001400041245008400055210006900139260006900208300001200277490000800289520111400297653001301411653001501424653005501439100002001494700001901514700002001533700001801553700001701571700002201588856011401610 2009 eng d a0925-838800aGas sensing properties of magnesium ferrite prepared by co-precipitation method0 aGas sensing properties of magnesium ferrite prepared by coprecip aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcNOV a270-2720 v4883 a

Polycrystalline magnesium ferrite (MgFe(2)O(4)) was prepared by the co-precipitation method. The synthesized compound was characterized for their phase and morphology by X-ray diffraction and scanning electron microscopy, respectively. Conductance responses of the (MgFe(2)O(4)) were measured towards gases like hydrogen sulfide (H(2)S), liquefied petroleum gas (LPG), ethanol vapors (C(2)H(5)OH), SO(x), H(2), NO(x), NH(3), methanol, acetone and petrol. The gas sensing characterstics were obtained by measuring the sensitivity as a function of various controlling factors like operating temperatures and concentrations of gases. It was found that the sensor exhibited various responses towards these gases at different operating temperatures. Furthermore; the MgFe(2)O(4) based sensor exhibited a fast response and a good recovery towards petrol at temperature 250 degrees C. The results of the response towards petrol reveal that (MgFe(2)O(4)) synthesized by a simple co-precipitation method, would be a suitable material for the fabrication of the petrol sensor. (C) 2009 Published by Elsevier B.V.

10aFerrites10aGas sensor10aX-ray diffraction and scanning electron microscopy1 aHankare, P., P.1 aJadhav, S., D.1 aSankpal, U., B.1 aPatil, R., P.1 aSasikala, R.1 aMulla, Imtiaz, S. uhttp://library.ncl.res.in/content/gas-sensing-properties-magnesium-ferrite-prepared-co-precipitation-method-001505nas a2200229 4500008004100000022001400041245016600055210006900221260010600290300001400396490000700410520050800417653003000925653005100955653001301006653004601019653001501065100002001080700002901100700001901129856012701148 2009 eng d a0040-402000aGeneral approach to medium-sized ring ethers via hydrolytic and oxidative kinetic resolutions: stereoselective syntheses of (-)-cis-lauthisan and (+)-isolaurepan0 aGeneral approach to mediumsized ring ethers via hydrolytic and o aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcMAR a2226-22310 v653 a

A short and enantioselective approach to medium ring ethers and its application to the syntheses of (-)-cis-lauthisan and (+)-isolaurepan are described. The synthetic strategy features Jacobson's Hydrolytic Kinetic Resolution (HKR), oxidative resolution of secondary alcohol, and highly diastereoselective Et(3)SiH/TMSOTf-promoted reductive cyclization of a hydroxy ketone to give exclusively the different medium-sized cis-disubstituted cyclic ethers. (C) 2009 Elsevier Ltd. All rights reserved.

10acis-Reductive cyclization10aJacobson's Hydrolytic Kinetic Resolution (HKR)10aOxepanes10aOxidative resolution of secondary alcohol10aRing ether1 aTripathi, Divya1 aPandey, Satyendra, Kumar1 aKumar, Pradeep uhttp://library.ncl.res.in/content/general-approach-medium-sized-ring-ethers-hydrolytic-and-oxidative-kinetic-resolutions-000961nas a2200181 4500008004100000022001400041245006000055210005700115260008000172300001200252490000700264520031500271100002400586700002600610700002600636700002600662856009100688 2009 eng d a0971-162700aGreen and sustainable approach to BIS-(INDOLYL) alkanes0 aGreen and sustainable approach to BISINDOLYL alkanes aC-85 SECTOR-B, ALIGANJ SCHEME, LUCKNOW, INDIA 226020 USAbDR R S VARMAcJAN a279-2820 v183 a

An efficient, high yielding, green and mild method has been developed for the synthesis of bis (indolyl) methanes using dodecylsulphonic acid as an effective surfactant type Bronsted acid catalyst in aq media. The method is excellent for various new bis-(indolyl) methanes derived from pyrazolaldehydes.

1 aGholap, Somnath, S.1 aWakchaure, Prasad, B.1 aPandhare, Gajanan, R.1 aGill, Charansingh, H. uhttp://library.ncl.res.in/content/green-and-sustainable-approach-bis-indolyl-alkanes-001390nas a2200229 4500008004100000022001400041245008200055210006900137260007700206300001000283490000700293520063100300653001900931653001900950653001000969653001200979653000800991100001800999700001801017700001301035856011201048 2009 eng d a0232-130000aGrowth of barium oxalate crystals in agar-agar gel and their characterization0 aGrowth of barium oxalate crystals in agaragar gel and their char aPO BOX 10 11 61, D-69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJAN a36-420 v443 a

{Single crystals of barium oxalate have been grown by get method using agar-agar gel as media of growth at ambient temperature. The optimum conditions were established by varying various parameters such as concentration of gel, concentration of reactant, gel setting time etc. Prismatic platy shaped transparent crystals were obtained. The grown crystals were characterized through powder X-ray diffraction (XRD), Fourier transform infrared (FT-IR) studies, Thermogravimetric (TGA) and Differential thermal analysis (DTA). The compound crystallizes under monoclinic structure with lattice parameters a = 6.6562 angstrom

10abarium oxalate10aCrystal growth10aFT-IR10aTGA/DTA10aXRD1 aDalai, P., V.1 aSaraf, K., B.1 aShah, S. uhttp://library.ncl.res.in/content/growth-barium-oxalate-crystals-agar-agar-gel-and-their-characterization-001883nas a2200253 4500008004100000022001400041245009800055210006900153260011000222300001000332490000700342520096700349653001701316653001601333653002001349653002201369653001401391100002201405700002501427700001901452700001501471700001801486856012501504 2010 eng d a0971-457X00aGas-phase oxidant-free oxidation of cyclohexanol over V2O5-MoO3-M2O (M = Na, K, Cs) catalysts0 aGasphase oxidantfree oxidation of cyclohexanol over V2O5MoO3M2O  aDR K S KRISHNAN MARG, PUSA CAMPUS, NEW DELHI 110 012, INDIAbNATL INST SCIENCE COMMUNICATION-NISCAIRcJAN a43-490 v173 a

Oxidant-free oxidation (dehydrogenation) of cyclohexanol is carried out in a down-flow integral laboratory scale reactor using different alkali doped catalysts. The effect of reaction temperature, contact time (W/F) and doping of alkali metals is studied to check its effect on nature of prominent products of the reaction (cyclohexanone and cyclohexene). At lower temperature the cyclohexanone prevails whereas at higher temperature cyclohexene is observed in prominence. Acid-modified catalysts (with boron and phosphorous) facilitated cyclohexene selectivity whereas alkali modified catalysts facilitated cyclohexanone selectivity. Calcination of sodium modified catalyst at different temperatures under static condition affect characteristic phase intensity and cyclohexanone selectivity. XRD investigation showed formation of different inorganic phases as the characteristic of dopant. Cesium modified catalyst showed better dehydrogenation activity.

10aCyclohexanol10adehydration10aDehydrogenation10aElectronegativity10aV2O5-MoO31 aVyawahare, Y., K.1 aChumbhale, Vilas, R.1 aPardhy, S., A.1 aSamuel, V.1 aAswar, A., S. uhttp://library.ncl.res.in/content/gas-phase-oxidant-free-oxidation-cyclohexanol-over-v2o5-moo3-m2o-m-na-k-cs-catalysts-001097nas a2200169 4500008004100000022001400041245012400055210006900179260011000248300001400358490000600372520036000378100001900738700002000757700002600777856012400803 2010 eng d a1477-052000aGeneral and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation0 aGeneral and concise asymmetric synthesis of sphingosine safingol aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a5074-50860 v83 a

A novel, practical and efficient enantioselective synthesis of sphingoid bases, L-threo-[2S,3S]-sphinganine (safingol), L-threo-[2S,3S]-sphingosine, L-arabino-[2R,3S,4R] and L-xylo-[2R,3S,4S]-C(18)-phytosphingosine is described. The synthetic strategy features the Sharpless kinetic resolution and tethered aminohydroxylation (TA) as the key steps.

1 aKumar, Pradeep1 aDubey, Abhishek1 aPuranik, Vedavati, G. uhttp://library.ncl.res.in/content/general-and-concise-asymmetric-synthesis-sphingosine-safingol-and-phytosphingosines-001253nas a2200229 4500008004100000022001400041245014100055210006900196260010300265300001400368490000700382520031000389653003800699653002900737653002300766653002700789653002300816653001400839100002200853700001900875856012900894 2010 eng d a0376-469900aGeneral approach to 2,4-dialkyl-3-carboxybutyrolactones: an efficient synthesis of (+/-)-striatisporolide A and (+/-)-lichesterinic acid0 aGeneral approach to 24dialkyl3carboxybutyrolactones an efficient aANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIAbCOUNCIL SCIENTIFIC & INDUSTRIAL REScAUG a1071-10750 v493 a

Starting from 2-alkylidene-3-methylsuccinimides, simple and efficient synthesis of the natural products striatisporolide A. lichesterinic acid and lichesterylic acid have been demonstrated via an acid catalyzed hydrolysis, esterification, OsO(4)-dihydroxylation and dehydrative cyclization pathway.

10a2-Alkylidene-3-methylsuccinimides10adehydrative cyclizations10alichesterinic acid10aOsO(4)-dihydroxylation10astriatisporolide A10asynthesis1 aPatel, Ramesh, M.1 aArgade, N., P. uhttp://library.ncl.res.in/content/general-approach-24-dialkyl-3-carboxybutyrolactones-efficient-synthesis-striatisporolide-000791nas a2200181 4500008004100000022001400041245012900055210006900184260007100253490000800324100002600332700002400358700002600382700002500408700002300433700002700456856012600483 2010 eng d a0065-772700aGlycerine to renewable amino alcohol: reaction mechanism and kinetics of the catalytic reductive amination of hydroxyacetone0 aGlycerine to renewable amino alcohol reaction mechanism and kine a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR0 v2391 aArredondo, Victor, M.1 aGibson, Michael, S.1 aFairweather, Neil, T.1 aDaniels, Angella, C.1 aKreuzer, David, P.1 aJaganathan, Rengaswamy uhttp://library.ncl.res.in/content/glycerine-renewable-amino-alcohol-reaction-mechanism-and-kinetics-catalytic-reductive-001032nas a2200157 4500008004100000022001400041245007200055210006800127260010600195300001400301490000700315520040500322100002400727700002000751856010300771 2010 eng d a0040-403900aGold-catalyzed glycosidations: synthesis of 1,6-anhydro saccharides0 aGoldcatalyzed glycosidations synthesis of 16anhydro saccharides aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV a5912-59140 v513 a

Various 1,6-anhydro sugars are synthesized utilizing salient features of gold-catalyzed glycosidations. All the reactions occurred under mild conditions in the presence of 7 mol % of AuBr(3) enabling easy synthesis of 1,6-anhydro sugars from corresponding 6-hydroxy propargyl/methyl monosaccharides, disaccharides, and trisaccharides in good yields. (C) 2010 Elsevier Ltd. All rights reserved.

1 aThadke, Shivaji, A.1 aHotha, Srinivas uhttp://library.ncl.res.in/content/gold-catalyzed-glycosidations-synthesis-16-anhydro-saccharides-001138nas a2200157 4500008004100000022001400041245014500055210006900200260010600269300001400375490000700389520041400396100002700810700002000837856012300857 2010 eng d a0040-403900aGold-catalyzed glycosidations: unusual cleavage of the interglycosidic bond while studying the armed/disarmed effect of propargyl glycosides0 aGoldcatalyzed glycosidations unusual cleavage of the interglycos aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcOCT a5269-52720 v513 a

Armed/disarmed effect of propargyl glycosides in the presence of AuBr(3) is studied. Observed that oxophilic AuBr(3) cleaves interglycosidic bond of an armed disaccharide resulting in the formation of a disaccharide and a 1,6-anhydro sugar. Trisaccharides were obtained after fine tuning the reactivity of the glycosyl donor with different protecting groups. (C) 2010 Elsevier Ltd. All rights reserved.

1 aKayastha, Abhijeet, K.1 aHotha, Srinivas uhttp://library.ncl.res.in/content/gold-catalyzed-glycosidations-unusual-cleavage-interglycosidic-bond-while-studying-001944nas a2200217 4500008004100000022001400041245009800055210006900153260008000222300001000302490000700312520112900319653003701448653001401485653002201499653001801521100002601539700001801565700001901583856012401602 2011 eng d a1319-802500aGamma-initiated oxidation of isotactic polypropylene: effect of gamma-dose rate on durability0 aGammainitiated oxidation of isotactic polypropylene effect of ga aTIERGARTENSTRASSE 17, D-69121 HEIDELBERG, GERMANYbSPRINGER HEIDELBERGcJAN a29-380 v363 a

The effect of gamma-irradiation dose rate on the chemical, molecular, and mechanical properties of isotactic polypropylene (iPP) films was investigated using three different Co-60 sources with dose rates of 600, 660, and 780 Gy h(-1). Fourier transform infrared spectroscopy coupled with chemical derivatization with NO and SF4, and measurements of the elongation at break, toughness, and molecular weight were used to describe the effects of gamma-dose rate on iPP. It was found that the formation of oxidation products depended significantly on the dose rate. However, the kinetic accumulation of ketones were more sensitive to the dose rate of gamma source. Degradation induced by gamma-radiation depends on the dose rate-the degradation of mechanical properties was more significant at a low dose rate than at a high dose rate. It was found that the lower the dose rate, the higher the degree of oxidation in terms of the formation of gamma-products. The mechanism of gamma-degradation is discussed based on the correlation between the changes in chemical and physical properties upon exposure to gamma-radiation.

10aChemical and physical properties10aDose rate10agamma-irradiation10apolypropylene1 aAlariqi, Sameh, A. S.1 aSingh, R., P.1 aRao, B., S. M. uhttp://library.ncl.res.in/content/gamma-initiated-oxidation-isotactic-polypropylene-effect-gamma-dose-rate-durability-000960nas a2200169 4500008004100000022001400041245008400055210006900139260007600208300001400284490000800298520031400306100002500620700001600645700001900661856011000680 2011 eng d a0021-919300aGenome sequence of idiomarina sp strain a28l, isolated from pangong lake, india0 aGenome sequence of idiomarina sp strain a28l isolated from pango a1752 N ST NW, WASHINGTON, DC 20036-2904 USAbAMER SOC MICROBIOLOGYcOCT a5875-58760 v1933 a

Idiomarina sp. strain A28L was isolated from the alkaline brackish water of a high-altitude lake, Pangong Lake. Here, we present the draft genome of Idiomarina sp. strain A28L, which contains 2,591,567 bp with a G + C content of 45.5 mol% and contains 2,299 protein-coding genes and 56 structural RNAs.

1 aGupta, Hemant, Kumar1 aSingh, Ajit1 aSharma, Rakesh uhttp://library.ncl.res.in/content/genome-sequence-idiomarina-sp-strain-a28l-isolated-pangong-lake-india-001164nas a2200193 4500008004100000022001400041245008600055210006900141260007600210300001400286490000800300520044200308100002500750700002400775700001600799700002400815700001900839856011200858 2011 eng d a0021-919300aGenome sequence of rheinheimera sp strain A13L, isolated from pangong lake, india0 aGenome sequence of rheinheimera sp strain A13L isolated from pan a1752 N ST NW, WASHINGTON, DC 20036-2904 USAbAMER SOC MICROBIOLOGYcOCT a5873-58740 v1933 a

Rheinheimera sp. strain A13L, which has antimicrobial activity, was isolated from alkaline brackish water of the high-altitude Pangong Lake of Ladakh, India. Here we report the draft genome sequence of Rhienheimera sp. strain A13L (4,523,491 bp with a G + C content of 46.23%). The genome is predicted to contain genes for marinocine and colicin V production, which may be responsible for the antimicrobial activity of the strain.

1 aGupta, Hemant, Kumar1 aGupta, Rinkoo, Devi1 aSingh, Ajit1 aChauhan, Nar, Singh1 aSharma, Rakesh uhttp://library.ncl.res.in/content/genome-sequence-rheinheimera-sp-strain-a13l-isolated-pangong-lake-india-001688nas a2200241 4500008004100000022001400041245010100055210006900156260009500225300001400320490000700334520080100341653002301142653001901165653001401184653002101198653000801219100001901227700002001246700003001266700001901296856013101315 2011 eng d a1533-488000aGlycerol mediated low temperature synthesis of nickel nanoparticles by solution reduction method0 aGlycerol mediated low temperature synthesis of nickel nanopartic a25650 NORTH LEWIS WAY, STEVENSON RANCH, CA 91381-1439 USAbAMER SCIENTIFIC PUBLISHERScJUN a5131-51360 v113 a

Phase pure Nickel nano-particles were synthesized by in-situ generation of nickel hydrazine hydrate complex (Ni-HH) followed by its decomposition in an alkaline glycerol medium. The synthesis can be performed in an open beaker with or without the use of surface protective reagents. By using the present method, Ni nano-particles can be prepared in large scale. The black nano-powders so-obtained were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), selected area electron diffraction (SAED), Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), Fourier transform infra-red (FTIR) spectroscopy and thermal analysis (TGA). XRD and SAED analysis revealed that the synthesized particles were pure crystalline nickel with FCC structure.

10aChemical Reduction10aNano-Particles10asynthesis10aTransition Metal10aXRD1 aSingh, Kalpana1 aKate, Kunal, H.1 aChilukuri, V., V. Satayan1 aKhanna, P., K. uhttp://library.ncl.res.in/content/glycerol-mediated-low-temperature-synthesis-nickel-nanoparticles-solution-reduction-method-001738nas a2200253 4500008004100000022001400041245010700055210006900162260009900231300001400330490000800344520081300352653001801165653002101183653001901204653001801223653001801241653000901259100002401268700001901292700002201311700002001333856013101353 2011 eng d a0008-621500aGold catalyzed glycosidations for the synthesis of sugar acrylate/acrylamide hybrids and their utility0 aGold catalyzed glycosidations for the synthesis of sugar acrylat aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcSEP a1511-15180 v3463 a

Propargyl glyco 1,2-orthoesters were exploited for the efficient synthesis of interesting glycomonomers such as glyco-acrylates and acrylamides using gold catalysts. It was observed that propargyl glyco 1,2-orthoesters with hydroxyethyl acrylates gives very good yield of the corresponding glyco-acrylates in a single step in the presence of catalytic amount of gold(III) catalyst; whereas, gold catalyzed glycosidation reaction on hydroxyethyl acrylamides was found to yield the corresponding acrylamidoyl 1,2-orthoester which was then converted to the corresponding glycol-acrylamide in the presence of catalytic amount of TMSOTf. Synthesized glyco-acrylate/acrylamide monomers are shown to undergo thiolate addition as well as free radical polymerization (C) 2011 Elsevier Ltd. All rights reserved.

10acarbohydrates10aGlycoacrylamides10aGlycoacrylates10aGlycopolymers10aglycosylation10aGold1 aThadke, Shivaji, A.1 aKar, Mritunjoy1 aGupta, Sayam, Sen1 aHotha, Srinivas uhttp://library.ncl.res.in/content/gold-catalyzed-glycosidations-synthesis-sugar-acrylateacrylamide-hybrids-and-their-utility-001217nas a2200229 4500008004100000022001400041245010400055210006900159260008600228300001800314490000700332520037500339653001700714653001200731653000700743653003000750653000900780100002200789700002700811700002600838856012300864 2011 eng d a0039-791100aGreener ullmann-type coupling of aryl halides for preparing biaryls using reusable Pd/ZrO2 catalyst0 aGreener ullmanntype coupling of aryl halides for preparing biary a325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcJAN aPII 9312497960 v413 a

Biaryls with excellent yields can be prepared by the Ullmann-type coupling of aryl halides in the presence of potassium carbonate (as a base) and dimethylformamide (as a solvent), at 140 degrees C, using a reusable Pd (2.5wt%)/ZrO2 catalyst. The product yield of 4-iodoanisole coupling is strongly influenced by the catalyst preparation method, solvent, and base.

10aAryl halides10aBiaryls10aPd10aUllmann coupling reaction10aZrO21 aDumbre, Deepa, K.1 aWakharkar, Radhika, D.1 aChoudhary, Vasant, R. uhttp://library.ncl.res.in/content/greener-ullmann-type-coupling-aryl-halides-preparing-biaryls-using-reusable-pdzro2-001834nas a2200193 4500008004100000022001400041245009700055210006900152260007100221300001600292490000800308520110200316100001801418700001501436700001801451700002201469700002301491856012601514 2011 eng d a1089-563900aGrowth and structural properties of Mg-N (N=10-56) clusters: density functional theory study0 aGrowth and structural properties of MgN N1056 clusters density f a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV a12307-123140 v1153 a

Using the minima hopping global geometry optimization method on density functional potential energy surface, we have studied the structural and electronic properties of magnesium clusters for a size range of Mg-N where N = 10-56. Our exhaustive search reveals that most of our global minima are nonsymmetric in the size range above N = 20. We elucidate the evolutionary trend of the entire series and present more details about the peculiar growth of the clusters. For N> 20, it is possible to divide the cluster into two regions: the core region and the surface region. It turns out that the growth follows a peculiar cyclic pattern where the core and surface grow alternatively. The surface energy, as a function of number of atoms shows a clear signature as the number of atoms in the core increases by one. We have also carried out stability analysis and the stable sizes(magic numbers) agree very well with the experimental magic numbers reported by Diederich [J. Chem. Phys. 2011, 134, 124302]. We point out the similarities and differences between our results and sodium clusters.

1 aHeidari, Ideh1 aDe, Sandip1 aGhazi, S., M.1 aGoedecker, Stefan1 aKanhere, Dilip, G. uhttp://library.ncl.res.in/content/growth-and-structural-properties-mg-n-n10-56-clusters-density-functional-theory-study-001854nas a2200217 4500008004100000022001400041245007800055210006900133260008300202300001400285490000700299520103900306653003101345653003001376653003701406100002401443700002101467700002001488700002401508856010401532 2011 eng d a1567-173900aGrowth of aligned ZnO nanorods array on ITO for dye sensitized solar cell0 aGrowth of aligned ZnO nanorods array on ITO for dye sensitized s aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbInt Union Mat Res Soc (IUMRS)cJAN aS113-S1160 v113 a

Aligned ZnO films of nanorods arrays were grown on Indium doped Tin oxide (ITO) glass substrate for the Dye Sensitized Solar Cells (DSSCs) applications. Two-step approach was employed for the deposition, which offers advantages such as excellent surface adhesion, large area deposition, high reproducibility and yield. Structural characterization using X-ray diffraction (XRD) shows a preferred c-axis (002) oriented growth. Scanning Electron Microscopy (SEM) images reveals uniformly distributed hexagonal ZnO nanorods with average diameter varying from 80 to 250 nm. Average growth rate of the films was estimated using Surface Profilometer which was found to be similar to 1 mu m/h. Optical characterizations were carried out using Photo-spectrometer and Raman spectroscopy. The DSSCs using these ZnO films of nanorods array as photo-electrodes show conversion efficiency ranging from 0.24 to -0.71 %, the maximum efficiency was obtained for films deposited for time duration 8 h. (C) 2010 Elsevier B.V. All rights reserved.

10aAligned ZnO nanorod growth10aDye sensitized solar cell10aOpen aqueous solution deposition1 aYengantiwar, Ashish1 aSharma, Ramakant1 aGame, Onkar, S.1 aBanpurkar, Arun, G. uhttp://library.ncl.res.in/content/growth-aligned-zno-nanorods-array-ito-dye-sensitized-solar-cell-001779nas a2200229 4500008004100000022001400041245011700055210006900172260007900241300001400320490000700334520086600341653002701207653003801234653003101272653003101303100002101334700002201355700002001377700002601397856012601423 2011 eng d a1044-580300aGrowth of hydrothermally stable meso-porous silica structure interconnected around micro-porous zeolite crystals0 aGrowth of hydrothermally stable mesoporous silica structure inte a360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USAbELSEVIER SCIENCE INCcDEC a1166-11720 v623 a

The growth of hydrothermally stable ordered meso-porous silica with M41S type structure interconnected around zeolite crystals was achieved from seeds normally nucleating the crystallization of micro-porous zeolite. The solid state NMR and FT-IR showed species like Si(OSi)(3)OH and Si(OSi)(2)(OH)(2) (or Q(3) and Q(2) sites, respectively) are formed during first hydrothermal treatment with surfactant and NaOH. These species and surface silanol group of zeolite crystal condense to give meso-porous silica structure interconnected around zeolite crystal during re-crystallization at lower pH. Resulting meso-micro-porous hybrid material is found to be highly active, selective and stable in the synthesis of 2-(phenylamino) ethanol from aniline and ethylene carbonate compare to parent ZSM-5 and pure MCM-41. (C) 2011 Elsevier Inc. All rights reserved.

10aHydrothermal stability10aInterconnected meso-porous silica10aMeso-micro hybrid material10aSynthesis of amino alcohol1 aKinage, Anil, K.1 aPrashar, Atul, K.1 aBerlier, Gloria1 aChaturvedi, Rajiv, K. uhttp://library.ncl.res.in/content/growth-hydrothermally-stable-meso-porous-silica-structure-interconnected-around-micro-003049nas a2200205 4500008004100000022001400041245013800055210006900193260011000262300001600372490000700388520217100395100001902566700003302585700002602618700001902644700002502663700003002688856012502718 2012 eng d a0959-942800aGamma-Al2-xMxO3 +/- y (M = Ti4+ through Ga3+): potential pseudo-3D mesoporous materials with tunable acidity and electronic structure0 aGammaAl2xMxO3 y M Ti4 through Ga3 potential pseudo3D mesoporous  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR a13484-134930 v223 a

A simple and highly efficient surfactant-free sol-gel process has been developed to obtain nanocrystalline mesoporous gamma-Al2O3 and metal ion incorporated mesoporous gamma-Al2O3 with general formula gamma-Al2-xMxO3 +/- y (where M = Ti4+ through Ga3+). Any one of the first row transition metal (TM) ions along with Ga3+ could be introduced into the gamma-Al2O3 framework in a direct one-pot synthesis process. The generality of the present synthesis recipe for metal ion incorporation in gamma-Al2O3 was demonstrated by preparation of an Al-Ga-M ternary oxide system with the metal ion composition of general formula Al9GaTM (TM = Ti4+ to Zn2+) and their characterization through various physicochemical and spectroscopic techniques. The mesoporous gamma-Al2-xMxO3 +/- y materials showed a BET surface area in the range of 200-400 m(2) g(-1) with a narrow pore size distribution. Wormhole mesoporosity makes the material pseudo-3D (p3D) with a small pore depth of few nm (<10 nm). Metal ions in gamma-Al2O3 lead to changes in the acidity and electronic environment. XRD, TEM, and Al-27 MAS NMR studies demonstrate that the sol-gel process and the disordered mesoporous structure allow Ga and TM ions to be highly distributed and integrated in the gamma-Al2O3 framework. The efficacy of these materials in catalysis has been successfully evaluated for steam reforming of dimethylether: Ni, Cu and Zn containing Al9GaTM oxides showed high activity and stability. The smaller mesochannel depth (<10 nm) and pseudo-3D characteristics that arise due to the wormhole-type disordered mesoporous framework of these alumina materials facilitate mass transport through them without any leaching of metal ions out of the lattice and pore blocking during the reaction, which makes them attractive in catalysis. This preparation method is versatile enough to be used for a reproducible synthesis of metal ion incorporated mesoporous gamma-Al2O3 by varying the metal content and their combinations, and it is expected that many other metal ions could be introduced into the lattice framework for a variety of applications by tuning acidity and electronic structure.

1 aMathew, Thomas1 aSivaranjani, Kumarsrinivasan1 aGnanakumar, Edwin, S.1 aYamada, Yusuke1 aKobayashi, Tetsuhiko1 aGopinath, Chinnakonda, S. uhttp://library.ncl.res.in/content/gamma-al2-xmxo3-y-m-ti4-through-ga3-potential-pseudo-3d-mesoporous-materials-tunable-002007nas a2200229 4500008004100000022001400041245016100055210006900216260011700285300001000402490000600412520109600418653001501514653001901529653001901548653001401567653001301581653001601594100002401610700002101634856012201655 2012 eng d a0973-626300aGellan Gum a novel polysaccharide matrix for immobilization of thermo-tolerant yeast cells with invertase activity: factorial design and rheological studies0 aGellan Gum a novel polysaccharide matrix for immobilization of t aSECTOR A-80, SCHEME NO 54, VIJAY NAGAR, A B ROAD, INDORE, 452 010 MP, INDIAbRESEARCH JOURNAL BIOTECHNOLOGYcNOV a81-870 v73 a

The microbial extracellular polysaccharide gellan gum has been explored for its application in whole cell immobilization. Preliminary evaluation of the physicochemical properties of gellan gum in the presence of monovalent cation tetramethyl ammonium chloride (TMACl) was carried out. Gellan gum immobilized cells demonstrated better rheological properties than gellan gum. Attempts have been made to reveal the evaluation of gellan gum as a matrix to immobilize a thermotolerant yeast Kluyveromyces marxianus NCYC 2675. A 3(2) factorial design was used to study the simultaneous effect of two variables. The effect of the polymer concentration and TMACl concentration on various dependent variables like gelling temperature, mean particle size and enzyme activity of the yeast cells was studied. A statistical model with a significant interaction term was obtained to predict the results. Further, optimized immobilized system was evaluated with significant storage stability at 10 C and enhanced reusability with maximum conversion of > 90 % when crosslinked with glutaraldehyde.

10aGellan gum10aGlutaraldehyde10aImmobilization10ainvertase10aRheology10ayeast cells1 aSulabha, Karandikar1 aAsmita, Prabhune uhttp://library.ncl.res.in/content/gellan-gum-novel-polysaccharide-matrix-immobilization-thermo-tolerant-yeast-cells-001544nas a2200193 4500008004100000022001400041245011300055210006900168260011000237300001200347490000600359520075400365100001801119700002301137700001501160700001801175700003001193856012701223 2012 eng d a2040-336400aGellan gum capped silver nanoparticle dispersions and hydrogels: cytotoxicity and in vitro diffusion studies0 aGellan gum capped silver nanoparticle dispersions and hydrogels  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT a563-5670 v43 a

The preparation of highly stable water dispersions of silver nanoparticles using the naturally available gellan gum as a reducing and capping agent is reported. Further, exploiting the gel formation characteristic of gellan gum silver nanoparticle incorporated gels have also been prepared. The optical properties, morphology, zeta potential and long-term stability of the synthesized silver nanoparticles were investigated. The superior stability of the gellan gum-silver nanoparticle dispersions against pH variation and electrolyte addition is revealed. Finally, we studied the cytotoxicity of AgNP dispersions in mouse embryonic fibroblast cells (NIH3T3) and also evaluated the in vitro diffusion of AgNP dispersions/gels across rat skin.

1 aDhar, Sheetal1 aMurawala, Priyanka1 aShiras, A.1 aPokharkar, V.1 aPrasad, Bhagavatula L. V. uhttp://library.ncl.res.in/content/gellan-gum-capped-silver-nanoparticle-dispersions-and-hydrogels-cytotoxicity-and-vitro-002270nas a2200229 4500008004100000022001400041245012800055210006900183260007300252300001200325490000700337520138600344653002301730653002001753653003401773653002201807653001901829653002201848100001801870700002401888856012801912 2012 eng d a0254-629900aGenetic homogeneity of in vitro raised plants of grapevine cv. crimson seedless revealed by ISSR and microsatellite markers0 aGenetic homogeneity of in vitro raised plants of grapevine cv cr aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJAN a302-3060 v783 a

The present study was conducted to test the clonal homogeneity of six month old tissue culture raised plants of grapevine cv. Crimson Seedless using Inter Simple Sequence Repeat (ISSR) and Simple Sequence Repeat (SSR) markers. Visible assessment of these in vitro raised plants maintained in polyhouse did not show any morphological differences among themselves. However, to test the genetic homogeneity of these plants, we screened 50 ISSR primers out of which, 22 primers produced scorable and repeatable bands. These 22 primers were used further for assessing genetic homogeneity of in vitro raised plants of Crimson Seedless. These 22 ISSR primers generated 134 distinct band classes with a total of 3216 scorable bands. All the primers showed uniform banding pattern for all the in vitro raised plants and the mother plant. In case of 5 SSR primers (VS I, VVMD5, VVS2, VMCNG4c8 and VVMD31) used, a total of 288 scorable bands were obtained. The allele sizes ranged from 98 to 254 bp. Allelic composition of 23 in vitro raised plants and the mother plant at 5 SSR loci did not show any polymorphism. The results of the two marker systems in the present study revealed the genetic uniformity among the in vitro raised plants demonstrating the reliability of in vitro propagation system used for the cultivar. (C) 2011 SAAB. Published by Elsevier B.V. All rights reserved.

10aAllele composition10aClonal fidelity10aInter Simple Sequence Repeats10aMonomorphic bands10aTissue culture10aVitis vinifera L.1 aNookaraju, A.1 aAgrawal, Dinesh, C. uhttp://library.ncl.res.in/content/genetic-homogeneity-vitro-raised-plants-grapevine-cv-crimson-seedless-revealed-issr-and-000928nas a2200181 4500008004100000022001400041245006400055210006400119260007600183300000900259490000800268520029100276100001600567700002600583700002100609700001900630856009700649 2012 eng d a0021-919300aGenome sequence of nitratireductor aquibiodomus strain RA220 aGenome sequence of nitratireductor aquibiodomus strain RA22 a1752 N ST NW, WASHINGTON, DC 20036-2904 USAbAMER SOC MICROBIOLOGYcNOV a63070 v1943 a

The genus Nitratireductor represents nitrate-reducing bacteria from the family Phyllobacteriaceae. Here we report the draft genome sequence of Nitratireductor aquibiodomus strain RA22, which contains 4,592,790 bp, with a G+C content of 61.30%, and has 4,241 protein coding genes.

1 aSingh, Ajit1 aJangir, Pramod, Kumar1 aKumari, Chanchal1 aSharma, Rakesh uhttp://library.ncl.res.in/content/genome-sequence-nitratireductor-aquibiodomus-strain-ra22-001055nas a2200181 4500008004100000022001400041245012500055210006900180260007600249300001400325490000800339520031900347100002600666700001600692700001600708700001900724856013000743 2012 eng d a0021-919300aGenome sequence of the alkaliphilic bacterium nitritalea halalkaliphila type strain LW7, isolated from Lonar Lake, India0 aGenome sequence of the alkaliphilic bacterium nitritalea halalka a1752 N ST NW, WASHINGTON, DC 20036-2904 USAbAMER SOC MICROBIOLOGYcOCT a5688-56890 v1943 a

An alkaliphilic bacterium, Nitritalea halalkaliphila LW7, which belongs to the family Cyclobacteriacae in the phylum Bacteroidetes, was isolated from Lonar Lake in Maharastra, India. Here we announce the draft genome sequence of the type strain LW7, which contains 3,633,701 bp with a G+C content of 48.58%.

1 aJangir, Pramod, Kumar1 aSingh, Ajit1 aShivaji, S.1 aSharma, Rakesh uhttp://library.ncl.res.in/content/genome-sequence-alkaliphilic-bacterium-nitritalea-halalkaliphila-type-strain-lw7-isolated-001857nas a2200241 4500008004100000022001400041245006800055210006800123260009900191300001000290490000800300520103900308653001001347653002601357653001301383653001401396100002201410700002501432700002301457700002001480700002101500856009401521 2012 eng d a0308-814600aGeographic variation in the flavour volatiles of alphonso mango0 aGeographic variation in the flavour volatiles of alphonso mango aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcJAN a58-660 v1303 a

Alphonso, one of the most popular cultivars of mango in India is known to exhibit geographic variation in the flavour of ripe fruits. To get chemical insight into this difference, volatiles were studied in the ripening fruits of Alphonso mangoes from three cultivation locations in India. Ripe fruits from Deogad had lower content of mono- and sesquiterpenes and higher content of lactones and furanones as compared to the fruits from Dapoli: whereas fruits from Vengurle had average quantities of these chemicals in comparison with Deogad and Dapoli fruits. This variation was clearly reflected as separate clustering of the localities in the Principal Component Analysis. The localities were indistinguishable from each other in terms of raw fruit volatiles. This study exemplifies a case of phenotypic plasticity; since the plants chosen were clonally propagated, such geographic variation in the volatiles can be attributed to varied abiotic conditions at these three localities. (C) 2011 Elsevier Ltd. All rights reserved.

10aMango10aPhenotypic plasticity10aRipening10aVolatiles1 aKulkarni, Ram, S.1 aChidley, Hemangi, G.1 aPujari, Keshav, H.1 aGiri, Ashok, P.1 aGupta, Vidya, S. uhttp://library.ncl.res.in/content/geographic-variation-flavour-volatiles-alphonso-mango-002005nas a2200217 4500008004100000022001400041245011000055210006900165260007300234300001200307490000700319520118700326653001301513653002501526653002701551653002001578653001801598100002101616700002001637856013001657 2012 eng d a0141-813000aGlycolic acid-g-chitosan-gold nanoflower nanocomposite scaffolds for drug delivery and tissue engineering0 aGlycolic acidgchitosangold nanoflower nanocomposite scaffolds fo aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcAPR a878-8830 v503 a

This paper reports a simple novel method for the synthesis of flower like gold nanoparticle (three dimensional branched nanoparticle) with >30 tips, under controlled temperature condition. Formation of flower like Au nanoparticle was confirmed by scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and gold nanoflower (AuNF) in controlled drug delivery and tissue engineering applications. The drug loaded novel nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Grafting of glycolic acid to the chitosan and incorporation of drug were evaluated by Fourier transform infrared spectroscopy (FTIR). The nanohybrid scaffolds were found to be stable towards the pH of the medium. The cell viability study shows that prepared nanohybrid scaffolds are biocompatible. Gold nanoflowers were found to control the drug release rate in the buffer solution (pH 7.4). Therefore, for the glycolic acid grafted chitosan based system, gold nanoflowers are the viable additive for drug delivery. (C) 2011 Elsevier B.V. All rights reserved.

