01257nas a2200169   4500008004100000022001400041245009100055210006900146260000800215300001600223490000700239520065800246100002200904700002600926700002000952856011500972       2019                        eng d  a0022-326300aNickel-catalyzed C(2)-H arylation of indoles with aryl chlorides under neat conditions0 aNickelcatalyzed C2H arylation of indoles with aryl chlorides und  cOCT  a12800-128080 v843 a<p>Nickel-catalyzed regioselective C(2)-H arylation of indoles and pyrroles with aryl chlorides is achieved under neat conditions. This method allows the efficient coupling of diverse aryl chlorides employing a user-friendly and inexpensive Ni(OAc)(2)/dppf catalyst system at 80 degrees C. Numerous functionalities, such as halides, alkyl ether, fluoro-alkyl ether, and thioether, and substituted amines, including heteroarenes like benzothiazolyl, pyrrolyl, indolyl, and carbazolyl, are well tolerated under the reaction conditions. The preliminary mechanistic study highlights a single-electron transfer (SET) pathway for the arylation reaction.</p>
1 aPandey, Dilip, K.1 aVijaykumar, Muniyappa1 aPunji, Benudhar  uhttp://library.ncl.res.in/content/nickel-catalyzed-c2-h-arylation-indoles-aryl-chlorides-under-neat-conditions01465nas a2200193   4500008004100000022001400041245011700055210006900172260000800241300001400249490000700263520077500270100002201045700002801067700001401095700001801109700002001127856012401147       2019                        eng d  a2041-652000aNickel-catalyzed C-H alkylation of indoles with unactivated alkyl chlorides: evidence of a Ni(i)/Ni(iii) pathway0 aNickelcatalyzed CH alkylation of indoles with unactivated alkyl   cNOV  a9493-95000 v103 a<p>A mild and efficient nickel-catalyzed method for the coupling of unactivated primary and secondary alkyl chlorides with the C-H bond of indoles and pyrroles is described which demonstrates a high level of chemo and regioselectivity. The reaction tolerates numerous functionalities, such as halide, alkenyl, alkynyl, ether, thioether, furanyl, pyrrolyl, indolyl and carbazolyl groups including acyclic and cyclic alkyls under the reaction conditions. Mechanistic investigation highlights that the alkylation proceeds through a single-electron transfer (SET) process with Ni(i)-species being the active catalyst. Overall, the alkylation follows a Ni(i)/Ni(iii) pathway involving the rate-influencing two-step single-electron oxidative addition of alkyl chlorides.</p>
1 aPandey, Dilip, K.1 aAnkade, Shidheshwar, B.1 aAli, Abad1 aVinod, C., P.1 aPunji, Benudhar  uhttp://library.ncl.res.in/content/nickel-catalyzed-c-h-alkylation-indoles-unactivated-alkyl-chlorides-evidence-niiniiii