01326nas a2200157   4500008004100000022001400041245009900055210006900154260009900223300001200322490000700334520064500341100002400986700003201010856012601042       2009                        eng d  a1359-644600aTraditional medicine-inspired approaches to drug discovery: can ayurveda show the way forward?0 aTraditional medicineinspired approaches to drug discovery can ay  aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLANDbELSEVIER SCI LTDcAUG  a804-8110 v143 a<p>Drug discovery strategies based on natural products and traditional medicines are re-emerging as attractive options. We suggest that drug discovery and development need not always be confined to new molecular entities. Rationally designed, carefully standardized, synergistic traditional herbal formulations and botanical drug products with robust scientific evidence can also be alternatives. A reverse pharmacology approach, inspired by traditional medicine and Ayurveda, can offer a smart strategy for new drug candidates to facilitate discovery process and also for the development of rational synergistic botanical formulations.</p>1 aPatwardhan, Bhushan1 aMashelkar, Raghunath, Anant  uhttp://library.ncl.res.in/content/traditional-medicine-inspired-approaches-drug-discovery-can-ayurveda-show-way-forward-001930nas a2200205   4500008004100000245016400041210006900205260000800274300001000282490000700292520115900299100001701458700001801475700002501493700001701518700002001535700001901555700002401574856012601598       2020                        eng d00aSimultaneous determination of anthraquinone, flavonoids, and phenolic antidiabetic compounds from cassia auriculata seeds by validated UHPLC based MS/MS method0 aSimultaneous determination of anthraquinone flavonoids and pheno  cDEC  a82-890 v113 aA systematic isolation and characterization study for Cassia auriculata (CA) seeds resulted in identifying antidiabetic compounds 1,3,8-trihydroxyanthraquinone and quercetin, quercetin-3-O-rutinoside, gallic acid, caffeic acid, ferulic acid, and ellagic acid. The ultra-high-performance liquid chromatography based triple quadrupole mass spectrometry methodology was developed and validated for simultaneous identification and confirmation of these compounds from CA seeds. Multiple reaction monitoring (MRM) based quantification method was developed with MRM optimizer software for MS1 and MS2 mass analysis. The method was optimized on precursor ions and product ions with the ion ratio of each compound. The calibration curves of seven bioactive analytes showed excellent linearity (r2 ≥ 0.99). The quantitation results found precise (RSD, < 10 %) with good recoveries (84.58 to 101.42%). The matrix effect and extraction recoveries were found within the range (91.66 to 102.11%) for the CA seeds. This is the first MS/MS-based methodology applied to quantifying seven antidiabetic compounds in CA seeds and its extract for quality control purposes.1 aGirme, Aboli1 aSaste, Ganesh1 aChinchansure, Ashish1 aJoshi, Swati1 aKunkulol, Rahul1 aHingorani, Lal1 aPatwardhan, Bhushan  uhttp://library.ncl.res.in/content/simultaneous-determination-anthraquinone-flavonoids-and-phenolic-antidiabetic-compounds