01539nas a2200157 4500008004100000245018200041210006900223260000800292300002400300520083000324100002401154700002101178700002401199700002801223856013001251 2010 eng d00aSynthesis and characterization of novel value added biodegradable poly(aleuritic acid) from renewable resources(shellac) and invertible amphiphilic behaviors in various solvents0 aSynthesis and characterization of novel value added biodegradabl cNOV aArticle Number: 1313 a

A novel biodegradable polymer poly(aleuritic acid) (PAA) ( M̄w 120,000) was prepared from aleuritic acid, which was obtained from renewable resources (Lac) by using tin catalyst. Aleuritic acid (AL) was protected at 9, 10 position by dimethoxy propane. The protected AL (Pro.AL) was further polymerized to obtain linear protected polyaleuritic acid (PAL) by dehydropolycondensation. Effects of various kinetic and thermodynamic parameters were studied. After polymerization, the deprotection of PAL was carried out. The synthesized PAL and PAA were characterized by using various techniques such as FT-IR, LC-MS, SEC, NMR (1H and 13C), 13C CP/MAS (Cross Polarization / Magic Angle Spinning) of solid PAA, DSC, SEM and TEM etc. The micelle and inverted micelle -structure in polar and nonpolar solvents are highlighted

1 aPandey, Asutosh, K.1 aNande, Smita, S.1 aSelukar, Balaji, S.1 aGarnaik, Baijayantimala uhttp://library.ncl.res.in/content/synthesis-and-characterization-novel-value-added-biodegradable-polyaleuritic-acid-renewable02721nas a2200301 4500008004100000022001400041245012500055210006900180260008400249300001400333490000600347520162800353653002701981653004202008653001102050653001702061653002002078653000802098653002402106653001902130100002202149700002502171700002302196700002402219700002102243700002802264856012702292 2014 eng d a1178-201300aSynthesis of ciprofloxacin-conjugated poly(L-lactic acid) polymer for nanofiber fabrication and antibacterial evaluation0 aSynthesis of ciprofloxacinconjugated polyLlactic acid polymer fo aPO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALANDbDOVE MEDICAL PRESS LTDcMAR a1463-14770 v93 a

Ciprofloxacin was conjugated with polylactide (PLA) via the secondary amine group of the piperazine ring using PLA and 7-(4-(2-Chloroacetyl) piperazin-1-yl)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic acid. Zinc prolinate, a biocompatible catalyst was synthesized, characterized, and used in ring opening polymerization of L-lactide. Five different kinds of OH-terminated poly(L-lactide) (two-, three-, four-, six-arm, star-shaped) homopolymers were synthesized by ring opening polymerization of L-lactide in the presence of dodecanol, glycerol, pentaerythritol, dipentaerythritol as initiator and zinc prolinate as a catalyst. The structures of the polymers and conjugates were thoroughly characterized by means of gel permeation chromatography, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, and nuclear magnetic resonance spectroscopy. PLA (molecular weight = 100,000) and ciprofloxacin conjugated PLA were used for fabrication of nonwoven nanofiber mat (diameter ranges; 150-400 nm) having pore size (62-102 nm) using electrospinning. The microbiological assessment shows that the release of ciprofloxacin possesses antimicrobial activity. The drug-release behavior of the mat was studied to reveal potential application as a drug delivery system. The result shows that the ciprofloxacin release rates of the PLA conjugate nonwoven nanofiber mat could be controlled by the drug loading content and the release medium. The development of a biodegradable ciprofloxacin system, based on nonwoven nanofiber mat, should be of great interest in drug delivery systems.

