02583nas a2200217 4500008004100000022001400041245013200055210006900187260008700256300001200343490000700355520170600362653004002068653001102108653002402119653001502143100002302158700002602181700002802207856013002235 2013 eng d a0954-008300aCyanate ester resins containing pentadecyl-substituted cyclohexyl moiety: synthesis, curing and structure-property relationship0 aCyanate ester resins containing pentadecylsubstituted cyclohexyl a1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLANDbSAGE PUBLICATIONS LTDcMAY a278-2860 v253 a

Cyanate ester (CE) monomers containing pentadecyl-substituted cyclohexyl moieties such as 1,1-bis(4-cyanatophenyl) 3-pentadecylcyclohexane and 1,1-bis(4-cyanatophenyl) cyclohexane were synthesized and characterized by Fourier transform infrared, proton-nuclear magnetic resonance (H-1-NMR) and carbon-nuclear magnetic resonance (C-13-NMR) spectroscopies as well as differential scanning calorimetry (DSC). Both 1,1-bis(4-cyanatophenyl) 3-pentadecylcyclohexane and 1,1-bis(4-cyanatophenyl) cyclohexane exhibited better processability coupled with lower melting points, lower cure onset with broad cure exotherm than the commercially available CE monomer, namely, 2,2-bis(4-cyanatophenyl) propane. Glass transition temperatures of cured 2,2-bis(4-cyanatophenyl) propane, 1,1-bis(4-cyanatophenyl) cyclohexane and 1,1-bis(4-cyanatophenyl) 3-pentadecylcyclohexane were observed to be 288 degrees C, 302 degrees C and 160 degrees C, respectively. Cured 1,1-bis(4-cyanatophenyl) cyclohexane displayed higher storage modulus (1.59 x 10(9) Pa) than 1,1-bis(4-cyanatophenyl) 3-pentadecylcyclohexane (1.07 x 10(9) Pa) and 2,2-bis(4-cyanatophenyl) propane (1.39 x 10(9) Pa). The order of thermal stability of cured polycyanurates was found to be 2,2-bis(4-cyanatophenyl) propane > 1,1-bis(4-cyanatophenyl) cyclohexane > 1,1-bis(4-cyanato phenyl) 3-pentadecylcyclohexane. The moisture absorption of cured resins derived from 1,1-bis(4-cyanatophenyl) 3-pentadecyl cyclohexane and 1,1-bis(4-cynatophenyl) cyclohexane was found to be lower than that of 2,2-bis(4-cynatophenyl) propane implying the role of pentadecyl substituent and/or cyclohexyl moiety in imparting hydrophobicity to the polycyanurates.

10a(pentadecyl substituted) cyclohexyl10acuring10acyanate ester resin10athermosets1 aKulkarni, Arun, D.1 aTawade, Bhausaheb, V.1 aWadgaonkar, Prakash, P. uhttp://library.ncl.res.in/content/cyanate-ester-resins-containing-pentadecyl-substituted-cyclohexyl-moiety-synthesis-curing-001389nas a2200193 4500008004100000022001400041245018500055210006900240260011000309300001600419490000600435520051000441100002300951700002200974700002000996700002701016700002801043856012401071 2014 eng d a2046-206900aCellulose supported cuprous iodide nanoparticles (Cell-CuI NPs): a new heterogeneous and recyclable catalyst for the one pot synthesis of 1,4-disubstituted-1,2,3-triazoles in water0 aCellulose supported cuprous iodide nanoparticles CellCuI NPs a n aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a42137-421460 v43 a

Cellulose supported cuprous iodide nanoparticles (Cell-CuI NPs) have been demonstrated for the first time as an efficient heterogeneous catalyst in the click synthesis of 1,4-disubstituted 1,2,3-triazoles by a one-pot three component reaction between aralkyl/alkyl bromides, alkynes and sodium azide in water. The catalyst has been characterized by XRD, HRTEM, SEM, ICP-AES, EDS as well as IR spectroscopy. It was found to be reusable for five consecutive runs without significant loss of activity.

1 aChavan, Pramod, V.1 aPandit, Kapil, S.1 aDesai, Uday, V.1 aKulkarni, Makarand, A.1 aWadgaonkar, Prakash, P. uhttp://library.ncl.res.in/content/cellulose-supported-cuprous-iodide-nanoparticles-cell-cui-nps-new-heterogeneous-and-001330nas a2200193 4500008004100000022001400041245011700055210006900172260011000241300001600351490000600367520051600373100002500889700002200914700002300936700002000959700002800979856012901007 2015 eng d a2046-206900aCobalt ferrite nanoparticles: a magnetically separable and reusable catalyst for Petasis-Borono-Mannich reaction0 aCobalt ferrite nanoparticles a magnetically separable and reusab aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcAUG a70586-705940 v53 a

Magnetically separable cobalt ferrite nanoparticles (CoFe2O4, NPS) have been demonstrated for the first time as an efficient catalyst in Petasis-Borono-Mannich (PBM) reaction between salicylaldehydes, sec. amines and aryl boronic acids to furnish alkylaminophenols in high yields. Relatively shorter reaction times, easy purification of the products and reusability of the catalyst for five consecutive runs without appreciable loss in it's activity are the noteworthy features of the developed protocol.