10aChitosan10aDrug delivery system10aGlycolic acid grafting10aGold nanoflower10aNanocomposite1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttp://library.ncl.res.in/content/glycolic-acid-g-chitosan-gold-nanoflower-nanocomposite-scaffolds-drug-delivery-and-tissue-002029nas a2200217 4500008004100000022001400041245011300055210006900168260007300237300001000310490000700320520120200327653001901529653001301548653001801561653002701579653003301606100002101639700002001660856013101680 2012 eng d a0141-813000aGlycolic acid-g-chitosan-Pt-Fe3O4 nanoparticles nanohybrid scaffold for tissue engineering and drug delivery0 aGlycolic acidgchitosanPtFe3O4 nanoparticles nanohybrid scaffold  aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcJUL a76-820 v513 a

This work presents the potential use of novel nanohybrid based on chitosan-g-glycolic acid and Pt-Fe3O4 composite nanoparticles in drug delivery and tissue engineering applications. The Pt-Fe3O4 hybrid nanoparticles are prepared by thermal decomposition of H2PtCl6 center dot 6H(2)O at high temperature. The prepared nanoparticles were characterized by transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and physical property measurement system (PPMS). Next step of this paper reveals the potential use of novel hybrids of chitosan-g-glycolic acid and Pt-Fe3O4 hybrid nanoparticles in controlled drug delivery applications. The drug loaded nanohybrid scaffold is prepared by freeze drying of grafted polymer solution. Drug loading and grafting of chitosan was characterized by Fourier transform infrared spectroscopy (FTIR). The cell proliferation also shows that the prepared nanohybrids are biocompatible. The nanohybrid was found to be stable regardless of pH of the medium. Therefore, Pt-Fe3O4 hybrid nanoparticles are viable additive for sustained drug delivery and it could be applied in the field of biomedical. (c) 2012 Elsevier B.V. All rights reserved.

10aCell viability10aChitosan10adrug delivery10aGlycolic acid grafting10aPt-Fe3O4 hybrid nanoparticle1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttp://library.ncl.res.in/content/glycolic-acid-g-chitosan-pt-fe3o4-nanoparticles-nanohybrid-scaffold-tissue-engineering-and-001954nas a2200241 4500008004100000022001400041245019800055210006900253260007300322300001200395490000800407520098500415653001401400653001401414653001901428653001801447653002201465100002001487700001901507700002501526700003001551856013101581 2012 eng d a0927-775700aGold nanoparticle embedded hydrogel matrices as catalysts: better dispersibility of nanoparticles in the gel matrix upon addition of N-bromosuccinimide leading to increased catalytic efficiency0 aGold nanoparticle embedded hydrogel matrices as catalysts better aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcNOV a296-3010 v4143 a

A simple and convenient method for generating and immobilizing gold NPs into polyethylene glycol-polyurethane (PEGPU) matrices is presented. The gold NP immobilized PEGPU (Au NP-PEGPU) hydrogel matrices are easy to handle and can be used as catalysts. The efficiency, reusability and durability of the Au NP-PEGPU catalyst matrices were investigated using the reduction of 4-nitroaniline (4NA) to p-phenylenediamine (p-PDA) by sodium borohydride in the presence of the catalyst as a test reaction. The Au NPs in the PEGPU matrix got aggregated after 3 cycles of catalysis but dispersion could be regenerated by the addition of N-bromosuccinimide (NBS). After this regeneration process the Au NPs-PEGPU matrix showed excellent efficiency without any aggregation, leaching or degradation. The reusability of the catalyst for 28 cycles yielding a total turnover number of 3220 and turn over frequency of 0.152 s(-1) is demonstrated. (C) 2012 Elsevier B.V. All rights reserved.

10acatalysis10ahydrogels10aImmobilization10aNanoparticles10aTurn over numbers1 aRamtenki, Vilas1 aAnumon, V., D.1 aBadiger, Manohar, V.1 aPrasad, Bhagavatula L. V. uhttp://library.ncl.res.in/content/gold-nanoparticle-embedded-hydrogel-matrices-catalysts-better-dispersibility-nanoparticles-002335nas a2200181 4500008004100000022001400041245013500055210006900190260011000259300001600369490000700385520154900392100002501941700002801966700001901994700002402013856011602037 2012 eng d a0959-942800aGraphene enriched with pyrrolic coordination of the doped nitrogen as an efficient metal-free electrocatalyst for oxygen reduction0 aGraphene enriched with pyrrolic coordination of the doped nitrog aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV a23506-235130 v223 a

We report an efficient template-free synthetic route for the preparation of mesoporous nitrogen-doped graphene (NGE) containing a high weight percentage of pyrrolic nitrogen, good specific surface area and comparable electrochemical oxygen reduction activity as that of the state-of-the-art 40 wt% Pt/C catalyst. The desired coordination of nitrogen in the carbon framework of graphene has been conceived by a mutually assisted redox reaction between graphene oxide (GO) and pyrrole, followed by thermal treatment at elevated temperatures. NGE exhibits a high surface area of 528 m(2) g(-1) and a pore diameter of similar to 3 to 7 nm. The heat treatment temperature plays a pivotal role in establishing the desired pyrrolic coordination of nitrogen in graphene for the electrochemical oxygen reduction reaction. The NGE sample obtained after heat treatment at 1000 degrees C (NGE-1000) has 53% pyrrolic nitrogen content compared to the similar samples prepared by treating at low temperatures. Most importantly, NGE-1000 has displayed a significantly low overpotential for oxygen reduction with the onset potential very closely matching that of the commercial 40 wt% Pt/C. It is noteworthy that the reaction involves the desired 4 electron transfer as observed in the case of the Pt based electrocatalysts, leading to a significantly high kinetic current density of 6 mA cm(-2) at -0.2 V. Moreover, the fuel tolerance and durability under the electrochemical environment of the NGE catalyst is found to be superior to the Pt/C catalyst.

1 aUnni, SreeKuttan, M.1 aDevulapally, Saikrishna1 aKarjule, Neeta1 aKurungot, Sreekumar uhttp://library.ncl.res.in/content/graphene-enriched-pyrrolic-coordination-doped-nitrogen-efficient-metal-free-002187nas a2200277 4500008004100000022001400041245013600055210006900191260011100260300001200371490000600383520117200389653001801561653001801579653000901597653001301606653001801619653001101637100001701648700002401665700002701689700003101716700002001747700001901767856012301786 2012 eng d a1573-413700aGreen approach towards size controlled synthesis of biocompatible antibacterial metal nanoparticles in aqueous phase using lysozyme0 aGreen approach towards size controlled synthesis of biocompatibl aEXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB EMIRATESbBENTHAM SCIENCE PUBL LTDcFEB a130-1400 v83 a

Inspired by array of proteins present in nature, we choose lysozyme (hen egg protein) as a model system to synthesize nanoparticles of noble metals to understand the mechanism of interaction as well as to use them for potential applications such as potent antibacterial agents. Lysozyme is a very well studied biomolecule containing aromatic amino acids like tryptophan and tyrosine. Tyrosine has phenoxy group which is considered to be responsible for interacting with the metal ions. Lysozyme can be suitably modified by treatment with N-bromosuccinimide/N-acetylimidazole to obtain tight control over size distribution of nanoparticles. Here we report the direct synthesis of nanocrystals of gold and silver at controlled pH and light conditions without using any known reducing agents. Out of these, synthesis of gold nanoparticles is assisted by the presence of low concentration of Ag+ ions through the galvanic exchange. It is remarkable to note that the structure of protein is not changed drastically as seen by the FTIR studies. As-synthesized lysozyme capped nanoparticles prepared by this method are biocompatible and retain antibacterial property.

10aAntibacterial10aBiocompatible10aGold10alysozyme10aNanoparticles10aSilver1 aKumar, Umesh1 aRanjan, Amaresh, K.1 aSharan, Chandrashekhar1 aHardikar, Anandwardhan, A.1 aPundle, Archana1 aPoddar, Pankaj uhttp://library.ncl.res.in/content/green-approach-towards-size-controlled-synthesis-biocompatible-antibacterial-metal-001844nas a2200229 4500008004100000022001400041245009500055210006900150260007300219300001200292490000700304520098700311653001701298653002401315653005101339653001901390100002101409700002201430700002001452700002101472856012101493 2012 eng d a0167-577X00aGreen synthesis of TiO2 nanoparticles by using aqueous extract of Jatropha curcas L. latex0 aGreen synthesis of TiO2 nanoparticles by using aqueous extract o aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAY a196-1990 v753 a

Present study deals with a green synthesis of TiO2 nanoparticles by using 0.3% aqueous extract prepared from latex of Jatropha curcas L. TiO2 nanoparticles were characterized by X-ray diffraction (XRD), Selected Area Electron Diffraction (SAED), Transmission Electron Microscopy (TEM), Energy Dispersive Analysis of X-rays (EDAX) and Fourier Transform Infrared Spectroscopy (FTIR). Fourier Transform Infrared Spectroscopy (FTIR) were performed to find the role of curcain (enzyme), cyclic peptides namely curcacycline A (an octapeptide) and curcacycline B (a nonapeptide) as a possible reducing and capping agents, present in the latex of J. curcas L. The average size of TiO2 nanoparticles was found to be in the range of 25 to 100 nm. Our result shows that there are two broad categories of nanoparticles, first having diameter from 25 to 50 nm which are mostly spherical in shape and second having some larger and uneven shapes. (C) 2012 Elsevier B.V. All rights reserved.

10aBiomaterials10aElectron microscopy10aFourier Transform Infrared Spectroscopy (FTIR)10aNanostructures1 aHudlikar, Manish1 aJoglekar, Shriram1 aDhaygude, Mayur1 aKodam, Kisan, M. uhttp://library.ncl.res.in/content/green-synthesis-tio2-nanoparticles-using-aqueous-extract-jatropha-curcas-l-latex-001042nas a2200169 4500008004100000022001400041245010500055210006900160260011000229300001400339490000600353520031500359100001800674700002900692700002100721856013000742 2012 eng d a2046-206900aGreen synthetic route to antimalarial and antibacterial agent CJ-15,801 and its isomer cis-CJ-15,8010 aGreen synthetic route to antimalarial and antibacterial agent CJ aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR a3596-35980 v23 a

An efficient and rapid synthesis of antiplasmodial and antibacterial agent CJ-15,801 and its isomer cis-CJ-15,801 is disclosed. We have made an attempt towards ``Ideal Synthesis'' or a step towards ``Dial-a-Molecule'' by reducing the number of steps, following atom economy, and a green synthetic route.

1 aKashinath, K.1 aSwaroop, Pandrangi, Siva1 aReddy, Srinivasa uhttp://library.ncl.res.in/content/green-synthetic-route-antimalarial-and-antibacterial-agent-cj-15801-and-its-isomer-cis-cj-001417nas a2200145 4500008004100000245008900041210006900130260000800199300001200207490000600219520088100225100002501106700002101131856011901152 2013 eng d00aGamma-glutamyl transferases: a structural, mechanistic and physiological perspective0 aGammaglutamyl transferases a structural mechanistic and physiolo cJAN a51–650 v93 a

Gamma glutamyl transferases (GGT) are highly conserved enzymes that occur from bacteria to humans. They remove terminal γ-glutamyl residue from peptides and amides. GGTs play an important role in the homeostasis of glutathione (a major cellular antioxidant) and in the detoxification of xenobiotics in mammals. They are implicated in diseases like diabetes, inflammation, neurodegenerative diseases and cardiovascular diseases. The physiological role of GGTs in bacteria is still unclear. Nothing is known about the basis for the strong conservation of the enzyme across the living system. The review focuses on the enzyme’s physiology, chemistry and structural properties of the enzyme with emphasis on the evolutionary relationships. The available data indicate that the members of the GGT family share common structural features but are functionally heterogenous.

1 aBalakrishna, Sharath1 aPrabhune, Asmita uhttp://library.ncl.res.in/content/gamma-glutamyl-transferases-structural-mechanistic-and-physiological-perspective02602nas a2200169 4500008004100000022001400041245006600055210006400121260007100185300001400256490000700270520198200277100003202259700002302291700002202314856009602336 2013 eng d a0888-588500aGas-liquid flow and mass transfer in an advanced-flow reactor0 aGasliquid flow and mass transfer in an advancedflow reactor a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcJUL a8996-90100 v523 a

Hydrodynamics and mass transfer of gas-liquid flow are explored under ambient conditions in an Advanced-Flow Reactor (AFR), an emerging commercial system designed for continuous manufacture. Carbon dioxide/water is the model system used in this study for a range of flow rates for gas and liquid of 5.6-103 mL/min and 10-80 mL/min, respectively. Bubble size distribution, gas holdup, specific interfacial area, pressure drop, and mass transfer coefficients are determined from flow visualization experiments and compared with conventional gas-liquid contactors. These variables are mainly influenced by the inlet flow rates and inlet composition. Average bubble sizes ((d) over bar (B)) of 0.9-3.8 mm, gas holdup (epsilon(G)) of 0.04-0.68, specific interfacial areas ((a) under bar) of 160-1300 m(2)/m(3), and overall mass transfer coefficients (k(L)(a) under bar) of 0.2-3 s(-1) were obtained for the vertical orientation of the AFR. Although effect of gravity is present for this system, no significant effect on the hydrodynamic properties was observed. The measured pressure drop for vertical orientation (3.6-53.4 kPa) was used to estimate power consumption, which is used as a metric to compare mass transfer efficiency among different gas-liquid contactors. A power law relationship was obtained for the overall mass transfer coefficients in terms of power input and gas holdup, given by kL (a) under bar = 0.101P(w)(0.443)epsilon(0.459)(G). The design of the AFR with a series of heart-shaped confined sections with obstacles enhances continuous breakup and coalescence of bubbles providing interfacial areas and mass transfer coefficients 1 order of magnitude larger than other gas-liquid contactors, such as bubble columns (50-600 m(2)/m(3); 0.005-0.24 s(-1)) and spray columns (75-170 m(2)/m(3); 0.015-0.022 s(-1)), and 1 order of magnitude smaller than gas-liquid microchannels (3400-9000 m(2)/m(3); 0.3-21 s(-1)) or falling film reactors (20,000 m(2)/m(3)).

1 aNieves-Remacha, Maria, Jose1 aKulkarni, Amol, A.1 aJensen, Klavs, F. uhttp://library.ncl.res.in/content/gas-liquid-flow-and-mass-transfer-advanced-flow-reactor-002426nas a2200301 4500008004100000022001400041245011800055210006900173260005700242300001400299490000800313520138600321653003201707653001701739653001201756653001001768653002801778653002201806100002501828700002501853700002101878700001701899700002101916700001601937700002101953700002401974856012601998 2013 eng d a0032-093500aGenome-wide identification and characterization of microRNA genes and their targets in flax (Linum usitatissimum)0 aGenomewide identification and characterization of microRNA genes a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcAPR a1149-11610 v2373 a

MicroRNAs (miRNAs) are small (20-24 nucleotide long) endogenous regulatory RNAs that play important roles in plant growth and development. They regulate gene expression at the post-transcriptional level by translational repression or target degradation and gene silencing. In this study, we identified 116 conserved miRNAs belonging to 23 families from the flax (Linum usitatissimum L.) genome using a computational approach. The precursor miRNAs varied in length; while most of the mature miRNAs were 21 nucleotide long, intergenic and showed conserved signatures of RNA polymerase II transcripts in their upstream regions. Promoter region analysis of the flax miRNA genes indicated prevalence of MYB transcription factor binding sites. Four miRNA gene clusters containing members of three phylogenetic groups were identified. Further, 142 target genes were predicted for these miRNAs and most of these represent transcriptional regulators. The miRNA encoding genes were expressed in diverse tissues as determined by digital expression analysis as well as real-time PCR. The expression of fourteen miRNAs and nine target genes was independently validated using the quantitative reverse transcription PCR (qRT-PCR). This study suggests that a large number of conserved plant miRNAs are also found in flax and these may play important roles in growth and development of flax.

10aDigital expression analysis10aGene cluster10aLinseed10amiRNA10aMiRNA target transcript10aPromoter analysis1 aBarvkar, Vitthal, T.1 aPardeshi, Varsha, C.1 aKale, Sandip, M.1 aQiu, Shuqing1 aRollins, Meaghen1 aDatla, Raju1 aGupta, Vidya, S.1 aKadoo, Narendra, Y. uhttp://library.ncl.res.in/content/genome-wide-identification-and-characterization-microrna-genes-and-their-targets-flax-002467nas a2200265 4500008004100000022001400041245015900055210006900214260012000283300001000403490000700413520142200420653000901842653003001851653001901881653001201900653002601912653002201938100002101960700002501981700002502006700002102031700002402052856012502076 2013 eng d a0831-279600aGenome-wide identification and characterization of nucleotide binding site leucine-rich repeat genes in linseed reveal distinct patterns of gene structure0 aGenomewide identification and characterization of nucleotide bin a1200 MONTREAL ROAD, BUILDING M-55, OTTAWA, ON K1A 0R6, CANADAbCANADIAN SCIENCE PUBLISHING, NRC RESEARCH PRESScFEB a91-990 v563 a

Plants employ different disease-resistance genes to detect pathogens and to induce defense responses. The largest class of these genes encodes proteins with nucleotide binding site (NBS) and leucine-rich repeat (LRR) domains. To identify the putative NBS-LRR encoding genes from linseed, we analyzed the recently published linseed genome sequence and identified 147 NBS-LRR genes. The NBS domain was used for phylogeny construction and these genes were classified into two well-known families, non-TIR (CNL) and TIR related (TNL), and formed eight clades in the neighbor-joining bootstrap tree. Eight different gene structures were observed among these genes. An unusual domain arrangement was observed in the TNL family members, predominantly in the TNL-5 clade members belonging to class D. About 12% of the genes observed were linseed specific. The study indicated that the linseed genes probably have an ancient origin with few progenitor genes. Quantitative expression analysis of five genes showed inducible expression. The in silico expression evidence was obtained for a few of these genes, and the expression was not correlated with the presence of any particular regulatory element or with unusual domain arrangement in those genes. This study will help in understanding the evolution of these genes, the development of disease resistant varieties, and the mechanism of disease resistance in linseed.

10aFlax10ain silico gene expression10amotif analysis10aNBS-LRR10aPhylogenetic analysis10aPromoter analysis1 aKale, Sandip, M.1 aPardeshi, Varsha, C.1 aBarvkar, Vitthal, T.1 aGupta, Vidya, S.1 aKadoo, Narendra, Y. uhttp://library.ncl.res.in/content/genome-wide-identification-and-characterization-nucleotide-binding-site-leucine-rich-001967nas a2200289 4500008004100000022001400041245008100055210006900136260006700205300001200272490000700284520110000291653000601391653000601397653002501403653000901428653000801437653000901445653000901454653000801463653001701471653001401488100002301502700001701525700002401542856011101566 2013 eng d a0749-158100aGIAO/DFT studies on 1,2,4-triazole-5-thiones and their propargyl derivatives0 aGIAODFT studies on 124triazole5thiones and their propargyl deriv a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcDEC a767-7740 v513 a

Density functional theory (DFT)/Becke-Lee-Yang-Parr (B3LYP) and gauge-including atomic orbital (GIAO) calculations were performed on a number of 1,2,4-triazole derivatives, and the optimized structural parameters were employed to ascertain the nature of their predominant tautomers. C-13 and N-15 NMR chemical shifts of 3-substituted 1,2,4-triazole-5-thiones and their propargylated derivatives were calculated via GIAO/DFT approach at the B3LYP level of theory with geometry optimization using a 6-311++G** basis set. A good agreement between theoretical and experimental C-13 and N-15 NMR chemical shifts could be found for the systems investigated. The data generated were useful in predicting N-15 chemical shifts of all the nitrogen atoms of the triazole ring, some of which could not be obtained in solution state N-15 HMBC/HSQC NMR measurements. The energy profile computed for the dipropargylated derivatives was found to follow the product distribution profile of regioisomers formed during propargylation of 1,2,4-triazole thiones. Copyright (c) 2013 John Wiley & Sons, Ltd.

10a110a210a4-triazole-5-thiones10aC-1310aDFT10aGIAO10aN-1510aNMR10aRegioisomers10atautomers1 aPhalgune, Usha, D.1 aVanka, Kumar1 aRajamohanan, P., R. uhttp://library.ncl.res.in/content/giaodft-studies-124-triazole-5-thiones-and-their-propargyl-derivatives-001672nas a2200181 4500008004100000022001400041245010700055210006900162260011000231300001400341490000600355520091600361100001701277700002101294700002901315700001901344856012701363 2013 eng d a2050-750X00aGlucose oxidase conjugated H2O2 sensitive CdTe QDs: an effective fluorescence tool for glucose sensing0 aGlucose oxidase conjugated H2O2 sensitive CdTe QDs an effective  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT a6538-65430 v13 a

Water-soluble quantum dots (QDs) are extensively used for molecular sensing because of the flexibility they offer in terms of modification of the QDs surface with a variety of functional groups using thiol chemistry and monitoring by fluorescence intensity. We describe a simple assay that allows the photoluminescence (PL) detection of H2O2 and glucose in aqueous samples and demonstrate its applicability by estimating glucose in blood. To enable the glucose detection, we functionalized the 3-mercaptopropanoic acid (MPA) capped CdTe QDs with glucose oxidase (GOx), the enzyme specific to b-D-glucose, using carbodiimide chemistry. The fluorescence of the GOx-functionalized CdTe QDs was quenched on the interaction with glucose. The same photoluminescence quenching was also observed in gel form, when a GOx modified CdTe QDs loaded agarose gel was dipped in H2O2 and glucose solutions, respectively.

1 aSingh, Pooja1 aPrabhune, Asmita1 aOgale, Satishchandra, B.1 aGuin, Debanjan uhttp://library.ncl.res.in/content/glucose-oxidase-conjugated-h2o2-sensitive-cdte-qds-effective-fluorescence-tool-glucose-001300nas a2200241 4500008004100000022001400041245005300055210005200108260007500160300001200235490000600247520057000253653001000823653001300833653001400846653000900860100002500869700002300894700001600917700002500933700002000958856008000978 2013 eng d a1862-834600aGlycated proteome: from reaction to intervention0 aGlycated proteome from reaction to intervention aPOSTFACH 101161, 69451 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJAN a155-1700 v73 a

Glycation, a nonenzymatic reaction between reducing sugars and proteins, is a proteome wide phenomenon, predominantly observed in diabetes due to hyperglycemia. Glycated proteome of plasma, kidney, lens, and brain are implicated in the pathogenesis of various diseases, including diabetic complications, neurodegenerative diseases, cancer, and aging. This review discusses the strategies to characterize protein glycation, its functional implications in different diseases, and intervention strategies to protect the deleterious effects of protein glycation.

10aaging10aDiabetes10aGlycation10aRAGE1 aKulkarni, Mahesh, J.1 aKorwar, Arvind, M.1 aMary, Sheon1 aBhonsle, Hemangi, S.1 aGiri, Ashok, P. uhttp://library.ncl.res.in/content/glycated-proteome-reaction-intervention-002161nas a2200205 4500008004100000022001400041245011500055210006900170260007300239300001200312490000700324520132300331653003401654653003601688653002501724653004101749100002101790700002001811856012401831 2013 eng d a0141-813000aGlycolic acid functionalized chitosan-Au-Fe3O4 hybrid nanoparticle based nanohybrid scaffold for drug delivery0 aGlycolic acid functionalized chitosanAuFe3O4 hybrid nanoparticle aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcMAR a244-2490 v543 a

The research on biomedical applications of nanoparticles has seen an upsurge in recent years due to their unique capabilities in treatment of ailments. The present paper reports the synthesis of Au-Fe3O4 hybrid nanoparticles. The formation of these nanoparticles was confirmed by transmission electron microscopy (TEM) and physical property measurement system (PPMS). Next step of this paper reveals potential use of novel hybrid of chitosan-g-glycolic acid and Au-Fe3O4 hybrid nanoparticles in controlled drug delivery and tissue engineering applications. Grafting of glycolic acid and drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of pH of the medium and play a key role in cell adhesion, proliferation and migration. Au-Fe3O4 hybrid nanoparticles reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Au-Fe3O4 hybrid nanoparticles are viable additive for formulating sustained drug delivery systems based on glycolic acid grafted chitosan. The cell proliferation profile also shows that prepared nanohybrid is biocompatible providing suitable substrates for tissue engineering. (C) 2012 Elsevier B.V. All rights reserved.

10aAu-Fe3O4 hybrid nanoparticles10aChitosan Glycolic acid grafting10aDrug delivery system10aPhysical property measurement system1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttp://library.ncl.res.in/content/glycolic-acid-functionalized-chitosan-au-fe3o4-hybrid-nanoparticle-based-nanohybrid-001756nas a2200157 4500008004100000022001400041245015200055210006900207260005700276300001400333490000700347520107700354100002101431700002001452856012601472 2013 eng d a0022-246100aGlycolic acid-functionalized chitosan-Co3O4-Fe3O4 hybrid magnetic nanoparticles-based nanohybrid scaffolds for drug-delivery and tissue engineering0 aGlycolic acidfunctionalized chitosanCo3O4Fe3O4 hybrid magnetic n a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcFEB a1524-15320 v483 a

In the present work, Co3O4 was prepared by hydrothermal process, which is further used for the synthesis of Co3O4-Fe3O4 hybrid nanoparticles. The formation of Co3O4-Fe3O4 nanoparticles was investigated by transmission electron microscopy and physical property measurement system. In the next step, the drug-loaded novel nanohybrid porous scaffold based on chitosan-g-glycolic acid and Co3O4-Fe3O4 nanoparticle was prepared by freeze drying technique. The grafting of glycolic acid on chitosan drug loading in porous scaffold was characterized by Fourier transform infrared spectroscopy. The nanohybrid scaffolds were found to be stable regardless of the pH of the medium and play an important role in cell adhesion, proliferation, and migration. Co3O4-Fe3O4 hybrid nanoparticles' reinforcement was found to control the drug (cyclophosphamide) release rate in phosphate buffer saline solution (pH 7.4). Therefore, Co3O4-Fe3O4 hybrid nanoparticles are viable additives for formulating sustained drug delivery systems and could be applied in the field of biomaterials.

1 aKumari, Sangeeta1 aSingh, Raj, Pal uhttp://library.ncl.res.in/content/glycolic-acid-functionalized-chitosan-co3o4-fe3o4-hybrid-magnetic-nanoparticles-based-002320nas a2200181 4500008004100000022001400041245010600055210006900161260007100230300001400301490000700315520160500322100002101927700002501948700001701973700001801990856013002008 2013 eng d a0006-296000aG-quadruplex augments translation in the 5 ` untranslated region of transforming growth factor beta 20 aGquadruplex augments translation in the 5 untranslated region of a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR a1528-15380 v523 a

Transforming growth factor beta 2 (TGF beta 2) is a versatile cytokine with a prominent role in cell migration, invasion, cellular development, and immunomodulation. TGF beta 2 promotes the malignancy of tumors by inducing epithelial-mesenchymal transition, angiogenesis, and immunosuppression. As it is well-documented that nucleic acid secondary structure can regulate gene expression, we assessed whether any secondary motif regulates its expression at the post-transcriptional level. Bioinformatics analysis predicts an existence of a 23-nucleotide putative G-quadruplex sequence (PG4) in the 5' untranslated region (UTR) of TGF beta 2 mRNA. The ability of this stretch of sequence to form a highly stable, intramolecular parallel quadruplex was demonstrated using ultraviolet and circular dichroism spectroscopy. Footprinting studies further validated its existence in the presence of a neighboring nucleotide sequence. Following structural characterization, we evaluated the biological relevance of this secondary motif using a dual luciferase assay. Although PG4 inhibits the expression of the reporter gene, its presence in the context of the entire 5' UTR sequence interestingly enhances gene expression. Mutation or removal of the G-quadruplex sequence from the 5' UTR of the gene diminished the level of expression of this gene at the translational level. Thus, here we highlight an activating role of the G-quadruplex in modulating gene expression of TGF beta 2 at the translational level and its potential to be used as a target for the development of therapeutics against cancer.

1 aAgarwala, Prachi1 aPandey, Satyaprakash1 aMapa, Koyeli1 aMaiti, Souvik uhttp://library.ncl.res.in/content/g-quadruplex-augments-translation-5-untranslated-region-transforming-growth-factor-beta-2-001527nas a2200229 4500008004100000022001400041245005000055210004900105260007700154300001400231490000700245520082100252653001901073653001401092653002201106653001301128653001301141100002101154700002501175700001801200856007901218 2013 eng d a1439-422700aG-Quadruplexes as tools for synthetic biology0 aGQuadruplexes as tools for synthetic biology aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcNOV a2077-20810 v143 a

With the potential to engineer biological systems, synthetic biology is an emerging field that combines various disciplines of sciences. It encompasses combinations of DNA, RNA and protein modules for constructing desired systems and the rewiring of existing signalling networks. Despite recent advances, this field still lags behind in the artificial reconstruction of cellular processes, and thus demands new modules and switches to create genetic circuits. The widely characterised noncanonical nucleic acid secondary structures, G-quadruplexes are promising candidates to be used as biological modules in synthetic biology. Structural plasticity and functional versatility are significant G-quadruplex traits for its integration into a biological system and for diverse applications in synthetic circuits.

10aG-quadruplexes10aribozymes10asynthetic biology10atopology10azipcodes1 aAgarwala, Prachi1 aPandey, Satyaprakash1 aMaiti, Souvik uhttp://library.ncl.res.in/content/g-quadruplexes-tools-synthetic-biology-001681nas a2200265 4500008004100000022001400041245005900055210005900114260006900173300000800242490000800250520082700258653001901085653002501104653002801129653000801157100002401165700001701189700002401206700002401230700002601254700002401280700001901304856009201323 2013 eng d a1010-603000aGreen synthesis of silver nanoparticles using sunlight0 aGreen synthesis of silver nanoparticles using sunlight aPO BOX 564, 1001 LAUSANNE, SWITZERLANDbELSEVIER SCIENCE SAcAPR a1-90 v2583 a

Silver nanoparticles (AgNPs) are currently among the most widely used man-made nanomaterials, present in a huge range of consumer products. Here we report a simple `green' method of AgNP synthesis of using an anionic surfactant without use of any additional reducing agents. It was observed that synthesis of AgNPs at room temperature (25-35 degrees C) using sodium dodecyl sulphate (SDS) and sunlight. The nanoparticles have been characterised using high-resolution transmission electron spectroscopy (HRTEM), UV-vis spectrophotometry, X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectroscopy (FTIR) and are found to have an average diameter of 30 nm. The nanoparticles are water soluble and the nature of the process is amenable to scaling up. (c) 2013 Elsevier B.V. All rights reserved.

10aphotochemistry10asilver nanoparticles10aSodium dodecyl sulphate10aXPS1 aBhaduri, Gaurav, A.1 aLittle, Ross1 aKhomane, Ramdas, B.1 aLokhande, Suhas, U.1 aKulkarni, Bhaskar, D.1 aMendis, Budhika, G.1 aSiller, Lidija uhttp://library.ncl.res.in/content/green-synthesis-silver-nanoparticles-using-sunlight-001745nas a2200157 4500008004100000022001400041245017100055210006900226260011000295300001600405490000600421520100600427100001701433700001901450856011801469 2013 eng d a2046-206900aGrowth of oriented single crystalline La-doped TiO2 nanorod arrays electrode and investigation of optoelectronic properties for enhanced photoelectrochemical activity0 aGrowth of oriented single crystalline Ladoped TiO2 nanorod array aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR a10363-103690 v33 a

Fabrication of single crystalline, oriented one-dimensional (1D) rods or wires of titania on transparent conducting oxide (TCO) substrates have enormous significance in the area of photoelectrochemical research owning to their unique optoelectronic properties. It is possible to modify the electrical conductivity and optoelectronic properties of titania by intentional inclusion of atomic impurity in the material. Here for the first time, we have doped lanthanum homogeneously in TiO2 nanorod arrays. The homogeneous distribution of lanthanum in titania lattice is confirmed by scanning transmission electron microscopy (STEM) elemental mapping and line scanning analysis. After doping with lanthanum, there is a negative shift of the flat-band potential of the TiO2 nanorods and the charge carrier density of the nanorods is also improved. The energy-conversion efficiency of a dye-sensitized solar cell based on 4 mol% La-doped nanorods is increased about 21% compared with the undoped one.

1 aSadhu, Subha1 aPoddar, Pankaj uhttp://library.ncl.res.in/content/growth-oriented-single-crystalline-la-doped-tio2-nanorod-arrays-electrode-and-001339nas a2200253 4500008004100000022001400041245013000055210006900185260007700254300001400331520038900345653001700734653001300751653002600764653001400790653002200804100002500826700001700851700002400868700002100892700002400913700002100937856012700958 2014 eng d a1434-193X00aGeneral approach to N-heterocyclic carbenes with a fused tetracyclic core: ligands for suzuki-miyaura cross-coupling reaction0 aGeneral approach to Nheterocyclic carbenes with a fused tetracyc aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcJUL a4482-44863 a

The synthesis of an N-heterocyclic carbene (NHC) based on a tetracyclic scaffold by using simple, general, and scalable chemistry is disclosed. The developed route is suitable for introducing multiple substitutions on the tetracyclic scaffold. The utility of the present NHC as a ligand in the Suzuki-Miyaura cross-coupling reaction is demonstrated with a low catalyst loading.

10aC-C coupling10acarbenes10aHomogeneous catalysis10aN ligands10asynthetic methods1 aSutar, Revannath, L.1 aKumar, Vinod1 aShingare, Rahul, D.1 aThorat, Shridhar1 aGonnade, Rajesh, G.1 aReddy, Srinivasa uhttp://library.ncl.res.in/content/general-approach-n-heterocyclic-carbenes-fused-tetracyclic-core-ligands-suzuki-miyaura-002430nas a2200253 4500008004100000022001400041245010900055210006900164260010600233300001600339490000700355520143700362653002801799653003001827653002701857653002301884653002701907653002001934100001601954700002401970700002601994700002502020856013102045 2014 eng d a0360-319900aGenesis of enhanced photoactivity of CdS/Ni-x nanocomposites for visible-light-driven splitting of water0 aGenesis of enhanced photoactivity of CdSNix nanocomposites for v aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcNOV a19424-194330 v393 a

A series of CdS/Ni-x nanocomposite photocatalysts, containing ca. 0.6-15 wt% Ni, were synthesized using a one-step hydrothermal method and characterized for their crystallographic, morphological, interfacial, and optical properties. Rietveld refinement of powder XRD data revealed the coexistence of wurtzite (hexagonal) and zinc blende (cubic) phases of CdS in ratios dependent on Ni content. Only a fraction of Ni existed as a secondary phase of NiS while the majority occupied the lattice positions of hexagonal CdS. Whereas up to 10-fold enhancement in H-2 evolution compared with pure CdS was observed for samples containing similar to 1.5-4.5 wt% Ni, samples with smaller or larger Ni content displayed poor activity for visible-light-induced splitting of water in presence of sulfide-sulphite ions as sacrificial electron donors. In contrary to recent findings, our study reveals that the enhanced CdS photoactivity is not a result of charge transfer between p-type NiS and n-type CdS, Ni-induced visible-region absorbance, or the coating of CdS particles by non-photoactive NiS. Instead, the preparation-dependent hexagonal/cubic CdS phase boundaries and particle morphology may play a crucial role. Additionally, certain Ni-doping-induced sub-bandgap shallow energy levels contribute to charge carrier separation. Copyright (C) 2014, Hydrogen Energy Publications, LLC. Published by Elsevier Ltd. All rights reserved.

10aCdS/Ni-x nanocomposites10aDominant hexagonal facets10aEnhanced photoactivity10aHydrogen evolution10aPhase boundary effects10awater splitting1 aDevi, Suman1 aKorake, Prakash, V.1 aAchary, Srungarpu, N.1 aGupta, Narencira, M. uhttp://library.ncl.res.in/content/genesis-enhanced-photoactivity-cdsni-x-nanocomposites-visible-light-driven-splitting-water-001962nas a2200217 4500008004100000022001400041245017400055210006900229260006700298300001000365490000800375520103500383653002401418653004101442653003601483100002501519700002201544700002301566700002401589856013101613 2014 eng d a0378-109700aGenome sequencing analysis reveals virulence-related gene content of Ochrobactrum intermedium strain 229E, a urease-positive strain isolated from the human gastric niche0 aGenome sequencing analysis reveals virulencerelated gene content a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcOCT a12-150 v3593 a

We report draft genome sequence of Ochrobactrum intermedium strain 229E concurrent with Helicobacter pylori in urease positive gastric biopsy of non-ulcer dyspeptic individual from Southern part of India. Since the role of Ochrobactrum in human gastric environment is poorly understood, comprehensive pathological, microbiological, and genome level understanding are necessary to evaluate its association with H. pylori in the gastric niche. Comparative analysis of O. intermedium 299E strain revealed functional similarities with virulence related gene clusters present in H. pylori genomes, which probably might aid in its ability to persist in the human gastric mucosa. However, H. pylori specific vacuolating cytotoxin (vacA) involved in vacuolization, cytotoxicity, and T-cell inhibition was absent in the O. intermedium 229E genome. Taken together, O. intermedium 229E shared numerous features like secretion system, urease, and flagella with H. pylori genome sequence that might aid concurrence in the gastric niche.

10aHelicobacter pylori10aOchrobactrum intermedium strain 229E10avirulence related gene clusters1 aKulkarni, Girish, J.1 aShetty, Sudarshan1 aDharne, Mahesh, S.1 aShouche, Yogesh, S. uhttp://library.ncl.res.in/content/genome-sequencing-analysis-reveals-virulence-related-gene-content-ochrobactrum-intermedium-001914nas a2200169 4500008004100000022001400041245016600055210006900221260009100290300001200381490000600393520118100399100001701580700001701597700001901614856011101633 2014 eng d a1932-620300aGenome-wide identification and tissue-specific expression analysis of UDP-glycosyltransferases genes confirm their abundance in cicer arietinum (chickpea) genome0 aGenomewide identification and tissuespecific expression analysis a1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USAbPUBLIC LIBRARY SCIENCEcOCT ae1097150 v93 a

UDP-glycosyltransferases (EC 2.4.1.x; UGTs) are enzymes coded by an important gene family of higher plants. They are involved in the modification of secondary metabolites, phytohormones, and xenobiotics by transfer of sugar moieties from an activated nucleotide molecule to a wide range of acceptors. This modification regulates various functions like detoxification of xenobiotics, hormone homeostasis, and biosynthesis of secondary metabolites. Here, we describe the identification of 96 UGT genes in Cicer arietinum (CaUGT) and report their tissue-specific differential expression based on publically available RNA-seq and expressed sequence tag data. This analysis has established medium to high expression of 84 CaUGTs and low expression of 12 CaUGTs. We identified several closely related orthologs of CaUGTs in other genomes and compared their exon-intron arrangement. An attempt was made to assign functional specificity to chickpea UGTs by comparing substrate binding sites with experimentally determined specificity. These findings will assist in precise selection of candidate genes for various applications and understanding functional genomics of chickpea.