10aantibacterial activity10aciprofloxacin conjugated polylactides10aCP-PLA10adrug release10aelectrospinning10aMDR10anonwoven nanofibers10azinc prolinate1 aParwe, Sharad, P.1 aChaudhari, Priti, N.1 aMohite, Kavita, K.1 aSelukar, Balaji, S.1 aNande, Smita, S.1 aGarnaik, Baijayantimala uhttp://library.ncl.res.in/content/synthesis-ciprofloxacin-conjugated-polyl-lactic-acid-polymer-nanofiber-fabrication-and-002070nas a2200145 4500008004100000245012800041210006900169260000800238300001600246490000700262520148300269100002101752700002801773856012301801 2017 eng d00aOrgano-clay hybrid hydrophobic spherical styrene divinylbenzene crosslink beads for high-performance carbon dioxide capture0 aOrganoclay hybrid hydrophobic spherical styrene divinylbenzene c cOCT a12326-123350 v413 aHerein, we report carbon dioxide sorption properties for a series of cloisite-containing crosslink hybrid materials. These materials were prepared by copolymerizing styrene divinylbenzene in the presence of various cloisites through suspension polymerization in one pot to obtain uniform spherical beads. The homopolymer formed during the polymerization was separated from the hybrid. The synthetic strategy is user-friendly and cost-effective, can be easily scaled up for production, and provides materials with good mechanical strength. The microporous polymeric spheres containing organo-clay (cloisite) showed a high surface area of similar to 80-370 m(2) g(-1) with a microsphere size of similar to 4.4 nm. These polymeric spherical beads were hydrophobic and thermally stable up to 300 degrees C. They showed high carbon dioxide uptake (up to similar to 20.7 wt% at 273 K/1.0 bar) due to lone pair electrons of heteroatom, which might sharpen the interaction between the CO2 molecules and polymeric matrices through local dipole/quadruple interaction. Moreover, they showed good capacity to store CO2 due to the presence of quaternary ammonium groups in the clay and a large amount of narrow microspheres (B4.4 nm). The equilibrium CO2 capacities of the prepared spherical beads were due to the interaction between quaternary ammonium and the negatively charged oxygen atoms of CO2, and these spherical beads showed potential applications in gas adsorption and separation.1 aNande, Smita, S.1 aGarnaik, Baijayantimala uhttp://library.ncl.res.in/content/organo-clay-hybrid-hydrophobic-spherical-styrene-divinylbenzene-crosslink-beads-high02546nas a2200193 4500008004100000022001400041245012200055210006900177260000800246300001300254490000700267520184000274100002602114700002102140700002102161700001802182700002802200856012402228 2018 eng d a0928-493100a Fast dissolving moxifloxacin hydrochloride antibiotic drug from electrospun Eudragit L-100 nonwoven nanofibrous mats0 aFast dissolving moxifloxacin hydrochloride antibiotic drug from  cNOV a 526-5390 v923 aAntimicrobial electrospun nonwoven Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) were fabricated for fast dissolving drug delivery systems (DDSs) associated with wound infection. The morphological characterization of nanofibers using ESEM revealed that the average diameter of non-woven nanofibrous mats ranges 200-600 nm. The nanofiber showed cylindrical shape with crack on the surface. Differential scanning calorimetric (DSC) and Wide Angle X-ray diffraction (WAXRD) demonstrate that the drug exists in an amorphous state in the nanofibers. Nanofibrous mats were also tested for mechanical strength, contact angle, swelling assay, haemolysis and disintegration test. In vitro disintegration tests demonstrated that the dissolution of Eudragit L-100 fiber mats was within 25 s which was higher compared to the pure drug. The Eudragit nanofibers showed pH-dependent drug release profiles, with slow release at pH 1.2 and burst release (around 30 s) at pH 6.8. The in-vitro quantitative and qualitative antimicrobial assay showed that the developed Eudragit L-100 nanofibrous mats with MOX-HCL concentration of 1%, 5% and 15 wt% exhibited antibacterial activities against both gram positive (Staphylococcus aureus) and gram negative (Escherichia coli) bacteria. The invitro cytotoxicity assay using mouse fibroblast NIH/3T3 cells demonstrated significant biocompatibility of nanofiber mats. As per the results of biological evaluation, Eudragit L-100 nanofibrous mats with 1wt% MOX-HCL could be a suitable substrate for biomedical applications. Eudragit L-100 nanofibrous mats containing Moxifloxacin hydrochloride (MOX-HCL) showed immediate DDSs for localized drug release in the wound infection at slightly acidic or alkaline conditions where faster drug release rate is required for wound healing.1 aGiram, Prabhanjan, S.1 aShitole, Ajinkya1 aNande, Smita, S.1 aSharma, Neeti1 aGarnaik, Baijayantimala uhttp://library.ncl.res.in/content/fast-dissolving-moxifloxacin-hydrochloride-antibiotic-drug-electrospun-eudragit-l-10003397nas a2200145 4500008004100000245009300041210007100134260000800205300001400213490000600227520284300233100002103076700002803097856012603125 2025 eng d00aSynthesis of amine-loaded styrene–divinylbenzene copolymers for carbon dioxide capture0 aSynthesis of amineloaded styrene–divinylbenzene copolymers for c cNOV a126–1410 v63 a

Carbon dioxide capture by various tertiary amines and quaternary bulky ammonium salts loaded in cross-link hybrid polymer (styrene–divinylbenzene copolymer) was explored. These polymeric materials were prepared by suspension polymerization in one pot using monomers like styrene and divinylbenzene in the presence of various amines to obtain uniform spherical beads. The homopolymer was separated from the cross-link hybrid product by Soxhlet extraction. The synthetic strategy is cost-effective and user-friendly, can be easily scaled up for production, and confirms better mechanical strength. The amine-loaded microporous polymeric spheres displayed a microsphere size of 5.2 nm with a high surface area of ∼25–310 m2 g–1. These hydrophobic polymeric spherical beads were thermally stable up to 200 °C. The quaternary ammonium group salt (bulky)-loaded beads presented high carbon dioxide uptake (up to ∼16.4 wt % at 273 K /1.0 bar) due to the presence of lone pair electrons of the heteroatom, which might improve the interaction between the polymeric matrices and CO2 molecules through local-dipole/quadruple interactions. In the case of tertiary amines, a high uptake of carbon dioxide (up to ∼15.2 wt % at 273 K /1.0 bar) was achieved, which is attributed to the formation of bicarbonate, as there may be the possibility of the presence of little moisture in the system, which facilitates the interaction. These hybrid polymeric materials exhibited a better storage capacity of CO2.

1 aNande, Smita, S.1 aGarnaik, Baijayantimala uhttp://library.ncl.res.in/content/synthesis-amine-loaded-styrene%E2%80%93divinylbenzene-copolymers-carbon-dioxide-capture