02269nas a2200253   4500008004100000022001400041245017900055210006900234260000800303300001500311490000600326520131200332653004101644653002001685653001801705653001901723653000801742100002601750700002701776700002701803700002701830700002801857856013001885       2023                        eng d  a2365-654900aSelective one pot multicomponent green synthesis of 3-[(aryl)(arylthio)methyl]-1H-indole derivatives utilizing enhanced Lewis acidic sites of Surfactant-assisted ZnO catalyst0 aSelective one pot multicomponent green synthesis of 3arylarylthi  cMAY  ae2023007360 v83 a<p>
	Five different ZnO nanocrystallites (ZnO-1 to ZnO-5) were successfully synthesized by a surfactant-assisted hydrothermal technique using various surfactants. All the ZnO nanocrystallites are thoroughly characterized by XRD, IR, UV-DRS spectroscopy and FESEM-EDS analysis. Among the synthesized ZnO nanocrystallites, the CTAB-assisted synthesized ZnO-4 exhibited a fine disc-like morphology with a minimum crystallite size (23 nm). Subsequent to reaction optimization studies, the ZnO-4 is utilized as an efficient catalyst for one pot-three component green synthesis of 3-[(aryl)(arylthio)methyl]-1H-indoles (4a-4p) via. condensation of a variety of indoles, aromatic aldehydes and aromatic thiols at room temperature in water. The single-crystal X-ray structure of 3-[(phenyl)(phenylthio)methyl]-1H-indole (4a) is also been reported (CCDC 2170437). The Lewis acidic property of the catalyst-supported probable mechanism is well proposed subsequent to pyridine-IR studies of the ZnO catalysts. Indeed, CTAB-assisted synthesized ZnO-4 was found to be most effective and selective Lewis acid catalyst for the synthesis of a variety of 3-[(aryl)(arylthio)methyl]-1H-indole derivatives in water at ambient temperature with merits like higher yields, lower reaction time, catalyst recovery and reuse.</p>
10a3-[(aryl)(arylthio)methyl]-1H-indole10agreen synthesis10aLewis acidity10aSingle crystal10aZnO1 aSangale, Vijay, B. B.1 aJagtap, Rohidas, M. M.1 aMali, Bhupendra, P. P.1 aGonnade, Rajesh, G. G.1 aPardeshi, Satish, K. K.  uhttp://library.ncl.res.in/content/selective-one-pot-multicomponent-green-synthesis-3-arylarylthiomethyl-1h-indole-derivatives