01594nas a2200193   4500008004100000245013500041210006900176260000800245300001400253490000700267520084500274100001901119700002201138700002001160700003101180700003701211700002401248856012801272       2013                        eng d00aSelf-assembly to function: design, synthesis and broad spectrum antimicrobial properties of short hybrid E-vinylogous lipopeptides0 aSelfassembly to function design synthesis and broad spectrum ant  cNOV  a8468-84740 v563 aNonribosomal E-vinylogous gamma-amino acids are widely present in many peptide natural products and have been exploited as inhibitors for serine and cysteine proteases. Here, we are reporting the broad spectrum antimicrobial properties and self-assembled nanostructures of various hybrid lipopeptides composed of 1:1 alternating alpha-and E-vinylogous residues. Analysis of the results revealed that self-assembled nanostructures also play a significant role in the antimicrobial and hemolytic activities. In contrast to the alpha-peptide counterparts, vinylogous hybrid peptides displayed excellent antimicrobial properties against various bacterial and fungal strains. Peptides that adopted nanofiber structures displayed less hemolytic activity, while peptides that adopted nanoneedle structures displayed the highest hemolytic activity.1 aShankar, Shiva1 aBenke, Sushil, N.1 aNagendra, Narem1 aSrivastava, Prabhakar, Lal1 aThulasiram, Hirekodathakallu, V.1 aGopi, Hosahudya, N.  uhttp://library.ncl.res.in/content/self-assembly-function-design-synthesis-and-broad-spectrum-antimicrobial-properties-short01386nas a2200157   4500008004100000245008100041210006900122260000800191300001400199490000700213520081400220100002201034700003701056700002401093856011101117       2017                        eng d00aPotent antimicrobial activity of lipidated short alpha,gamma-hybrid peptides0 aPotent antimicrobial activity of lipidated short alphagammahybri  cOCT  a1610-16150 v123 aHerein we report the potent antimicrobial activity of alpha,gamma-hybrid lipopeptides composed of 1:1 alternating - and gamma-amino acids. Along with their potent antimicrobial activity against various Gram-positive and Gram-negative bacteria, these hybrid lipopeptides were found to be less hemolytic. Studies into the mechanism of action revealed that these short cationic lipopeptides bind and disrupt the bacterial cell membrane. Time-kill kinetics analyses revealed that the potent alpha,gamma-hybrid lipopeptides completely inhibit bacterial growth in less than 20 minutes. Overall, the promising antimicrobial activity along with lower hemolytic activity displayed by these alpha,gamma-hybrid lipopeptides make them well suited for further exploration into the design of potent lipopeptide antibiotics.1 aBenke, Sushil, N.1 aThulasiram, Hirekodathakallu, V.1 aGopi, Hosahudya, N.  uhttp://library.ncl.res.in/content/potent-antimicrobial-activity-lipidated-short-alphagamma-hybrid-peptides