1 aSharma, Ranu1 aRawat, Vimal1 aSuresh, C., G. uhttp://library.ncl.res.in/content/genome-wide-identification-and-tissue-specific-expression-analysis-udp-001482nas a2200157 4500008004100000022001400041245011100055210006900166260008700235300002300322490000800345520081000353100001701163700001801180856012601198 2014 eng d a0021-960600aGeometry-dependent lifetime of Interatomic coulombic decay using equation-of-motion coupled cluster method0 aGeometrydependent lifetime of Interatomic coulombic decay using  a1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USAbAMER INST PHYSICScDEC aArticle No. 2341080 v1413 a

Electronically excited atom or molecule in an environment can relax via transferring its excess energy to the neighboring atoms or molecules. The process is called Interatomic or Intermolecular coulombic decay (ICD). The ICD is a fast decay process in environment. Generally, the ICD mechanism predominates in weakly bound clusters. In this paper, we have applied the complex absorbing potential approach/equation-of-motion coupled cluster (CAP/EOMCCSD) method which is a combination of CAP and EOMCC approach to study the lifetime of ICD at various geometries of the molecules. We have applied this method to calculate the lifetime of ICD in Ne-X; X = Ne, Mg, Ar, systems. We compare our results with other theoretical and experimental results available in literature. (C) 2014 AIP Publishing LLC.

1 aGhosh, Aryya1 aVaval, Nayana uhttp://library.ncl.res.in/content/geometry-dependent-lifetime-interatomic-coulombic-decay-using-equation-motion-coupled-002422nas a2200229 4500008004100000022001400041245012500055210006900180260007700249300001200326490000600338520156500344653001301909653001401922653001901936653001901955653001301974100002901987700002302016700002202039856013102061 2014 eng d a2194-428800aGlycerol etherification using n-butanol to produce oxygenated additives for biodiesel fuel over H-beta zeolite catalysts0 aGlycerol etherification using nbutanol to produce oxygenated add aBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANYbWILEY-V C H VERLAG GMBHcMAY a446-4520 v23 a

The catalytic etherification of glycerol has been systematically studied in batch process by using n-butanol to produce oxygenated additives for biodiesel fuels over various solid-acid catalysts, such as H-beta zeolite, ZSM-5, K10, etc.. The present work includes a detailed study of the optimization of the etherification process parameters, such as catalyst loading (7-20 wt% of glycerol), molar ratio of glycerol/n-butanol (1: 6 to 1: 15), speed of agitation (100-400 rpm), reaction temperature (413-453 K), and reaction time (0.5-4 h) in view of maximizing the glycerol conversion and selectivity towards mono-butyl-glycerol ether (ME). The catalyst reusability was studied using the optimized process parameters. Amongst the studied catalysts, the H-beta zeolite was found to be the most promising for the etherification of glycerol with glycerol conversion of 55% and a 98% selectivity towards ME formation. The H-beta zeolite was found to be an active and stable catalyst for up to 4 cycles. The use of n-butanol as alkylating agent is presented for first time, to the authors knowledge. The reaction was performed at milder operating conditions (0.5 MPa) than previously reported (2 MPa). A kinetic model was developed for the etherification reaction and the data obtained at optimized process parameters was used to calculate the kinetic parameters. The reaction rate constants at different reaction temperatures, activation energies, and pre-exponential factors were obtained for the etherification reaction with an accuracy of R-2 > 0.989.

10abiofuels10acatalysis10aetherification10afuel additives10azeolites1 aNandiwale, Kakasaheb, Y.1 aPatil, Shivraj, E.1 aBokade, Vijay, V. uhttp://library.ncl.res.in/content/glycerol-etherification-using-n-butanol-produce-oxygenated-additives-biodiesel-fuel-over-h-000921nas a2200157 4500008004100000022001400041245006700055210005800122260011000180300001400290490000700304520030700311100002900618700002400647856009200671 2014 eng d a1359-734500aGold(I)-catalysed [1,3] O -> C rearrangement of allenyl ethers0 aGoldIcatalysed 13 O C rearrangement of allenyl ethers aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJAN a2152-21540 v503 a

A simple and rapid access to the alpha-substituted acryl aldehydes has been provided by developing a gold-catalysed [1,3] rearrangement of the allenyl ethers importantly with a record turnover frequency of 4600 h(-1) (at 0.05 mol% of the catalyst concentration) in homogeneous gold(I) catalysis.

1 aKona, Chandrababu, Naidu1 aRamana, Chepuri, V. uhttp://library.ncl.res.in/content/goldi-catalysed-13-o-c-rearrangement-allenyl-ethers-002007nas a2200205 4500008004100000022001400041245011900055210006900174260011000243300001400353490000600367520117900373100001801552700002101570700002001591700002301611700001801634700001901652856013001671 2014 eng d a2050-750X00aGraphene quantum dots conjugated albumin nanoparticles for targeted drug delivery and imaging of pancreatic cancer0 aGraphene quantum dots conjugated albumin nanoparticles for targe aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN a3190-31950 v23 a

Pancreatic cancer is considered to be the deadliest of all cancers due to its poor prognosis and resistance to conventional therapies. In this study, the potential of hyaluronic acid functionalized and green fluorescent graphene quantum dot (GQD)-labeled human serum albumin nanoparticles for pancreatic cancer specific drug delivery and bioimaging was explored. GQDs with tunable fluorescence properties and biocompatibility have attracted much more interest in recent years as compared to their metal semiconductor counterparts. We adopted lawsone (2-hydroxy-1,4-naphthoquinone) as a novel reducing agent for the synthesis of quantum dots and, in addition to excellent fluorescence of the synthesized GQDs, a good quantum yield of similar to 14% was also obtained. Gemcitabine, the most preferred drug for pancreatic cancer treatment, was encapsulated in albumin nanoparticles, and it was observed that our nanoformulation significantly enhanced the bioavailability and sustained release property of the drug to pancreatic cancer cells in vitro. Moreover, the GQD-mediated bioimaging was excellent and enhanced the efficacy of our system as a drug delivery vehicle.

1 aNigam, Preeti1 aWaghmode, Shobha1 aLouis, Michelle1 aWangnoo, Shishanka1 aChavan, Pooja1 aSarkar, Dhiman uhttp://library.ncl.res.in/content/graphene-quantum-dots-conjugated-albumin-nanoparticles-targeted-drug-delivery-and-imaging-002170nas a2200169 4500008004100000022001400041245016900055210006900224260011000293300001600403490000600419520139500425100001801820700001701838700001801855856012701873 2014 eng d a2046-206900aGreen chemical incorporation of silicon into polyoxoanions of molybdenum: characterization, thermal kinetics study and their photocatalytic water splitting activity0 aGreen chemical incorporation of silicon into polyoxoanions of mo aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV a63328-633370 v43 a

Cetylpyridinium silicomolybdate (CSM) nanorods were successfully synthesized by applying green chemistry principles using sodium molybdate and a structure directing cationic surfactant, cetyl pyridinium chloride (CPC) at room temperature. The composition and morphology of the nanorods were established by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), thermogravimetric analysis (TG) and inductively coupled plasma atomic emission spectroscopic (ICP-AES) techniques. The thermal decomposition kinetics of CSM nanorods were investigated by a non-isothermal thermogravimetric analyzer at various heating rates. The thermal decomposition of CSM occurred in two stages. The activation energies of the first and second stages of thermal decomposition for all heating rates have been estimated using the iso-conventional methods of Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunose (KAS) and the results are found to be in good agreement with each other. The invariant kinetic parameter (IKP) method and master plot method were also used to evaluate the kinetic parameters and mechanism for the thermal decomposition of CSM. The photocatalytic water oxidation mechanism using the CSM catalyst in the presence of platinum (Pt) co-catalyst enhances the H-2 evolution and was found to be 1.946 mmol g(-1) h(-1).

1 aD'Cruz, Bessy1 aSamuel, Jadu1 aGeorge, Leena uhttp://library.ncl.res.in/content/green-chemical-incorporation-silicon-polyoxoanions-molybdenum-characterization-thermal-002177nas a2200193 4500008004100000022001400041245008900055210006900144260011000213300001600323490000600339520138500345100002401730700003701754700002601791700002201817700003001839856011401869 2014 eng d a2046-206900aGreen chemistry approach to styrene from ethylbenzene and air on MnxTi1-xO2 catalyst0 aGreen chemistry approach to styrene from ethylbenzene and air on aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT a57087-570970 v43 a

Styrene (ST) is an industrially important commodity chemical, and design of a suitable catalyst, which provides high ethyl benzene (EB) conversion and styrene selectivity at Lower temperature with sustainable activity, is one of the major challenges in the field of heterogeneous catalysis. Manganese incorporated in titania (MnxT1-xO2) anatase Lattice, prepared via the solution combustion method, was evaluated for oxidative dehydrogenation (ODH) of EB with O-2 or air. MnxTi1-xO2 catalysts were characterized by different physiochemical methods. Up to 15% Mn could be introduced into the TiO2 Lattice. TEM and XRD indicate disordered mesoporosity, further confirmed by adsorption isotherm analysis. MnxTi1-xO2 catalysts were evaluated for ST synthesis from EB using air or oxygen as oxidant between 440 and 570 degrees C. Reaction conditions have been varied systematically, such as catalyst composition, and EB/air/O-2 flow. MnxTi1-xO2 shows sustainable 55% styrene yield for 45 h without deactivation under optimum conditions. A thorough analysis of spent catalysts demonstrates the conversion of initial anatase phase MnxTi1-xO2 to Mn3O4 supported on the rutile (R) phase of TiO2. The above change occurs in the first few hours of reaction and the Mn3O4 on R-TiO2 phase is the active phase of the catalyst and responsible for sustainable activity for Longer duration.

1 aNegi, Sanjay, Singh1 aVenugopalan, Aswathy, Thareparam1 aRaja, Thirumalaiswamy1 aSingh, Anand, Pal1 aGopinath, Chinnakonda, S. uhttp://library.ncl.res.in/content/green-chemistry-approach-styrene-ethylbenzene-and-air-mnxti1-xo2-catalyst-001836nas a2200157 4500008004100000022001400041245012400055210006900179260011000248300001600358490000600374520112900380100001601509700002401525856012901549 2014 eng d a2046-206900aGreen synthesis of noble metal nanoparticles using cysteine-modified silk fibroin: catalysis and antibacterial activity0 aGreen synthesis of noble metal nanoparticles using cysteinemodif aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a46285-462920 v43 a

Noble metal nanoparticles (NPs) have shown remarkable potential for numerous applications. In this work, a simple, one-pot, green method for the synthesis of gold, silver, palladium, and platinum NPs by using thiol-modified silk fibroin (SF-SH) has been described. The incorporation of thiol groups into silk fibroin (SF) yields small, mono-dispersed metal nanoparticles with good colloidal stability. UV-Vis, transmission electron microscopy (TEM), and X-ray powder diffraction (XRD) analyses show the formation of NPs, and thermo-gravimetric analysis (TGA) data reveal interaction of the NPs with thiol-modified SF. We also show that all the NP-SF conjugates catalyse the reduction of p-nitrophenol to p-aminophenol in the presence of NaBH4 at room temperature. The NP-SF conjugate materials were processed into different material formats like porous scaffolds and films without compromising their individual properties. The Au-SF-SH composite scaffold was used successfully in the heterogeneous catalysis of p-nitrophenol reduction using NaBH4 while the Ag-SF-SH conjugated film showed good antibacterial activity.

1 aDas, Soumen1 aDhar, Basab, Bijayi uhttp://library.ncl.res.in/content/green-synthesis-noble-metal-nanoparticles-using-cysteine-modified-silk-fibroin-catalysis-002193nas a2200181 4500008004100000022001400041245017800055210006900233260011000302300001400412490000700426520137300433100001801806700001701824700003401841700001801875856011801893 2014 eng d a1144-054600aGreen synthesis of novel polyoxoanions of tungsten containing phosphorus as a heteroatom: characterization, non-isothermal decomposition kinetics and photocatalytic activity0 aGreen synthesis of novel polyoxoanions of tungsten containing ph aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a5436-54440 v383 a

Synthesis of cetylpyridinium phosphotungstate (CPW) nanospheres was carried out by using sodium tungstate and a structure directing cationic surfactant, cetyl pyridinium chloride (CPC), at room temperature by applying green chemistry principles. The composition and morphology of the nanospheres were established by Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), thermogravimetric analysis (TGA) and inductively coupled plasma atomic emission spectroscopic (ICP-AES) techniques. Thermal properties of the nanoparticles were investigated by nonisothermal analysis under a nitrogen atmosphere at four different heating rates 10, 15, 20 and 25 degrees C min(-1). The thermal decomposition of CPW occurred in two stages. The activation energy values at each stage of thermal decomposition for all heating rates were calculated by Flynn-Wall-Ozawa (FWO) and Kissinger-Akahira-Sunnose (KAS) methods. The invariant kinetic parameter (IKP) method and the master plot method were also used to evaluate the kinetic parameters and mechanism for the thermal decomposition of CPW. The photocatalytic water oxidation mechanism using a CPW catalyst in the presence of a platinum (Pt) co-catalyst enhances the H-2 evolution, which was found to be 2.0 mmol g(-1) h(-1).

1 aD'Cruz, Bessy1 aSamuel, Jadu1 aSreedhar, Mulloor, Kesavapill1 aGeorge, Leena uhttp://library.ncl.res.in/content/green-synthesis-novel-polyoxoanions-tungsten-containing-phosphorus-heteroatom-001979nas a2200205 4500008004100000022001400041245014100055210006900196260011000265300001600375490000600391520111700397100002701514700002301541700001901564700001601583700002201599700002601621856012601647 2014 eng d a2046-206900aGreen synthesis of polysaccharide stabilized gold nanoparticles: chemo catalytic and room temperature operable vapor sensing application0 aGreen synthesis of polysaccharide stabilized gold nanoparticles  aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY a24014-240190 v43 a

A facile, one pot, completely green, and cheap route for the synthesis of gold nanoparticles (AuNPs) has been developed by using locust bean gum (LBG), both as a reducing and a stabilizing agent. Synthesized AuNPs were characterized by UV-vis spectroscopy, TEM, XRD, dynamic light scattering analysis (DLS) and EDAX. A characteristic surface plasmon peak at 537 nm confirmed the formation of AuNPs. Synthesized AuNPs were found to be an efficient catalyst for the reduction of 4-nitrophenol (4-NP) to 4-aminophenol (4-AP). The reaction follows pseudo-first order kinetics with a rate constant of 14.46 X 10(-2) min(-1). Furthermore, the catalytic efficiency of AuNPs for ethanol vapor sensing was investigated by doping AuNPs in a tin oxide (SnO2) matrix synthesized by a single step thermal decomposition method. The AuNPs doped SnO2 sensor showed a fast response (similar to 5 seconds) and excellent ethanol sensing behavior in the range of 10 to 120 ppm at room temperature. A two fold increase in ethanol vapor sensing response was observed with AuNPs doped SnO2 as compared with the pure SnO2 sensor.

1 aTagad, Chandrakant, K.1 aRajdeo, Kishor, S.1 aKulkarni, Atul1 aMore, Pooja1 aAiyer, Rohini, C.1 aSabharwal, Sushma, G. uhttp://library.ncl.res.in/content/green-synthesis-polysaccharide-stabilized-gold-nanoparticles-chemo-catalytic-and-room-001512nas a2200181 4500008004100000022001400041245005700055210005500112260008700167300001100254490000800265520088000273100002701153700002801180700001801208700001601226856008801242 2014 eng d a0021-960600aGround state of naphthyl cation: singlet or triplet?0 aGround state of naphthyl cation singlet or triplet a1305 WALT WHITMAN RD, STE 300, MELVILLE, NY 11747-4501 USAbAMER INST PHYSICScMAR a1143120 v1403 a

We present a benchmark theoretical investigation on the electronic structure and singlet- triplet(ST) gap of 1- and 2-naphthyl cations using the CCSD(T) method. Our calculations reveal that the ground states of both the naphthyl cations are singlet, contrary to the results obtained by DFT/B3LYP calculations reported in previous theoretical studies. However, the triplet states obtained in the two structural isomers of naphthyl cation are completely different. The triplet state in 1-naphthyl cation is (pi,sigma) type, whereas in 2-naphthyl cation it is (pi,sigma) type, The S-T gaps in naphthyl cations and the relative stability ordering of the singlet and the triplet states are highly sensitive to the basis set quality as well as level of correlation, and demand for inclusion of perturbative triples in the coupled-cluster ansatz. (c) 2014 AIP Publishing LLC.

1 aDutta, Achintya, Kumar1 aManohar, Prashant, Uday1 aVaval, Nayana1 aPal, Sourav uhttp://library.ncl.res.in/content/ground-state-naphthyl-cation-singlet-or-triplet-002651nas a2200205 4500008004100000022001400041245013700055210006900192260009100261300001300352490000700365520181000372100002102182700001902203700002202222700002402244700003302268700002202301856012202323 2015 eng d a1932-620300aGedunin and azadiradione: human pancreatic alpha-amylase inhibiting limonoids from neem (azadirachta indica) as anti-diabetic agents0 aGedunin and azadiradione human pancreatic alphaamylase inhibitin a1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USAbPUBLIC LIBRARY SCIENCEcOCT ae01401130 v103 a

Human pancreatic alpha-amylase (HPA) inhibitors offer an effective strategy to lower postprandial hyperglycemia via control of starch breakdown. Limonoids from Azadirachta indica known for their therapeutic potential were screened for pancreatic alpha-amylase inhibition, a known anti-diabetic target. Studies were carried out to reveal their mode of action so as to justify their hypoglycemic potential. Of the nine limonoids isolated/semi-synthesized from A. indica and screened for alpha-amylase inhibition, azadiradione and exhibited potential inhibition with an IC50 value of 74.17 and 68.38 mu M, respectively against HPA under in vitro conditions. Further screening on AR42J alpha-amylase secretory cell line for cytotoxicity and bioactivity revealed that azadiradione and gedunin exhibited cytotoxicity with IC50 of 11.1 and 13.4 mu M. Maximal secreted alpha-amylase inhibition of 41.8% and 53.4% was seen at 3.5 and 3.3 mu M, respectively. Michaelis-Menten kinetics suggested a mixed mode of inhibition with maltopentaose (K-i 42.2, 18.6 mu M) and starch (K-i' 75.8, 37.4 mu M) as substrate with a stiochiometry of 1: 1 for both azadiradione and gedunin, respectively. The molecular docking simulation indicated plausible p-alkyl and alkyl-alkyl interactions between the aromatic amino acids and inhibitors. Fluorescence and CD confirmed the involvement of tryptophan and tyrosine in ligand binding to HPA. Thermodynamic parameters suggested that binding is enthalpically and entropically driven with Delta G degrees of -21.25 kJ mol(-1) and -21.16 kJ mol(-1) for azadiradione and gedunin, respectively. Thus, the limonoids azadiradione and gedunin could bind and inactivate HPA (anti-diabetic target) and may prove to be lead drug candidates to reduce/control post-prandial hyperglycemia.

1 aPonnusamy, Sudha1 aHaldar, Saikat1 aMulani, Fayaj, A.1 aZinjarde, Smita, S.1 aThulasiram, Hirekodathakallu1 aRaviKumar, Ameeta uhttp://library.ncl.res.in/content/gedunin-and-azadiradione-human-pancreatic-alpha-amylase-inhibiting-limonoids-neem-101943nas a2200289 4500008004100000022001400041245009300055210006900148260007100217300001600288490000800304520090600312100002201218700002301240700002501263700002701288700002801315700003201343700002401375700002001399700001901419700001901438700002501457700002201482700002201504856012701526 2015 eng d a0002-786300aGelation landscape engineering using a multi-reaction supramolecular hydrogelator system0 aGelation landscape engineering using a multireaction supramolecu a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcNOV a14236-142390 v1373 a

Simultaneous control of the kinetics and thermodynamics of two different types of covalent chemistry allows pathway selectivity in the formation of hydrogelating molecules from a complex reaction network. This can lead to a range of hydrogel materials with vastly different properties, starting from a set of simple starting compounds and reaction conditions. Chemical reaction between a trialdehyde and the tuberculosis drug isoniazid can form one, two, or three hydrazone connectivity products, meaning kinetic gelation pathways can be addressed. Simultaneously, thermodynamics control the formation of either a keto or an enol tautomer of the products, again resulting in vastly different materials. Overall, this shows that careful navigation of a reaction landscape using both kinetic and thermodynamic selectivity can be used to control material selection from a complex reaction network.

1 aFoster, Jamie, S.1 aZurek, Justyna, M.1 aAlmeida, Nuno, M. S.1 aHendriksen, Wouter, E.1 ale Sage, Vincent, A. A.1 aLakshminarayanan, Vasudevan1 aThompson, Amber, L.1 aBanerjee, Rahul1 aEelkema, Rienk1 aMulvana, Helen1 aPaterson, Martin, J.1 avan Esch, Jan, H.1 aLloyd, Gareth, O. uhttp://library.ncl.res.in/content/gelation-landscape-engineering-using-multi-reaction-supramolecular-hydrogelator-system-001741nas a2200181 4500008004100000022001400041245010900055210006900164260007100233300001600304490000700320520102000327100002201347700001901369700002201388700002601410856012301436 2015 eng d a0888-588500aGeneric framework for crystallization processes using the population balance model and its applicability0 aGeneric framework for crystallization processes using the popula a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcOCT a10539-105480 v543 a

A generic modeling framework for batch cooling crystallization processes has been developed to understand the crystallization process from operational and modeling point of view. The generic framework for crystallization process modeling incorporates the characteristic dimensions of crystals and polymorphic transformation, as well as the hydrodynamic mixing effects in the crystallizer. This Polyhedral Polymorphic Multizonal Population Balance (PPMPBM) model considers bottom-up and top-down approaches for specific systems with specific targets. The PPMPBM framework allows switching between complex and simple models to study different crystallization systems with different scenarios and combination thereof. This framework uses gPROMS software (PSE, UK) and the Microsoft Excel front-end, along with the Polytope module in Matlab, to predict the crystal size and shape evolution as well as supersaturation profiles inside the crystallizer, which can be implemented for various crystallization systems.

1 aShaikh, Latif, J.1 aBari, Atul, H.1 aRanade, Vivek, V.1 aPandit, Aniruddha, B. uhttp://library.ncl.res.in/content/generic-framework-crystallization-processes-using-population-balance-model-and-its-003060nas a2200265 4500008004100000022001400041245012400055210006900179260007300248300001100321490000900332520205300341653002802394653002302422653002402445653002702469653002602496653005102522100001602573700001802589700001502607700001802622700002302640856013102663 2015 eng d a0021-967300aGenetic programming based quantitative structure-retention relationships for the prediction of Kovats retention indices0 aGenetic programming based quantitative structureretention relati aPO BOX 211, 1000 AE AMSTERDAM, NETHERLANDSbELSEVIER SCIENCE BVcNOV a98-1090 v14203 a

The development of quantitative structure-retention relationships (QSRR) aims at constructing an appropriate linear/nonlinear model for the prediction of the retention behavior (such as Kovats retention index) of a solute on a chromatographic column. Commonly, multi-linear regression and artificial neural networks are used in the QSRR development in the gas chromatography (GC). In this study, an artificial intelligence based data-driven modeling formalism, namely genetic programming (GP), has been introduced for the development of quantitative structure based models predicting Kovats retention indices (KRI). The novelty of the GP formalism is that given an example dataset, it searches and optimizes both the form (structure) and the parameters of an appropriate linear/nonlinear data-fitting model. Thus, it is not necessary to pre-specify the form of the data-fitting model in the GP-based modeling. These models are also less complex, simple to understand, and easy to deploy. The effectiveness of GP in constructing QSRRs has been demonstrated by developing models predicting KRIs of light hydrocarbons (case study-I) and adamantane derivatives (case study-II). In each case study, two-, three- and four-descriptor models have been developed using the KRI data available in the literature. The results of these studies clearly indicate that the GP-based models possess an excellent KRI prediction accuracy and generalization capability. Specifically, the best performing four-descriptor models in both the case studies have yielded high (>0.9) values of the coefficient of determination (R-2) and low values of root mean squared error (RMSE) and mean absolute percent error (MAPE) for training, test and validation set data. The characteristic feature of this study is that it introduces a practical and an effective GP-based method for developing QSRRs in gas chromatography that can be gainfully utilized for developing other types of data-driven models in chromatography science. (C) 2015 Elsevier B.V. All rights reserved.

10aArtificial intelligence10aGas chromatography10agenetic programming10aKovats retention index10aMolecular descriptors10aQuantitative structure-retention relationships1 aGoel, Purva1 aBapat, Sanket1 aVyas, Renu1 aTambe, Amruta1 aTambe, Sanjeev, S. uhttp://library.ncl.res.in/content/genetic-programming-based-quantitative-structure-retention-relationships-prediction-kovats-002808nas a2200265 4500008004100000022001400041245012900055210006900184260010600253300001000359490000700369520184100376653001102217653002002228653002002248653002302268653002202291653003402313653001002347653001402357653001402371100001702385700001902402856012102421 2015 eng d a0010-482500aGenome-wide identification and structure-function studies of proteases and protease inhibitors in cicer arietinum (chickpea)0 aGenomewide identification and structurefunction studies of prote aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN a67-810 v563 a

Background: Proteases are a family of enzymes present in almost all living organisms. In plants they are involved in many biological processes requiring stress response in situations such as water deficiency, pathogen attack, maintaining protein content of the cell, programmed cell death, senescence, reproduction and many more. Similarly, protease inhibitors (PIs) are involved in various important functions like suppression of invasion by pathogenic nematodes, inhibition of spores-germination and mycelium growth of Alternaria alternata and response to wounding and fungal attack. As much as we know, no genome-wide study of proteases together with proteinaceous PIs is reported in any of the sequenced genomes till now. Methods: Phylogenetic studies and domain analysis of proteases were carried out to understand the molecular evolution as well as gene and protein features. Structural analysis was carried out to explore the binding mode and affinity of PIs for cognate proteases and prolyl oligopeptidase protease with inhibitor ligand. Results: In the study reported here, a significant number of proteases and PIs were identified in chickpea genome. The gene expression profiles of proteases and Pis in five different plant tissues revealed a differential expression pattern in more than one plant tissue. Molecular dynamics studies revealed the formation of stable complex owing to increased number of protein-ligand and inter and intramolecular protein-protein hydrogen bonds. Discussion: The genome-wide identification, characterization, evolutionary understanding, gene expression, and structural analysis of proteases and Pis provide a framework for future analysis when defining their roles in stress response and developing a more stress tolerant variety of chickpea. (C) 2014 Elsevier Ltd. All rights reserved.

10aDomain10aGene expression10aGenome analysis10aHomology modelling10aMolecular docking10amolecular dynamics simulation10aMotif10aOrthologs10aPhylogeny1 aSharma, Ranu1 aSuresh, C., G. uhttp://library.ncl.res.in/content/genome-wide-identification-and-structure-function-studies-proteases-and-protease-002393nas a2200301 4500008004100000022001400041245011400055210006900169260009000238300001000328490000700338520136900345653001801714653001901732653001401751653000801765100002001773700002001793700001501813700001801828700001801846700002601864700001501890700001901905700002401924700001701948856012601965 2015 eng d a0733-521000aGenotype x environment interactions and QTL clusters underlying dough rheology traits in triticum aestivum L.0 aGenotype x environment interactions and QTL clusters underlying  a24-28 OVAL RD, LONDON NW1 7DX, ENGLANDbACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDcJUL a82-910 v643 a

Genetic dissection of dough rheology traits (DRT) in hexaploid wheat was carried out using nine mixograph characters evaluated in two consecutive years in three agro-climatic zones in India in an RIL population (HI977 x HD2329). Pearson correlations determined in each year-location indicated 15 stable trait inter-relationships among them but inconsistent correlations with loaf volume (LV) were observed. Using AMMI analysis we derived patterns in G x E interactions (GEI) indicating 6-47% contribution for the DRT. Composite interval mapping using a linkage map of 202 SSR markers identified 144 DRT QTLs of which, 96 were detected in single- and the rest in two to five year-locations. Sixteen QTL clusters located on ten chromosomes were identified and only three of them on chromosomes 1B, 5B and 6D involved LV QTLs. For each trait, majority of the DRT QTLs detected in single as well as multiple environments showed location-specificity and suggested that owing to GEI, breeding for wheat dough quality might need careful selection of QTLs targeted for individual agro-climatic zones. The inconsistent correlations of DRT and LV and differential locations of their QTLs in this population corroborated that using dough rheological traits alone to predict LV might pose challenges during wheat improvement. (C) 2015 Elsevier Ltd. All rights reserved.

10aAMMI analysis10aDough rheology10aMixograph10aQTL1 aPrashant, Ramya1 aMani, Elangovan1 aRai, Richa1 aGupta, R., K.1 aTiwari, Ratan1 aDholakia, Bhushan, B.1 aOak, Manoj1 aRoeder, Marion1 aKadoo, Narendra, Y.1 aGupta, Vidya uhttp://library.ncl.res.in/content/genotype-x-environment-interactions-and-qtl-clusters-underlying-dough-rheology-traits-001079nas a2200181 4500008004100000022001400041245008500055210006900140260007100209300001400280490000700294520039100301100002000692700001900712700002300731700002600754856011700780 2015 eng d a1043-180200aGlycine-linked nucleoside-beta-amino acids: polyamide analogues of nucleic acids0 aGlycinelinked nucleosidebetaamino acids polyamide analogues of n a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAUG a1737-17420 v263 a

3'-5'-Deoxyribose-sugar-phoshate backbone in DNA is completely replaced by 2'-deoxyribonucleoside-based beta-amino acids interlinked by glycine to create uncharged polyamide DNA with 3'-5'-directionality. These oligomers as conjugates of alpha-amino acids and nucleoside-beta-amino acids bind strongly and sequence-specifically only to the antiparallel complementary RNA and DNA.

1 aBanerjee, Anjan1 aBagmare, Seema1 aVarada, Manojkumar1 aKumar, Vaijayanti, A. uhttp://library.ncl.res.in/content/glycine-linked-nucleoside-beta-amino-acids-polyamide-analogues-nucleic-acids-001074nas a2200169 4500008004100000022001400041245005800055210005500113260011000168300001400278490000700292520044000299100002900739700002300768700002400791856008900815 2015 eng d a1477-052000aGold(I)-catalyzed hydroindolylation of allenyl ethers0 aGoldIcatalyzed hydroindolylation of allenyl ethers aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAPR a5358-53620 v133 a

The gold(I)-catalyzed reaction/rearrangement of allenyl ethers has been investigated in the presence of indoles. Either hydroindolylation or alkylation of an indole with the pendant group of allenyl ether has been observed. The reaction outcome seems to be decided mainly by the nature of the pendant group of the allenyl ether. Control experiments are indicative of an inner sphere mechanism for the hydroindolylation reaction.

1 aKona, Chandrababu, Naidu1 aShinde, Mahesh, H.1 aRamana, Chepuri, V. uhttp://library.ncl.res.in/content/goldi-catalyzed-hydroindolylation-allenyl-ethers-000719nas a2200169 4500008004100000245017600041210007000217260000800287300001200295490000700307100002300314700002000337700001700357700002000374700002100394856013400415 2015 eng d00aGold(I)/chiral brønsted acid catalyzed enantioselective hydroamination-hydroarylation of alkynes: effect of remote hydroxyl group in the reactivity and enantioselectivity0 aGoldIchiral brønsted acid catalyzed enantioselective hydroaminat cJAN a975-9790 v211 aShinde, Valmik, S.1 aMane, Manoj, V.1 aVanka, Kumar1 aMallick, Arijit1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/goldichiral-br%C3%B8nsted-acid-catalyzed-enantioselective-hydroamination-hydroarylation-alkynes01615nas a2200205 4500008004100000245005400041210005400095260000800149300002700157490000800184520096300192100002301155700002401178700002401202700002301226700002101249700003001270700002401300856008501324 2015 eng d00aGraphene nanoribbons as prospective field emitter0 aGraphene nanoribbons as prospective field emitter cJAN aArticle Number: 0231110 v1063 a

Field emission characteristics of graphene nanoribbons (GNRs) synthesized by unzipping of multiwall carbon nanotubes using a facile hydrothermal route have been investigated at a base pressure of 1 x 10(-8) mbar. The values of turn-on field, required to draw an emission current densities of 1 and 10 mu A/cm(2), are found to be 2.8 and 5.8 V/mu m, respectively, and a maximum emission current density of 500 mu A/cm(2) has been drawn at an applied field of 9.8 V/mu m. The emission current stability of the GNRs emitter was studied at preset values of 1 and 10 mu A over a period of 3 h, and is found to be excellent. The field emission results demonstrated herein suggest that GNRs based field emitters can open up many opportunities for their potential utilization as large area field emitters in various vacuum micro-nanoelectronic devices such as flexible field emission displays, portable X-ray, and microwave tubes. (C) 2015 AIP Publishing LLC.

1 aKhare, Ruchita, T.1 aShinde, Dhanraj, B.1 aBansode, Sanjeewani1 aMore, Mahendra, A.1 aMajumder, Mainak1 aPillai, Vijayamohanan, K.1 aLate, Dattatray, J. uhttp://library.ncl.res.in/content/graphene-nanoribbons-prospective-field-emitter01554nas a2200229 4500008004100000022001400041245010200055210006900157260006700226300001400293490000700307520071500314653001201029653000901041653002601050653001901076653002701095100002301122700002401145700002401169856013101193 2015 eng d a0022-514200aGraphene quantum dots as enhanced plant growth regulators: effects on coriander and garlic plants0 aGraphene quantum dots as enhanced plant growth regulators effect a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcOCT a2772-27780 v953 a

BACKGROUNDWe report investigations on the use of graphene quantum dots for growth enhancement in coriander (Coriandrum sativam L.) and garlic (Allium sativum) plants. The as-received seeds of coriander and garlic were treated with 0.2 mg mL(-1) of graphene quantum dots for 3 h before planting. RESULTSGraphene quantum dots enhanced the growth rate in coriander and garlic plants, including leaves, roots, shoots, flowers and fruits, when the seeds were treated with graphene quantum dots. CONCLUSIONOur investigations open up the opportunity to use graphene quantum dots as plant growth regulators that can be used in a variety of other food plants for high yield. (c) 2015 Society of Chemical Industry

10afarming10afood10agraphene quantum dots10ananotechnology10aplant growth regulator1 aChakravarty, Disha1 aErande, Manisha, B.1 aLate, Dattatray, J. uhttp://library.ncl.res.in/content/graphene-quantum-dots-enhanced-plant-growth-regulators-effects-coriander-and-garlic-plants-002031nas a2200217 4500008004100000022001400041245020200055210006900257260011000326300001400436490000700450520106400457100002001521700001901541700002601560700001901586700003301605700002501638700002001663856013001683 2015 eng d a1144-054600aGreen approach for the decoration of Pd nanoparticles on graphene nanosheets: an in situ process for the reduction of C-C double bonds and a reusable catalyst for the suzuki cross-coupling reaction0 aGreen approach for the decoration of Pd nanoparticles on graphen aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcJUN a6631-66410 v393 a

A new strategy for in situ synthesis of palladium nanoparticles (Pd NPs) decorated on reduced graphene oxide (rGO) nanosheets with controlled size and shape is reported. This strategy was designed as three processes in one pot, namely, (a) reduction of graphene oxide, (b) formation of Pd NPs on the rGO nanosheets and (c) simultaneous reduction of olefin. In this synthesis process, a hydrogen atmosphere was used to develop the Pd NPs-rGO nanocatalyst, which is reusable and easily separable. The influence of the size and morphology of the Pd-rGO-H-2 catalyst on the catalytic activity in the Suzuki cross-coupling reaction was investigated by comparing with other catalysts, Pd-rGO-As and Pd-rGO-Gl, and they were synthesized by different reducing agents, ascorbic acid and glucose, respectively. The catalysts were characterized by electron microscopy (HRTEM, SEM), FT-IR, XRD and XPS. The Pd-rGO-H-2 catalyst was found to possess excellent catalytic activity and recyclability in the Suzuki cross-coupling reaction under mild reaction conditions.

1 aHussain, Najrul1 aBorah, Ashwini1 aDarabdhara, Gitashree1 aGogoi, Pranjal1 aAzhagan, Muniraj, Vedi Kuyil1 aShelke, Manjusha, V.1 aDas, Manash, R. uhttp://library.ncl.res.in/content/green-approach-decoration-pd-nanoparticles-graphene-nanosheets-situ-process-reduction-c-c-001906nas a2200253 4500008004100000022001400041245008900055210006900144260009200213300001200305490000600317520099800323653002201321653002101343653001701364653002301381653002101404100001801425700002501443700002401468700001801492700002501510856011701535 2015 eng d a2158-584900aGreen synthesis of silver nanoribbons from waste X-ray films using alkaline protease0 aGreen synthesis of silver nanoribbons from waste Xray films usin a26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USAbAMER SCIENTIFIC PUBLISHERScAPR a165-1700 v53 a

This work illustrates a facile approach to synthesize silver nanoribbons from waste X-ray films using alkaline protease from Beauveria sp. MTCC 5184 (BAP). The green synthesized nanoribbons have been characterized by UV-Vis spectroscopy, TEM, and FTIR. The UV-visible spectra gave maximum absorbance at 400 nm. TEM micrograph showed well-dispersed silver nanoribbons with an average length of 200-400 nm. FTIR result demonstrated the respective bands of the silver nanoribbons and proteins. XRD data revealed crystalline nature of silver nanoribbons dominated with (111) facets. In vitro antibacterial activity in terms of minimum inhibitory concentrations (MIC) and minimum bactericidal concentration (MBC) showed 8/16 mu g/mL (MIC/MBC) against Staphylococcus aureus ATCC 29213 and 4/8 mu g/mL (MIC/MBC) against Escherichia coli ATCC 25922. The green synthesized silver nanoribbons showed excellent biocompatibility up to 40 mu g/mL concentrations on mouse fibroblast cell line (L929).

