01341nas a2200265 4500008004100000022001400041245014000055210006900195260000800264300001500272490000600287520042800293653000600721653000600727653003100733653001800764653002800782653001700810653002100827653002600848100002600874700002300900700002600923856012600949 2022 eng d a2365-654900aTransition metal- and oxidant-free regioselective synthesis of 3,4,5-trisubstituted pyrazoles by means of [3+2] cycloaddition reactions0 aTransition metal and oxidantfree regioselective synthesis of 345 cMAR ae2022006050 v73 a
A highly efficient regioselective synthesis of 3,4,5-trisubstituted pyrazoles via transition metal- and oxidant-free, three component [3+2] cycloaddition with thiazolidinedione chalcones, benzaldehydes and N-tosylhydrazine is described. The reaction proceeds through C-C and C-N bond formations under mild reaction conditions to produce structurally diverse polysubstituted pyrazoles in moderate to good yields.
10a310a410a5-trisubstituted pyrazoles10aCycloaddition10aMulticomponent reaction10aOxidant free10aRegioselectivity10aTransition metal free1 aAllaka, Bhargava, Sai1 aBasavoju, Srinivas1 aGamidi, Rama, Krishna uhttp://library.ncl.res.in/content/transition-metal-and-oxidant-free-regioselective-synthesis-345-trisubstituted-pyrazoles