02425nas a2200265   4500008004100000022001400041245013100055210006900186260005700255300001400312490000700326520142100333653001801754653004401772653003301816653001401849653003701863100001801900700002401918700002501942700002201967700001701989700002302006856013002029       2009                        eng d  a1530-993200aNovel/conceptual floating pulsatile system using high internal phase emulsion based porous material intended for chronotherapy0 aNovelconceptual floating pulsatile system using high internal ph  a233 SPRING ST, NEW YORK, NY 10013 USAbSPRINGERcDEC  a1368-13800 v103 a<p>The aim of the present study was to design a novel/conceptual delivery system using ibuprofen, anticipated for chronotherapy in arthritis with porous material to overcome the formulation limits (multiple steps, polymers, excipients) and to optimize drug loading for a desired release profile suitable for in vitro investigations. The objective of this delivery system lies in the availability of maximum drug amount for absorption in the wee hours as recommended. Drug loading using 3(2) factorial design on porous carrier, synthesized by high internal phase emulsion technique using styrene and divinylbenzene, was done via solvent evaporation using methanol and dichloromethane. The system was evaluated in vitro for drug loading, encapsulation efficiency, and surface characterization by scanning electron, atomic force microscopy, and customized drug release study. This study examined critical parameters such as solvent volume, drug amount, and solvent polarity on investigations related to drug adsorption and release mostly favoring low-polarity solvent dichloromethane. Overall release in all batches ranged 0.98-52% in acidic medium and 71-94% in basic medium. These results exhibit uniqueness in achieving the least drug release of 0.98%, an ideal one, without using any release modifiers, making it distinct from other approaches/technologies for time and controlled release and for chronotherapy.</p>10achronotherapy10afloating pulsatile drug delivery system10ahigh internal phase emulsion10aibuprofen10amultiparticulate porous carriers1 aSher, Praveen1 aIngavle, Ganesh, C.1 aPonrathnam, Surendra1 aBenson, James, R.1 aLi, Nai-Hong1 aPawar, Atmaram, P.  uhttp://library.ncl.res.in/content/novelconceptual-floating-pulsatile-system-using-high-internal-phase-emulsion-based-porous-001996nas a2200241   4500008004100000022001400041245013000055210006900185260009200254300000800346490000700354520104500361653002001406653003301426653002401459653003001483100002901513700001901542700001901561700001801580700002901598856012701627       2014                        eng d  a1385-772X00aPhotopolymerization of high internal phase emulsions based on 2-ethylhexyl (meth)acrylates and ethylene glycol dimethacrylate0 aPhotopolymerization of high internal phase emulsions based on 2e  a4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLANDbTAYLOR & FRANCIS LTDcJAN  a1-60 v173 a<p>Photopolymerization of high internal phase emulsions based on 2-ethylhexyl (meth)acrylates and ethylene glycol dimethacrylate was carried out in presence of low concentration of different photoinitiators. The stable emulsions obtained by mixing with individual photoinitiators were subjected to low-intensity photopolymerization under UV-Visible lamp. Identical samples were irradiated for differing periods ranging from 2 to 10min at an interval of 2min. The percentage conversions of each monomer in the compositions with respect to the time of irradiation were determined using gas chromatography. It was observed that the formulations containing IRGACURE 819 showed the highest conversion while that containing IRGACURE 2959 showed the least conversion. The former showed high conversion due to the proximity of the absorption maxima of photoinitiator to the major emission line of mercury spectrum at 365nm while the latter showed least conversion due to non-availability of major absorption maxima within the irradiation range.</p>10a(meth)acrylates10ahigh internal phase emulsion10aPhotopolymerization10aresidual monomer analysis1 aHarikrishna, Reghunathan1 aShaikh, A., W.1 aPonrathnam, S.1 aRajan, C., R.1 aBhongale, Sunil, Sitaram  uhttp://library.ncl.res.in/content/photopolymerization-high-internal-phase-emulsions-based-2-ethylhexyl-methacrylates-and-0