01084nas a2200349 4500008004100000245009600041210006900137260000900206490000700215653001200222653002300234653001200257653002400269653001600293100001700309700001600326700002700342700002000369700002200389700001800411700001800429700001700447700001900464700001700483700001900500700002200519700001800541700002000559700001900579700001800598856011800616 2024 eng d00aBiocatalysis enables the scalable conversion of biobased furans into various furfurylamines0 aBiocatalysis enables the scalable conversion of biobased furans  cJUL 0 v1510aBiomass10aOMEGA-TRANSAMINASE10aOXIDASE10aReductive amination10aSPECIFICITY1 aGiri, Pritam1 aLim, Seonga1 aKhobragade, Taresh, P.1 aPagar, Amol, D.1 aPatil, Mahesh, D.1 aSarak, Sharad1 aJeon, Hyunwoo1 aJoo, Sangwoo1 aGoh, Younghwan1 aJung, Seohee1 aJang, Yu-Jeong1 aChoi, Seung, Beom1 aKim, Ye, Chan1 aKang, Taek, Jin1 aHeo, Yong-Seok1 aYun, Hyungdon uhttp://library.ncl.res.in/content/biocatalysis-enables-scalable-conversion-biobased-furans-various-furfurylamines03678nas a2200205 4500008004100000245009500041210007100136260000800207300001400215490000600229520297300235100001903208700001903227700002203246700002403268700001703292700001703309700002103326856012503347 2024 eng d00aphotoarchitectonic hydrogel for synergistic in vitro chemo–phototherapy of breast cancer0 aphotoarchitectonic hydrogel for synergistic in vitro chemo–photo cJAN a1903-19160 v53 a

Currently, combinatorial therapy has evoked interest in cancer treatment, and may promote achieving a synergistic effect using cancer medicines. Laser-assisted and pH-responsive therapies have attracted significant attention, and their combination leads to high efficiency cancer treatment. Herein, we developed a chemo–phototherapeutic hydrogel comprised of doxorubicin (DOX, a chemotherapeutic drug) and zinc phthalocyanine (ZnPc, a phototherapeutic drug) for combinatorial and synergistic treatment of breast cancer. Firstly, we have developed carbon dots (CDs, size of ∼5 nm) utilizing lignin and folic acid as biocompatible sources. Then doxorubicin was loaded on the surface of the carbon dots via conjugation (DOX@CDs). Later on, zinc phthalocyanine and acrylic acid derivatives were utilized to develop a laser-responsive hydrogel (ZnPc-PP H). Afterward, doxorubicin-conjugated carbon dots were incorporated into the photoarchitectonic hydrogel to develop a chemo–phototherapeutic drug-loaded hydrogel (DOX@CDs–ZnPc-PP H). Subsequently, the in vitro pH-triggering experiments demonstrated that the hydrogel loaded with both DOX and ZnPc could release the drugs in an acidic environment. Interestingly, in vitro assays confirmed that DOX@CDs–ZnPc-PP H could effectively target breast cancer cells (MCF-7). Furthermore, the developed chemo–phototherapeutic hydrogel exhibited non-cytotoxic behavior. Owing to laser assisted reactive oxygen species generation from ZnPc present in the hydrogel, the growth of MCF-7 cells was significantly lowered. In conclusion, all experimental outcomes indicate that the photoarchitectonic hydrogel has the potential to be applied in synergistic chemo- and photodynamic therapy of cancer.

1 aPaul, Shatabdi1 aYadav, Binduma1 aPatil, Mahesh, D.1 aPujari, Anil, Kumar1 aSingh, Umesh1 aRishi, Vikas1 aBhaumik, Jayeeta uhttp://library.ncl.res.in/content/photoarchitectonic-hydrogel-synergistic-vitro-chemo%E2%80%93phototherapy-breast-cancer