10aAlkaline Protease10aCharacterization10aCytotoxicity10aSilver Nanoribbons10aWaste X-ray Film1 aShankar, Shiv1 aPrasad, R., G. S. V.1 aSelvakannan, P., R.1 aJaiswal, Lily1 aLaxman, Ryali, Seeta uhttp://library.ncl.res.in/content/green-synthesis-silver-nanoribbons-waste-x-ray-films-using-alkaline-protease-001735nas a2200193 4500008004100000022001400041245020100055210006900256260011000325300001400435490000600449520084500455100002001300700001901320700003301339700002501372700002001397856012401417 2015 eng d a2044-475300aGreen synthesis of stable Cu(0) nanoparticles onto reduced graphene oxide nanosheets: a reusable catalyst for the synthesis of symmetrical biaryls from arylboronic acids under base-free conditions0 aGreen synthesis of stable Cu0 nanoparticles onto reduced graphen aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcNOV a1251-12600 v53 a

Highly stable Cu(0) nanoparticles were synthesized on reduced graphene oxide (rGO) sheets using a cost-effective and green method. The synthesized Cu(0)-nanoparticle-rGO composites exhibit excellent catalytic activity for the synthesis of symmetrical biaryls from arylboronic acids under microwave irradiation. The reaction proceeds smoothly in base-free conditions with easy recovery and reuse of the catalyst. The methodology is compatible with various functional groups and provides an attractive protocol for the synthesis of symmetrical biaryls with very good yields. HRTEM, XPS and XRD analyses showed the catalyst to be recyclable. The Cu(0) nanoparticles are stable in the rGO nanosheets, and the particle size distribution and oxidation state of the Cu(0) nanoparticle remain the same after performing the chemical reaction.

1 aHussain, Najrul1 aGogoi, Pranjal1 aAzhagan, Muniraj, Vedi Kuyil1 aShelke, Manjusha, V.1 aDas, Manash, R. uhttp://library.ncl.res.in/content/green-synthesis-stable-cu0-nanoparticles-reduced-graphene-oxide-nanosheets-reusable-301031nas a2200169 4500008004100000245009000041210006900131260000800200300001200208490000700220520043600227100001700663700001900680700002200699700002000721856012000741 2016 eng d00aGadolinium(III)-based porous luminescent metal-organic frameworks for bimodal imaging0 aGadoliniumIIIbased porous luminescent metalorganic frameworks fo cAUG a728-7320 v813 aGd-III-based metal-organic frameworks, Gd-pDBI-1 and Gd-pDBI-2, have been synthesized using the linker pDBI (pDBI=1,4-bis(5-carboxy-1H-benzimidazole-2yl)benzene). They exhibited structural diversity due to subtle change in reaction constituents. Owing to the judicious choice of the fluorescent linker, the materials could be used for bimodal imaging (fluorescent and magnetic resonance) and displayed a modest T1 relaxivity value.1 aKundu, Tanay1 aMitra, Shouvik1 aDiaz, David, Diaz1 aBanerjee, Rahul uhttp://library.ncl.res.in/content/gadoliniumiii-based-porous-luminescent-metal-organic-frameworks-bimodal-imaging-002263nas a2200301 4500008004100000022001400041245011700055210006900172260009000241300002600331490000600357520118200363100002401545700002701569700001901596700002701615700002001642700002001662700001401682700001601696700002001712700002101732700002001753700002001773700001801793700001901811856013101830 2016 eng d a2041-172300aGAME9 regulates the biosynthesis of steroidal alkaloids and upstream isoprenoids in the plant mevalonate pathway0 aGAME9 regulates the biosynthesis of steroidal alkaloids and upst aMACMILLAN BUILDING, 4 CRINAN ST, LONDON N1 9XW, ENGLANDbNATURE PUBLISHING GROUPcFEB aArticle Number: 106540 v73 a

Steroidal glycoalkaloids (SGAs) are cholesterol-derived molecules produced by solanaceous species. They contribute to pathogen defence but are toxic to humans and considered as anti-nutritional compounds. Here we show that GLYCOALKALOID METABOLISM 9 (GAME9), an APETALA2/Ethylene Response Factor, related to regulators of alkaloid production in tobacco and Catharanthus roseus, controls SGA biosynthesis. GAME9 knockdown and overexpression in tomato and potato alters expression of SGAs and upstream mevalonate pathway genes including the cholesterol biosynthesis gene STEROL SIDE CHAIN REDUCTASE 2 (SSR2). Levels of SGAs, C24-alkylsterols and the upstream mevalonate and cholesterol pathways intermediates are modified in these plants. Delta(7)-STEROL-C5(6)-DESATURASE (C5-SD) in the hitherto unresolved cholesterol pathway is a direct target of GAME9. Transactivation and promoter-binding assays show that GAME9 exerts its activity either directly or cooperatively with the SlMYC2 transcription factor as in the case of the C5-SD gene promoter. Our findings provide insight into the regulation of SGA biosynthesis and means for manipulating these metabolites in crops.

1 aCardenas, Pablo, D.1 aSonawane, Prashant, D.1 aPollier, Jacob1 aBossche, Robin, Vanden1 aDewangan, Veena1 aWeithorn, Efrat1 aTal, Lior1 aMeir, Sagit1 aRogachev, Ilana1 aMalitsky, Sergey1 aGiri, Ashok, P.1 aGoossens, Alain1 aBurdman, Saul1 aAharoni, Asaph uhttp://library.ncl.res.in/content/game9-regulates-biosynthesis-steroidal-alkaloids-and-upstream-isoprenoids-plant-mevalonate-102277nas a2200169 4500008004100000245009600041210006900137260000800206300001400214490000900228520167400237100001701911700001801928700002001946700002801966856011301994 2016 eng d00aGanglioside GM1 interacts with the serotonin1A receptor via the sphingolipid binding domain0 aGanglioside GM1 interacts with the serotonin1A receptor via the  cNOV a2818-28260 v18583 a

Glycosphingolipids are minor yet essential components of eukaryotic cell membranes and are involved in a variety of cellular processes. Although glycosphingolipids such as GM1 have been previously reported to influence the function of G protein-coupled receptors (GPCRs), the molecular mechanism remains elusive. In this paper, we have explored the interaction of GM1 with the serotonin1A receptor, an important neurotransmitter receptor that belongs to the GPCR family. To examine the molecular basis of the interaction of GM1 with the serotonin1A receptor, we performed a series of coarse-grain molecular dynamics simulations of the receptor embedded in membrane bilayers containing GM1. Our results show that GM1 interacts with the serotonin1A receptor predominantly at the extracellular loop 1 and specifically at the sphingolipid binding domain (SBD). The SBD motif consists of a characteristic combination of aromatic, basic and turn-inducing residues, and is evolutionarily conserved in case of the serotonin1A receptor. The interaction of the SBD site with GM1 appears to stabilize a 'flip-out' conformation in which W102 of the extracellular loop 1 flips out from the central lumen of the receptor toward the membrane. The population of the 'flip-out' conformation is increased in the presence of cholesterol. Our data strongly suggest that a direct interaction between GM1 and the SBD site of the serotonin1A receptor may occur in vivo. In view of the reported role of GM1 and the serotonin1A receptor in neurodegenerative diseases, GM1-receptor interaction assumes significance in the context of malfunctioning of neuronal GPCRs under such conditions.

1 aPrasanna, X.1 aJafurulla, M.1 aSengupta, Durba1 aChattopadhyay, Amitabha uhttp://library.ncl.res.in/content/ganglioside-gm1-interacts-serotonin1a-receptor-sphingolipid-binding-domain02571nas a2200181 4500008004100000022001400041245011600055210006900171260011000240300001400350490000600364520180000370100001602170700001802186700002702204700003002231856012802261 2016 eng d a2044-475300aGas-solid interaction of H-2-Ce0.95Zr0.05O2: new insights into surface participation in heterogeneous catalysis0 aGassolid interaction of H2Ce095Zr005O2 new insights into surface aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcOCT a1746-17560 v63 a

A direct interaction between a reduction medium (H-2) and a Ce0.95Zr0.05O2 (CZ) solid surface was explored through ambient pressure photoelectron spectroscopy (APPES), with conventional X-ray and He-I photon sources, in H-2 atmosphere up to 0.1 mbar pressure and 773 K. A porous CZ thin film was prepared by a combination of sol-gel and spin-coating methods, and was employed to understand the redox nature of ceria under reduction conditions. The maximum of 45% Ce3+ along with the corresponding oxygen vacancy was observed due to reduction. An unprecedented decrease in the valence band (VB) energy up to 1.4 eV was observed on reduction along with a narrowing of VB. The highest occupied energy band derived from Ce 4f also shifts closer to E-F. H-2 molecular vibration observed in VB-APPES was employed as a probe to explore the surface potential changes along with the dynamic change in the nature of the surface under reduction conditions. The surface potential decreases by 0.27 eV up to 673 K, and then it reverts by 0.24 eV on further reduction at 773 K for different reasons. Further, an enhancement in the Ce 5d-O 2p interaction occurs at the expense of the Ce 4f-O 2p interaction under the above reduction conditions. Vacuum annealing and H-2 reduction after that show significantly more VB shift and enhanced reduction than H-2 reduction alone. Although Ce reduction occurs on high temperature vacuum annealing of CZ, a significantly lower amount of oxygen vacancies appears. This study shows the dynamic changes in the nature of the surface due to a gas (H-2)-solid (CZ) interaction and ensuing electronic structure changes that influence heterogeneous catalysis. It also underscores the necessity to study the catalytic materials under in situ conditions or closer to that.

1 aJain, Ruchi1 aDubey, Anjani1 aGhosalya, Manoj, Kumar1 aGopinath, Chinnakonda, S. uhttp://library.ncl.res.in/content/gas-solid-interaction-h-2-ce095zr005o2-new-insights-surface-participation-heterogeneous-001593nas a2200193 4500008004100000022001400041245007700055210006900132260011000201300001600311490000600327520084100333100002301174700002301197700002301220700002401243700002601267856010601293 2016 eng d a2046-206900aGlucose sensing and low-threshold field emission from MnCo2O4 nanosheets0 aGlucose sensing and lowthreshold field emission from MnCo2O4 nan aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAR a29734-297400 v63 a

Manganese cobalt oxide (MnCo2O4) nanosheets were grown on nickel (Ni) foam by a simple electrodeposition method. The as-synthesized nanosheets were characterized using X-ray diffraction and scanning electron microscopy. The Ni foam supports the growth of MnCo2O4 nanosheets without any aggregation, thereby increasing its catalytic and electronic properties. The electrochemical studies show that MnCo2O4 exhibits excellent electrocatalytic activity towards glucose sensing applications. The MnCo2O4 based glucose sensor shows a good sensitivity value of 8.2 mA mM(-1) cm(-2), with a response time of 19 s. In addition to this, field emission studies of as-synthesized MnCo2O4 reveal a low turn-on field value of 1.9 V mm(-1) and good emission current stability, demonstrating MnCo2O4 nanosheets as a good field emitter material.

1 aNaik, Kusha, Kumar1 aKhare, Ruchita, T.1 aMore, Mahendra, A.1 aLate, Dattatray, J.1 aRout, Chandra, Sekhar uhttp://library.ncl.res.in/content/glucose-sensing-and-low-threshold-field-emission-mnco2o4-nanosheets01533nas a2200253 4500008004100000022001400041245011700055210006900172260007100241300001400312490000600326520059000332653001900922653002200941653001700963653002500980653002201005100002901027700002201056700002301078700002501101700002301126856013001149 2016 eng d a1944-824400aGlucose-derived porous carbon-coated silicon nanowires as efficient electrodes for aqueous micro-supercapacitors0 aGlucosederived porous carboncoated silicon nanowires as efficien a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcFEB a4298-43020 v83 a

In this study, we report on carbon coating of vertically aligned silicon nanowire (SiNWs) arrays via a simple hydrothermal process using glucose as carbon precursor. Using this process, a thin carbon layer is uniformly deposited on the SiNWs. Under optimized conditions, the coated SiNWs electrode showed better electrochemical energy storage capacity as well as exceptional stability in aqueous system as compared to uncoated SiNWs. The as-measured capacitance reached 25.64 mF/cm(2) with a good stability up to 25000 charging/discharging cycles in 1 M Na2SO4 aqueous solution.

10acarbon coating10aglucose precursor10ahydrothermal10amicrosupercapacitors10asilicon nanowires1 aDevarapalli, Rami, Reddy1 aSzunerits, Sabine1 aCoffinier, Yannick1 aShelke, Manjusha, V.1 aBoukherroub, Rabah uhttp://library.ncl.res.in/content/glucose-derived-porous-carbon-coated-silicon-nanowires-efficient-electrodes-aqueous-micro-000643nas a2200157 4500008004100000245012600041210006900167260000800236300001600244490000700260100001900267700002500286700002500311700002500336856012400361 2016 eng d00aGlycation induces conformational changes in Amyloid-? peptide and enhances its aggregation propensity: molecular insights0 aGlycation induces conformational changes in Amyloid peptide and  cOCT a31446-314580 v181 aJana, Asis, K.1 aBatkulwar, Kedar, B.1 aKulkarni, Mahesh, J.1 aSengupta, Neelanjana uhttp://library.ncl.res.in/content/glycation-induces-conformational-changes-amyloid-peptide-and-enhances-its-aggregation02831nas a2200217 4500008004100000022001400041245012000055210006900175260000800244300001200252490000600264520205600270100002002326700002102346700002702367700001602394700003002410700002202440700002302462856012802485 2016 eng d a2470-134300aGlycopolypeptide-grafted bioactive polyionic complex vesicles (PICsomes) and their specific polyvalent interactions0 aGlycopolypeptidegrafted bioactive polyionic complex vesicles PIC cOCT a600-6120 v13 a

Glycopolypeptide-based self-assembled nano-/microstructures with surface-tethered carbohydrates are excellent mimics of glycoproteins on the cell surface. To expand the broad repertoire of glycopolypeptide-based supramolecular soft structures such as polymersomes formed via self-assembly of amphiphilic polymers, we have developed a new class of polyionic complex vesicles (PICsomes) with glycopolypeptides grafted on the external surface. Oppositely charged hydrophilic block copolymers of glycopolypeptide(20)-b-poly-L-lysine(100) and PEG(2k)-b-poly-L-glutamate(100) [PEG = poly(ethylene glycol)] were synthesized using a combination of ring-opening polymerization of N-carboxyanhydrides and ``click'' chemistry. Under physiological conditions, the catiomer and aniomer self-assemble to form glycopolypeptide-conjugated PICsomes (GP-PICsomes) of micrometer dimensions. Electron and atomic force microscopy suggests a hollow morphology of the PICsomes, with inner aqueous pool (core) and peripheral PIC (shell) regions. Owing to their relatively large (similar to micrometers) size, the hollowness of the supramolecular structure could be established via fluorescence microscopy of single GP-PICsomes, both in solution and under dry conditions, using spatially distributed fluorescent probes. Furthermore, the dynamics of single PICsomes in solution could be imaged in real time, which also allowed us to test for multivalent interactions between PICsomes mediated by a carbohydrate (mannose)-binding protein (lectin, Con-A). The immediate association of several GP-PICsomes in the presence of Con-A and their eventual aggregation to form large insoluble aggregate clusters reveal that upon self-assembly carbohydrate moieties protrude on the outer surface which retains their biochemical activity. Challenge experiments with excess mannose reveal fast deaggregation of GP-PICsomes as opposed to that in the presence of excess galactose, which further establishes the specificity of lectin-mediated polyvalent interactions of the GP-PICsomes.

1 aPandey, Bhawana1 aMahato, Jaladhar1 aCotta, Karishma, Berta1 aDas, Soumen1 aSharma, Dharmendar, Kumar1 aGupta, Sayam, Sen1 aChowdhury, Arindam uhttp://library.ncl.res.in/content/glycopolypeptide-grafted-bioactive-polyionic-complex-vesicles-picsomes-and-their-specific01769nas a2200205 4500008004100000022001400041245011600055210006900171260006500240300000800305490000700313520097500320653002301295653002001318653000901338653001501347100003701362700003601399856012801435 2016 eng d a1420-304900aGold incorporated mesoporous silica thin film model surface as a robust SERS and catalytically active substrate0 aGold incorporated mesoporous silica thin film model surface as a aST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLANDbMDPI AGcMAY a6670 v213 a

Ultra-small gold nanoparticles incorporated in mesoporous silica thin films with accessible pore channels perpendicular to the substrate are prepared by a modified sol-gel method. The simple and easy spin coating technique is applied here to make homogeneous thin films. The surface characterization using FESEM shows crack-free films with a perpendicular pore arrangement. The applicability of these thin films as catalysts as well as a robust SERS active substrate for model catalysis study is tested. Compared to bare silica film our gold incorporated silica, GSM-23F gave an enhancement factor of 10(3) for RhB with a laser source 633 nm. The reduction reaction of p-nitrophenol with sodium borohydride from our thin films shows a decrease in peak intensity corresponding to -NO2 group as time proceeds, confirming the catalytic activity. Such model surfaces can potentially bridge the material gap between a real catalytic system and surface science studies.

10agold nanoparticles10amodel catalysis10aSERS10aThin films1 aSekhar, Anandakumari, Chandrasek1 aVinod, Chathakudath, Prabhakara uhttp://library.ncl.res.in/content/gold-incorporated-mesoporous-silica-thin-film-model-surface-robust-sers-and-catalytically01031nas a2200169 4500008004100000022001400041245011500055210006900170260007100239300001400310490000700324520033800331100002200669700002300691700002100714856012600735 2016 eng d a1523-706000aGold vs rhodium catalysis: tuning reactivity through catalyst control in the C-H alkynylation of isoquinolones0 aGold vs rhodium catalysis tuning reactivity through catalyst con a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAR a1056-10590 v183 a

A site-selective C-4/C-8 alkynylation of isoquinolones catalyzed by gold and rhodium complexes is reported. A broad range of synthetically useful functional groups (-F, -Cl, -Br, -CF3, -OMe, alkyl, etc.) were tolerated, providing an efficient and robust protocol for the synthesis either C-4- or C-8-alkynylated isoquinolones.

1 aShaikh, Aslam, C.1 aShinde, Dinesh, R.1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/gold-vs-rhodium-catalysis-tuning-reactivity-through-catalyst-control-c-h-alkynylation-000893nas a2200169 4500008004100000022001400041245007100055210006300126260007200189300001200261490000600273520027500279100002900554700002200583700002400605856009400629 2016 eng d a2052-412900aGold(I) catalyzed [1,3] O -> C rearrangement of benzylvinyl ethers0 aGoldI catalyzed 13 O C rearrangement of benzylvinyl ethers aPO BOX 1-18, NANKANG, TAIPEI 115, TAIWANbCHINESE CHEMICAL SOCcJAN a453-4560 v33 a

A simple procedure for the preparation of 3-(hetero) arylpropionaldehydes has been developed employing a gold-catalyzed [1,3]-rearrangement of vinyl ethers. Using this protocol, Canthoxal, an aromatic aldehyde used in perfumery, has been prepared on a gram scale.

1 aKona, Chandrababu, Naidu1 aPatil, Mahesh, N.1 aRamana, Chepuri, V. uhttp://library.ncl.res.in/content/goldi-catalyzed-13-o-c-rearrangement-benzylvinyl-ethers00931nas a2200157 4500008004100000022001400041245010300055210006900158260007100227300001400298490000700312520029700319100001900616700002100635856011700656 2016 eng d a1523-706000aGold(I)-catalyzed hydroaminaloxylation and petasis-ferrier rearrangement cascade of aminaloalkynes0 aGoldIcatalyzed hydroaminaloxylation and petasisferrier rearrange a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAPR a1844-18470 v183 a

An efficient method has been developed to generate a diverse array of indolizidines and quinolizidines from readily available aminaloalkynes via a gold(I)-catalyzed hydroaminaloxylation and Petasis-Ferrier rearrangement cascade. The method enabled a formal synthesis of (+/-)-antofine.

1 aGade, Amol, B.1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/goldi-catalyzed-hydroaminaloxylation-and-petasis-ferrier-rearrangement-cascade01643nas a2200205 4500008004100000245012900041210006900170260000800239300001000247490000800257520088300265100002401148700002701172700001801199700002201217700001601239700002401255700002901279856012901308 2016 eng d00aGraphene based nanocomposites for alloy (SnO2), and conversion (Fe3O4) type efficient anodes for Li-ion battery applications0 aGraphene based nanocomposites for alloy SnO2 and conversion Fe3O cJUN a88-950 v1303 aTwo types of trigol reduced one pot synthesized graphene (TRG) based nanocomposites (SnO2-TRG, and Fe3O4-TRG) are examined as potential anodes for Lithium ion battery (LIB) applications. The two specific systems represent different electrode reaction mechanisms, namely alloying, and conversion respectively. The high resolution transmission electron microscopy (HR-TEM) analysis confirms the uniform distribution of SnO2 (similar to 2 nm), and Fe3O4 (similar to 8 nm) particulates on ultrathin TRG nanosheets and highlights the importance of surfactant free synthesis. The SnO2-TRG, and Fe3O4-TRG exhibited the maximum reversible capacity of similar to 947, and similar to 1024 mA h g(-1), respectively. The results show that such graphene based composite materials can be effectively used as prospective anodes for LIB applications. (C) 2016 Elsevier Ltd. All rights reserved.1 aMhamane, Dattakumar1 aAravindan, Vanchiappan1 aTaneja, Divya1 aSuryawanshi, Anil1 aGame, Onkar1 aSrinivasan, Madhavi1 aOgale, Satishchandra, B. uhttp://library.ncl.res.in/content/graphene-based-nanocomposites-alloy-sno2-and-conversion-fe3o4-type-efficient-anodes-li-ion02004nas a2200301 4500008004100000022001400041245016600055210006900221260000800290300001600298490000600314520094300320653002301263653001901286653001901305653003001324653001801354653001001372100001801382700002601400700002401426700002401450700003101474700003001505700002101535700002001556856012601576 2016 eng d a1944-824400aGraphene oxide sheathed ZIF-8 microcrystals: engineered precursors of nitrogen-doped porous carbon for efficient oxygen reduction reaction (ORR) electrocatalysis0 aGraphene oxide sheathed ZIF8 microcrystals engineered precursors cNOV a29373-293820 v83 a

Nitrogen containing mesoporous carbon obtained by the pyrolysis of graphene oxide (GO) wrapped ZIF-8 (Zeolitic Imidazolate Frameworks-8) micro crystals is demonstrated to be an efficient catalyst for the oxygen reduction reaction (ORR). ZIF-8 synthesis in the presence of GO sheets helped to realize layers of graphene oxide over ZIF-8 microcrystals and the sphere-like structures thus obtained, on heat treatment, transformed to highly porous carbon with a nitrogen content of about 6.12% and surface area of 502 m(2)/g. These catalysts with a typical micromeso porous architecture exhibited an onset potential of 0.88Vvs RHE in a four electron pathway and also demonstrated superior durability in alkaline medium compared to that of the commercial Pt/C catalyst. The N-doped porous carbon derived from GO sheathed ZIF-8 core shell structures could therefore be employed as an efficient electrocatalyst for fuel cell applications.

10aalkaline fuel cell10agraphene oxide10aN-doped carbon10aoxygen reduction reaction10aporous carbon10aZIF-81 aThomas, Minju1 aIllathvalappi, Rajith1 aKurungot, Sreekumar1 aNair, Balagopal, N.1 aMohamed, Abdul, Azeez Peer1 aAnilkumar, Gopinathan, M.1 aYamaguchi, Takeo1 aHareesh, U., S. uhttp://library.ncl.res.in/content/graphene-oxide-sheathed-zif-8-microcrystals-engineered-precursors-nitrogen-doped-porous00540nas a2200133 4500008004100000245010200041210006900143260000800212300001000220490000600230100002500236700001600261856012900277 2016 eng d00aGraphene quantum dot-based on-chip electrochemical DNA hybridization sensor for pancreatic cancer0 aGraphene quantum dotbased onchip electrochemical DNA hybridizati cNOV a31-400 v61 aJoshi, Preeti, Nigam1 aWaghmode, S uhttp://library.ncl.res.in/content/graphene-quantum-dot-based-chip-electrochemical-dna-hybridization-sensor-pancreatic-cancer00521nas a2200133 4500008004100000245007500041210006900116260002000185100002500205700001700230700002200247700001900269856009900288 2016 eng d00aGraphene quantum dots - from emergence to nanotheranostic applications0 aGraphene quantum dots from emergence to nanotheranostic applicat aCroatiabIntech1 aJoshi, Preeti, Nigam1 aKundu, Subir1 aSanghi, Sunil, K.1 aSarkar, Dhiman uhttp://library.ncl.res.in/content/graphene-quantum-dots-emergence-nanotheranostic-applications02327nas a2200253 4500008004100000022001400041245006700055210006700122260007100189300001400260490000600274520150100280653001601781653001601797653002301813653001701836653001401853100001701867700003201884700002401916700001301940700002201953856009801975 2016 eng d a2168-048500aGreen approach to dye wastewater treatment using biocoagulants0 aGreen approach to dye wastewater treatment using biocoagulants a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY a2495-25070 v43 a

The present study focuses on newer biocoagulants, bioformulations, and the understanding of coagulant behavior with biocoagulants in relation to chemical coagulants. Newer biocoagulants, seeds of Azadirachta indica (AI) and pads of Acanthocereus tetragonus, are discussed along with two known biocoagulants, Moringa oleifera and Cicer arietinum seeds. Dye removal studies were carried out using widely reported Congo red dye to facilitate easy comparison with other conventional coagulants and the effect of various parameters such as initial dye concentration, pH, coagulant dose, etc. are discussed in detail. The use of biocoagulant was found to be highly effective, and up to 99% dye removal was achieved for coagulant doses in the range of 300-1500 mg/L. It was also observed that coagulation is pH sensitive, similar to chemical coagulants. Although the biocoagulant dose is relatively higher than the conventional chemical coagulants, a good value for the sludge volume index, similar to 50 mL/g for 1 h and 30 min, respectively, was obtained for the two coagulants, Acanthocereus tetragonus and Moringa oleifera. A very high particle count compared to chemical coagulants was observed using a focused beam reflectance measurement. Bioformulation with chemical coagulants such as alum, ferric, and aluminum based coagulants can, not only lower doses of biocoagulants (up to one-third) but can also result in significant improvement in the coagulation performance, up to 50% or more.

10acoagulation10adye removal10aEffluent treatment10aflocculation10apollution1 aChethana, M.1 aSorokhaibam, Laxmi, Gayatri1 aBhandari, Vinay, M.1 aRaja, S.1 aRanade, Vivek, V. uhttp://library.ncl.res.in/content/green-approach-dye-wastewater-treatment-using-biocoagulants00459nas a2200121 4500008004100000245007500041210006900116260000800185300000800193490000600201100002500207856010500232 2016 eng d00aGreen chemistry in nanotechnology: opportunities and future challenges0 aGreen chemistry in nanotechnology opportunities and future chall cJAN a3-40 v51 aJoshi, Preeti, Nigam uhttp://library.ncl.res.in/content/green-chemistry-nanotechnology-opportunities-and-future-challenges01435nas a2200157 4500008004100000245005400041210005300095260000800148300001400156490000700170520094700177100002201124700002201146700003001168856007901198 2016 eng d00aGreen leaf to inorganic leaf: a case study of ZnO0 aGreen leaf to inorganic leaf a case study of ZnO cSEP a9203-92080 v163 a

Can we use green leaves, available freely in our gardens, as a template for making inorganic leaf, while retaining the nanospace available within the leaf architecture. The answer is 'yes', and it is demonstrated with inorganic leaf made up of ZnO, by intercalating Zn2+ ions into the porous channels of the champa (Plumeria, Magnolia champaca) tree leaves. TEM studies reveal a variety of macro-micro-nanospace available in the inorganic leaf ZnO (IL-ZnO), and suggest the possibility of exploiting the same to produce natural nano-architecture for various applications. A speciality of the present work is the maximum suppression of defects in photoluminescence of IL-ZnO leaf, compared to the commercial ZnO, which is exploited for light harvesting through chemical conversion. Benzene to phenol conversion was studied in UV light and IL-ZnO show significant conversion and yield demonstrating C-H activation at ambient temperature.

1 aSathu, Naveen, K.1 aDevaraji, Perumal1 aGopinath, Chinnakonda, S. uhttp://library.ncl.res.in/content/green-leaf-inorganic-leaf-case-study-zno01857nas a2200241 4500008004100000022001400041245012900055210006900184260009200253300001000345490000700355520092100362653002001283653002301303653002801326653002501354100001701379700002301396700001901419700002101438700002501459856013101484 2016 eng d a1745-808000aGreen synthesis of silver nanoparticles from purple acid phosphatase apoenzyme isolated from a new source limonia acidissima0 aGreen synthesis of silver nanoparticles from purple acid phospha a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcJAN a28-370 v113 a

Green synthesis of nanoparticles is regarded as a safe and non-toxic process whereas conventional synthesis using chemical methods produces toxic substance. This study provides a novel insight for enzymatic synthesis method of silver nanoparticles using purple acid phosphatase, isolated from Limonia acidissima (wood apple) as a new source and used in the synthesis of silver nanoparticles. Stable silver nanoparticles were produced by sonochemical method using apoenzyme as a stabilising and capping agent and were characterised by various physicochemical techniques like UV-Visible spectroscopy, Fourier-transform infrared, X-ray diffraction and transmission electron microscopy. X-ray study shows that nanoparticles are composed of silver and silver oxide. The synthesised nanoparticles exhibited excellent antimicrobial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus.

10agreen synthesis10aLimonia acidissima10apurple acid phosphatase10asilver nanoparticles1 aPawar, Omkar1 aDeshpande, Neelima1 aDagade, Sharda1 aWaghmode, Shobha1 aJoshi, Preeti, Nigam uhttp://library.ncl.res.in/content/green-synthesis-silver-nanoparticles-purple-acid-phosphatase-apoenzyme-isolated-new-source-001212nas a2200193 4500008004100000022001400041245022400055210006900279260011000348300001400458490000600472520029900478100002000777700001900797700003300816700002500849700002000874856012400894 2016 eng d a2044-475300aGreen synthesis of stable Cu(0) nanoparticles onto reduced graphene oxide nanosheets: a reusable catalyst for the synthesis of symmetrical biaryls from arylboronic acids under base-free conditions (vol 5, pg 1251, 2015)0 aGreen synthesis of stable Cu0 nanoparticles onto reduced graphen aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcFEB a1234-12340 v63 a

Correction for ‘Green synthesis of stable Cu(0) nanoparticles onto reduced graphene oxide nanosheets: a reusable catalyst for the synthesis of symmetrical biaryls from arylboronic acids under base-free conditions’ by Najrul Hussain et al., Catal. Sci. Technol., 2015, 5, 1251–1260.

1 aHussain, Najrul1 aGogoi, Pranjal1 aAzhagan, Muniraj, Vedi Kuyil1 aShelke, Manjusha, V.1 aDas, Manash, R. uhttp://library.ncl.res.in/content/green-synthesis-stable-cu0-nanoparticles-reduced-graphene-oxide-nanosheets-reusable-203044nas a2200229 4500008004100000245017800041210006900219260000800288300001400296490000700310520219500317100001502512700001602527700001902543700002302562700002102585700001902606700002102625700002502646700001702671856012602688 2016 eng d00aGSH Induced controlled release of levofloxacin from a purpose-built prodrug: luminescence response for probing the drug release in escherichia coli and staphylococcus aureus0 aGSH Induced controlled release of levofloxacin from a purposebui cSEP a2062-20700 v273 a

Fluoroquinolones are third-generation broad spectrum bactericidal antibiotics and work against both Gram-positive and Gram-negative bacteria. Levofloxacin (L), a fluoroquinolone, is widely used in anti-infective chemotherapy and treatment of urinary tract infection and pneumonia. The main pathogen for urinary tract infections is Escherichia colt, and Streptococcus pneumoniae is responsible for pneumonia, predominantly a lower respiratory tract infection. Poor permeability of L leads to the use of higher dose of this drug and excess drug in the outer cellular fluid leads to central nervous system (CNS) abnormality. One way to counter this is to improve the lipophilicity of the drug molecule, and accordingly, we have synthesized two new Levofloxacin derivatives, which participated in the spatiotemporal release of drug via disulfide bond cleavage induced by glutathione (GSH). Recent studies with Streptococcus mutants suggest that it is localized in epithelial lining fluid (ELF) of the normal lower respiratory tract and the effective [GSH] in ELF is similar to 430 mu M. E. coli typically cause urinary tract infections and the concentration of GSH in porcine bladder epithelium is reported as 0.6 mM for a healthy human. Thus, for the present study we have chosen two important bacteria (Gram + ve and Gram - ve), which are operational in regions having high extracellular GSH concentration. Interestingly, this supports our design of new lipophilic Levofloxacin based prodrugs, which released effective drug on reaction with GSH. Higher lipophilicity favored improved uptake of the prodrugs. Site specific release of the drug (L) could be achieved following a glutathione mediated biochemical transformation process through cleavage of a disulfide bond of these purpose-built prodrugs. Further, appropriate design helped us to demonstrate that it is possible also to control the kinetics of the drug release from respective prodrugs. Associated luminescence enhancement helps in probing the release of the drug from the prodrug in bacteria and helps in elucidating the mechanistic pathway of the transformation. Such an example is scarce in the contemporary literature.

1 aPal, Suman1 aRamu, Vadde1 aTaye, Nandaraj1 aMogare, Devraj, G.1 aYeware, Amar, M.1 aSarkar, Dhiman1 aReddy, Srinivasa1 aChattopadhyay, Samit1 aDas, Amitava uhttp://library.ncl.res.in/content/gsh-induced-controlled-release-levofloxacin-purpose-built-prodrug-luminescence-response01921nas a2200241 4500008004100000245014000041210006900181260000800250300001400258490000700272520108800279653002001367653001901387653001101406653001701417653002101434653002101455100002001476700001901496700001801515700002101533856012501554 2017 eng d00aG - C3N4 (2D)/CdS (1D)/rGO (2D) dual-interface nano-composite for excellent and stable visible light photocatalytic hydrogen generation0 aG C3N4 2DCdS 1DrGO 2D dualinterface nanocomposite for excellent  cMAR a5971-59840 v423 a

A 2D/1D/2D dual-interface nano-composite configuration in the form of CdS nanorods sandwiched between g-C3N4 and rGO sheets with intimate interfacial contact is synthesized by a facile wet-chemical method and is shown to exhibit excellent photocatalytic H2 generation under visible-light irradiation. In particular, the optimal g-C3N4/CdS/rGO dual-interface nano-composite shows H2 production rate of ∼4800 μmol h-1 g-1, which is almost 44, 11 and 2.5 times higher than that shown by pure g-C3N4 nanosheets, and the g-C3N4/rGO and g-C3N4/CdS single interface heterostructures, respectively. It is shown that the synergic effects involving the band structure match and close interfacial contact, which can accelerate the separation and transfer of photoinduced charge carriers, and the enhanced visible-light absorption together contribute to the impressive photocatalytic performance and photostability of the g-C3N4/CdS/rGO ternary nano-composite system. Specific advantages of a dual-interface triple-composite system over a single interface case(s) are also brought out.

10acharge transfer10aDual Interface10aG - CN10aH Generation10aHetero Structure10aNano - Composite1 aTonda, Surendar1 aKumar, Santosh1 aGawli, Yogesh1 aBhardwaj, Monika uhttp://library.ncl.res.in/content/g-c3n4-2dcds-1drgo-2d-dual-interface-nano-composite-excellent-and-stable-visible-light02525nas a2200157 4500008004100000022001400041245018900055210006900244260000800313300001400321490000700335520183700342100003102179700002002210856013702230 2017 eng d a1466-803300aGalvanic replacement-based Cu2O self-templating strategy for the synthesis and application of Cu2O–Ag heterostructures and monometallic (Ag) and bimetallic (Au–Ag) hollow mesocages0 aGalvanic replacementbased Cu2O selftemplating strategy for the s cFEB a1669-16790 v193 aPolyhedral Cu2O microparticles as self-templates have been well-demonstrated for the synthesis of Cu2O–M heterostructures (M = Au, Pd, Pt) and Au nano/mesocages utilizing the galvanic replacement reaction (GRR) strategy. However, reports on GRR-based fabrication of Cu2O–Ag heterostructures and the ensuing Ag mesocages are scanty. There is no report that describes the phenomenon of facet selectivity during the GRR-based deposition of Ag on Cu2O template particles. Here, we have identified the underlying rationale behind the observed difficulty in nucleating Ag nanoparticles on an octahedral Cu2O self-template particle. Utilization of an appropriately chosen surfactant/complexant for the silver precursor helps in demonstrating the successful fabrication of Cu2O–Ag heterostructures (octahedral, cubic) with a tunable loading density of Ag NPs on the Cu2O surfaces. This is achieved using Cu2O template particles that undergo GRR with silver nitrate in the presence of nitric acid, and 5-sulfosalicylic acid as the surfactant (key role players). We provide evidence that supports facet selectivity during the deposition of Ag NPs on Cu2O cuboctahedral particles. Hollow octahedral Ag and Au–Ag bimetallic mesocages are fabricated that have rough surfaces, uniform morphology, and excellent shape retention. The fabricated heterostructures and mesocages act as an excellent SERS substrate. This is the first report on the rational synthesis of octahedral Cu2O–Ag heterostructures and octahedral hollow metallic mesocages utilizing the Cu2O self-templating strategy along with the demonstration of facet selectivity of Ag deposition on Cu2O template particles through GRR. The current approach offers a facile and versatile protocol for the synthesis of Cu2O–metal heterostructures and hollow noble metal mesocages.1 aBakthavatsalam, Rangarajan1 aKundu, Janardan uhttp://library.ncl.res.in/content/galvanic-replacement-based-cu2o-self-templating-strategy-synthesis-and-application-cu2o%E2%80%93ag01528nas a2200169 4500008004100000245010700041210006900148260000800217300001400225490000700239520088800246100002001134700003201154700001801186700003101204856012301235 2017 eng d00aGeneral nickel-catalyzed method for C-H bond alkynylation of heteroarenes through chelation assistance0 aGeneral nickelcatalyzed method for CH bond alkynylation of heter cFEB a2907-29140 v233 a

A general nickel-catalyzed method for the alkynylation of heteroarenes through monodentate chelation assistance is described. Many heterocycles, including indoles, pyrroles, imidazoles and pyrazole, efficiently coupled with (triisopropylsilyl)alkynyl bromide, and synthetically important functional groups, such as halides, ether, nitrile, nitro were tolerated. Synthetic applicability of this Ni-catalyzed method is demonstrated by the removal of triisopropylsilyl (-SiiPr₃) group, and further functionalization into triazolyl, benzofuranyl and alkynyl arene derivatives. Preliminary mechanistic investigations on the alkynylation of indole suggest that the reaction proceeds through kinetically relevant C-H activation and follows the two-electron redox pathway. A catalytically competent Ni-species, [(Phen)₃Ni].NiBr₄ has been isolated and structurally characterized.

