02395nas a2200241   4500008004100000245010500041210006900146260000800215300001400223490000600237520156300243653002501806653001701831653003201848653002501880100002501905700001701930700001801947700001701965700002101982700002002003856013002023       2016                        eng d00aSynthesis and characterization of novel polymer-hybrid silver nanoparticles and its biomedical study0 aSynthesis and characterization of novel polymerhybrid silver nan  cJUN  a1949-19570 v33 a<p>Hybrid polymer metal nanoparticles have advantages over conventional metal nanoparticles with respect to their stability, chemical resistance, antibacterial activity and drug delivery properties. In the current work, we have synthesized novel stimuli-responsive polymer hybrid silver nanoparticles using green synthesis method, where the plant extract is used as a reducing agent in the synthesis. Encapsulating metal nanoparticles with stimuli-responsive soft-polymeric system is novel and provides additional versatility whose functions and properties can be tailored by controlling any of the stimuli such as pH, temperature, ionic strength with respect to their antibacterial activity and physiological condition. Moreover, green synthesis methods have advantages over conventional methods involving chemical reducing agents that are often associated with environmental toxicity because of their enhanced antibacterial and other biological effects. The synthesized hybrid particles were characterized using Dynamic light scattering, UV-Visible spectroscopy and Small angle x-ray scattering. Further, we have investigated the antibacterial and cytotoxicity effect of these hybrid particles against different bacterial cells ( Salmonella) and mammalian cell lines (HCT116) respectively. These results are discussed in the light of previous studied work and these results suggest that our synthesized polymer hybrid nanoparticles are more antibacterial and less cytotoxic than the usual silver nanoparticles. (C) 2015Elsevier Ltd.All rights reserved.</p>10aAntibacterial effect10aCytotoxicity10aPolymeric hybrid particless10asilver nanoparticles1 aVerma, Suresh, Kumar1 aJha, Ealisha1 aKiran, K., J.1 aBhat, Suresh1 aSuar, Mrutyunjay1 aMohanty, P., S.  uhttp://library.ncl.res.in/content/synthesis-and-characterization-novel-polymer-hybrid-silver-nanoparticles-and-its-biomedical