01990nas a2200217   4500008004100000022001400041245006100055210006100116260000800177300001100185490000800196520135900204653001401563653001201577653001401589653002101603653002301624100001701647700002401664856008401688       2022                        eng d  a0022-328X00aHydroformylation of olefins by metals other than rhodium0 aHydroformylation of olefins by metals other than rhodium  cFEB  a1222310 v9603 aMetal catalyzed hydroformylation of alkenes is an atom economic transformation to construct useful aldehydes and is being industrially practiced for decades. The most commonly used metal for this transformation on an industrial scale is rhodium. However, rhodium is rare, costly, and is depleting at a skyrocketing rate. Therefore, finding a suitable alternative to rhodium for metal-catalyzed hydroformylation has been on the radar of many academic and industrial researchers. This review presents the scientific advancements reported in the hydroformylation reaction using metals other than rhodium. An overview of recent progress in palladium, iridium, ruthenium, cobalt, platinum, and iron-catalyzed hydroformylation is presented. Hydroformylation of alkenes and alkynes, using syngas as well as syngas surrogates is examined. The evaluation of the current status of non-rhodium metals in hydroformylation suggests that the field is still in a nascent stage and, except cobalt, no other metal poses a significant challenge to the dominance of rhodium. Deep mechanistic understanding of rate-limiting elementary steps in the non-rhodium metals is largely missing and thus only limited success is reported. Intense research on ligand design, mechanistic understanding, and choice of non-rhodium metal precursors may change this scenario in near future.10aaldehydes10aalkenes10acatalysis10aHydroformylation10aNon-rhodium metals1 aKumar, Rohit1 aChikkali, Samir, H.  uhttp://library.ncl.res.in/content/hydroformylation-olefins-metals-other-rhodium02052nas a2200277   4500008004100000022001400041245011600055210006900171260000800240300001500248490000900263520112800272653002901400653001401429653001901443653002201462653003101484100001701515700001701532700002201549700001501571700001701586700001701603700002401620856013001644       2022                        eng d  a1434-193X00aMechanistically guided one pot synthesis of phosphine-phosphite and its implication in asymmetric hydrogenation0 aMechanistically guided one pot synthesis of phosphinephosphite a  cJAN  ae2021014470 v20223 a<p>
	Although hybrid bidentate ligands are known to yield highly enantioselective products in asymmetric hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an 0-nucleophile versus C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72%). When L1 was treated with [Rh], P-31 NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H-2 pressure, at room temperature. The practical relevance of Ll is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson's disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.</p>
10aasymmetric hydrogenation10acatalysis10aDOPA synthesis10aOne pot synthesis10aPhosphine-phosphite ligand1 aSen, Anirban1 aKumar, Rohit1 aPandey, Swechchha1 aRaj, Vipin1 aKumar, Pawan1 aVanka, Kumar1 aChikkali, Samir, H.  uhttp://library.ncl.res.in/content/mechanistically-guided-one-pot-synthesis-phosphine-phosphite-and-its-implication-asymmetric