1 aPunji, Benudhar1 aKhake, Shrikant, manmathapp1 aSoni, Vineeta1 aGonnade, Rajesh, Ghanshyam uhttp://library.ncl.res.in/content/general-nickel-catalyzed-method-c-h-bond-alkynylation-heteroarenes-through-chelation00632nas a2200169 4500008004100000022001400041245010000055210006900155260000800224490000700232100002200239700001800261700001900279700001800298700002100316856012500337 2017 eng d a2016-021000aGenetic programming based drag model with improved prediction accuracy for fluidization systems0 aGenetic programming based drag model with improved prediction ac cAPR0 v151 aSonolikar, R., R.1 aPatil, M., P.1 aMankar, R., B.1 aTambe, S., S.1 aKulkarni, B., D. uhttp://library.ncl.res.in/content/genetic-programming-based-drag-model-improved-prediction-accuracy-fluidization-systems02349nas a2200145 4500008004100000245015500041210006900196260000800265300001200273490000700285520173400292100002302026700002302049856013102072 2017 eng d00aGenetic programming based high performing correlations for prediction of higher heating value of coals of different ranks and from diverse geographies0 aGenetic programming based high performing correlations for predi cJUN a476-4840 v903 a

The higher heating value (HHV) is the most important indicator of a coal's potential energy yield. It is commonly used in the efficiency and optimal design calculations pertaining to the coal combustion and gasification processes. Since the experimental determination of coal's HHV is tedious and time-consuming, a number of proximate and/or ultimate analyses based correlations which are mostly linear have been proposed for its estimation. Owing to the fact that relationships between some of the constituents of the proximate/ultimate analyses and the HHV are nonlinear, the linear models make suboptimal predictions. Also, a majority of the currently available HHV models are restricted to the coals of specific ranks or particular geographical regions. Accordingly, in this study three proximate and ultimate analysis based nonlinear correlations have been developed for the prediction of HHV of coals by utilizing the computational intelligence (CI) based genetic programming (GP) formalism. Each of these correlations possesses following noteworthy characteristics: (i) the highest HHV prediction accuracy and generalization capability as compared to the existing models, (ii) wider applicability for coals of different ranks and from diverse geographies, and (iii) structurally lower complex than the other CI-based existing HHV models. It may also be noted that in this study, the GP technique has been used for the first time for developing coal specific HHV models. Owing to the stated attractive features, the GP-based models proposed here possess a significant potential to replace the existing models for predicting the HHV of coals. (C) 2016 Energy Institute. Published by Elsevier Ltd. All rights reserved.

1 aGhugare, Suhas, B.1 aTambe, Sanjeev, S. uhttp://library.ncl.res.in/content/genetic-programming-based-high-performing-correlations-prediction-higher-heating-value-coals02838nas a2200325 4500008004100000245014800041210006900189260000800258490000700266520174000273653001002013653002202023653001902045653002602064653001402090653002202104653002202126653002702148653001202175653001402187653000802201653001002209653004502219653002702264100002802291700001902319700001902338700002602357856012902383 2017 eng d00aGenetic variability in Indian populations of banana corm weevil [Cosmopolites sordidus (Coleoptera: Curculionidae)] assessed by RAPDs and AFLPs0 aGenetic variability in Indian populations of banana corm weevil  cSEP0 v373 a

Cosmopolites sordidus (Germar), commonly known as banana corm weevil, is an important economic pest in Asia that can cause severe yield loss depending upon the stage at which infestation occurs. In spite of its economic importance, little is known about the population structure of this pest in India. Random amplified polymorphic DNA (RAPD) and amplified fragment length polymorphism (AFLP) were used to characterize the population genetic structure of C. sordidus collected from five hot spot locations in India. Nineteen RAPD primers and five selective AFLP primer combinations generated 147 and 304 amplification products, respectively. UPGMA dendrograms generated with both marker systems failed to reveal populations clustered based on geographic distance, which was confirmed by the Mantel test, which did not show a strong correlation between genetic distance and geographic distance. Values of indices of genetic identity showed that the populations were closely related. Though the gene flow estimate (Nm) between the populations was 0.469, suggesting restricted gene flow, the populations are not genetically distinct. These observations suggest that the range expansion of this banana pest in India has taken place through transport of infested corms and plant material, resulting in genetically close populations that are geographically distinct. These results provide important information on the population structure of this pest in India, which will aid in designing suitable strategies for its control and management, especially with respect to insecticide resistance.

10aAflps10aArbitrary Primers10aBemisia-tabaci10aCosmopolites Sordidus10adiversity10aGenetic diversity10aGermar Coleoptera10ainsecticide resistance10aMarkers10aMusa Spp.10aPcr10aRapds10aRestricted Gene Flow Natural-populations10aScirpophaga-incertulas1 aYadav, Sweta, Kumari U.1 aSingh, Jyotsna1 aPadmanaban, B.1 aKumar, Lalitha, Sunil uhttp://library.ncl.res.in/content/genetic-variability-indian-populations-banana-corm-weevil-cosmopolites-sordidus-coleoptera02141nas a2200181 4500008004100000020002200041245014800063210006900211250000800280260002900288300001200317490000600329520145500335100001701790700000501807700001601812856013101828 2017 eng d a978-0-12-811519-000aGenetically engineered crops: Opportunities, constraints, and food security at a glance of human health, environmental impact, and food quality0 aGenetically engineered crops Opportunities constraints and food  a1st aSingaporebElsevier Inc. a311-3340 v63 a

Genetic modification (GM) is an incredible technology and it will be among the top 10 technologies developed in the 20th century. People believe that GM technology will answer the future food demand and enable the world to feed millions of people; however, there are apprehensions about the impact of GM crops on human health, the environment, and food quality. Due to the controversy over GM crops, it is important to think about their economic and social effects. GM plants are likely to have increased nutrient levels, produce pharmaceuticals, and show resistance to disease, cold, and drought, and thus increase food security. Conversely, they may also lead to the emergence of new allergens. When thinking about food quality, these crops have the ability to generate more nutritious varieties, which may be of benefit to malnourished populations. However, with the exception of Golden Rice (which was developed to face vitamin A deficiency) achievements in this field are a long way off. These crops also have the potential to have a positive environmental impact as herbicide-tolerant plants can be cultivated on all types of land; however, this also brings about the possibility of generating herbicide-resistant weeds. Overall, GM crops can increase incomes for farmers and aid in drug production; however, care should be taken before releasing GM crops into the environment because once they are planted there will be no turning back.

1 aDawkar, V.V.1 a1 aBarvkar, V. uhttp://library.ncl.res.in/content/genetically-engineered-crops-opportunities-constraints-and-food-security-glance-human-health01802nas a2200169 4500008004100000022001300041245016700054210006900221260000800290300001100298490000700309520115000316100001501466700000501481700001701486856012901503 2017 eng d a2213596000aGenome-wide identification and tissue-specific expression analysis of nucleotide binding site-leucine rich repeat gene family in Cicer arietinum (kabuli chickpea)0 aGenomewide identification and tissuespecific expression analysis cDEC a 24-310 v143 aThe nucleotide binding site-leucine rich repeat (NBS-LRR) proteins play an important role in the defense mechanisms against pathogens. Using bioinformatics approach, we identified and annotated 104 NBS-LRR genes in chickpea. Phylogenetic analysis points to their diversification into two families namely TIR-NBS-LRR and non-TIR-NBS-LRR. Gene architecture revealed intron gain/loss events in this resistance gene family during their independent evolution into two families. Comparative genomics analysis elucidated its evolutionary relationship with other fabaceae species. Around 50% NBS-LRRs reside in macro-syntenic blocks underlining positional conservation along with sequence conservation of NBS-LRR genes in chickpea. Transcriptome sequencing data provided evidence for their transcription and tissue-specific expression. Four cis-regulatory elements namely WBOX, DRE, CBF, and GCC boxes, that commonly occur in resistance genes, were present in the promoter regions of these genes. Further, the findings will provide a strong background to use candidate disease resistance NBS-encoding genes and identify their specific roles in chickpea.1 aSharma, R.1 a1 aSuresh, C.G. uhttp://library.ncl.res.in/content/genome-wide-identification-and-tissue-specific-expression-analysis-nucleotide-binding-site02628nas a2200229 4500008004100000245012800041210006900169260000800238300001200246490001000258520179900268100002002067700002402087700001902111700002602130700002202156700002302178700002102201700002602222700002002248856013002268 2017 eng d00aGenomic and functional characterization of coleopteran insect-specific alpha-amylase inhibitor gene from amaranthus species0 aGenomic and functional characterization of coleopteran insectspe cJUN a319-3320 v 94 3 aThe smallest 32 amino acid alpha-amylase inhibitor from Amaranthus hypochondriacus (AAI) is reported. The complete gene of pre-protein (AhAI) encoding a 26 amino acid (aa) signal peptide followed by the 43 aa region and the previously identified 32 aa peptide was cloned successfully. Three cysteine residues and one disulfide bond conserved within known alpha-amylase inhibitors were present in AhAI. Identical genomic and open reading frame was found to be present in close relatives of A. hypochondriacus namely Amaranthus paniculatus, Achyranthes aspera and Celosia argentea. Interestingly, the 3'UTR of AhAI varied in these species. The highest expression of AhAI was observed in A. hypochondriacus inflorescence; however, it was not detected in the seed. We hypothesized that the inhibitor expressed in leaves and inflorescence might be transported to the seeds. Sub-cellular localization studies clearly indicated the involvement of AhAI signal peptide in extracellular secretion. Full length rAhAI showed differential inhibition against alpha-amylases from human, insects, fungi and bacteria. Particularly, alpha-amylases from Helicoverpa armigera (Lepidoptera) were not inhibited by AhAI while Tribolium castaneum and Callosobruchus chinensis (Coleoptera) alpha-amylases were completely inhibited. Molecular docking of AhAI revealed tighter interactions with active site residues of T. castaneum alpha-amylase compared to C. chinensis alpha-amylase, which could be the rationale behind the disparity in their IC50. Normal growth, development and adult emergence of C. chinensis were hampered after feeding on rAhAI. Altogether, the ability of AhAI to affect the growth of C. chinensis demonstrated its potential as an efficient bio-control agent, especially against stored grain pests.1 aBhide, Amey, J.1 aChannale, Sonal, M.1 aYadav, Yashpal1 aBhattacharjee, Kabita1 aPawar, Pankaj, K.1 aMaheshwari, V., L.1 aGupta, Vidya, S.1 aRamasamy, Sureshkumar1 aGiri, Ashok, P. uhttp://library.ncl.res.in/content/genomic-and-functional-characterization-coleopteran-insect-specific-alpha-amylase-inhibitor02557nas a2200169 4500008004100000245006800041210006800109260003200177300001000209490000900219520198900228100001902217700001902236700001502255700002102270856009602291 2017 eng d00aGlobal conformation of Tau protein mapped by Raman spectroscopy0 aGlobal conformation of Tau protein mapped by Raman spectroscopy aNew YorkbHumana Press Inc. a21-310 v15233 aAlzheimer’s disease (AD) is one of the neurodegenerative disease characterized by progressive neuronal loss in the brain. Its two major hallmarks are extracellular senile plaques and intracellular neurofibrillary tangles (NFTs), formed by aggregation of amyloid β-42 (Aβ-42) and Tau protein respectively. Aβ-42 is a transmembrane protein, which is produced after the sequential action of β- and γ-secretases, thus obtained peptide is released extracellularly and gets deposited on the neuron forming senile plaques. NFTs are composed of microtubule-associated protein-Tau (MAPT). Tau protein’s major function is to stabilize the microtubule that provides a track on which the cargo proteins are shuttled and the stabilized microtubule also maintains shape and integrity of the neuronal cell. Tau protein is subjected to various modifications such as phosphorylation, ubiquitination, glycation, acetylation, truncation, glycosylation, deamination, and oxidation; these modifications ultimately lead to its aggregation. Phosphorylation is the major modification and is extensively studied with respect to Tau protein. Tau protein, however, undergoes certain level of phosphorylation and dephosphorylation, which regulates its affinity for microtubule and ultimately leading to microtubule assembly and disassembly. Our main aim was to study the native state of longest isoform of Tau (hTau40WT-4R2N) and its shortest isoform, (hTau23WT-3R0N), at various temperatures such as 10, 25, and 37 °C. Raman spectroscopic results suggested that the proportion of random coils or unordered structure depends on the temperature of the protein environment. Upon increase in the temperature from 10 to 37 °C, the proportion of random coils or unordered structures increased in the case of hTau40WT. However, we did not find a significant effect of temperature on the structure of hTau23WT. This current approach enables one to analyze the global conformation of soluble Tau in solution. 1 aGorantla, N.V.1 aKhandelwal, P.1 aPoddar, P.1 aChinnathambi, S. uhttp://library.ncl.res.in/content/global-conformation-tau-protein-mapped-raman-spectroscopy01947nas a2200217 4500008004100000245014600041210006900187260000800256300001400264490000700278520115500285100001801440700002101458700002001479700002701499700002301526700001501549700002101564700002101585856012301606 2017 eng d00aGlucosylation of smoke-derived volatiles in grapevine (vitis vinifera) is catalyzed by a promiscuous resveratrol/guaiacol glucosyltransferase0 aGlucosylation of smokederived volatiles in grapevine vitis vinif cJUL a5681-56890 v653 aVinification of grapes (Vitis vinifera) exposed to forest fire smoke can yield unpalatable wine due to the presence of taint compounds from smoke and the release of smoke derived volatiles from their respective glycosides during the fermentation process or in-mouth during consumption. To identify glycosyltransferases (GTs) involved in the formation of glycosidically bound smoke-derived volatiles we performed gene expression analysis of candidate GTs in different grapevine tissues. Second, substrates derived from bushfire smoke or naturally occurring in grapes were screened with the candidate recombinant GTs. A resveratrol GT (UGT72B27) gene, highly expressed in grapevine leaves and berries was identified to be responsible for the production of the phenolic glucosides. UGT72B27 converted the stilbene trans-resveratrol mainly to the 3-O-glucoside. Kinetic analyses yielded specificity constants (k(cat)/K-m) of 114, 17, 9, 8, and 2 mM(-1) s(-1) for guaiacol, trans-resveratrol, syringol, methylsyringol, and methylguaiacol, respectively. This knowledge will help to design strategies for managing the risk of producing smoke-affected wines.1 aHaratl, Katja1 aHuang, Fong-Chin1 aGiri, Ashok, P.1 aFranz-Oberdorf, Katrin1 aFrotscher, Johanna1 aShao, Yang1 aHoffmann, Thomas1 aSchwab, Wilfried uhttp://library.ncl.res.in/content/glucosylation-smoke-derived-volatiles-grapevine-vitis-vinifera-catalyzed-promiscuous02879nas a2200193 4500008004100000245017800041210006900219260000800288300001200296490000800308520208800316100002102404700002402425700002402449700002102473700003902494700002502533856012702558 2017 eng d00aGlycation inhibitors extend yeast chronological lifespan by reducing advanced glycation end products and by back regulation of proteins involved in mitochondrial respiration0 aGlycation inhibitors extend yeast chronological lifespan by redu cMAR a104-1120 v1563 aAdvanced Glycation End products (AGEs) are implicated in aging process. Thus, reducing AGEs by using glycation inhibitors may help in attenuating the aging process. In this study using Saccharomyces cerevisiae yeast system, we show that Aminoguanidine (AMG), a well-known glycation inhibitor, decreases the AGE modification of proteins in non-calorie restriction (NR) (2% glucose) and extends chronological lifespan (CLS) similar to that of calorie restriction (CR) condition (0.5% glucose). Proteomic analysis revealed that AMG back regulates the expression of differentially expressed proteins especially those involved in mitochondrial respiration in NR condition, suggesting that it switches metabolism from fermentation to respiration, mimicking CR. AMG induced back regulation of differentially expressed proteins could be possibly due to its chemical effect or indirectly by glycation inhibition. To delineate this, Metformin (MET), a structural analog of AMG and a mild glycation inhibitor and Hydralazine (HYD), another potent glycation inhibitor but not structural analog of AMG were used. HYD was more effective than MET in mimicking AMG suggesting that glycation inhibition was responsible for restoration of differentially expressed proteins. Thus glycation inhibitors particularly AMG, HYD and MET extend yeast CLS by reducing AGEs, modulating the expression of proteins involved in mitochondrial respiration and possibly by scavenging glucose. Significance: This study reports the role of glycation in aging process. In the non-caloric restriction condition, carbohydrates such as glucose promote protein glycation and reduce CLS. While, the inhibitors of glycation such as AMC, HYD, MET mimic the caloric restriction condition by back regulating deregulated proteins involved in mitochondria( respiration which could facilitate shift of metabolism from fermentation to respiration and extend yeast CLS. These findings suggest that glycation inhibitors can be potential molecules that can be used in management of aging. (C) 2017 Elsevier B.V. All rights reserved.1 aKazi, Rubina, S.1 aBanarjee, Reema, M.1 aDeshmukh, Arati, B.1 aPatil, Gouri, V.1 aJagadeeshaprasad, Mashanipalya, G.1 aKulkarni, Mahesh, J. uhttp://library.ncl.res.in/content/glycation-inhibitors-extend-yeast-chronological-lifespan-reducing-advanced-glycation-end02382nas a2200205 4500008004100000245017400041210006900215260000800284300001400292490000700306520157700313100002301890700002301913700002001936700002601956700002001982700002602002700002202028856012602050 2017 eng d00aGlycoprotein alpha-amylase inhibitor from Withania somnifera differentially inhibits various alpha-amylases and affects the growth and development of Tribolium castaneum0 aGlycoprotein alphaamylase inhibitor from Withania somnifera diff cJUL a1382-13900 v733 a

BACKGROUND: Identification and characterisation of plant defensive molecules enrich our resources to design crop protection strategies. In particular, plant-derived proteinaceous inhibitor(s) of insect digestive enzymes appear to be a safe, sustainable and attractive option. RESULTS: A glycoprotein having non-competitive alpha-amylase inhibitory activity with a molecular weight of 8.3 kDa was isolated and purified from seeds of Withania somnifera alpha-amylase inhibitor (WSAI). Its mass spectrometry analysis revealed 59% sequence coverage with Wrightide II-type alpha-amylase inhibitor from Wrightia religiosa. A dose-dependent inhibition of alpha-amylases from Aspergillus oryzae, Bacillus subtilis, Helicoverpa armigera and Tribolium castaneumwas recorded. Interestingly, WSAI did not inhibit human salivary alpha-amylase significantly. When adults of T. castaneum were fed with WSAI (1.6mg g(-1)), decrease inconsumption, growthandefficiency of conversion of ingested foodwas evident, along withover fourfold increases in feedingdeterrence index. Adecline inlarval residual alpha-amylase activity after feedingofWSAI resulted ina reduction in longevity of T. castaneum. CONCLUSION: The study reflects the significance of WSAI in affecting the overall growth and development of T. castaneum. Pre-and post-harvest pest resistive capability makes WSAI a potential candidate for insect pest management. Further, the effectiveness of this inhibitor could be explored either in formulations or through a transgenic approach. (C) 2016 Society of Chemical Industry

1 aKasar, Sainath, S.1 aMarathe, Kiran, R.1 aBhide, Amey, J.1 aHerwade, Abhijeet, P.1 aGiri, Ashok, P.1 aMaheshwari, Vijay, L.1 aPawar, Pankaj, K. uhttp://library.ncl.res.in/content/glycoprotein-alpha-amylase-inhibitor-withania-somnifera-differentially-inhibits-various02945nas a2200337 4500008004100000245008600041210006900127260000800196300001200204490000800216520197300224653001002197653001702207653001302224653001702237653002202254653002902276653000902305653002202314653002302336100001302359700001502372700001302387700001302400700001302413700001902426700001402445700002002459700001502479856011302494 2017 eng d00aGold nanoconjugates reinforce the potency of conjugated cisplatin and doxorubicin0 aGold nanoconjugates reinforce the potency of conjugated cisplati cDEC a254-2640 v1603 aOsteosarcoma or osteogenic sarcoma is the most common and prevalent cancerous tumor of bone and occurs especially in children and teens. Recent treatment strategy includes a combination of both chemotherapy and surgeries. Although, the use of single drug-based chemotherapy treatment remains unsatisfactory. Therefore, combinatorial therapy has emerged as a potential strategy for treatment with limited side- effects. Here, we evaluated the combinatorial anticancerous effect of cisplatin (CIS) and doxorubicin (DOX) bioconjugated bromelain encapsulated gold nanoparticles (B-AuNPs conjugated CIS and DOX) in the treatment of osteosarcoma. The synthesized B-AuNPs conjugated CIS and DOX were characterized by various characterization techniques like UV–vis spectroscopy, TEM, DLS and zeta potential to ensure the synthesis, size, shape, size distribution and stability. Drug loading efficiency bioconjugation of CIS and DOX was ensured by UV–vis spectroscopy. Bioconjugation of CIS and DOX was further confirmed using UV–vis spectroscopy, TEM, DLS, Zeta potential and FT-IR analysis. The combinatorial effect of CIS and DOX in B-AuNPs conjugated CIS and DOX showed highly improved potency against MG-63 and Saos-2 cells at a very low concentration where primary osteoblasts didn't show any cytotoxic effect. The apoptotic effect of B-AuNPs conjugated CIS and DOX on osteosarcoma and primary osteoblasts cells were analyzed by increased permeability of the cell membrane, condensed chromatin and deep blue fluorescent condensed nucleus. The results clearly showed that B-AuNPs conjugated CIS and DOX significantly improved the potency of both the chemotherapeutic drugs by delivering them specifically into the nucleus of cancer cells through caveolae-dependent endocytosis. Thus, the greater inhibitory effect of combinatorial drugs (B-AuNPs conjugated CIS and DOX) over single drug based chemotherapy would be of great advantage during osteosarcoma treatment. 10acells10achemotherapy10aCytology10aCytotoxicity10aDrug interactions10adynamic light scattering10aGold10aMolecular Biology10aPlatinum Compounds1 aIram, S.1 aZahera, M.1 aKhan, S.1 aKhan, I.1 aSyed, A.1 aAnsary, A., A.1 aAmeen, F.1 aShair, O., H. M1 aKhan, M.S. uhttp://library.ncl.res.in/content/gold-nanoconjugates-reinforce-potency-conjugated-cisplatin-and-doxorubicin00893nas a2200133 4500008004100000245014800041210006900189260000800258300001400266520031800280100002200598700002100620856011800641 2017 eng d00aGold-catalyzed dehydrazinative C(sp)-S coupling reactions of arylsulfonyl hydrazides with ethynylbenziodoxolones for accessing alkynyl sulfones0 aGoldcatalyzed dehydrazinative CspS coupling reactions of arylsul cJUN a3512-35153 aA gold(III)-catalyzed dehydrazinative coupling reaction between arylsulfonyl hydrazides and ethynylbenziodoxolone reagents was realized for the synthesis of alkynyl sulfones. The scope and versatility of the reaction were demonstrated by the efficient synthesis of 23 derivatives with diverse structural features.1 aShinde, Popat, S.1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/gold-catalyzed-dehydrazinative-csp-s-coupling-reactions-arylsulfonyl-hydrazides01668nas a2200169 4500008004100000022001400041245011900055210006900174260000900243300001400252490000600266520104300272100001501315700002101330700002401351856012301375 2017 eng d a2040-336400aGrafoil-scotch tape-derived highly conducting flexible substrate and its application as a supercapacitor electrode0 aGrafoilscotch tapederived highly conducting flexible substrate a cMAR  a3593-36000 v93 a

Development of flexible supercapacitors is limited by the availability of flexible and durable conducting substrates; a conducting and cheap substrate for the active material deposition is essential for breakthrough progress in this direction. In this report, a highly flexible, conducting, and cheap substrate is prepared by simple stick and peel-off method involving Scotch tape and Grafoil. A Grafoil-Scotch tape derived flexible substrate exhibits a sheet resistance of 7 Omega square(-1) along with a high degree of flexibility and durability. Moreover, its properties are further enhanced by the anodization in order to increase the hydrophilicity and surface area. The substrate is highly thin with a thickness of just 74 mu m. Its practical utility has been demonstrated by electrodepositing MnO2 as an active material and, thereafter, fabricating a solid-state flexible supercapacitor. The fabricated device exhibits high capacitance retention under bent (99%) and twisted (98%) conditions along with a low ESR of 7 Omega.

1 aSoni, Roby1 aRaveendran, Alka1 aKurungot, Sreekumar uhttp://library.ncl.res.in/content/grafoil-scotch-tape-derived-highly-conducting-flexible-substrate-and-its-application01398nas a2200169 4500008004100000245007100041210006900112260010900181300001200290490001000302520074200312100001901054700001901073700001801092700002401110856009401134 2017 eng d00aGrowth of flower-like patterns of TiO2 nanorods over FTO substrate0 aGrowth of flowerlike patterns of TiO2 nanorods over FTO substrat a Univ Delhi, New Delhi, IndiabTaylor & Francis Group 2&4 Park Square Milton Park Abingdon OX14 4RNcNOV a166-1710 v 184 3 a

Nanostructures such as nanoparticles, nanowires, nanorods, nanotubes have attracted great interest with the understanding of shape and size dependence in the electronic and sensing properties. This work demonstrates growth and characterization of one-dimensional nanorods of titanium-dioxide (TiO2) on the fluorine doped tin oxide (FTO) substrate by using hydrothermal method. Field effect scanning electron microscopy shows flower-like morphology, and energy-dispersive X-ray spectroscopy confirms the presence of Ti and O. The X-ray diffraction peaks agree well with the JCPDS data. Initially, the 1D nanorods are formed and high concentration of precursor assists evolution of the short branches to form flower-like structures.

1 aIssar, Sheetal1 aPoddar, Pankaj1 aMehra, N., C.1 aMahapatro, Ajit, K. uhttp://library.ncl.res.in/content/growth-flower-patterns-tio2-nanorods-over-fto-substrate02985nas a2200265 4500008004100000022001400041245019100055210006900246260000800315300001400323490000700337520201800344653002302362653001702385653002702402653001202429653002602441653001902467100002302486700001702509700002102526700002402547700002102571856012702592 2018 eng d a1438-793X00aGA3 application in grapes (Vitis vinifera L.) modulates different sets of genes at cluster emergence, full bloom, and berry stage as revealed by RNA sequence-based transcriptome analysis0 aGA3 application in grapes Vitis vinifera L modulates different s cJUL a439–4550 v183 aIn grapes (Vitis vinifera L.), exogenous gibberellic acid (GA3) is applied at different stages of bunch development to achieve desirable bunch shape and berry size in seedless grapes used for table purpose. RNA sequence-based transcriptome analysis was used to understand the mechanism of GA3 action at cluster emergence, full bloom, and berry stage in table grape variety Thompson Seedless. At cluster emergence, rachis samples were collected at 6 and 24 h after application of GA3, whereas flower clusters and berry samples were collected at 6, 24, and 48 h after application at full bloom and 3–4 mm berry stages. Seven hundred thirty-three genes were differentially expressed in GA3-treated samples. At rachis and flower cluster stage respectively, 126 and 264 genes were found to be significantly differentially expressed within 6 h of GA3 application. The number of DEG reduced considerably at 24 h. However, at berry stage, major changes occurred even at 24 h and a number of DEGs at 6 and 24 h were 174 and 191, respectively. As compared to upregulated genes, larger numbers of genes were downregulated. Stage-specific response to the GA3 application was observed as evident from the unique set of DEGs at each stage and only a few common genes among three stages. Among the DEGs, 67 were transcription factors. Functional categorization and enrichment analysis revealed that several transcripts involved in sucrose and hexose metabolism, hormone and secondary metabolism, and abiotic and biotic stimuli were enriched in response to application of GA3. A high correlation was recorded for real-time PCR and transcriptome data for selected DEGs, thus indicating the robustness of transcriptome data obtained in this study for understanding the GA3 response at different stages of berry development in grape. Chromosomal localization of DEGs and identification of polymorphic microsatellite markers in selected genes have potential for their use in breeding for varieties with improved bunch architecture.10aBunch architecture10aGA3 response10aMicrosatellite markers10aRNA seq10aTranscription factors10aVitis vinifera1 aUpadhyay, Anuradha1 aMaske, Smita1 aJogaiah, Satisha1 aKadoo, Narendra, Y.1 aGupta, Vidya, S. uhttp://library.ncl.res.in/content/ga3-application-grapes-vitis-vinifera-l-modulates-different-sets-genes-cluster-emergence01816nas a2200181 4500008004100000245012100041210006900162260000800231300001400239490000700253520114300260100002001403700001901423700002101442700001801463700002501481856012801506 2018 eng d00aG-C3N4/NiAl-LDH 2D/2D hybrid heterojunction for high-performance photocatalytic reduction ofco2 into renewable fuels0 aGC3N4NiAlLDH 2D2D hybrid heterojunction for highperformance phot cJAN a2667-26780 v103 a2D/2D interface heterostructures of g-C3N4 and NiAl-LDH are synthesized utilizing strong electrostatic interactions between positively charged 2D NiAl-LDH sheets and negatively charged 2D g-C3N4 nanosheets. This new 2D/2D interface heterojunction showed remarkable performance for photocatalytic CO, reduction to produce renewable fuels such as CO and H-2 under visible-light irradiation, far superior to that of either single phase g-C3N4 or NiAl-LDH nanosheets. The enhancement of photocatalytic activity could be attributed mainly to the excellent interfacial contact at the heterojunction of gC(3)N(4)/NiAl-LDH, which subsequently results in suppressed recombination, and improved transfer and separation of photogenerated charge carriers. In addition, the optimal g-C3N4/NiAl-LDH nanocomposite possessed high photostability after successive experimental runs with no obvious change in the production of CO from CO, reduction. Our findings regarding the design, fabrication and photophysical properties of 2D/2D heterostructure systems may find use in other photocatalytic applications including H-2 production and water purification.1 aTonda, Surendar1 aKumar, Santosh1 aBhardwaj, Monika1 aYadav, Poonam1 aOgale, Satishchandra uhttp://library.ncl.res.in/content/g-c3n4nial-ldh-2d2d-hybrid-heterojunction-high-performance-photocatalytic-reduction-ofco202128nas a2200181 4500008004100000245012800041210006900169260000800238300001400246490000700260520143600267100001801703700002201721700002701743700001901770700003001789856012701819 2018 eng d00aGeneric and scalable method for the preparation of monodispersed metal sulfide nanocrystals with tunable optical properties0 aGeneric and scalable method for the preparation of monodispersed cMAY a5788-57970 v343 a

A rational synthetic method that produces monodisperse and air-stable metal sulfide colloidal quantum dots (CQDs) in organic nonpolar solvents using octyl dithiocarbamic acid (C(8)DTCA) as a sulfur source, is reported. The fast decomposition of metal-C(8)DTCA complexes in presence of primary amines is exploited to achieve this purpose. This novel technique is generic and can be applied to prepare diverse CQDs, like CdS, MnS, ZnS, SnS, and In2S3, including more useful and in-demand PbS CQDs and plasmonic nanocrystals of Cu2S. Based on several control reactions, it is postulated that the reaction involves the in situ formation of a metal-C(8)DTCA complex, which then reacts in situ with oleylamine at slightly elevated temperature to decompose into metal sulfide CQDs at a controlled rate, leading to the formation of the materials with good optical characteristics. Controlled sulfur precursor's reactivity and stoichiometric reaction between C(8)DTCA and metal salts affords high conversion yield and large-scale production of monodisperse CQDs. Tunable and desired crystal size could be achieved by controlling the precursor reactivity by changing the reaction temperature and reagent ratios. Finally, the photovoltaic devices fabricated from PbS CQDs displayed a power conversion efficiency of 4.64% that is comparable with the reported values of devices prepared with PbS CQDs synthesized by the standard methods.

1 aBera, Abhijit1 aMandal, Debranjan1 aGoswami, Prasenjit, N.1 aRath, Arup, K.1 aPrasad, Bhagavatula L. V. uhttp://library.ncl.res.in/content/generic-and-scalable-method-preparation-monodispersed-metal-sulfide-nanocrystals-tunable02889nas a2200265 4500008004100000022001400041245017300055210006900228260000800297300001000305490000800315520189700323100001902220700002902239700002402268700001902292700002802311700003102339700002702370700003402397700002102431700002602452700001702478856012802495 2018 eng d a0031-942200aGenetic and phytochemical investigations for understanding population variability of the medicinally important tree Saraca asoca to help develop conservation strategies0 aGenetic and phytochemical investigations for understanding popul cDEC a43-540 v1563 aSaraca asoca (Roxb.) De Wilde (Caesalpiniaceae) is a highly traded IUCN red listed tree species used in Ayurvedic medicines for the treatment of various disorders, especially gynaecological problems. However, information about the genetic variations between populations and corresponding variation in specialized metabolites of S. asoca remains unclear. To address this issue, we analysed 11 populations of S. asoca with 106 accessions collected from Western Ghats of India using ISSR markers along with selected phytocompounds using RP-HPLC. Twenty primers were screened, out of which seven were selected for further analysis based on generation of clear polymorphic banding patterns. These seven ISSR primers produced 74 polymorphic loci. AMOVA showed 43% genetic variation within populations and 57% among the populations of S. asoca. To estimate the genetic relationships among S. asoca populations, UPGMA and Bayesian Models were constructed, which revealed two clusters of similar grouping patterns. However, excluding minor deviations, UPGMA and dissimilarity analysis showed close association of genotypes according to their geographical locations. Catechin (CAT), epicatechin (EPI) and gallic acid (GA) were quantified from bark and leaf samples of corresponding genotypes collected from 106 accessions. ROC plots depicted the sensitivity and specificity of the concentrations of tested phytocompounds at various cut-off points. Although, multiple logistic regression analysis predicted some association between few loci with GA, EPI and CAT, but PCA for phytochemical data failed to distinguish the populations. Overall, there were no significant trends observed to distinguish the populations based on these phytocompounds. Furthermore, the study advocates the delineate provenance regions of S. asoca genotypes/chemotype snapshots for in-situ conservation and ex-situ cultivation.1 aHegde, Satisha1 aPai, Sandeep, Ramchandra1 aBhagwat, Rasika, M.1 aSaini, Archana1 aRathore, Poonam, Kanwar1 aJalalpure, Sunil, Satyappa1 aHegde, Harsha, Vasudev1 aSugunan, Attayoor, Purushotta1 aGupta, Vidya, S.1 aKholkute, Sanjiva, D.1 aRoy, Subarna uhttp://library.ncl.res.in/content/genetic-and-phytochemical-investigations-understanding-population-variability-medicinally02441nas a2200193 4500008004100000245020200041210006900243260000800312300000900320520163600329653002101965653003501986653003802021100001502059700001402074700001502088700001702103856012702120 2018 eng d00aGenetic engineering approach using early Vinca alkaloid biosynthesis genes led to increased tryptamine and terpenoid indole alkaloids biosynthesis in differentiating cultures of catharanthus roseus0 aGenetic engineering approach using early Vinca alkaloid biosynth cAUG a1-113 a

Catharanthus roseus today occupies the central position in ongoing metabolic engineering efforts in medicinal plants. The entire multi-step biogenetic pathway of its very expensive anticancerous alkaloids vinblastine and vincristine is fairly very well dissected at biochemical and gene levels except the pathway steps leading to biosynthesis of monomeric alkaloid catharanthine and tabersonine. In order to enhance the plant-based productivity of these pharma molecules for the drug industry, cell and tissue cultures of C. roseus are being increasingly tested to provide their alternate production platforms. However, a rigid developmental regulation and involvement of different cell, tissues, and organelles in the synthesis of these alkaloids have restricted the utility of these cultures. Therefore, the present study was carried out with pushing the terpenoid indole alkaloid pathway metabolic flux towards dimeric alkaloids vinblastine and vincristine production by over-expressing the two upstream pathway genes tryptophan decarboxylase and strictosidine synthase at two different levels of cellular organization viz. callus and leaf tissues. The transformation experiments were carried out using Agrobacterium tumefaciens LBA1119 strain having tryptophan decarboxylase and strictosidine synthase gene cassette. The callus transformation reported a maximum of 0.027% dry wt vindoline and 0.053% dry wt catharanthine production, whereas, the transiently transformed leaves reported a maximum of 0.30% dry wt vindoline, 0.10% catharanthine, and 0.0027% dry wt vinblastine content. © 2017 Springer-Verlag GmbH Austria