1 aKulkarni, Aparna, M.1 aPandit, Kapil, S.1 aChavan, Pramod, V.1 aDesai, Uday, V.1 aWadgaonkar, Prakash, P. uhttp://library.ncl.res.in/content/cobalt-ferrite-nanoparticles-magnetically-separable-and-reusable-catalyst-petasis-borono-003021nas a2200265 4500008004100000022001400041245021600055210006900271260006700340300001200407490000700419520185700426653002602283653003702309653007102346653001602417653004102433653002502474653003202499653002002531100002202551700002602573700002802599856012802627 2016 eng d a0887-624X00aConvenient synthesis of alpha,alpha `- homo- and alpha,alpha `-hetero-bifunctionalized poly(epsilon-caprolactone)s by ring opening polymerization: the potentially valuable precursors for miktoarm star copolymers0 aConvenient synthesis of alphaalpha homo and alphaalpha heterobif a111 RIVER ST, HOBOKEN 07030-5774, NJ USAbWILEY-BLACKWELLcMAR a844-8600 v543 a

Two new ring opening polymerization (ROP) initiators, namely, (3-allyl-2-(allyloxy)phenyl)methanol and (3-allyl-2-(prop-2-yn-1-yloxy)phenyl)methanol each containing two reactive functionalities viz. allyl, allyloxy and allyl, propargyloxy, respectively, were synthesized from 3-allylsalicyaldehyde as a starting material. Well defined -allyl, -allyloxy and -allyl, -propargyloxy bifunctionalized poly(epsilon-caprolactone)s with molecular weights in the range 4200-9500 and 3600-10,900 g/mol and molecular weight distributions in the range 1.16-1.18 and 1.15-1.16, respectively, were synthesized by ROP of epsilon-caprolactone employing these initiators. The presence of -allyl, -allyloxy and -allyl, -propargyloxy functionalities on poly(epsilon-caprolactone)s was confirmed by FT-IR, H-1, C-13 NMR spectroscopy, and MALDI-TOF analysis. The kinetic study of ROP of epsilon-caprolactone with both the initiators revealed the pseudo first order kinetics with respect to epsilon-caprolactone consumption and controlled behavior of polymerization reactions. The usefulness of -allyl, -allyloxy functionalities on poly(epsilon-caprolactone) was demonstrated by performing the thiol-ene reaction with poly(ethylene glycol) thiol to obtain (mPEG)(2)-PCL miktoarm star copolymer. -Allyl, -propargyloxy functionalities on poly(epsilon-caprolactone) were utilized in orthogonal reactions i.e copper catalyzed alkyne-azide click (CuAAC) with azido functionalized poly(N-isopropylacrylamide) followed by thiol-ene reaction with poly(ethylene glycol) thiol to synthesize PCL-PNIPAAm-mPEG miktoarm star terpolymer. The preliminary characterization of A(2)B and ABC miktoarm star copolymers was carried out by H-1 NMR spectroscopy and gel permeation chromatography (GPC). (c) 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 844-860

10a3-allylsalicyaldehyde10aalpha `-allyloxy and alpha-allyl10aalpha `-propargyloxy bifunctionalized poly (epsilon-caprolactone)s10aalpha-allyl10aatom transfer radical polymerization10aorthogonal reactions10aring-opening polymerization10astar copolymers1 aPatil, Sachin, S.1 aTawade, Bhausaheb, V.1 aWadgaonkar, Prakash, P. uhttp://library.ncl.res.in/content/convenient-synthesis-alphaalpha-homo-and-alphaalpha-hetero-bifunctionalized-polyepsilon-000767nas a2200193 4500008004100000245016500041210006900206260000800275300001400283490000700297100002300304700002200327700002000349700002800369700001900397700002000416700001900436856011800455 2017 eng d00aClick-chemistry-based multicomponent condensation approach for design and synthesis of spirochromene-tethered 1,2,3-triazoles as potential antitubercular agents0 aClickchemistrybased multicomponent condensation approach for des cOCT a5675-56900 v431 aChavan, Pramod, V.1 aPandit, Kapil, S.1 aDesai, Uday, V.1 aWadgaonkar, Prakash, P.1 aNawale, Laxman1 aBhansali, Sujit1 aSarkar, Dhiman uhttp://library.ncl.res.in/content/click-chemistry-based-multicomponent-condensation-approach-design-and-synthesis02530nas a2200325 4500008004100000022001400041245014900055210006900204260000800273300001200281490000700293520147400300653000601774653000601780653003801786653001501824653002001839653002001859653001701879653002801896653002901924100000501953700000501958700002801963700002301991700002102014700002002035700001902055856013002074 2019 eng d a0045-206800aClick chemistry based multicomponent approach in the synthesis of spirochromenocarbazole tethered 1,2,3-triazoles as potential anticancer agents0 aClick chemistry based multicomponent approach in the synthesis o cAPR a475-4860 v853 a

