02348nas a2200217 4500008004100000022001400041245009600055210006900151260010900220300001200329490000800341520153200349653001301881653001401894653002101908653002001929653001801949100002001967700001801987856012502005 2011 eng d a0378-874100aMicroencapsulation enhances the anti-ulcerogenic properties of entada africana leaf extract0 aMicroencapsulation enhances the antiulcerogenic properties of en aELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELANDbELSEVIER IRELAND LTDcSEP a553-5610 v1373 a

Ethnopharmacological relevance: The antiulcer potentials of most plants still remain largely unexplored, despite their prospects evidenced by their use as ethnomedicine. Entada africana (Mimosaceae) has been widely used in Africa for the treatment of skin infections, wounds, tonic for stomach troubles and against diphtheria-like throat complaints. The aim of the present study was to evaluate the anti-ulcer properties of Entada africana (EA) ethanol leaf extract and to obtain a novel multiparticulate pharmaceutical formulation (ACE) with it. Materials and methods: Ethanol or Indomethacin was administered to rats after oral administration of EA (200, 400 and 800 mg extract/kg b.w), ACE (400 and 800 mg/kg bw), cimetidine (100 mg/kg bw), misoprostol (40 mu g/kg bw) or distilled water/saline (vehicle). Anti ulcer property was evaluated by examining and scoring stomach lesions. Results: The extract exhibited significant (P < 0.01) cytoprotective effect against ethanol and indomethacin induced gastro ulceration. The microcapsules showed enhanced cytoprotective effect against ethanol and indomethacin induced gastro ulceration. Histopathologically, the effects of EA and ACE on mucus epithelia were mild with reduced neutrophil, eosinophil and lymphocytic infiltration in stomach tissues of rats ulcerated with ethanol. Conclusions: Our current findings show that EA and its multiparticulate formulation may be a useful preparation in peptic ulcer disease. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

10aAlginate10aAntiulcer10aCalcium chloride10aEntada africana10aMicrocapsules1 aObidike, I., C.1 aEmeje, M., O. uhttp://library.ncl.res.in/content/microencapsulation-enhances-anti-ulcerogenic-properties-entada-africana-leaf-extract-002263nas a2200229 4500008004100000022001400041245010800055210006900163260009900232300001000331490000700341520139900348653001801747653001301765653001901778653001301797653002201810100002801832700002901860700002601889856011801915 2016 eng d a0032-386100aImproved performance of microcapsules with polymer nanocomposite wall: preparation and characterization0 aImproved performance of microcapsules with polymer nanocomposite aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcJAN a27-330 v833 a

Polyurea/clay nanocomposite microcapsules containing dimethyl phthalate (DMP) as a model compound were prepared by interfacial polymerization technique. Nanoclays namely, montmorillonite Na+ (MMT) and Laponite were incorporated into microcapsule wall and their effects on morphology, thermal properties and release of DMP from microcapsules were investigated. All microcapsules were characterized using scanning electron microscope (SEM), X-ray diffraction (XRD), transmission electron microscope (TEM), thermogravimetric analysis (TGA) and Fourier transform infrared (FTIR) spectroscopy. The present preparation process results in formation of polyurea/clay nanocomposite microcapsule wall with intercalated clay layered as evidenced by XRD and TEM. Nanocomposite microcapsules have shown significant reduction in release of DMP and change in release mechanism as compared to the pristine microcapsules. Nanocomposite microcapsules show good improvement in the fracture strength as compared to pristine microcapsules. The approach used herein is simple and can be adopted to many other polymeric microcapsule systems prepared by different microencapsulation techniques, requiring reduction in release rate and/or mechanism for several applications like pharmaceuticals, agrochemicals, industrially important chemicals, consumer products, etc. (C) 2015 Elsevier Ltd. All rights reserved.

10aMicrocapsules10aNanoclay10aNanocomposites10aPolyurea10aRelease mechanism1 aJagtap, Siddheshwar, B.1 aMohan, Muthu, Subramania1 aShukla, Parshuram, G. uhttp://library.ncl.res.in/content/improved-performance-microcapsules-polymer-nanocomposite-wall-preparation-and-001839nas a2200277 4500008004100000022001400041245012000055210006900175260000900244300002600253490000800279520088000287653002401167653002301191653001801214653001801232653001701250653002301267100002201290700002001312700002201332700002201354700002601376700003101402856012801433 2019 eng d a0927-775700aSustained release insect repellent microcapsules using modified cellulose nanofibers (mCNF) as pickering emulsifier0 aSustained release insect repellent microcapsules using modified  cDEC  aArticle Number:1238830 v5823 a

We report here an approach to encapsulate N, N-diethyl-3-methylbenzamide (DEET), an insect repellent, through interfacial polycondensation using modified cellulose nanofiber (CNF) as pickering emulsifier. We found that stearic acid functionalized CNF (mCNF) can be used to form stable pickering emulsions (oil-in-oil and water-in-oil), and further encapsulate DEET using interfacial polycondensation with very high encapsulation efficiency of about 98%. Another major advantage of this approach is that mCNF can act both as pickering emulsifier and also strengthen the barrier properties of microcapsules resulting in significant reduction in release rate of DEET. Interpretation of the release profiles using standard mathematical models proposed by Ritger-Peppas show a factor of three reduction in release rate constant for the microcapsules reinforced with mCNF.

10aCellulose nanofiber10aControlled release10aMicrocapsules10aNanocomposite10ananoparticle10aPickering emulsion1 aKadam, Sandip, L.1 aYadav, Prashant1 aBhutkar, Siddhant1 aPatil, Vishal, D.1 aShukla, Parshuram, G.1 aShanmuganathan, Kadhiravan uhttp://library.ncl.res.in/content/sustained-release-insect-repellent-microcapsules-using-modified-cellulose-nanofibers-mcnf02072nas a2200265 4500008004100000022001400041245010100055210006900156260000800225300001100233490000800244520120200252653002301454653002501477653001801502653002301520653001901543653001801562100002401580700001701604700001901621700001701640700003101657856011801688 2023 eng d a0927-775700aDouble encapsulation of liquid active compounds using nanoclay reinforced polyurea microcapsules0 aDouble encapsulation of liquid active compounds using nanoclay r cDEC a1325470 v6793 a

In recent years, there has been growing interest in the double encapsulation of drugs, agrochemicals, and fragrances, aiming to achieve the highest encapsulation efficiency and preserve the activity of the encapsulated core over an extended duration. However, when active ingredients in liquid form are double encapsulated, preventing the rupture of primary microcapsules during the second encapsulation process and the leakage of the encapsulated core are major challenges. This report describes a method that utilizes polyurea and starch for successful double encapsulation of dimethyl phthalate (DMP), a liquid insect-repellent, as a model active component. We demonstrate that the incorporation of 3 wt% montmorillonite (MMT) nanoclay strengthens the polyurea wall of the primary microcapsule and prevents its rupture during double encapsulation with starch. This process facilitates the uniform distribution of polyurea microcapsules within the starch matrix and significantly improves the mechanical integrity of the nanocomposite microcapsules embedded in starch. The double-encapsulated system developed in this study significantly reduces the release rate of encapsulated DMP.

10aControlled release10aDouble encapsulation10aMicrocapsules10aMicroencapsulation10aNanocomposites10aStarch matrix1 aAher, Yogeshwar, P.1 aTorris, Arun1 aAdhikari, Benu1 aShukla, Ravi1 aShanmuganathan, Kadhiravan uhttp://library.ncl.res.in/content/double-encapsulation-liquid-active-compounds-using-nanoclay-reinforced-polyurea