10aAgroinfiltration10aStrictosidine Synthase (CrSTR)10aTerpenoid Indole Alkaloids (TIAs)1 aSharma, A.1 aVerma, P.1 aMathur, A.1 aMathur, A.K. uhttp://library.ncl.res.in/content/genetic-engineering-approach-using-early-vinca-alkaloid-biosynthesis-genes-led-increased02364nas a2200145 4500008004100000245008000041210006900121260000800190300001000198490000700208520184900215100002402064700002302088856010702111 2018 eng d00aGenetic programming based models for prediction of vapor-liquid equilibrium0 aGenetic programming based models for prediction of vaporliquid e cMAR a68-800 v603 aThe design, operation, and control of chemical separation processes heavily rely on the knowledge of the vapor liquid equilibrium (VLE). Often, conducting experiments to gain an insight into the separation behavior becomes tedious and expensive. Thus, standard thermodynamic models are used in the VLE prediction. Sometimes, exclusively data-driven models are also used in VLE prediction although this method too possesses drawbacks such as a trial and error approach in specifying the data-fitting function. For overcoming these difficulties, this paper employs a machine learning (ML) formalism namely "genetic programming (GP)" possessing certain attractive features for the VLE prediction. Specifically, three case studies have been performed wherein GP-based models have been developed using experimental data, for predicting the vapor phase composition of a ternary, and a group of non ideal binary systems. The inputs to models consists of three pure component attributes (acentric factor, critical temperature, and critical pressure), and as many intensive thermodynamic parameters (liquid phase composition, pressure, and temperature). A comparison of the VLE prediction and generalization performance of the GP-based models with the corresponding standard thermodynamic models reveals that the former class of models possess either superior or closely comparable performance vis-a-vis thermodynamic models. Noteworthy features of this study are: (i) a single GP-based model can predict VLE of a group of binary systems, and (ii) applicability of a GP-based model trained on an alcohol-acetate series data for its higher homolog. The VLE modeling approach exemplified here can be gainfully extended to other ternary and non-ideal binary systems, and for designing corresponding experiments in different pressure and temperature ranges.1 aPatil-Shinde, Veena1 aTambe, Sanjeev, S. uhttp://library.ncl.res.in/content/genetic-programming-based-models-prediction-vapor-liquid-equilibrium02280nas a2200193 4500008004100000020001900041245007700060210006900137260001300206300001200219490000600231520164800237100001901885700001801904700001901922700002101941700002001962856010401982 2018 eng d a978-331990317000aGenomic roadmaps for augmenting salinity stress tolerance in crop plants0 aGenomic roadmaps for augmenting salinity stress tolerance in cro bSpringer a189-2160 v23 aSerious antagonistic impacts of saline environment on plant growth, development, and yield are well established. In this regard, researchers and breeders have been utilizing many conventional as well as modern approaches to aid the pro- cess of developing salt-tolerant crops. Biotechnological tools have made the task of engineering salinity tolerance in plants easier. Currently, two major annexes are effectively employed to develop salt-tolerant crops, first, investigation of genetic variation via marker-assisted selection (MAS) and second the transgenic technology. Sustenance of plants under dynamically growth-limiting saline environment depends on alterations and/or switching between multiple biochemical pathways involved in response. A number of key regulatory genes have been successfully identified and characterized in this context which can be explored to serve the purpose of alleviation in salt-tolerant nature of plants. Several genomics-abetted approaches have been reported aiming toward improvement in growth and yield of crops under saline envi- ronment. Present chapter focuses on genomic roadmaps for augmentation of crop salt tolerance by various methods including MAS, transgenic breeding, manipulations in small non-coding RNAs, and genome editing. These approaches utilize key players involved in salinity-mediated plant defense mechanisms, such as ion transporters, osmolytes, antioxidants, transcription factors, signaling proteins, and microRNA. The chapter attempts to summarize the effective targets and exploration of these key entities to raise salt-tolerant plants through various genomics-related tools. 1 aSuprasanna, P.1 aGhuge, S., A.1 aPatade, V., Y.1 aMirajkar, S., J.1 aNikalje, G., C. uhttp://library.ncl.res.in/content/genomic-roadmaps-augmenting-salinity-stress-tolerance-crop-plants02706nas a2200205 4500008004100000245019500041210006900236260000800305300001200313490000800325520187900333100002302212700001902235700002602254700002102280700002402301700002002325700002702345856012802372 2018 eng d00aGlobal transcriptome analysis of grapevine ( Vitis vinifera L.) leaves under salt stress reveals differential response at early and late stages of stress in table grape cv. Thompson Seedless0 aGlobal transcriptome analysis of grapevine Vitis vinifera L leav cMAY a168-1790 v1293 aAmong the different abiotic stresses, salt stress has a significant effect on the growth and yield of grapevine (Vitis vinifera L.). In this study, we employed RNA sequence based transcriptome analysis to study salinity stress response in grape variety Thompson Seedless. Salt stress adversely affected the growth related and physiological parameters and the effect on physiological parameters was significant within 10 days of stress imposition. A total of 343 genes were differentially expressed in response to salt stress. Among the differentially expressed genes (DEGs) only 42 genes were common at early and late stages of stress. The gene enrichment analysis revealed that GO terms related to transcription factors were over-represented. Among the DEGs, 52 were transcription factors belonging to WRKY, EREB, MYB, NAC and bHLH families. Salt stress significantly affected several pathways like metabolic pathways, biosynthesis of secondary metabolites, membrane transport development related pathways etc. 343 DEGs were distributed on all the 19 chromosomes, however clustered regions of DEGs were present on chromosomes 2, 5, 6 and 12 suggesting probable QTLs for imparting tolerance to salt and other abiotic stresses. Real-time PCR of selected genes in control and treated samples of grafted and own root vines demonstrated that rootstock influenced expression of salt stress responsive genes. Microsatellite regions were identified in ten selected salt responsive genes and highly polymorphic markers were identified using fifteen grape genotypes. This information will be useful for the identification of key genes involved in salt stress tolerance in grape. The identified DEGs could also be useful for genome wide analysis for the identification of polymorphic markers for their subsequent use in molecular breeding for developing salt tolerant grape genotypes.1 aUpadhyay, Anuradha1 aGaonkar, Tulsi1 aUpadhyay, Ajay, Kumar1 aJogaiah, Satisha1 aShinde, Manisha, P.1 aKadoo, Narendra1 aGupta, Vidya, Shrikant uhttp://library.ncl.res.in/content/global-transcriptome-analysis-grapevine-vitis-vinifera-l-leaves-under-salt-stress-reveals01175nas a2200217 4500008004100000022001400041245012300055210006900178260000800247300001500255490000600270520038500276100002800661700002000689700002900709700002500738700002100763700002200784700002200806856012900828 2018 eng d a2398-490200a Glucose isomerization catalyzed by bone char and the selective production of 5-hydroxymethylfurfural in aqueous media0 aGlucose isomerization catalyzed by bone char and the selective p cOCT a 2148-21530 v23 aThe selective production of 5-hydroxymethylfurfural (HMF) is important, and it is difficult with glucose substrates in a water solvent. Here we demonstrate a selective method for glucose-to-HMF conversion using the combined catalysis of bone char and 1-methyl-3-(3-sulfopropyl)-imidazolium hydrogen sulfate acidic ionic liquid catalysts with a high HMF selectivity (54%) in water.1 aMatsagar, Babasaheb, M.1 aVan Nguyen, Chi1 aHossain, Md., Shahriar A1 aIslam, Md., Tofazzal1 aYamauchi, Yusuke1 aDhepe, Paresh, L.1 aWu, Kevin, C. -W. uhttp://library.ncl.res.in/content/glucose-isomerization-catalyzed-bone-char-and-selective-production-5-hydroxymethylfurfural02705nas a2200265 4500008004100000022001500041245011400056210006900170260000800239300001200247490000700259520181200266100001902078700002602097700001902123700002402142700002102166700002002187700001402207700002302221700002002244700002002264700002802284856012702312 2018 eng d a 0020-751900a Glycolysis is important for optimal asexual growth and formation of mature tissue cysts by Toxoplasma gondii0 aGlycolysis is important for optimal asexual growth and formation cOCT a955-9680 v483 aToxoplasma gondii can grow and replicate using either glucose or glutamine as the major carbon source. Here, we have studied the essentiality of glycolysis in the tachyzoite and bradyzoite stages of T. gondii, using transgenic parasites that lack a functional hexokinase gene (Delta hk) in RH (Type-1) and Prugniaud (Type-II) strain parasites. Tachyzoite stage 411k parasites exhibit a fitness defect similar to that reported previously for the major glucose transporter mutant, and remain virulent in mice. However, although Prugniaud strain Delta hk tachyzoites were capable of transforming into bradyzoites in vitro, they were severely compromised in their ability to make mature bradyzoite cysts in the brain tissue of mice. Isotopic labelling studies reveal that glucose-deprived tacyzoites utilise glutamine to replenish glycolytic and pentose phosphate pathway intermediates via gluconeogenesis. Interestingly, while glutaminedeprived intracellular Delta hk tachyzoites continued to replicate, extracellular parasites were unable to efficiently invade host cells. Further, studies on mutant tachyzoites lacking a functional phosphoenolpyruvate carboxykinase (Delta pepck1) revealed that glutaminolysis is the sole source of gluconeogenic flux in glucose-deprived parasites. In addition, glutaminolysis is essential for sustaining oxidative phosphorylation in zihk parasites, while wild type (wt) and Delta pepck1 parasites can obtain ATP from either glycolysis or oxidative phosphorylation. This study provides insights into the role of nutrient metabolism during asexual propagation and development of T. gondii, and validates the versatile nature of central carbon and energy metabolism in this parasite. (C) 2018 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.1 aShukla, Anurag1 aOlszewski, Kellen, L.1 aLlinas, Manuel1 aRommereim, Leah, M.1 aFox, Barbara, A.1 aBzik, David, J.1 aXia, Dong1 aWastling, Jonathan1 aBeiting, Daniel1 aRoos, David, S.1 aShanmugam, Dhanasekaran uhttp://library.ncl.res.in/content/glycolysis-important-optimal-asexual-growth-and-formation-mature-tissue-cysts-toxoplasma01034nas a2200169 4500008004100000245009100041210006900132260000800201300001400209490000700223520042800230100002200658700002200680700002600702700002100728856011500749 2018 eng d00aGold(I)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes0 aGoldIcatalyzed crosscoupling reactions of aryldiazonium salts wi cAPR a2865-28690 v163 a

Gold(I)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes are described. This redox neutral strategy offers an efficient approach to diverse biaryls, vinyl arenes and arylacetylenes. Monitoring the reaction with NMR and ESI-MS provided strong evidence for the in situ formation of Ph3PAuIR (R = aryl, vinyl and alkynyl) species which is crucial for the activation of aryldiazonium salts.

1 aAkram, Manjur, O.1 aShinde, Popat, S.1 aChintawar, Chetan, C.1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/goldi-catalyzed-cross-coupling-reactions-aryldiazonium-salts-organostannanes01756nas a2200229 4500008004100000022001400041245010000055210006900155260000800224300001400232490000700246520099300253100001701246700001801263700002001281700001601301700001801317700002301335700002701358700001801385856012301403 2018 eng d a1359-734500aG-quadruplex motif at the 3' end of sgRNAs improves CRISPR-Cas9 based genome editing efficiency0 aGquadruplex motif at the 3 end of sgRNAs improves CRISPRCas9 bas cMAR a2377-23800 v543 aOriginating as a component of prokaryotic adaptive immunity, the type II CRISPR/Cas9 system has been repurposed for targeted genome editing in various organisms. Although Cas9 can bind and cleave DNA efficiently under in vitro conditions, its activity inside a cell can vary dramatically between targets owing to differences between genomic loci and availability of enough Cas9/sgRNA (single guide RNA) complex molecules for cleavage. Most methods to improve CRISPR/Cas9 activity have so far relied on Cas9 protein engineering or base modifications in the sgRNA sequence. Here we demonstrate that a structure based rational design of sgRNAs can enhance the efficiency of Cas9 cleavage in vivo. By appending a naturally forming RNA G-quadruplex motif to the 3′ end of sgRNAs we can improve its stability and target cleavage efficiency in zebrafish embryos without inducing off-target activity, thereby underscoring its value in the design of better and optimized genome editing triggers.1 aNahar, Smita1 aSehgal, Paras1 aAzhar, Mohammad1 aRai, Manish1 aSingh, Amrita1 aSivasubbu, Sridhar1 aChakraborty, Debojyoti1 aMaiti, Souvik uhttp://library.ncl.res.in/content/g-quadruplex-motif-3-end-sgrnas-improves-crispr-cas9-based-genome-editing-efficiency01965nas a2200169 4500008004100000022001400041245014300055210007000198260000900268300001500277490000600292520132300298100001401621700001501635700001501650856013001665 2018 eng d a2470-134300aGraphene quantum dots-driven multiform morphologies of β-NaYF4:Gd3+/Tb3+ phosphors: the underlying mechanism and their optical properties0 aGraphene quantum dotsdriven multiform morphologies of βNaYF4Gd3T cFEB  a1834 -18490 v33 aDimension and shape tunable architectures of inorganic crystals are of extreme interest because of morphology-dependent modulation of the properties of the materials. Herein, for the first time, we present a novel impurity-driven strategy where we studied the influence of in situ incorporation of graphene quantum dots (GQDs) on the growth of β-NaYF4:Gd3+/Tb3+ phosphor crystals via a hydrothermal route. The GQDs function as a nucleation site and by changing the concentration of GQDs, the morphology of β-NaYF4:Gd3+/Tb3+ phosphors was changed from rod to flowerlike structure to disklike structure, without phase transformation. The influence of size and functionalization of GQDs on the size and shape of phosphor crystals were also systematically studied and discussed. Plausible mechanisms of formation of multiform morphologies are proposed based on the heterogeneous nucleation and growth. Most interestingly, the experimental results indicate that the photoluminescence properties of β-NaYF4:Gd3+/Tb3+ phosphor crystals are strongly dependent on the crystallite size and morphology. This study would be suggestive for the precisely controlled growth of inorganic crystals; consequently, it will open new avenues and thus may possess potential applications in the field of materials and biological sciences.1 aMalik, M.1 aPadhye, P.1 aPoddar, P. uhttp://library.ncl.res.in/content/graphene-quantum-dots-driven-multiform-morphologies-%CE%B2-nayf4gd3tb3-phosphors-underlying02212nas a2200145 4500008004100000245011800041210006900159260000800228520162300236100002401859700001901883700002201902700002001924856012201944 2018 eng d00aGreener L-lactic acid production through in situ extractive fermentation by an acid-tolerant Lactobacillus strain0 aGreener Llactic acid production through in situ extractive ferme cMAY3 aLactic acid (LA) fermentation requires a neutralizer for a physiologically acceptable range. However, a neutralizer generates a large amount of gypsum, an environmental pollutant. Furthermore, the downstream processing is complicated and expensive, comprising 50–70% of the total cost. We previously developed a Lactobacillus delbrueckii FM1, which can produce undissociated LA without neutralizer. Here, we improved FM1 by adaptive evolution at pH 4.5, which generated Adp FM1 showing an ~ 1.80-fold increase in LA production compared to FM1. The LA production via fed-batch fermentation yielded 36.2 g/L of LA, with a productivity of 0.500 g/L/h. However, cell viability was reduced due to the acidic pH and/or end-product inhibition. Therefore, an in situ LA recovery process using an extractive solvent was employed to maintain cell viability. Adp FM1 produced 49.2 g/L of LA via in situ LA-extractive fed-batch fermentation, which was ~ 1.4-fold higher than that without LA extraction. Adp FM1 provided a total LA productivity of 0.512 g/L/h in 96 h. Among the tested strains, Adp FM1 exhibited the highest H⁺-ATPase activity and a 415-fold increase in H⁺-ATPase gene expression compared to the parent strain. These results suggest that the in situ LA extractive fermentation process will ease downstream processing and prove to be a more economical and environmentally friendly option compared to the present fermentation. To our knowledge, this is the first report on the production of undissociated L-LA by Lactobacillus using an in situ recovery process, with high LA production levels and productivity.1 aSinghvi, Mamata, S.1 aZendo, Takeshi1 aGokhale, Digambar1 aSonomoto, Kenji uhttp://library.ncl.res.in/content/greener-l-lactic-acid-production-through-situ-extractive-fermentation-acid-tolerant02529nas a2200169 4500008004100000245012000041210006900161260000900230490000700239520187400246100002302120700002002143700002402163700002302187700002102210856012802231 2019 eng d00aGlobal study of MFS superfamily transporters in arabidopsis and grapes reveals their functional diversity in plants0 aGlobal study of MFS superfamily transporters in arabidopsis and  cJUN 0 v183 aThe Major Facilitator Superfamily (MFS) is the largest superfamily of secondary transporters present in all organisms, from prokaryotes to higher eukaryotes, that facilitates transport of diverse molecules like sugars, vitamins, amino-acids, hormones, etc. across cell membranes. The superfamily was further expanded to MFS Superfamily (MFSS) to integrate MFS with nine more families. The present study revealed their land plant specific diversity through identification across six species from unicellular alga to higher flowering plants. We identified 71, 131, 254, 260, 213 and 203 MFSS transporters in Chlamydomonas reinhardtii, Physcomitrella patens, Selaginella moellendorffii, Oryza sativa (var. Japonica), Arabidopsis thaliana and Vitis vinifera, respectively and classified them into MFSS families and subfamilies based on their transporter classification identifiers (TCIDs). Detailed analysis of 20 land plant specific subfamilies was conducted in A. thaliana and V. vinifera. Phylogenetic and gene duplication studies revealed the expansion of sugar porter and proton dependent oligopeptide transporter families in Arabidopsis and grape. The subcellular localization of the majority of the transporters was predicted to be in the plasma membrane. Furthermore, the microarray expression analysis of MFSS transporters from Arabidopsis and grapes revealed their multi-tissue-specificity and differential regulation under biotic and abiotic stress conditions. Studies of the transmembrane topology highlighted the presence of central cytoplasmic loop along with family specific topological variations that were evident from phylogenetic analysis. Overall, this study adds to the knowledge of functional and structural diversity and evolution of MFSS transporters in plants and opens the scope for detailed physiological and functional studies on these proteins.1 aPatil, Sucheta, S.1 aPrashant, Ramya1 aKadoo, Narendra, Y.1 aUpadhyay, Anuradha1 aGupta, Vidya, S. uhttp://library.ncl.res.in/content/global-study-mfs-superfamily-transporters-arabidopsis-and-grapes-reveals-their-functional02849nas a2200181 4500008004100000245011200041210006900153260000800222520215600230100001602386700002002402700002902422700001402451700002102465700002502486700002502511856013102536 2019 eng d00aGlycation of glucose sensitive lysine residues K36, K438 and K549 of albumin is associated with prediabetes0 aGlycation of glucose sensitive lysine residues K36 K438 and K549 cAUG3 a

Prediabetes is a risk factor for the development of diabetes. Early diagnosis of prediabetes may prevent the onset and progression of diabetes and its associated complications. Therefore, this study aimed at the identification of novel markers for efficient prediction of prediabetes. In this pursuit, we have evaluated the ability of glycated peptides of albumin in predicting prediabetes. Glycated peptides of in vitro glycated albumin were characterized by data dependent acquisition and parallel reaction monitoring using LC-HRMS. Amongst 14 glycated peptides characterized in vitro, four peptides, particularly, FK(CML)DLGEENFK, K(AML)VPQVSTPTLVEVSR, K(CML)VPQVSTPTLVEVSR, and K(AML)QTALVELVK, corresponding to 3 glucose sensitive lysine residues K36, K438, and K549, respectively showed significantly higher abundance in prediabetes than control. Additionally, the abundance of three of these peptides, namely K(AML)QTALVELVK, K(CML)VPQVSTPTLVEVSR and FK(CML)DLGEENFK was >1.8-fold in prediabetes, which was significantly higher than the differences observed for FBG, PPG, and HbA1c. Further, the four glycated peptides showed a significant correlation with FBG, PPG, HbA1c, triglycerides, VLDL, and HDL. This study supports that glycated peptides of glucose sensitive lysine residues K36, K438 and K549 of albumin could be potentially useful markers for prediction of prediabetes. SIGNIFICANCE: Undiagnosed prediabetes may lead to diabetes and associated complications. This study reports targeted quantification of four glycated peptides particulary FK(CML)DLGEENFK, K(AML)VPQVSTPTLVEVSR, K(CML)VPQVSTPTLVEVSR, and K(AML)QTALVELVK, corresponding to 3 glucose sensitive lysine residues K36, K438 and K549 respectively by parallel reaction monitoring in healthy and prediabetic subjects. These peptides showed significantly higher abundance in prediabetes than healthy subjects, and showed significant correlation with various clinical parameters including FBG, PPG, HbA1c, and altered lipid profile. Therefore, together these four peptides constitute a panel of markers that can be useful for prediction of prediabetes.

1 aRathore, R.1 aSonwane, B., P.1 aJagadeeshaprasad, M., G.1 aKahar, S.1 aSanthakumari, B.1 aUnnikrishnan, A., G.1 aKulkarni, Mahesh, J. uhttp://library.ncl.res.in/content/glycation-glucose-sensitive-lysine-residues-k36-k438-and-k549-albumin-associated-prediabetes01697nas a2200253 4500008004100000022001400041245006000055210006000115260000800175300001200183490000700195520090500202653002201107653003501129653002501164100002601189700002101215700002001236700002201256700002801278700002301306700002001329856009401349 2019 eng d a0538-806600aGlycerol acetylation considering competing dimerization0 aGlycerol acetylation considering competing dimerization cAUG a634-6400 v513 a

Glycerol acetylation is a very interesting reaction for studies of consecutive kinetics. In this short communication, we present a pseudo-homogeneous model for the synthesis of triacetyl glycerol from the reaction of glycerol and acetic acid over strongly acidic Amberlyst-15 and Amberlyst-70 catalysts, considering a dimerization of diacetyl glycerol (DAG) into diglycerol tetraacetate as a parallel reaction and compare the results with a model without side reactions. The best fits were obtained for apparent zeroth-order dimerization and first-order consecutive reactions in the presence of acetic acid in excess and with removal of water. An adaptation was made for DAG. The proposed model shows that the formation of DAG is faster than the consumption of glycerol, which could be an explanation for the occurrence of DAG dimerization instead of other parallel reactions in acetylation.

10aapparent kinetics10adiacetyl glycerol dimerization10aglycerol acetylation1 aSoares, Andre, V. -H.1 aKale, Sumeet, S.1 aArmbruster, Udo1 aPassos, Fabio, B.1 aUmbarkar, Shubhangi, B.1 aDongare, Mohan, K.1 aMartin, Andreas uhttp://library.ncl.res.in/content/glycerol-acetylation-considering-competing-dimerization01992nas a2200205 4500008004100000022001400041245012600055210006900181260000800250520124400258653001101502653002101513653002801534653001301562653002001575100002101595700002001616700002401636856012601660 2019 eng d a1864-563100aGlycine-induced electrodeposition of nanostructured cobalt hydroxide: a bifunctional catalyst for overall water splitting0 aGlycineinduced electrodeposition of nanostructured cobalt hydrox cNOV3 a

Herein, an interconnected alpha-Co(OH)(2) structure with a network-like architecture was used as a bifunctional electrocatalyst for the overall water splitting reaction in alkaline medium. The complexing ability of glycine with a transition metal was exploited to form [Co(gly)(3)](-) dispersion at pH 10, which was used for the electrodeposition. High-resolution TEM, UV/Vis-diffuse reflectance spectroscopy, and X-ray photoelectron spectroscopy were used to confirm that the as-synthesized materials had an alpha-Co(OH)(2) phase. The electrocatalytic oxygen and hydrogen evolution activity of the glycine-coordinated alpha-Co(OH)(2) was found to be approximately 320 and 145 mV, respectively, at 10 mA cm(-2). The material required approximately 1.60 V (vs. reversible hydrogen electrode; RHE) to achieve the benchmark of 10 mA cm(-2) for overall water splitting with a mass activity of approximately 63.7 A g(-1) at 1.60 V (vs. RHE). The chronoamperometric response was measured to evidence the stability of the material for overall water splitting for up to 24 h. Characterization of the catalyst after the oxygen and hydrogen evolution reactions was performed by XPS and showed the presence of a Co-II/Co-III oxidation state.

10acobalt10aElectrochemistry10aheterogeneous catalysis10aHydrogen10awater splitting1 aShilpa, Nagaraju1 aNadeema, Ayasha1 aKurungot, Sreekumar uhttp://library.ncl.res.in/content/glycine-induced-electrodeposition-nanostructured-cobalt-hydroxide-bifunctional-catalyst01163nas a2200169 4500008004100000022001400041245008500055210006900140260000800209300001200217490000700229520057800236100002300814700002500837700002100862856011000883 2019 eng d a1523-706000aGold-catalyzed 1,2-oxyalkynylation of N-Allenamides with ethylnylbenziodoxolones0 aGoldcatalyzed 12oxyalkynylation of NAllenamides with ethylnylben cJAN a180-1840 v213 a

A gold-catalyzed 1,2-oxyalkynylation of N-allenamides with ethylnylbenziodoxolones (EBXs) has been achieved for the first time. The reaction, which follows a redox-neutral Au(I)/Au(III) catalytic pathway, was enabled in an attempt to exhaust the EBX reagents atom-economically by putting the nucleophilic carboxylate part of EBXs to appropriate use. This constitutes the first example for gold-catalyzed beta-alkynylation of N-allenamides to construct highly valuable 1,3-enynes. The potential of the sequence is further documented by some follow-up transformations.

1 aBanerjee, Somsuvra1 aSenthilkumar, Beeran1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/gold-catalyzed-12-oxyalkynylation-n-allenamides-ethylnylbenziodoxolones01227nas a2200181 4500008004100000245012300041210006900164260000800233300001400241490000700255520054500262100002600807700002000833700002100853700002200874700002100896856012800917 2019 eng d00aGold-catalyzed cycloisomerization of pyridine-bridged 1,8-Diynes: An expedient access to luminescent cycl[3.2.2]azines0 aGoldcatalyzed cycloisomerization of pyridinebridged 18Diynes An  cSEP a7109-71130 v213 a

Gold-catalyzed diyne cycloisomerizations involving carbene/alkyne metathesis have been the focal point of attention for the past few years as it offers great potential to build complex polycyclic architectures. However, the design of novel cycloisomerizations has been mostly limited to 1,5/1,6-diynes and has remained very challenging to apply for higher 1,n-diynes. Herein, we disclose an unprecedented cycloisomerization of pyridine-bridged 1,8-diynes involving carbene/alkyne metathesis to access luminescent cycl[3.2.2]azines.

1 aChintawar, Chetan, C.1 aMane, Manoj, V.1 aTathe, Akash, G.1 aBiswas, Suprakash1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/gold-catalyzed-cycloisomerization-pyridine-bridged-18-diynes-expedient-access-luminescent01149nas a2200217 4500008004100000022001400041245013000055210006900185260000900254300001200263490000700275520036900282100002200651700002000673700002700693700001900720700002200739700001800761700002100779856013100800 2019 eng d a1523-706000aGold(I)-catalyzed hydroxy group assisted C(sp(2))-H alkylation of enaminones with diazo compounds to access 3-alkyl chromones0 aGoldIcatalyzed hydroxy group assisted Csp2H alkylation of enamin cJAN  a335-3390 v213 a

A strategy for expedient synthesis of 3-substituted chromones from easily available o-hydroxyarylenaminones and diazo compounds has been developed. Carefully conducted experimental and computational studies led us to propose an uncommon mechanistic pathway involving the hydroxyl group assisted alkylation of enaminones with in situ generated gold carbenes.

1 aBagle, Pradip, N.1 aMane, Manoj, V.1 aSancheti, Shashank, P.1 aGade, Amol, B.1 aShaikh, Samir, R.1 aBaik, Mu-Hyun1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/goldi-catalyzed-hydroxy-group-assisted-csp2-h-alkylation-enaminones-diazo-compounds-access-302850nas a2200253 4500008004100000022001400041245010500055210006900160260000800229300001100237490000600248520197200254653002102226653001902247653004502266653001602311100002302327700002402350700002502374700002302399700002402422700002802446856012202474 2019 eng d a2053-159100aGraphene nanosheets assisted carbon hollow cylinder for high-performance field emission applications0 aGraphene nanosheets assisted carbon hollow cylinder for highperf cSEP a0950660 v63 a

Electron sources are critical constituents for myriad many electronic applications including electron imaging, mass spectroscopy etc. Here, we report the realization of high-performance field emission from graphene assisted carbon hollow cylinders (Gr-CHCs) composed of multi-stacked radially aligned CNTs. These CHCs have built-in synthesis related Fe nanoparticles (NPs). This engineered nano-structure exhibits excellent field emission properties such as one of the ultra-low turn-on field (0.64V mu m(-1) at 10 mu A cm(-2)), low threshold field (0.74V mu m(-1) at 100 mu A cm(-2)), very high current density (15.49 mA cm(-2) at 1.32V mu m(-1)) which is nearly double the current density obtained in our previous study. High field enhancement factor (0.72. x. 10(4)) with highly stable emission current at 100 mu A was observed for more than 3 hrs at the base pressure of similar to 1. x. 10(-8) mbar. This study suggests an approach to enhance the current density using the proposed innovative nanostructure and forms the basic theme of this communication. Highly efficient and stable field emissions observed are attributed to the geometry of cylinder and the production of the high density of sharp protrusions within the graphene sheets which enhance the local electric field and dramatically enhance field emission. This innovative cylindrical geometry associated with graphene assisted on Fe bearing aligned CNTs along with the periphery of the bulk cylinder provides an easy injection of electrons from the conduction band of CHCs into the vacuum in the presence of an external electric field. The tunability of field emission properties of these CHCs can be easily achieved by tailoring their diameter (10 and 20 mm) and different concentrations of the precursor. This new approach of the graphene assisted cylindrical geometry-based field emitter source provides enormous prospects and demand for next-generation high resolutions display devices.

10aCarbon nanotubes10afield emission10agraphene assisted carbon hollow cylinder10aprotrusions1 aTripathi, Prashant1 aGupta, Bipin, Kumar1 aBankar, Prashant, K.1 aMore, Mahendra, A.1 aLate, Dattatray, J.1 aSrivastava, Onkar, Nath uhttp://library.ncl.res.in/content/graphene-nanosheets-assisted-carbon-hollow-cylinder-high-performance-field-emission02120nas a2200205 4500008004100000245012900041210006900170260000800239300001600247490000600263520136900269100002101638700002001659700002001679700002401699700002101723700002201744700002701766856012101793 2019 eng d00aGraphene oxide supported liposomes as red emissive theranostics for phototriggered tissue visualization and tumor regression0 aGraphene oxide supported liposomes as red emissive theranostics  cJUL a3312–33200 v23 a

Selective tissue visualization and localized tumor regression without affecting the surrounding healthy tissues are critical concerns in cancer nanomedicine. Importantly, the complete wrapping of a flimsy matrix like liposome by multifunctional graphene oxide is an interesting engineering idea for nanomedicine design. Moreover, designing a safe and biodegradable nanohybrid with significant theranostic ability is a current need for targeted combined therapies. Here, we report a comprehensive result of in vivo tumor diagnosis and phototriggered tumor regression using a biodegradable red emissive nanotheranostic system, viz., graphene oxide flakes fortified liposome (GOF-Lipo), functionalized with folic acid (FA): GOF-Lipo-FA. Graphene oxide support enhances the stability of drug-loaded liposomes in an extracellular environment that prevents the premature release of loaded anticancer drug from the liposomal cavity. Promising outcomes of tumor regression (∼300 to 25 mm3) from organized cellular and animal studies are demonstrated in this work. These studies reveal superior biocompatibility, deep intracellular localization, 4T1 breast tumor diagnosis, and long time tumor binding ability of an injected emissive nanohybrid. Overall, a single dose of designed multifunctional systems demonstrates the best tumor regression.

1 aPrasad, Rajendra1 aYadav, Amit, S.1 aGorain, Mahadeo1 aChauhan, Deepak, S.1 aKundu, Gopal, C.1 aSrivastava, Rohit1 aSelvaraj, Kaliaperumal uhttp://library.ncl.res.in/content/graphene-oxide-supported-liposomes-red-emissive-theranostics-phototriggered-tissue01951nas a2200277 4500008004100000022001400041245008700055210006900142260000800211300001400219490000800233520105700241653002601298653001601324653004201340653001001382100002201392700002201414700001201436700001901448700002301467700002401490700002301514700002201537856011401559 2019 eng d a1618-264200aGraphene-modified electrodes for sensing doxorubicin hydrochloride in human plasma0 aGraphenemodified electrodes for sensing doxorubicin hydrochlorid cMAR a1509-15160 v4113 a

Doxorubicin (DOX), an anthracycline molecule, is currently one of the most widely used anticancer drugs in clinics. Systematic treatment of patients with DOX is known to be accompanied by several unpleasant side effects due to the toxicity of the drug. Thus, monitoring of DOX concentration in serum samples has become increasingly important to avoid side effects and ensure therapeutic efficiency. In this study, we discuss the construction of a disposable electrochemical sensor for the direct monitoring of DOX in clinical blood samples. The sensor is based on coating a gold electrode in a flexible integrated electrode construct formed on polyimide sheets using photolithography, with nitrogen-doped reduced graphene oxide (N-rGO) suspended in chitosan. Under optimized conditions, a linear relationship between the oxidative peak current and the concentration of DOX in the range of 0.010-15M with a detection limit of 10nM could be achieved. The sensor was adapted to monitor DOX in serum samples of patients under anticancer treatment.

10aDisposable electrodes10adoxorubicin10aNitrogen-doped reduced graphene oxide10aSerum1 aChekin, Fereshteh1 aMyshin, Vladyslav1 aYe, Ran1 aMelinte, Sorin1 aSingh, Santosh, K.1 aKurungot, Sreekumar1 aBoukherroub, Rabah1 aSzunerits, Sabine uhttp://library.ncl.res.in/content/graphene-modified-electrodes-sensing-doxorubicin-hydrochloride-human-plasma02858nas a2200193 4500008004100000022001400041245014100055210006900196260000800265300001600273490000700289520211300296100002702409700002902436700002302465700001702488700003002505856012902535 2020 eng d a1463-907600aGas-solid interactions with reactive and inert gas molecules by NAPUPS: can work function be a better descriptor of chemical reactivity?0 aGassolid interactions with reactive and inert gas molecules by N cJUL a15528-155400 v223 a

The gas-phase vibrational spectra of reactive (H(2)and O-2) and inert gases (N(2)and Ar) have been studied by near-ambient pressure (NAP) ultraviolet photoelectron spectroscopy (NAPUPS) up to 0.3 mbar pressure. The results obtained are divided into two parts and discussed. In the first part, the photoelectron spectra of monoatomic Ar and some homonuclear diatomic molecules, such as H-2, O-2, and N-2, have been recorded by NAPUPS and the effect of pressure on their energy position has been studied. It has been demonstrated that NAPUPS could be an essential tool to determine the intermolecular or interatomic interactions. In the second part, we have evaluated the influence of different solid surfaces on the binding energy (BE) position, the pattern of the vibrational features of diatomic N(2)molecules, and the first atomic levels (3p(3/2)and 3p(1/2)) of monoatomic Ar. It has been observed that with a change in the (electronic/chemical) nature of the surface, the BE of the above features also changes and reflects the change in the work function (phi) of the material. It is to be noted that Ar is an inert/noble gas and N(2)is the most stable molecule, and the above changes observed underscore that they can be employed as probe atoms/molecules to explore even the minor changes that occur on a solid surface due to a variety of reasons. Further, if the solid surface undergoes any chemical/electronic changes due to gas-solid interaction, such as oxidation/reduction, the phi of the surface changes again; this highlights the precise identification of the changes that occur under the reaction/measurement conditions. Therefore, the change in the BE of the gas-phase features can be used to determine even the minor changes in the phi of solid surfaces during the reaction or due to the reaction. The present findings have implications in probing the surface changes that occur in any surface-dependent phenomena, such as heterogeneous catalysis, electrochemistry, and materials that are predominantly controlled by surface contribution, such as layered (2D) materials, nanomaterials.

1 aGhosalya, Manoj, Kumar1 aReddy, Kasala, Prabhakar1 aMhamane, Nitin, B.1 aRanjan, Ravi1 aGopinath, Chinnakonda, S. uhttp://library.ncl.res.in/content/gas-solid-interactions-reactive-and-inert-gas-molecules-napups-can-work-function-be-better00642nas a2200157 4500008004100000022001400041245014700055210006900202260000800271300000900279490000700288100001900295700002000314700002600334856012400360 2020 eng d a1477-052000aGeneral and concise asymmetric synthesis of sphingosine, safingol and phytosphingosines via tethered aminohydroxylation (vol 8, pg 5074, 2010)0 aGeneral and concise asymmetric synthesis of sphingosine safingol cJUL a52650 v181 aKumar, Pradeep1 aDubey, Abhishek1 aPuranik, Vedavati, G. uhttp://library.ncl.res.in/content/general-and-concise-asymmetric-synthesis-sphingosine-safingol-and-phytosphingosines-101200nas a2200193 4500008004100000022001400041245009700055210006900152260000900221300001400230490000700244520052300251100001900774700002200793700001900815700002400834700002400858856012400882 2020 eng d a1528-748300aGeneration and evaluation of pharmacologically relevant drug-drug cocrystal for gout therapy0 aGeneration and evaluation of pharmacologically relevant drugdrug cJUN  a3577-35830 v203 a

The present study reports a novel drug-drug cocrystal of febuxostat and piroxicam for the treatment of gout. Single crystal X-ray diffraction revealed a monoclinic system with P2(1)/c space group. The prepared cocrystal enhanced the solubility of febuxostat and piroxicam and improved the dissolution rate of piroxicam in pH 6.8 as compared to the pure drug. Further, the compressibility assessment of cocrystal by Aulton and Wells method confirmed its plastic behavior and suitability for direct compression.

1 aModani, Sheela1 aGunnam, Anilkumar1 aYadav, Balvant1 aNangia, Ashwini, K.1 aShastri, Nalini, R. uhttp://library.ncl.res.in/content/generation-and-evaluation-pharmacologically-relevant-drug-drug-cocrystal-gout-therapy02439nas a2200277 4500008004100000022001400041245013600055210006900191260000800260300001100268490000800279520148000287653001401767653001801781653003401799653002501833653001701858653002501875653001101900100002201911700002901933700002401962700002601986700002002012856012902032 2020 eng d a0926-669000aGeneration of novelties in the genus Ocimum as a result of natural hybridization: a morphological, genetical and chemical appraisal0 aGeneration of novelties in the genus Ocimum as a result of natur cNOV a1128590 v1563 a

The genus Ocimum is a boutique of a diverse set of specialized metabolites such as terpenoids and phenylpropanoids. Each Ocimum species and its cultivars represent a characteristic chemical profile. The present study explored the two interspecific Ocimum hybrids originating through a serendipitous natural cross between O. kilimandscharicum and O. basilicum. These two novel Ocimum hybrids exhibited intermediate morphological features of two parental species. Inter simple sequence repeats (ISSR) analysis and DNA barcoding with the plastid non-coding trnH-psbA intergenic spacer region reaffirmed unambiguous parental identification and differentiation of these natural hybrids from other available Ocimum species. Consequently, gas chromatographymass spectrometry-based metabolite profiling of two hybrids identified them as specific chemotypes with the presence of a unique blend of specialized metabolites from the parental species, which are either rich in terpenes or phenylpropanoids. Additionally, expression analysis of key genes from terpenoid and phenylpropanoid pathways corroborated with differential metabolite accumulation. Thus, these two Ocimum hybrids represented the novel chemotypes, which could be useful in commercial cultivation to produce novel essential oil and bioactive constituents. Further, the resulting metabolite diversity could have potential industrial applications in the areas of healthcare, bioremediation, and crop protection.

