01731nas a2200193   4500008004100000022001400041245011300055210006900168260000900237300001600246490000700262520102600269100001601295700002201311700002701333700001901360700003001379856012801409       2023                        eng d  a0020-166900aSquarate-tethered enantiomeric Imido-Pd(II) cages for recognition and separation of chiral organic molecules0 aSquaratetethered enantiomeric ImidoPdII cages for recognition an  cNOV   a19375-193810 v623 a<p>
	Chiral coordination cages have emerged as an efficient platform for enantioselective processes via host-guest interactions. Here, we report an enantiomeric pair of tetrahedral cages of formula [(Pd-3[PO(N(*CH(CH3)Ph)(3)])(4)(C4O4)(6)] supported by chiral tris(imido)phosphate trianions and squarate (C4O4)(2-) linkers. These cages exhibit unusual coordination isomerism for Pd(II)-linker bonds compared with the other Pd(II) cages of this family. Further, they were employed for the recognition and separation of small chiral molecules containing various functionalities. High enantioselectivities of 67 and 41 were found in the case of R-4-hydroxydihydrofuran-2(3H)-one and S-epichlorohydrin, recognized by the R-isomer of the cage. Chiral separation studies showed remarkable enantiomeric excess values of 93 and 85% for S-epichlorohydrin and R-4-benzyl-2-oxazolidinone, respectively, from their racemic mixtures. These studies showcase the potential of coordination cages for enantioselective applications.</p>
1 aJose, Cavya1 aSarkar, Meghamala1 aRajasekar, Prabhakaran1 aTewari, Tanuja1 aBoomishankar, Ramamoorthy  uhttp://library.ncl.res.in/content/squarate-tethered-enantiomeric-imido-pdii-cages-recognition-and-separation-chiral-organic02235nas a2200181   4500008004100000022001400041245012100055210006900176260000800245300001600253490000700269520155800276100001601834700002201850700002401872700003001896856012701926       2025                        eng d  a0020-166900aPortal substituent modulations in chiral imido-Pd(II) cages for the enhanced separation of styrene oxide enantiomers0 aPortal substituent modulations in chiral imidoPdII cages for the  cMAY  a10313-103190 v643 a<p>
	Sensing and separation of enantiomers are crucial for the synthesis of biologically relevant compounds as well as for applications in catalysis and pharmaceutical development. Chiral coordination cages have gained significant attention as effective platforms for enantioselective processes through their well-defined, tunable cavities that facilitate host-guest interactions. In this study, we systematically explored the enantioselective binding and separation properties of two tetrahedral Pd(II) cages, 1-R and 2-R, with the molecular formula [Pd3(PO[N(RCH(CH3)Ph)3])4(C6O4X2)6] (X = Cl for 1-R, and X = F for 2-R). Their enantioselective abilities were investigated for small chiral molecules with diverse functional groups. Notably, the 2-R cage demonstrated a high enantioselectivity value of 88 for R-styrene oxide. Chiral separation experiments further revealed impressive enantiomeric excess (ee) values of 98% for R-styrene oxide from their racemic mixtures upon desorption from 2-R. The enhanced selectivity and separation efficiency were attributed to an optimal guest-to-cavity fit and the presence of multiple interaction sites within the host framework. Remarkably, portal substituent modulation in 2-R led to a 16-fold enhancement in enantioselective separation efficiency compared to 1-R, primarily due to improved portal dimensions, tighter molecular packing, and increased hydrogen bonding interactions. These findings highlight the potential of neutral chiral coordination cages for various enantioselective applications.</p>
1 aJose, Cavya1 aSarkar, Abhradeep1 aKhopade, Kishor, V.1 aBoomishankar, Ramamoorthy  uhttp://library.ncl.res.in/content/portal-substituent-modulations-chiral-imido-pdii-cages-enhanced-separation-styrene-oxide