A series of spirochromenocarbazole tethered 1,2,3-triazoles were synthesized via click chemistry based one-pot, five component reaction between N-propargyl isatins, malononitrile, 4-hydroxycarbazole, aralkyl halides and sodium azide using cellulose supported CuI nanoparticles (Cell-CuI NPs) as the heterogeneous catalyst. Antiproliferative activity of all the synthesized compounds was investigated against panel of cancer cell lines such as MCF-7, MDA-MB-231, HeLa, PANG-1, A-549, and THP-1. Many of the synthesized compounds exhibited good anti-proliferative activity against breast (MCF-7 and MDA-MB-231) and cervical (HeLa) cancer cells with IC50 values less than 10 mu M. In case of MCF-7 cells, among the nine compounds that showed good anti-proliferative activity, compounds 6f and 6j were found to be highly potent (IC50 , = 2.13 mu M and 4.80 mu M, respectively). In case of MDA-MB-231, three compounds (6k, 6j and 6s) showed antiproliferative activity amongst which 6k was the most potent one (IC50 = 3.78 mu M). On the other hand, in cervical cancer HeLa cells, compounds 6b, 6g, 6s and 6u showed excellent antiproliferative activity (IC50 = 4.05, 3.54, 3.83, 3.35 mu M, respectively). All the compounds were found to be nontoxic to the human umbilical vein endothelial cells (HUVECs). AO and EtBr staining and fluorescence microscopy studies of the active compounds (IC50 < 5 mu M) suggested that these compounds induce cell death by apoptosis.

10a110a210a3-Triazolylspirochromenocarbazole10aAnticancer10aApoptotic assay10aClick chemistry10aCytotoxicity10aheterogeneous catalysis10aMulticomponent synthesis1 a1 a1 aWadgaonkar, Prakash, P.1 aTapase, Savita, R.1 aKodam, Kisan, M.1 aChoudhari, Amit1 aSarkar, Dhiman uhttp://library.ncl.res.in/content/click-chemistry-based-multicomponent-approach-synthesis-spirochromenocarbazole-tethered-12302476nas a2200301 4500008004100000022001400041245012900055210006900184260000800253300001100261490000800272520146800280653002901748653001301777653001801790653001601808653001401824653001401838653002301852100002201875700002301897700002601920700002301946700002501969700002601994700002802020856012602048 2024 eng d a0014-305700aCatechol- and phenolic hydroxyl-functionalized partially bio-based (Co) poly(ether sulfone)s with multifarious applicability0 aCatechol and phenolic hydroxylfunctionalized partially biobased  cNOV a1134840 v2203 a

A largely bio-based new bisphenol, namely, 4,4 `-((3,4-dimethoxyphenyl)methylene)-bis(2-methoxyphenol) (DMBM) was synthesized by the reaction of veratraldehyde with guaiacol. DMBM and varying compositions of DMBM and bisphenol A were polycondensed with bis(4-fluorophenyl) sulfone to afford reasonably high molecular weight film-forming (co)poly(ether sulfone)s possessing built-in methoxyl groups. T10 and Tg values of (co)poly(ether sulfone)s were in the range 382-478 degrees C and 171-187 degrees C, respectively indicating their good thermal stability and the values decreased with increase in mol % incorporation of DMBM. The methoxyl groups present in (co)poly (ether sulfone)s were quantitatively de-blocked resulting in the formation of corresponding polymers possessing pendant catechol moieties and free phenolic hydroxyl groups. By virtue of the presence of these functional moieties, (co)poly(ether sulfone)s are amenable for post-polymerization modifications, and exhibited properties such as antimicrobial (23 mm against Staphylococcus aureus and 18 mm against Escherichia coli)), antioxidant (72 % scavenger of free radicals), adhesive (2.24 MPa lap shear strength) and usefulness as redox-active agent in zinc-ion batteries. These data underscore the promise of DMBM as a versatile monomer of wider utility for the synthesis of functional (co)poly(ether sulfone)s capable of expanding their applicability beyond the conventional ones.

10a(Co)poly(ether sulfone)s10aadhesive10aAntimicrobial10aAntioxidant10abio-based10abisphenol10aZinc-ion batteries1 aWale, Apparav, K.1 aJagtap, Ashish, S.1 aPandey, Priyanshi, R.1 aDastager, Syed, G.1 aShelke, Manjusha, V.1 aAmbade, Ashootosh, V.1 aWadgaonkar, Prakash, P. uhttp://library.ncl.res.in/content/catechol-and-phenolic-hydroxyl-functionalized-partially-bio-based-co-polyether-sulfones