10aChemotype10aDNA barcoding10aInter Simple Sequence Repeats10aInterspecific hybrid10aO. basilicum10aO. kilimandscharicum10aOcimum1 aGurav, Tanuja, P.1 aJayaramaiah, Ramesha, H.1 aPunekar, Sachin, A.1 aDholakia, Bhushan, B.1 aGiri, Ashok, P. uhttp://library.ncl.res.in/content/generation-novelties-genus-ocimum-result-natural-hybridization-morphological-genetical-and01939nas a2200229 4500008004100000022001400041245005900055210005900114260000800173300001400181490000700195520116800202100003001370700001901400700004801419700002501467700002501492700003201517700003601549700003101585856009301616 2020 eng d a0003-270000aGeometrical isomerism directed electrochemical sensing0 aGeometrical isomerism directed electrochemical sensing cMAR a4541-45470 v923 a

We report the independent role of isomerism of secondary sphere substituents over their nature, a factor often overlooked in molecular electrocatalysis pertaining to electrochemical sensing, by establishing that isomerism redefines the electronic structure at the catalytic reaction center via geometrical factors. UV-vis spectroscopy and X-ray photoelectron spectroscopy suggest that a substituent's isomerism in molecular catalysts conjoins molecular planarity and catalytic activation through competing field effects and resonance effects. As a classical example, we demonstrate the influence of isomerism of the -NO2 substituents for the electrocatalytic multi electron oxidation of As(III), a potentially important electrochemical pathway for water remediation and arsenic detection. The isomerism dependent oxidative activation of catalytic center leads to a nonprecious molecular catalyst capable for direct As(III) oxidation with an experimental detection limit close to WHO guidelines. This work opens up an unusual approach in analytical chemistry for developing various sensing platforms for challenging chemical and electrochemical reactions.

1 aKottaichamy, Alagar, Raja1 aBegum, Shabbah1 aDevendrachari, Mruthyunjayachar, Chattanaha1 aBhat, Zahid, Manzoor1 aThimmappa, Ravikumar1 aKotresh, Harish, Makri Nimb1 aVinod, Chathakudath, Prabhakara1 aThotiyl, Musthafa, Ottakam uhttp://library.ncl.res.in/content/geometrical-isomerism-directed-electrochemical-sensing02203nas a2200205 4500008004100000022001400041245014700055210006900202260000900271300001200280490000700292520144700299653003301746653003401779653001301813653001101826100002001837700001501857856012501872 2020 eng d a1539-445X00aGlass transition temperature of polybutadiene and polyisoprene from high temperature segmental relaxation correlation using molecular dynamics0 aGlass transition temperature of polybutadiene and polyisoprene f cJUL  a290-2960 v183 a

Predicting glass transition temperature for rubber and rubber composites is immensely important for tire industry for the development of products and fine-tune process conditions. Molecular dynamics simulation is been used to predict glass transition temperature as a function of molecular-level structural changes, e.g., composition (functional groups), topology, and polymerization. However, prediction of glass transition temperature within experimental error bar from molecular dynamics simulation is only possible from all atomistic description (model) of the system as united atom and coarse-grained models under-predict the values. Conventional way of calculation of glass transition temperature from density (or any other properties which show sharp transition)-temperature plots are computationally very demanding because of atomistic simulations and simulations below the glass transition point, i.e., in glassy state. Here we report a novel method for calculation of glass transition temperature using only segmental relaxation correlation functions calculated at higher temperatures, i.e., above glass transition temperature. We have presented a protocol here and shown for two polymeric systems polybutadiene and polyisoprene. We believe this method cuts the computational cost of predicting glass transition temperature by one-third and will be applicable for industrial applications for structure-property validations.

10aGlass transition temperature10amolecular dynamics simulation10aPolymers10arubber1 aSharma, Pragati1 aRoy, Sudip uhttp://library.ncl.res.in/content/glass-transition-temperature-polybutadiene-and-polyisoprene-high-temperature-segmental01354nas a2200169 4500008004100000022001400041245011500055210006900170260000900239300001400248490000700262520071800269100002300987700002301010700002101033856013001054 2020 eng d a1359-734500aGold and hypervalent iodine(iii): liaisons over a decade for electrophilic functional group transfer reactions0 aGold and hypervalent iodineiii liaisons over a decade for electr cMAR  a2677-26900 v563 a

Over the last two decades, hypervalent iodine(iii) reagents have evolved from being `bonding curiosities' to mainstream reagents in organic synthesis, in particular, electrophilic functional group transfer reactions. In this context, gold catalysts have not only emerged as a unique toolbox to facilitate such reactions (especially alkynylations) but also opened new possibilities with their different modes of reactivities for other functional group transfer reactions (acetoxylations and arylations). This feature article critically summarizes hitherto all such Au-catalyzed electrophilic functional group transfer reactions with hypervalent iodine(iii) reagents, emphasizing their mechanistic aspects.

1 aBanerjee, Somsuvra1 aBhoyare, Vivek, W.1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/gold-and-hypervalent-iodineiii-liaisons-over-decade-electrophilic-functional-group-transfer01279nas a2200193 4500008004100000022001400041245006100055210005900116260000800175300001400183490000700197520066800204100002300872700002600895700002300921700002500944700002100969856009500990 2020 eng d a1523-706000aGold-catalyzed alkynylative meyer-schuster rearrangement0 aGoldcatalyzed alkynylative meyerschuster rearrangement cJUN a4792-47960 v223 a

By applying the ``interplay'' mode, which consolidates two key reactivity modes of gold catalysis, namely pi-activation mode and cross-coupling mode, the first alkynylative Meyer-Schuster rearrangement is designed and successfully implemented. The current protocol gives straightforward access to enynones, a highly valuable building block, from easily available propargyl alcohol feedstocks. Control experiments suggest an Au(III) catalyst triggers the Meyer-Schuster rearrangement, whereas monitoring the reaction with ESI-HRMS provided strong evidence in favor of a key alkynylgold(III) intermediate which supports the proposed ``interplay'' scenario.

1 aBanerjee, Somsuvra1 aAmbegave, Shivhar, B.1 aMule, Ravindra, D.1 aSenthilkumar, Beeran1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/gold-catalyzed-alkynylative-meyer-schuster-rearrangement02673nas a2200229 4500008004100000022001400041245007900055210006900134260000900203300001200212490000800224520191600232653002402148653001002172653001402182653002402196653002402220653002002244100003402264700003602298856010902334 2020 eng d a0306-452200aG-protein coupled receptors and tau-different roles in alzheimer's disease0 aGprotein coupled receptors and taudifferent roles in alzheimers  cJUL  a198-2140 v4383 a

Post-translational modification of Tau, a microtubule-associated protein in the neuronal cell, plays a major role in Alzheimer's disease. Tau is an axonal protein expressed in mature neurons that promote the self-assembly of tubulin into microtubules and its stabilization in neurons. Phosphorylation of Tau makes it prone to aggregation at the intra-neuronal region leading to impaired neurotransmission and dementia. Tau aggregates undergo trans-cellular propagation by the release of fibrillar species into the extra-cellular environment from damaged and infected neurons that can be internalized by neighbouring neuronal and glia cells and promotes aggregation in healthy cells. G-protein coupled receptors, the largest group of seven transmembrane receptors, are involved in neuronal signal transduction in response to various signals such as hormones and neurotransmitters. In Alzheimer's disease, GPCRs are involved in phosphorylation of Tau through various downstream kinases such as GSK-3b, CDK-5 and ERKs signalling cascade. Several neuronal GPCRs that are involved in Tau phosphorylation are elaborated in this review. The astrocytic GPCR, Tau phosphorylation mediated by CaS receptors and its propagation by exosomes are also elaborated. In the microglia, the extra-cellular Tau binding to a chemokine GPCR, CX3CR1 triggers its internalization, whereas Tau phosphorylation at specific sites decreases its binding affinity to this receptor. Here we highlight the role of GPCRs in Tau phosphorylation and Tau interaction in different cells of the nervous system. Hence, the role of GPCRs are attaining more attention in the therapeutic field of Alzheimer's disease. Specific agonists/antagonists and allosteric modulators could be the potential target for therapy against GPCR-mediated Tau phosphorylation in Alzheimer's disease. (C) 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

10aAlzheimer's disease10aGPCRs10amicroglia10aTau internalization10aTau phosphorylation10aTau propagation1 aChidambaram, Hariharakrishnan1 aChinnathambi, Subashchandrabose uhttp://library.ncl.res.in/content/g-protein-coupled-receptors-and-tau-different-roles-alzheimers-disease02154nas a2200193 4500008004100000022001400041245014300055210006900198260000800267300001400275490000700289520141100296100002101707700002301728700002801751700002601779700002501805856013001830 2020 eng d a1144-054600aGraphene-MnO2 composite supercapacitor material accomplished tactically using liquid-liquid and solid-liquid interface reaction techniques0 aGrapheneMnO2 composite supercapacitor material accomplished tact cMAY a6853-68610 v443 a

A novel methodology is described to grow architectures of 3-dimensional graphene nanosheet (GNS)-manganese oxide (MnO2) composite materials to be used in supercapacitors. The in situ growth of the three-dimensional MnO2 fiber-network over the surface of graphene layers is achieved at the solid-liquid interface. The composite electrode shows good electron and charge transfer, rapid plus reversible faradaic reactions and excellent cyclic ability in electrochemical studies. The electrochemical properties of the as-prepared GNS-MnO2/FTO electrode material were assessed by cyclic voltammetry and galvanostatic charge/discharge tests. The specific capacitance of GNS-MnO2 reaches 683 F g(-1) at a current density of 2.2 A g(-1) and shows excellent cycle stability, retaining 96.9% of its initial capacitance up to 5000 cycles. A coulomb efficiency of about 99% displayed by the GNS-MnO2/FTO electrode is an excellent performance for a desired supercapacitor material. Herein, the charge storage mechanism in 3-dimensional graphene nanosheet (GNS)-manganese oxide (MnO2) composite is discussed in detail. Furthermore, at an elevated current density of similar to 10.86 A g(-1), a power density of similar to 6.235 kW kg(-1) is achieved, maintaining an energy density of similar to 7.99 kW h kg(-1); thus, it demonstrates promising potential as an electrode material for supercapacitor application.

1 aPatil, Sagar, H.1 aGaikwad, Aarti, P.1 aWaghmode, Babasaheb, J.1 aSathaye, Shivaram, D.1 aPatil, Kashinath, R. uhttp://library.ncl.res.in/content/graphene-mno2-composite-supercapacitor-material-accomplished-tactically-using-liquid-liquid01403nas a2200241 4500008004100000022001400041245008500055210006900140260000800209300001600217490000600233520059500239653003300834653001500867653002200882653003500904653001800939653002600957100002600983700002301009700002601032856010301058 2020 eng d a2365-654900aGreen catalyst Fe(OTs)(3)/SiO2 for the synthesis of 4-Pyrrolo-12-oxoquinazolines0 aGreen catalyst FeOTs3SiO2 for the synthesis of 4Pyrrolo12oxoquin cDEC a14721-147280 v53 a

An efficient and eco-friendly diversity-oriented synthetic protocol has been presented to synthesize structurally versatile drug-like molecules under solvent-free grinding in the presence of Fe(OTs)(3)/SiO2 as a catalyst. The use of Fe(OTs)(3)/SiO2 as a recyclable and reusable catalyst has been explored in the synthetic domino protocol involving one-pot, three component reaction for the synthesis of 4-pyrrolo-12-oxoquinazolines with special features of the protocol like high atom-economy, operational simplicity, short reaction time and high selectivity with excellent yields.

10a4-Pyrrolo-12-oxoquinazolines10aFe(OTs)(3)10aGreen methodology10aLiquid Assisted Grinding (LAG)10aSiO2 catalyst10aSolvent-free grinding1 aAllaka, Bhargava, Sai1 aBasavoju, Srinivas1 aKrishna, Gamidi, Rama uhttp://library.ncl.res.in/content/green-catalyst-feots3sio2-synthesis-4-pyrrolo-12-oxoquinazolines01880nas a2200277 4500008004100000022001400041245020500055210006900260260000800329300001400337490000700351520083000358653002201188653003201210653001301242653002101255653003501276653002101311653001401332100002801346700001801374700002401392700002101416700003601437856012901473 2021 eng d a0022-152X00agamma-Al2O3/triflic acid as cooperative catalysts for the tandem Michael addition/carbocyclization: an easy access to 2-substituted pyrrolo[2,1-a]isoquinolines and 3-substituted pyrrolidine-2,5-diones0 agammaAl2O3triflic acid as cooperative catalysts for the tandem M cJUL a1415-14280 v583 a

A tandem Michael addition/carbocyclization of 3,4-dimethoxyphenethyl maleimide with carbon and sulfur nucleophiles is accomplished via a relay catalysis using gamma-Al2O3/TfOH binary system. The X-ray Photoelectron Spectroscopy (XPS) analysis of binary system indicates the presence of AlF3, AlO(OH) species(.) This approach provides an easy access to 2-aryl or 2-thio aryl pyrrolo[2,1-a]isoquinolines in good yields in a tandem fashion. With suitable ratio of gamma-Al2O3/TfOH binary system, the Michael addition of N/C/S nucleophiles to N-benzyl maleimide is also achieved. A key to the success of these reactions would be the generation of AlF3, AlO(OH) species from gamma-Al2O3 and TfOH, which might have delineated the disadvantageous background reactions usually displayed by a strong Bronsted acid such as TfOH.

10a1-a]isoquinolines10a3-substituted pyrrolidine-210a5-diones10acarbocyclization10agamma-Al2O3/TfOH binary system10aMichael addition10apyrrolo[21 aRao, Ramana, Sreenivasa1 aSahani, Anita1 aAli, Sheikh, Haider1 aPradhan, Sumanta1 aRamanathan, Chinnasamy, Ramaraj uhttp://library.ncl.res.in/content/gamma-al2o3triflic-acid-cooperative-catalysts-tandem-michael-additioncarbocyclization-easy01472nas a2200229 4500008004100000022001400041245013000055210006900185260000900254300001400263490000800277520066900285653001900954653002100973653002400994653002901018100002001047700002101067700001601088700001701104856012101121 2021 eng d a0011-389100aGenome wide analysis of 14-3-3 proteins in Cicer arietinum L. and identification of isoforms responsive to Fusarium oxysporum0 aGenome wide analysis of 1433 proteins in Cicer arietinum L and i cOCT  a1039-10450 v1213 aIn the present study, we have identified and characterized two 14-3-3 isoforms, namely isoform A and C from chickpea (Cicer arietinum L.), that might play a crucial role during disease resistance. Further, in silico analysis of these 14-3-3 proteins was accomplished, including motif identification and structure prediction from deduced amino acid sequences. Expression profiling of the two representative 14-3-3 isoforms in the roots of wilt resistant and susceptible chickpea varieties upon Fusarium oxysporum f. sp ciceri race 1 (FOC1) challenge, revealed time dependent isoform specific differential expression in induced chickpea roots upon FOC1 colonization.10aBioinformatics10achickpea 14-3-3s10apathogen responsive10atranscriptional analysis1 aGurjar, Gayatri1 aNimbalkar, Suhas1 aGiri, Ashok1 aGupta, Vidya uhttp://library.ncl.res.in/content/genome-wide-analysis-14-3-3-proteins-cicer-arietinum-l-and-identification-isoforms02008nas a2200217 4500008004100000020001400041245013100055210006900186260000800255300001400263490000700277520121500284100001601499700002001515700002001535700002101555700002301576700002101599700002401620856014601644 2021 eng d a1435-810700aGibberellic acid induces unique molecular responses in ‘thompson seedless’ grapes as revealed by non-targeted metabolomics0 aGibberellic acid induces unique molecular responses in thompson  cFEB a293 - 3040 v403 aCompact clusters and small berry size are the major problems associated with the commercialization of table grapes. The application of gibberellic acid 3 (GA3) has been a long-followed practice to overcome these issues. To analyze the molecular response of ‘Thompson Seedless’ grapes to GA3 treatment, we investigated the metabolomes of its rachises, clusters, and berries, 6 h and 24 h after the treatment. Metabolite profiling using non-targeted metabolomics approach revealed several metabolites, including arginine, proline, tyrosine, kaempferol, resveratrol, catechin, and so on as possible biomarkers of GA3 treatment in grapes. GA3 treatment greatly impacted the alanine, aspartate, and glutamate metabolism pathways, and the GA3-mediated alterations in the levels of certain plant growth regulators and primary metabolites were in accordance with important growth and developmental processes in grapes. This study highlights the effect of GA3 on the profiles of certain polyphenols impacting the flavone and flavonol biosynthesis pathways and hence the nutritional aspect of grapes. The results of this study would be useful to develop self-elongating varieties simplifying the grape cultivation.1 aJadhav, Uma1 aMundhe, Swapnil1 aKumar, Yashwant1 aJogaiah, Satisha1 aUpadhyay, Anuradha1 aGupta, Vidya, S.1 aKadoo, Narendra, Y. uhttp://library.ncl.res.in/content/gibberellic-acid-induces-unique-molecular-responses-%E2%80%98thompson-seedless%E2%80%99-grapes-revealed-non02171nas a2200277 4500008004100000022001400041245012700055210006900182260000800251300001200259490000700271520123000278653002601508653001901534653002001553653001901573653002801592100001601620700002001636700002001656700002101676700002301697700002101720700002401741856012801765 2021 eng d a0721-759500aGibberellic acid induces unique molecular responses in `thompson seedless' grapes as revealed by non-targeted metabolomics0 aGibberellic acid induces unique molecular responses in thompson  cFEB a293-3040 v403 a

Compact clusters and small berry size are the major problems associated with the commercialization of table grapes. The application of gibberellic acid 3 (GA(3)) has been a long-followed practice to overcome these issues. To analyze the molecular response of `Thompson Seedless' grapes to GA(3) treatment, we investigated the metabolomes of its rachises, clusters, and berries, 6 h and 24 h after the treatment. Metabolite profiling using non-targeted metabolomics approach revealed several metabolites, including arginine, proline, tyrosine, kaempferol, resveratrol, catechin, and so on as possible biomarkers of GA(3) treatment in grapes. GA(3) treatment greatly impacted the alanine, aspartate, and glutamate metabolism pathways, and the GA(3)-mediated alterations in the levels of certain plant growth regulators and primary metabolites were in accordance with important growth and developmental processes in grapes. This study highlights the effect of GA(3) on the profiles of certain polyphenols impacting the flavone and flavonol biosynthesis pathways and hence the nutritional aspect of grapes. The results of this study would be useful to develop self-elongating varieties simplifying the grape cultivation.

10aBiosynthetic pathways10aGA(3) response10aGA(3) signaling10aSultana grapes10aUntargeted metabolomics1 aJadhav, Uma1 aMundhe, Swapnil1 aKumar, Yashwant1 aJogaiah, Satisha1 aUpadhyay, Anuradha1 aGupta, Vidya, S.1 aKadoo, Narendra, Y. uhttp://library.ncl.res.in/content/gibberellic-acid-induces-unique-molecular-responses-thompson-seedless-grapes-revealed-non02570nas a2200241 4500008004100000022001400041245009300055210006900148260000800217300000700225490000700232520178400239653001902023653001802042653001602060653001702076653002102093100002102114700002202135700002502157700002202182856012402204 2021 eng d a2190-572X00aGlucosinolate induces transcriptomic and metabolic reprogramming in Helicoverpa armigera0 aGlucosinolate induces transcriptomic and metabolic reprogramming cJAN a260 v113 a

Glucosinolates protect plants from herbivory. Lepidopteran insects have developed resistance to glucosinolates which is well studied. However, the molecular effects of glucosinolate intake on insects are unexplored. To elucidate this, we performed transcriptomics and metabolomics of sinigrin-fed Helicoverpa armigera. Transcriptomics exhibits significant dysregulation of 2375 transcripts, of which 1575 are upregulated and 800 downregulated. Gene Ontology analysis of differentially expressed genes reveals that key hydrolases, oxidoreductases, and transferases are majorly affected. The negative impact of sinigrin is significant and localized in the endomembrane system and mitochondria. It also disturbs various biological processes such as regulation of protein metabolism and cytoskeletal organization. Furthermore, H. armigera putative myrosinase-like enzymes may catalyze the breakdown of sinigrin to allyl isothiocyanate (AITC). AITC targets the electron transport chain causing oxidative stress. KEGG pathway enrichment shows significant upregulation of oxidative phosphorylation, glutathione metabolism and amino acid metabolism. Activation of these pathways induces glutathione synthesis for sinigrin detoxification. Differential gene expression indicates upregulation of glutathione S-transferase and succinate dehydrogenase suggesting mitochondrial impact. Transcriptomics data correlated with metabolomics show changes in serine, methionine, ornithine, and other metabolite levels. It corroborates well with the transcript alterations supporting the increased glutathione production. Thus, our data suggest that sinigrin generates oxidative stress in H. armigera and insects alter their metabolic wiring to overcome sinigrin-mediated deleterious effects.

10aDetoxification10aGlucosinolate10aGlutathione10amitochondria10aOxidative stress1 aJagdale, Shounak1 aTellis, Meenakshi1 aBarvkar, Vitthal, T.1 aJoshi, Rakesh, S. uhttp://library.ncl.res.in/content/glucosinolate-induces-transcriptomic-and-metabolic-reprogramming-helicoverpa-armigera01394nas a2200265 4500008004100000022001400041245009200055210006900147260000800216300001400224490000600238520057700244653001600821653000800837653001300845653001600858653001300874100002000887700002100907700001700928700002500945700002200970700001800992856011801010 2021 eng d a2365-654900aGlycerol-triazole conjugated rhodamine as colorimetric and fluorimetric sensor for Cu2+0 aGlyceroltriazole conjugated rhodamine as colorimetric and fluori cSEP a9288-92920 v63 a{A glycerol-triazole tethered rhodamine based colorimetric and fluorimetric sensor 3 `,6 `-bis(diethylamino)-2-(((1-(1,3-dihydroxypropan-2-yl)-1H-1,2,3-triazol-4 -yl)methylene)aminospiro [isoindoline-1,9 `-xanthen]-3-one (L1) is designed and synthesized for the selective recognition of Cu2+ ion. The sensor L1 allows naked eye detection of Cu2+ ion with a fast response (<1 min). Among the various metal ions tested, the sensor L1 shows selective binding with Cu2+ through turn-on fluorescence mechanism. The sensor shows 1 : 2 binding stoichiometry with binding constant10aCu2+ Sensor10aDFT10aGlycerol10aRhodamine B10aTriazole1 aVerma, Abhishek1 aGahlyan, Parveen1 aBawa, Rashim1 aDash, Soumya, Ranjan1 aPrasad, Ashok, K.1 aKumar, Rakesh uhttp://library.ncl.res.in/content/glycerol-triazole-conjugated-rhodamine-colorimetric-and-fluorimetric-sensor-cu201918nas a2200241 4500008004100000022001400041245007400055210006900129260000800198490000700206520118700213653002001400653001901420653001601439653003101455653001201486100001501498700001601513700001801529700001501547700001401562856010001576 2021 eng d a0962-107500aGlycosyltransferases: the multifaceted enzymatic regulator in insects0 aGlycosyltransferases the multifaceted enzymatic regulator in ins cAPR0 v303 a

Glycosyltransferases (GTs) catalyse the reaction of glyco-conjugation of various biomolecules by transferring the saccharide moieties from an activated nucleotide sugar to nucleophilic glycosyl acceptor. In insects, GTs show diverse temporal and site-specific expression patterns and thus play significant roles in forming the complex biomolecular structures that are necessary for insect survival, growth and development. Several insects exhibit GT-mediated detoxification as a key defence strategy against plant allelochemicals and xenobiotic compounds, as well as a mechanism for pesticide cross-resistance. Also, these enzymes act as crucial effectors and modulators in various developmental processes of insects such as eye development, UV shielding, cuticle formation, epithelial development and other specialized functions. Furthermore, many of the known insect GTs have been shown to play a fundamental role in other physiological processes like body pigmentation, cuticular tanning, chemosensation and stress response. This review provides a detailed overview of the multifaceted functionality of insect GTs and summarizes numerous case studies associated with it.

10aAllelochemicals10aDetoxification10aDevelopment10aglycosyltransferases (GTs)10ainsects1 aNagare, M.1 aAyachit, M.1 aAgnihotri, A.1 aSchwab, W.1 aJoshi, R. uhttp://library.ncl.res.in/content/glycosyltransferases-multifaceted-enzymatic-regulator-insects01743nas a2200217 4500008004100000022001400041245007000055210006700125260000800192490000700200520104300207653002701250653001401277653001901291653003101310653001301341100002101354700002401375700002401399856010201423 2021 eng d a1527-899900aGold-catalysed nitroalkyne cycloisomerization - synthetic utility0 aGoldcatalysed nitroalkyne cycloisomerization synthetic utility cDEC0 v213 a

The gold-catalysed intramolecular redox cyclization of o-alkynylnitrobenzens documented by Professors Naoki Asao and Yoshinori Yamamoto is an important discovery that has opened two complementary research domains. Advancing this cyclization with other metals as well as developing new methods around the products that result from this reaction is one aspect that has seen growing interest. On the other hand, the idea of generating alpha-oxo gold carbenes via oxygen transfer to alkynes has established another important aspect in gold-catalysis. In this account, we will be dealing with the first aspect, which revolves around the internal redox cyclization of nitroalkynes (trivially called as nitroalkyne cycloisomerization), focusing mainly on the gold-complexes and the synthetic methods developed around it from our group and from other groups, and also providing the details of similar transformations documented with other metals so that the complementary reactivity/diversity of these transformations could be appreciated.

10aalpha-Oxo Gold Carbene10aAnthranil10aGold-catalysis10aInternal Redox Cyclization10aIsatogen1 aDhote, Pawan, S.1 aHalnor, Swapnil, V.1 aRamana, Chepuri, V. uhttp://library.ncl.res.in/content/gold-catalysed-nitroalkyne-cycloisomerization-synthetic-utility01654nas a2200241 4500008004100000022001400041245008100055210006900136260000800205300001100213490000600224520087900230653002701109653002301136653002001159653001901179653001901198100001501217700002401232700001701256700002701273856011201300 2021 eng d a2296-264600aGold-catalyzed complementary nitroalkyne internal redox process: a DFT study0 aGoldcatalyzed complementary nitroalkyne internal redox process a cJUL a6897800 v93 aGold-catalysis, in this century, is one of the most emerging and promising new areas of research in organic synthesis. During the last two decades, a wide range of distinct synthetic methodologies have been unveiled employing homogeneous gold catalysis and aptly applied in the synthesis of numerous natural products and biologically active molecules. Among these, the reactions involving alpha-oxo gold carbene/alpha-imino gold carbene intermediates are of contemporary interest, in view of their synthetic potential and also due to the need to understand the bonding involved in these complexes. In this manuscript, we document the theoretical investigations on the regio-selectivity dependence of substitution on the gold-catalyzed cycloisomerization of o-nitroarylalkyne derivatives. We have also studied the relative stabilities of alpha-oxo gold carbene intermediates.10aalpha-Oxo Gold Carbene10acycloisomerization10aDFT calculation10aGold-catalysis10ainternal redox1 aRaj, Vipin1 aDhote, Pawan, S. S.1 aVanka, Kumar1 aRamana, Chepuri, V. V. uhttp://library.ncl.res.in/content/gold-catalyzed-complementary-nitroalkyne-internal-redox-process-dft-study01808nas a2200133 4500008004100000245006200041210006200103260000800165300000900173520136400182100002101546700002001567856008701587 2021 eng d00aGPCRs that Rh oar the Guanine nucleotide exchange factors0 aGPCRs that Rh oar the Guanine nucleotide exchange factors cAPR a1-163 a

Cell migration, a crucial step in numerous biological processes, is tightly regulated in space and time. Cells employ Rho GTPases, primarily Rho, Rac, and Cdc42, to regulate their motility. Like other small G proteins, Rho GTPases function as biomolecular switches in regulating cell migration by operating between GDP bound 'OFF' and GTP bound 'ON' states. Guanine nucleotide exchange factors (GEFs) catalyse the shuttling of GTPases from OFF to ON state. G protein-coupled receptors (GPCRs) are the largest family of cell surface receptors that are involved in many signalling phenomena including cell survival and cell migration events. In this review, we summarize signalling mechanisms, involving GPCRs, leading to the activation of RhoGEFs. GPCRs exhibit diverse GEF activation modes that include the interaction of heterotrimeric G protein subunits with different domains of GEFs, phosphorylation, protein-protein interaction, protein-lipid interaction, and/or a combination of these processes.

1 aOmble, Aishwarya1 aKulkarni, Kiran uhttp://library.ncl.res.in/content/gpcrs-rh-oar-guanine-nucleotide-exchange-factors02264nas a2200169 4500008004100000022001400041245018100055210006900236260000900305300001400314490000700328520153700335100004301872700002601915700002701941856012601968 2021 eng d a1144-054600aGraphene-based frustrated Lewis pairs as bifunctional catalysts for CO2 reduction via the dissociative chemisorption of molecular H-2: a periodic density functional perspective0 aGraphenebased frustrated Lewis pairs as bifunctional catalysts f cJUN  a9959-99660 v453 a

Nanocarbon-based frustrated Lewis pair (FLP) bifunctional catalysts, on account of their unquenched electron transfer property, are becoming increasingly attractive as catalysts for the CO2 reduction reaction via the dissociative chemisorption of H-2. In the present study, we propose a nanocarbon-based FLP catalyst. The pair comprises nitrogen doped/phosphorus doped graphene as Lewis bases and M(C6F5)(3) (M = B, Al, Ga, and In) as Lewis acids. The computational investigation reveals that the carbon atoms adjacent to the doped N and P atoms are the active sites towards the dissociative chemisorption of hydrogen molecule. The analyses of the Bader charges and difference charge densities validate the dissociative chemisorption of H-2 molecule and the fact that a significant electron redistribution promotes the polarization of the hydrogen molecule. Density of states confirms the hybridization between the p-states of the nitrogen/phosphorus atom and the s-state of hydrogen atom in all FLPs. The dissociative chemisorption of hydrogen is noted in all FLP complexes, thereby facilitating a low barrier reaction path for CO2 reduction. Between P-doped and N-doped FLPs, N-doped FLP catalysts prove to be a more promising counterpart with considerably low activation barriers, ranging between 0.01 and 0.11 eV, towards CO2 reduction. Thus, the present study demonstrates the great potential of doped carbon-based FLPs as novel nanostructure catalysts for CO2 reduction via the direct utilization of molecular hydrogen.

1 aSenthamaraikannan, Thillai, Govindaraj1 aKrishnamurty, Sailaja1 aKaliaperumal, Selvaraj uhttp://library.ncl.res.in/content/graphene-based-frustrated-lewis-pairs-bifunctional-catalysts-co2-reduction-dissociative02458nas a2200277 4500008004100000020001300041245007900054210006900133260000800202300000900210490000700219520159500226653002501821653002001846653001401866653003001880653002601910653002601936100002201962700002001984700001802004700002202022700002102044700001702065856009802082 2021 eng d a0971119800aGreen antibacterial molecules: sophorolipids with varying fatty acid chain0 aGreen antibacterial molecules sophorolipids with varying fatty a cNOV a431+0 v353 aAntibiotic resistance is a rising problem of over the last decade making it difficult to treat infections caused by various pathogenic bacteria. To tackle this problem, newer antimicrobial strategies are being explored. Sophorolipids (SLs) are a class of biomolecules produced by a non-pathogenic yeast Starmarella bombicola (S. bombicold) with surfactant as well as potent broad spectrum antibacterial activity. In this work, we have successfully synthesized sophorolipids using different fatty acids with increasing chain length of hydrophobic tail; Lauric acid (C12)-LASL, Myristic acid (C14)-MASL, Palmitic acid (C16)-PASL and Stearic acid (C18)-SASL. We have used various techniques like FTIR, HRMS to characterize the synthesized SL. Further, we have measured properties like the critical micellar concentration for these biosurfactants and the SL's showed CMC less than or equal to 100 mg/L indicating excellent surface-active property. We have studied the antibacterial activity against gram-negative and gram-positive bacteria. Interestingly, the antibacterial activity was found to be more potent as the chain length of the fatty acid in the SL decreased. This trend was found to be reverse for toxicity towards mammalian cells. The shorter chain fatty acid SL's were found to be less cytotoxic. These results indicate that the sophorolipid candidates with shorter chain lengths would be beneficial for various biomedical applications such as tissue engineering, regenerative medicine and wound healing. Keywords: sophorolipid, biosurfactant, short chain fatty acid, antibacterial10aAntibacterial agents10aCells (Biology)10aInfection10aMicrobial drug resistance10aSaturated fatty acids10aSurface active agents1 aHirlekar, Swarali1 aAbhyankar, Isha1 aKane, Kartiki1 aTrimukhe, Kalpana1 aPrabhune, Asmita1 aNisal, Anuya uhttps://link.gale.com/apps/doc/A684660702/AONE?u=anon~d0cd1b4e&sid=googleScholar&xid=1a6d61d912210nas a2200289 45000080041000000220014000412450146000552100069002012600008002703000011002784900008002895201119900297653001111496653000811507653005211515653002111567100002011588700002311608700003011631700002511661700001911686700002211705700001811727700002111745700002711766856012711793 2021 eng d a1385-894700aGreen route for carbonylation of amines by CO2 using Sn-Ni-O bifunctional catalyst and theoretical study for finding best suited active sites0 aGreen route for carbonylation of amines by CO2 using SnNiO bifun cSEP a1294390 v4193 a

Reaction between n-alkylamine and CO2 has gained interest due to the demand for the dialkylurea for various applications. For the first time, the tool Mathematica was used to analyze the experimental data with an idea to derive an equation which determines the best suited active sites for any given input set of dependent parameters. The equation can further be used to predict the product yield with the known values of active sites for a reaction. Among several Sn containing mixed oxides, Sn-Ni oxide (Sn-Ni-O) was found to be the better performing catalyst. The studies indicate that the formation of new defect sites when NiO and SnO2 are in the mixed state and possibly a solid solution enhances the catalytic efficiency. There are two main reasons for improved catalytic performance; one, mixing of SnO2 into NiO which reduces the number of holes (h+) localized on lattice oxygen (O2−+ h+→ O•−) and two, smaller SnO2 particles are dispersed on the bigger particle NiO which alters the acidic and basic active sites in the catalyst. FT-IR adsorption study with amine and CO2 helped in deriving a plausible mechanism for this reaction. Under optimized reaction condition, Sn1.1-Ni-O-600 gave 77.3% of n-butylamine conversion and 75.7% of yield for 1,3-dibutylurea. The versatility of the catalyst was tested for carbonylation of different aliphatic and aromatic amines, diamine and hydroxy amine with CO2.

10aamines10aCO210aMixed oxide catalyst and bi-functional catalyst10aSubstituted urea1 aKulal, Nagendra1 aVetrivel, Rajappan1 aGopinath, Chinnakonda, S.1 aRavindran, Rahul, K.1 aRao, Vinod, N.1 aShetty, Manjunath1 aShrikanth, R.1 aRangappa, Dinesh1 aShanbhag, Ganapati, V. uhttp://library.ncl.res.in/content/green-route-carbonylation-amines-co2-using-sn-ni-o-bifunctional-catalyst-and-theoretical02369nas a2200253 4500008004100000022001400041245019400055210006900249260000800318300001200326490000600338520140500344100002601749700002501775700002201800700002301822700002101845700001801866700002201884700002401906700002801930700002601958856013101984 2021 eng d a2047-483000aGreen synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactide-co-glycolide) copolymer using zinc proline as a biocompatible initiator for irinotecan delivery to colon cancer in vivo0 aGreen synthesis of methoxypolyethylene glycolblockpolyllactideco cFEB a795-8060 v93 a

Poly(lactic-co-glycolic acid) (PLGA) is the most commonly described biocompatible copolymer used in biomedical applications. In this work, a green synthetic approach based on the biocompatible zinc proline complex, as an initiator for PLGA synthesis, is reported for the first time for the synthesis of methoxy-poly(ethylene glycol)-block-poly(l-lactic-co-glycolic acid) (mPEG-PLGA). mPEG-PLGA with controlled molecular weight and narrow polydispersity was synthesised. Its potential for delivery of irinotecan (Ir), a poorly water-soluble chemotherapeutic drug used for the treatment of colon and pancreatic cancer, was studied. Nanoparticles of controlled size (140-160 nm), surface charge (similar to-10 mV), release properties and cytotoxicity against CT-26 (colon) and BxPC-3 (pancreatic) cancer cells, were prepared. Tumor accumulation was confirmed by optical imaging of fluorescently labelled nanoparticles. Unlike Tween (R) 80 coated NP-Ir, the Pluronic (R) F-127 coated NP-Ir exhibits significant tumor growth delay compared to untreated and blank formulation treated groups in the CT-26 subcutaneous tumor model, after 4 treatments of 30 mg irinotecan per kg dose. Overall, this proof-of-concept study demonstrates that the newly synthesized copolymer, via a green route, is proven to be nontoxic, requires fewer purification steps and has potential applications in drug delivery.

1 aGiram, Prabhanjan, S.1 aWang, Julie, Tzu-Wen1 aWalters, Adam, A.1 aRade, Priyanka, P.1 aAkhtar, Muhammad1 aHan, Shunping1 aFaruqu, Farid, N.1 aAbdel-Bar, Hend, M.1 aGarnaik, Baijayantimala1 aAl-Jamal, Khuloud, T. uhttp://library.ncl.res.in/content/green-synthesis-methoxy-polyethylene-glycol-block-polyl-lactide-co-glycolide-copolymer-using01536nas a2200265 4500008004100000022001400041245010300055210006900158260000800227520062000235653002000855653001700875653002800892653001700920653001800937100002300955700002100978700002700999700002201026700002101048700002001069700002301089700003001112856012801142 2021 eng d a1610-365300aGreen synthesis of xanthene and acridine-based heterocycles of pharmaceutical importance: a review0 aGreen synthesis of xanthene and acridinebased heterocycles of ph cMAR3 a

Xanthene and acridine-based heterocyclic compounds find applications in cancer chemotherapy, biological staining and laser dyes and are known for their antibacterial and anti-tumor properties. Here we review green catalytic routes for the synthesis of 1,8-dioxo-octahydroxanthenes, 1,8-dioxo-decahydroacridines and related heterocyclic molecules with catalysts such as metal oxides, mixed metal oxides, resins, supported organocatalysts, heteropolyacids, carbon-based materials, zeolites, sulfides and ionic liquids. We compare protocols for their catalytic activities, and proposed mechanisms are discussed.

10agreen chemistry10aheterocycles10aheterogeneous catalysis10aMetal oxides10ananocatalysis1 aBurange, Anand, S.1 aGadam, Komal, G.1 aTugaonkar, Prajyot, S.1 aThakur, Seema, D.1 aSoni, Ravish, K.1 aKhan, Rubej, R.1 aTai, Mubashira, S.1 aGopinath, Chinnakonda, S. uhttp://library.ncl.res.in/content/green-synthesis-xanthene-and-acridine-based-heterocycles-pharmaceutical-importance-review02526nas a2200241 4500008004100000022001400041245014400055210006900199260000800268300001200276490000700288520167700295653001901972653001401991653001802005653002602023653001102049653002802060100002202088700002602110700002002136856012802156 2022 eng d a1568-776700aGlance at the chemodiversity of Ocimum species: Trends, implications, and strategies for the quality and yield improvement of essential oil0 aGlance at the chemodiversity of Ocimum species Trends implicatio cJUN a879-9130 v213 a

Ocimum species represent commercially important medicinal and aromatic plants. The essential oil biosynthesized by Ocimum species is enriched with specialized metabolites specifically, terpenoids and phenylpropanoids. Interestingly, various Ocimum species are known to exhibit diverse chemical profiles, and this chemical diversity has been at the center of many studies to identify commercially important chemotypes. Here, we present various chemotypes from the Ocimum species and emphasize trends, implications, and strategies for the quality and yield improvement of essential oil. Globally, many Ocimum species have been analyzed for their essential oil composition in over 50 countries. Asia represents the highest number of chemotypes, followed by Africa, South America, and Europe. Ocimum basilicum L. has been the most widespread and well-studied species, followed by O. gratissimum L., O. tenuiflorum L., O. canum Sims, O. americanum and O. kilimandscharicum Gurke. Moreover, various molecular reasons, benefits, adverse health effects and mechanisms behind this vast chemodiversity have been discussed. Different strategies of plant breeding, metabolic engineering, transgenic, and tissue-culture, along with anatomical modifications, are surveyed to enhance specific chemotypic profiles and essential oil yield in numerous Ocimum species. Consequently, chemical characterization of the essential oil obtained from Ocimum species has become indispensable for its proper utilization. The present chemodiversity knowledge from Ocimum species will help to exploit various applications in the industrial, agriculture, biopharmaceutical, and food sectors.

10aChemodiversity10aChemotype10aEssential oil10aMetabolic engineering10aOcimum10aSpecialized metabolites1 aGurav, Tanuja, P.1 aDholakia, Bhushan, B.1 aGiri, Ashok, P. uhttp://library.ncl.res.in/content/glance-chemodiversity-ocimum-species-trends-implications-and-strategies-quality-and-yield01782nas a2200157 4500008004100000245014300041210006900184260000800253300001600261490000700277520113400284100002401418700002601442700002801468856012801496 2022 eng d00aGlycal mediated synthesis of piperidine alkaloids: fagomine, 4-epi-fagomine, 2-deoxynojirimycin, and an advanced intermediate, iminoglycal0 aGlycal mediated synthesis of piperidine alkaloids fagomine 4epif cNOV a33021-330310 v123 a

Glucal and galactal are transformed into 2-deoxyglycolactams, which are important building blocks in the synthesis of biologically active piperidine alkaloids, fagomine and 4-epi-fagomine. In one of the strategies, reduction of 2-deoxyglycolactam-N-Boc carbonyl by lithium triethylborohydride (Super-Hydride (R)) has been exploited to generate lactamol whereas reduction followed by dehydration was utilized as the other strategy to functionalize the C-1-C-2 bond in the iminosugar substrate. The strategies provide the formal synthesis of 2-deoxynojirimycin, nojirimycin and nojirimycin B. DFT studies were carried out to determine the reason for the failure of the formation of the 2-deoxygalactonojirimycin derivative. Further, DFT studies suggest that phenyl moieties of protecting groups and lone pairs of oxygen in carbamate group plays a vital role in deciphering the conformational space of the reaction intermediates and transition-state structures through cation-pi or cation-lone pair interactions. The influence of these interactions is more pronounced at low temperature when the entropy factor is small.

1 aChand, Hemender, R.1 aTiwari, Mritunjay, K.1 aBhattacharya, Asish, K. uhttp://library.ncl.res.in/content/glycal-mediated-synthesis-piperidine-alkaloids-fagomine-4-epi-fagomine-2-deoxynojirimycin02538nas a2200241 4500008004100000022001400041245015800055210006900213260000800282300001100290490000800301520167700309653002401986653002002010653001402030653001102044653001702055653001202072100003402084700001602118700003602134856012602170 2022 eng d a0171-933500aG-protein coupled purinergic P2Y12 receptor interacts and internalizes Tau(RD)-mediated by membrane-associated actin cytoskeleton remodeling in microglia0 aGprotein coupled purinergic P2Y12 receptor interacts and interna cAPR a1512010 v1013 a

In Alzheimer's disease, the microtubule-associated protein, Tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. Microglial cells are the resident brain macrophage cells involved in constant surveillance and activated by the extracellular deposits. Purinergic receptors are involved in the chemotactic migration of microglial cells towards the site of inflammation. From our recent study, we have observed that the microglial P2Y12 receptor is involved in phagocytosis of full-length Tau species such as monomers, oligomers and aggregates by actin-driven chemotaxis. This study shows the interaction of repeat-domain of Tau (Tau(RD)) with the microglial P2Y12 receptor and the corresponding residues for interaction have been analysed by various in-silico approaches. In the cellular studies, Tau(RD) was found to interact with microglial P2Y12R and induces its cellular expression confirmed by co-immunoprecipitation and western blot analysis. Furthermore, the P2Y12R-mediated Tau(RD) internalization has demonstrated activation of microglia with an increase in the Iba1 level, and Tau(RD) becomes accumulated at the peri-nuclear region for the degradation. Similarly, immunofluorescence microscopic studies emphasized that Tau(RD) is phagocytosed by microglial P2Y12R via the membrane-associated actin remodeling as filopodia extension. Upon internalization, we have demonstrated the P2Y12R signaling-mediated degradation of accumulated Tau(RD) by lysosomal pathway. Altogether, microglial P2Y12R interacts with Tau(RD) and mediates directed migration and activation for its internalization and degradation.

10aAlzheimer's disease10aInternalization10amicroglia10aP2Y12R10aPhagocytosis10aTau(RD)1 aChidambaram, Hariharakrishnan1 aDas, Rashmi1 aChinnathambi, Subashchandrabose uhttp://library.ncl.res.in/content/g-protein-coupled-purinergic-p2y12-receptor-interacts-and-internalizes-taurd-mediated-002456nas a2200241 4500008004100000022001400041245015600055210006900211260000800280300001100288490000800299520165300307653002601960653002001986653001402006653001102020653001702031653000802048100003402056700001602090700003602106856007202142 2022 eng d a0171-933500aG-protein coupled purinergic P2Y12 receptor interacts and internalizes TauRD-mediated by membrane-associated actin cytoskeleton remodeling in microglia0 aGprotein coupled purinergic P2Y12 receptor interacts and interna cAPR a1512010 v1013 aIn Alzheimer’s disease, the microtubule-associated protein, Tau misfolds to form aggregates and filaments in the intra- and extracellular region of neuronal cells. Microglial cells are the resident brain macrophage cells involved in constant surveillance and activated by the extracellular deposits. Purinergic receptors are involved in the chemotactic migration of microglial cells towards the site of inflammation. From our recent study, we have observed that the microglial P2Y12 receptor is involved in phagocytosis of full-length Tau species such as monomers, oligomers and aggregates by actin-driven chemotaxis. This study shows the interaction of repeat-domain of Tau (TauRD) with the microglial P2Y12 receptor and the corresponding residues for interaction have been analysed by various in-silico approaches. In the cellular studies, TauRD was found to interact with microglial P2Y12R and induces its cellular expression confirmed by co-immunoprecipitation and western blot analysis. Furthermore, the P2Y12R-mediated TauRD internalization has demonstrated activation of microglia with an increase in the Iba1 level, and TauRD becomes accumulated at the peri-nuclear region for the degradation. Similarly, immunofluorescence microscopic studies emphasized that TauRD is phagocytosed by microglial P2Y12R via the membrane-associated actin remodeling as filopodia extension. Upon internalization, we have demonstrated the P2Y12R signaling-mediated degradation of accumulated TauRD by lysosomal pathway. Altogether, microglial P2Y12R interacts with TauRD and mediates directed migration and activation for its internalization and degradation.10aAlzheimer’s disease10aInternalization10amicroglia10aP2Y12R10aPhagocytosis10aTau1 aChidambaram, Hariharakrishnan1 aDas, Rashmi1 aChinnathambi, Subashchandrabose uhttps://www.sciencedirect.com/science/article/pii/S017193352200004802521nas a2200229 4500008004100000022001400041245013800055210006900193260000800262300001100270490000800281520168400289653002401973653001001997653004502007653003302052100002202085700002202107700002202129700002002151856012002171 2022 eng d a1047-847700aGraphical Biology Insights into the dynamic interactions at chemokine-receptor interfaces and mechanistic models of chemokine binding0 aGraphical Biology Insights into the dynamic interactions at chem cSEP a1078770 v2143 a

Chemokine receptors are the central signaling hubs of several processes such as cell migration, chemotaxis and cell positioning. In this graphical review, we provide an overview of the structural and mechanistic principles governing chemokine recognition that are currently emerging. Structural models of chemokine-receptor cocomplexes with endogenous chemokines, viral chemokines and therapeutics have been resolved that highlight multiple interaction sites, termed as CRS1, CRS1.5 etc. The first site of interaction has been shown to be the Nterminal domain of the receptors (CRS1 site). A large structural flexibility of the N-terminal domain has been reported that was supported by both experimental and simulation studies. Upon chemokine binding, the Nterminal domain appears to show constricted dynamics and opens up to interact with the chemokine via a large interface. The subsequent sites such as CRS1.5 and CRS2 sites have been structurally well resolved although differences arise such as the localization of the N-terminus of the ligand to a major or minor pocket of the orthosteric binding site. Several computational studies have highlighted the dynamic protein-protein interface at the CRS1 site that seemingly appears to resolve the differences in NMR and mutagenesis studies. Interestingly, the differential dynamics at the CRS1 site suggests a mixed model of binding with complex signatures of both conformational selection and induced fit models. Integrative experimental and computational approaches could help unravel the structural basis of promiscuity and specificity in chemokine-receptor binding and open up new avenues of therapeutic design.

10aChemokine receptors10aGPCRs10aIntrinsically disordered protein domains10aprotein-protein interactions1 aSonawani, Archana1 aKharche, Shalmali1 aDasgupta, Debjani1 aSengupta, Durba uhttp://library.ncl.res.in/content/graphical-biology-insights-dynamic-interactions-chemokine-receptor-interfaces-and01591nas a2200289 4500008004100000022001400041245010800055210006900163260000800232300001100240490000800251520061400259653001600873653002700889653002200916653001700938100002500955700002100980700002701001700002301028700001901051700002901070700002201099700002601121700002601147856012801173 2022 eng d a1566-736700aGreen synthesis of cyclohexanone to adipic acid over Fe-W oxides incorporated mesoporous carbon support0 aGreen synthesis of cyclohexanone to adipic acid over FeW oxides  cAUG a1064660 v1683 a

We have prepared iron and tungsten oxides incorporated mesoporous carbon (MC) catalysts using a simple hydrothermal methodology with different carbon sources, and the catalytic performance was investigated for cyclohexanone oxidation. An adequate amount of metal oxide loading has displayed a key role in the selective catalyst for adipic acid (AA) synthesis. The MC catalyst has shown its prime activity under the influence of redox properties of W5+/W6+ and Fe2+/Fe3+ as promoters. The 10%Fe 90%W-MC fructose as a carbon source catalyst has provided its best selectivity of 87% for AA at 120 ?C.

10aAdipic Acid10aLiquid phase oxidation10amesoporous carbon10aRedox center1 aMekala, Siva, Prasad1 aPrabu, Marimuthu1 aGawali, Sheetal, Datta1 aGopakumar, Karthik1 aGogoi, Pranjal1 aBhatkar, Akash, Ravindra1 aMohapatra, Gourab1 aUnnikrishanan, Eeswar1 aRaja, Thirumalaiswamy uhttp://library.ncl.res.in/content/green-synthesis-cyclohexanone-adipic-acid-over-fe-w-oxides-incorporated-mesoporous-carbon02445nas a2200229 4500008004100000022001400041245007300055210006900128260000800197300001100205490000800216520167500224653003401899653002101933653002801954653003101982653003202013100002202045700002302067700002102090856010402111 2022 eng d a1387-700300aGreen synthesis of highly dispersed Cu metal nanoparticles catalysts0 aGreen synthesis of highly dispersed Cu metal nanoparticles catal cDEC a1101180 v1463 a

Bionanotechnology approach for metal nanoparticles (NPs) synthesis is cost-effective and environmentally friendly. Organic molecules present in plant extracts can be efficiently utilized for bio-reduction of metal ions into metal NPs in a one-step green synthesis methodology. The biosynthesis procedure for metal NPs synthesis is quick, easy to scale up and can be perform at ambient conditions. The present investigations propose the biosynthesis of highly dispersed and stable copper NPs (Cu NPs) supported on NaY zeolite using plant extract of Tinospora cordifolia and Andrographis paniculata for the first time. The structural and morphological attributes of Cu NPs were explored by adopting various physico-chemical techniques, for example Inductively Coupled Plasma-Optical Emission Spectrometry (ICP-OES), X-ray diffraction (XRD), Temperature Programmed Desorption (CO2-TPD and NH3-TPD), Temperature Programmed Reduction (H2-TPR), N2 sorption, Electron Microscopy (SEM, TEM and HR-TEM), X-ray Photoelectron Spectroscopy (XPS), etc. The experimental study (XRD, SEM, TEM, and HR-TEM) recommend that the green synthesis method by using plant extract has promising effect for the synthesis of nano-sized, stable and homogeneously dispersed Cu NPs catalysts (Cu NPs average size of 1.6 and 1.8 nm) as compared to chemical synthesis approach. The present result is better than those of many state-ofthe art techniques reported for green synthesis of Cu NPs using plant extract. According to the current study, it is advantageous to prepare highly dispersed metal NPs with desired size, shape, morphology and the required properties by using plant extract.

10aBiosynthesis of nanomaterials10aCu nanoparticles10aHeterogeneous catalysts10aSupport -Metal interaction10aZeolite supported catalysts1 aNagpure, Atul, S.1 aMohture, Vikas, M.1 aKayarkar, Ankush uhttp://library.ncl.res.in/content/green-synthesis-highly-dispersed-cu-metal-nanoparticles-catalysts02944nas a2200265 4500008004100000022001400041245013300055210006900188260001200257300001200269490000700281520196100288653002302249653004802272653002002320653002902340653002802369653002202397100002802419700002702447700002502474700003102499700002802530856012002558 2022 eng d a0973-129600aGreen synthesis-mediated iron oxide nanoparticles using sphagneticola trilobata (L.) for antibacterial and anticancer assessment0 aGreen synthesismediated iron oxide nanoparticles using sphagneti cOCT-DEC a953-9610 v183 a

Background: Green chemistry is widely accepted phenomenon to synthesize iron oxide nanoparticles (Fe-NPs) used in several biomedical and technological applications. Metal oxide nanoparticles are useful in biomedical, clearing environmental pollutants, enzyme immobilization, etc., Objectives: The synthesis of Fe-NPs using Sphagneticola trilobata leaf extract using ferric chloride solution and its biological assessment. Materials and Methods: The present study involved the synthesis of Fe-NPs using S. trilobata leaf extract using ferric chloride solution by the co-precipitation method. The synthesized nanoparticles were characterized for Fourier-transform infrared spectroscopy, scanning electron microscopy, powder X-ray diffraction spectroscopy, particle size analysis, and magnetization studies. The nanoparticles were biologically evaluated for microbiological, antioxidant, and in vitro cytotoxicity activity. Results: Magnetic nanoparticles were appeared in dark brown color. The change in color might result due to the presence of polyphenols in S. trilobata leaf extract. The characterization studies confirmed morphology, shape, and size of the nanoparticles. The mean diameter of Fe-NPs and S. trilobata-Fe-NPs was found to be 42.2 +/- 2.6 and 62.54 +/- 2.01 nm, respectively. Magnetization studies of nanoparticles revealed ferromagnetic behavior with the saturation magnetization at 57 emugm(-1). S. trilobata-Fe-NPs showed significant antibacterial action against Staphylococcus aureus and Bacillus subtilis by the well-diffusion method. Antioxidant activity of S. trilobata-Fe-NPs exhibited 65.78% inhibition in comparison with ascorbic acid. The cytotoxicity assay of S. trilobata-Fe-NPs on HCT-15 colon adenocarcinoma cells showed significant anticancer activity (56.44%) cytotoxic inhibition. Conclusion: Green synthesis-mediated S. trilobata-Fe-NPs appeared to produce significant antimicrobial and anticancer potential.

10aElemental analysis10afield emission scanning electron microscopy10agreen synthesis10airon oxide nanoparticles10aSphagneticola trilobata10aX-ray diffraction1 aDhavale, Rakesh, Pandit1 aPatil, Swapnil, Sanjay1 aJadhav, Sagar, Ujwal1 aDhavale, Rushikesh, Pandit1 aAgawane, Sachin, Bharat uhttp://library.ncl.res.in/content/green-synthesis-mediated-iron-oxide-nanoparticles-using-sphagneticola-trilobata-l01988nas a2200193 4500008004100000022001400041245014000055210006900195260000900264300001400273490000700287520127000294100001501564700001601579700001501595700002801610700002501638856013101663 2022 eng d a1754-569200aGreen transformation of CO2 to ethanol using water and sunlight by the combined effect of naturally abundant red phosphorus and Bi2MoO60 aGreen transformation of CO2 to ethanol using water and sunlight  cMAY  a1967-19760 v153 a

Direct photocatalytic conversion of CO2 to ethanol remains a scientific challenge because of the sluggish kinetics of C-C coupling and complex multielectron transfer processes. To achieve a green transformation of CO2 to C1+ products using naturally abundant sunlight and water requires the smart design of an efficient catalyst by selecting the right combination of atoms either in elemental or in compound form. Herein, we report a composite photocatalyst composed of earth abundant red phosphorus (RP) in nano-sheet morphology decorated with Bi2MoO6 nano-particles. The composite synthesised by a facile ultrasonication method produces 51.8 mu mol g(-1) h(-1) of ethanol from CO2. The ability of RP for the conversion of CO2 to C1 has been altered by the introduction of Bi2MoO6. In situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) and Kinetic Isotopic Effect (KIE) analysis shed light on the mechanistic pathway, which propose that the presence of Bi-Mo dual sites play a crucial role in the C-C coupling toward the formation of ethanol. Spectroscopic evidence and isotope labeling experiments suggest that the intermediate OCH3* is the key active species for ethanol formation via self-coupling followed by proton transfer.

1 aDas, Risov1 aDas, Kousik1 aRay, Bitan1 aVinod, Chathakudath, P.1 aPeter, Sebastian, C. uhttp://library.ncl.res.in/content/green-transformation-co2-ethanol-using-water-and-sunlight-combined-effect-naturally-abundant00780nas a2200205 4500008004100000022001400041245012100055210006900176260001200245300000900257490000700266100002300273700001800296700002300314700001800337700002300355700004200378700002700420856012700447 2022 eng d a0972-232700aGut microbiota dysbiosis in patients with intracranial sino-venous thrombosis and acute ischemic stroke in the young0 aGut microbiota dysbiosis in patients with intracranial sinovenou cSEP-OCT a980+0 v251 aPrabhu, Varsha, A.1 aRajput, Vinay1 aYadav, Rakeshkumar1 aGohil, Kushal1 aDharne, Mahesh, S.1 aUnnikrishnan, Mazhuvancherry, Kesavan1 aGorthi, Sankar, Prasad uhttp://library.ncl.res.in/content/gut-microbiota-dysbiosis-patients-intracranial-sino-venous-thrombosis-and-acute-ischemic02518nas a2200385 4500008004100000245010900041210006900150260000900219300001200228490000700240520127600247653002001523653002301543653003101566653003001597653002101627100002501648700001801673700002601691700002101717700001701738700001901755700001801774700002001792700002801812700001801840700001801858700001801876700002301894700001801917700002601935700001801961700002401979856012902003 2023 eng d00aG4-binding drugs, chlorpromazine and prochlorperazine, repurposed against COVID-19 infection in hamsters0 aG4binding drugs chlorpromazine and prochlorperazine repurposed a cMAR  a11331230 v103 a

The COVID-19 pandemic caused by SARS-CoV-2 has caused millions of infections and deaths worldwide. Limited treatment options and the threat from emerging variants underline the need for novel and widely accessible therapeutics. G-quadruplexes (G4s) are nucleic acid secondary structures known to affect many cellular processes including viral replication and transcription. We identified heretofore not reported G4s with remarkably low mutation frequency across >5 million SARS-CoV-2 genomes. The G4 structure was targeted using FDA-approved drugs that can bind G4s - Chlorpromazine (CPZ) and Prochlorperazine (PCZ). We found significant inhibition in lung pathology and lung viral load of SARS-CoV-2 challenged hamsters when treated with CPZ or PCZ that was comparable to the widely used antiviral drug Remdesivir. In support, in vitro G4 binding, inhibition of reverse transcription from RNA isolated from COVID-infected humans, and attenuated viral replication and infectivity in Vero cell cultures were clear in case of both CPZ and PCZ. Apart from the wide accessibility of CPZ/PCZ, targeting relatively invariant nucleic acid structures poses an attractive strategy against viruses like SARS-CoV-2, which spread fast and accumulate mutations quickly.

10aConserved motif10aFDA-approved drugs10aG-quadruplex binding drugs10ahamster model of COVID-1910aRNA G-quadruplex1 aRoy, Shuvra, Shekhar1 aSharma, Shalu1 aRizvi, Zaigham, Abbas1 aSinha, Dipanjali1 aGupta, Divya1 aRophina, Mercy1 aSehgal, Paras1 aSadhu, Srikanth1 aTripathy, Manas, Ranjan1 aSamal, Sweety1 aMaiti, Souvik1 aScaria, Vinod1 aSivasubbu, Sridhar1 aAwasthi, Amit1 aHarshan, Krishnan, H.1 aJain, Sanjeev1 aChowdhury, Shantanu uhttp://library.ncl.res.in/content/g4-binding-drugs-chlorpromazine-and-prochlorperazine-repurposed-against-covid-19-infection02629nas a2200241 4500008004100000022001400041245009400055210006900149260000800218300001200226490000700238520179800245100002902043700001602072700002602088700002502114700001802139700002502157700003102182700002802213700002802241856011802269 2023 eng d a0022-246100aGas sensors and factors influencing sensing mechanism with a special focus on MOS sensors0 aGas sensors and factors influencing sensing mechanism with a spe cJAN a559-5820 v583 a

Industrialization and its progress are very important for the economy and to move towards prosperity, stimulating innovation and creating jobs. Nonetheless, industrialization has negative impacts, if not done judiciously, such as pollution, increased greenhouse gas emissions, and global warming. Therefore, amenity-with-security is of fundamental significance in a new and dynamic lifestyle. A gas sensor is one of the crucial devices for monitoring and subsequently preserving the clean atmosphere among a number of other safety technologies. In-depth assessments of gas sensors and their necessity in the environment (air) pollution are provided in the current review. With a special emphasis on metal oxide semiconductor (MOS)-based gas sensors, the review includes a thorough study of gas sensors and the factors relating to sensing mechanisms. It not only describes the basic concepts and brief history of gas sensors, but also highlights the schemes responsible for improving the gas sensing properties and state-of-art literature review. These schemes include (1) surface engineering/morphological tuning and (2) bulk and surface doping. To keep scientific rigour and in-depth analyses, this review focuses on these two schemes only. In the doping area, the emphasis is given on graphene loading, decorated with nanoparticles of noble metals, spillover mechanism, and heterojunction (p-n, n-n, and p-p) formation. The conclusion summarizes the most optimized MOS gas sensors with enhanced gas sensing capabilities. The emphasis is given to formulate the article in such a way that it will be useful for the beginners who wish to explore the gas sensor research field, as well as to the established researchers to further improve the sensing capabilities of MOS gas sensors.

1 aNadargi, Digambar, Y. Y.1 aUmar, Ahmad1 aNadargi, Jyoti, D. D.1 aLokare, Smita, A. A.1 aAkbar, Sheikh1 aMulla, Imtiaz, S. S.1 aSuryavanshi, Sharad, S. S.1 aBhandari, Nagesh, L. L.1 aChaskar, Manohar, G. G. uhttp://library.ncl.res.in/content/gas-sensors-and-factors-influencing-sensing-mechanism-special-focus-mos-sensors02467nas a2200229 4500008004100000022001400041245009600055210006900151260000800220300001400228490000700242520169800249653001401947653001601961653002901977653001402006653001802020100002702038700002102065700003002086856012102116 2023 eng d a1415-475700aGenetic diversity of toxigenic Fusarium verticillioides associated with maize grains, India0 aGenetic diversity of toxigenic Fusarium verticillioides associat cMAY ae202200730 v463 a

In the present investigation, prevalence, genetic diversity, and mycotoxin producing potential of Fusarium species associated with maize grain samples were studied from different geographical regions of India. The highest prevalence of Fusarium verticillioides was recorded as 88.52%, followed by F. coffeatum, F. foetens, and F. euwallaceae, 6.55%, 3.27%, and 1.63%, respectively. We isolated 54 strains of F. verticillioides, and their genetic diversity was studied by inter simple sequence repeats (ISSR). The ISSR fingerprints (AG) 8C and (AG) 8G showed 252 and 368 microsatellite sites in the genome of F. verticillioides and resulted in 99-100% repeatability and reproducibility. The Simpson (SID) and Shannon (H) indices (0.78 and 2.36) suggest that F. verticillioides strains exhibit moderate to high diversity. Molecular detection of fumonisin B1 (FB1) biosynthetic genes (FUM1 and FUM13) involved in FB1 production in F. verticillioides was confirmed by polymerase chain reaction (PCR). Furthermore, 91% of the strains were positive for FB1 production, which was affirmed by liquid chromatography with tandem mass spectrometry (LC-MS-MS). In-vitro appurtenance of F. verticillioides spores exhibited a high to moderate effect on the growth and development of the maize. The current finding demonstrated that most F. verticillioides strains showed a wide range of genetic diversity with varied toxigenic and pathogenic potentials. In conclusion, for the first time, F. coffeatum, F. foetens, and F. euwallaceae species were reported from maize grain samples in India. They were positive for FB1 and negatively affecting grain quality, which is a major concern in food safety.

10adiversity10aFood safety10aFusarium verticillioides10aMycotoxin10apathogenicity1 aNavale, Vishwambar, D.1 aSawant, Amol, M.1 aVamkudoth, Koteswara, Rao uhttp://library.ncl.res.in/content/genetic-diversity-toxigenic-fusarium-verticillioides-associated-maize-grains-india01934nas a2200253 4500008004100000022001400041245008900055210006900144260000800213300001000221490000700231520111400238653001501352653001501367653002101382653002701403653002301430653001701453100002601470700002301496700002401519700002001543856011701563 2023 eng d a0095-362800aGenomic determinants of entomopathogenic fungi and their involvement in pathogenesis0 aGenomic determinants of entomopathogenic fungi and their involve cJAN a49-600 v853 a

Entomopathogenic fungi offer an effective and eco-friendly alternative to curb insect populations in biocontrol strategy. The evolutionary history of selected entomopathogenic fungi indicates their ancestral relationship with plant endophytes. During this host shifting, entomopathogenic fungi must have acquired multiple mechanisms, including a combination of various biomolecules that make them distinguishable from other fungi. In this review, we focus on understanding various biochemical and molecular mechanisms involved in entomopathogenesis. In particular, we attempt to explain the indispensable role of enlarged gene families of various virulent factors, viz. chitinases, proteases, lipases, specialized metabolites, and cytochrome P450, in entomopathogenesis. Our analysis suggests that entomopathogenic fungi recruit a different set of gene products during the progression of pathogenesis. Knowledge of these bio-molecular interactions between fungi and insect hosts will allow researchers to execute pointed efforts towards the development of improved entomopathogenic fungal strains.

10aBiocontrol10aChitinases10aEndophytic fungi10aEntomopathogenic fungi10aHydrolytic enzymes10aInsect pests1 aVidhate, Ravindra, P.1 aDawkar, Vishal, V.1 aPunekar, Sachin, A.1 aGiri, Ashok, P. uhttp://library.ncl.res.in/content/genomic-determinants-entomopathogenic-fungi-and-their-involvement-pathogenesis02399nas a2200217 4500008004100000022001400041245011200055210006900167260000800236300001200244490000700256520161500263653001301878653003401891653003101925653002401956653003301980100002302013700001502036856013002051 2023 eng d a0887-358500aGoverning dynamics and preferential binding of the AXH domain influence the aggregation pathway of Ataxin-10 aGoverning dynamics and preferential binding of the AXH domain in cMAR a380-3940 v913 a

The present state of understanding the mechanism of Spinocerebellar Ataxia-1, a fatal neurodegenerative disease linked to the protein Ataxin-1 (ATXN1), is baffled by a set of self-contradictory, and hence, inconclusive observations. This fallacy poses a bottleneck to the effective designing of curable drugs as the field is currently missing the specific druggable site. To understand the fundamentals of pathogenesis, we tried to decipher the intricacies of the extremely complicated landscape by targeting the relevant species that supposedly dictate the structure-function paradigm. The atomic-level description and characterization of the dynamism of the systems reveal the existence of structural polymorphism in all the leading stakeholders of the overall system. The very existence of conformational heterogeneity in every species creates numerous possible combinations of favorable interactions because of the variability in segmental cross-talks and hence claims its role in the choice of routes between functional activity and dysfunctional disease-causing aggregation. Despite this emergent configurational diversity, there is a common mode of operative intermolecular forces that dictates the extent of stability of all the multimeric complexes due to the localized population of a specific type of residue. The present research proposes a dynamic switch mechanism between aggregability and functional activity, based on the logical interpretation of the estimated variables, which is practically dictated by the effective concentration of the interacting species involved in the cell.

10aAtaxin-110amolecular dynamics simulation10aneurodegenerative diseases10aProtein aggregation10aprotein misfolding disorders1 aTammara, Vaishnavi1 aDas, Atanu uhttp://library.ncl.res.in/content/governing-dynamics-and-preferential-binding-axh-domain-influence-aggregation-pathway-ataxin04222nas a2200277 4500008004100000022001400041245011700055210006900172260000800241300000700249490000700256520327800263653002603541653002303567653002603590653002103616653001303637100002103650700002303671700002203694700002603716700002403742700002403766700002803790856012603818 2023 eng d a1868-695800aGreen adeptness in synthesis of non-toxic copper and cobalt oxide nanocomposites with multifaceted bioactivities0 aGreen adeptness in synthesis of nontoxic copper and cobalt oxide cDEC a790 v143 a

Background: In the present era, we are facing different health problems mainly concerning with drug resistance in microorganisms as well as in cancer cells. In addition, we are also facing the problems of controlling oxidative stress and insect originated diseases like dengue, malaria, chikungunya, etc. originated from mosquitoes. In this investigation, we unfurled the potential of Achatina fulica mucus in green synthesis of mucus mediated copper oxide bio-nanocomposites (SM-CuONC) and cobalt oxide bio-nanocomposites (SM-Co3O4NC). Herein we carried out the physico-chemical characterization like UV-Vis spectra, X-ray diffraction (XRD), Field Emission Scanning Electron Microscopy (FESEM), Transmission electron microscopy (TEM), Energy Dispersive X-ray Analysis (EDAX) and X-ray photoelectron spectroscopy (XPS) of as synthesized bio-nanocomposites. Both the bio-nanocomposites were tested for their potential as antimicrobial activity using well diffusion assay, anticancer activity by MTT assay, antioxidant activity by phosphomolybdenum assay and mosquito larvicidal activity.Results: The results of this study revealed that, SM-CuONC and SM-Co3O4NC were synthesized successfully using A. fulica mucus. The FESEM and TEM data reveal the formation of nanoparticles with quasi-spherical morphology and average particle size of similar to 18 nm for both nanocomposites. The EDAX peak confirms the presence of elemental copper and cobalt in the analyzed samples. The X-ray diffraction analysis confirmed the crystalline nature of the CuO and Co3O4. The result of anti microbial study exhibited that, SM-CuONC showed maximum antimicrobial activity against Escherichia coli NCIM 2065 and Aspergillus fumigatus NCIM 902 which were noted as 2.36 +/- 0.31 and 2.36 +/- 0.59 cm resp. at 60 mu g/well concentration. The result of anticancer activity for SM-CuONC was exhibited as, 68.66 +/- 3.72, 62.66 +/- 3.61 and 71.00 +/- 2.36 percent kill, while SM-Co3O4NC exhibited 61.00 +/- 3.57, 72.66 +/- 4.50 and 71.66 +/- 4.22 percent kill against Human colon cancer (HCT-15), Cervical cancer (HeLa), and Breast cancer (MDA-MB-231) cell lines, respectively, at 20 mu g/well concentration. Both the nanocomposites also exhibited better antioxidant activity. Total antioxidant activity for SM-CuONC at 50 mu g/ml concentration was found to be highest as 55.33 +/- 3.72 while that of SM-Co(3)O(4)Ns was 52.00 +/- 3.22 mM of ascorbic acid/mu g respectively. Both bio-nanocomposites also exhibited 100% mosquito larvicidal activity at concentration ranging from 40 to 50 mg/l. During cytotoxicity study it is noted that at 5 mu g/well concentration, SM-CuO and SM-Co3O4NCs suspension showed more than 97% viability of normal (L929) cell lines. We also studied phytotoxicity of both bio-nanocomposites on Triticum aestivum. In this study, 100% seed germination was observed when seeds are treated with SM-CuONC and SM-Co3O4NC at 500 mg/l and 250 mg/l concentration respectively.Conclusions: This study concludes that in future as synthesized SM-CuONC and SM-Co3O4NC can be used in pharmaceutical, health care system for betterment and welfare of human life as both bio-nanocomposites exhibits better antimicrobial, anticancer, antioxidant and mosquito larvicidal potential.

10aAchatina fulica mucus10aBio-nanocomposites10aBiological activities10aCharacterization10aToxicity1 aMane, Pramod, C.1 aKadam, Deepali, D.1 aKhadse, Ashok, N.1 aChaudhari, Aditya, R.1 aUghade, Supriya, P.1 aAgawane, Sachin, B.1 aChaudhari, Ravindra, D. uhttp://library.ncl.res.in/content/green-adeptness-synthesis-non-toxic-copper-and-cobalt-oxide-nanocomposites-multifaceted02159nas a2200169 4500008004100000022001400041245014800055210006900203260000800272300001600280490000700296520147700303100002401780700002501804700002501829856013501854 2023 eng d a1144-054600aGreen, practical & scalable approach towards the synthesis of valuable α-keto amides using a metal-free catalyst under solvent-free conditions0 aGreen practical scalable approach towards the synthesis of valua cOCT a19679-196870 v473 a

alpha-Ketoamides are very important motifs as they are present in many natural products, drugs & biologically important molecules. We synthesized a very simple, cheap, eco-friendly & reusable glucose-based carbonaceous material (GCM), which showed high performance as a catalyst in the oxidative cross-dehydrogenative coupling (CDC) reaction of alpha-ketoaldehydes with amines for the synthesis of alpha-ketoamides. The GCM catalyst was also very efficient for one-pot two-step synthesis of alpha-ketoamides from alpha-ketoalcohols as well. The GCM catalyst was able to catalyze alcohol oxidation in alpha-ketoalcohols followed by CDC reaction with amines to form alpha-ketoalcohols. The reactions were found to proceed smoothly at a low temperature of 50 degrees C using a green & economical metal-free catalyst under base-free, ligand-free & solvent-free reaction conditions to get the corresponding alpha-ketoamides in good to excellent yields. The results demonstrated that the GCM catalyst showed acidic as well as superior oxidising catalytic activity due to the presence of a carboxylic acid (-COOH) and hydroxyl (-OH)-enriched carbonaceous framework, which enabled the synthesis of important alpha-ketoamide motifs. The applicability of the catalyst was also evaluated for the synthesis of an anti-HIV agent drug molecule. Greener, cheaper & eco-friendly GCM catalyst as well as catalytic process for synthesis of alpha-Keto Amides.

1 aBankar, Shubham, R.1 aGhadge, Sambhaji, S.1 aJadhav, Vrushali, H. uhttp://library.ncl.res.in/content/green-practical-scalable-approach-towards-synthesis-valuable-%CE%B1-keto-amides-using-metal-free02036nas a2200229 4500008004100000022001400041245008500055210006900140260000800209300000900217490000700226520126700233100002601500700002301526700002601549700002301575700002201598700001601620700003101636700002801667856011101695 2023 eng d a0957-452200aGreen synthesis of GO-loaded Ag/ZnO nanocomposites for methyl orange degradation0 aGreen synthesis of GOloaded AgZnO nanocomposites for methyl oran cJUL a15680 v343 a

Nature is a perfect laboratory for creating novel nanomaterials for a variety of applications. A robust green synthesis approach to GO-loaded Ag/ZnO nanocomposite materials using medicinal plant extraction and their potential application in methyl orange dye degradation are reported. The straightforward technique employs zinc and silver nitrate precursors in an aqueous solution of medicinal plant extract, causing the precipitation process. Prior to photocatalytic investigations, the physico-chemical properties of the material are analysed using TG-DTA, XRD, FE-SEM, TEM, EDAX and BET. The developed material showcase hexagonal wurtzite structure of ZnO, with face-centered-cubic phase of Ag and AgCl. All the samples exhibit aggregated, irregular rounded grains, as expected in the precipitation synthesis process. Pristine ZnO showed 15.5% degradation efficiency towards methyl orange, which was further improved by doping Ag from 0.5 to 2 mol%. The catalyst with 1 mol% Ag doping resulted in the better photocatalytic activity (26.30%), which has again improved by loading the GO (27.46%). The outcome of this study provides the new insights to GO-loaded Ag/ZnO nanocomposites by green synthesis route, in view of photocatalytic applications.

1 aNadargi, Digambar, Y.1 aNadargi, Jyoti, D.1 aTamboli, Mohaseen, S.1 aTamboli, Asiya, M.1 aMulla, Imitaz, S.1 aUmar, Ahmad1 aTruong, Nguyen, Tam Nguyen1 aSuryavanshi, Sharad, S. uhttp://library.ncl.res.in/content/green-synthesis-go-loaded-agzno-nanocomposites-methyl-orange-degradation