01551nas a2200181   4500008004100000022001400041245006700055210006700122260000800189300001400197490000700211520097800218100002101196700002001217700001701237700002401254856009101278       2021                        eng d  a1477-052000aTotal synthesis of the pseudoindoxyl class of natural products0 aTotal synthesis of the pseudoindoxyl class of natural products  cOCT  a7970-79940 v193 aThe pseudoindoxyl sub-structural motif, amongst the large set of the indole class of alkaloids, represents a unique subset of the oxygenated indole class of the alkaloid family. A majority of this class of natural products contains complex bridged/polycyclic scaffolds with interesting biological profiles. They are thus attractive synthetic targets. Starting from 1963, twenty-eight natural products having the pseudoindoxyl scaffold have been isolated, among which the synthesis of 13 natural products has been accomplished. In this review, we highlight the completed as well as the formal total synthesis of the natural products with a spiro-pseudoindoxyl ring, with a focus on their development. The challenges and the future perspective based on the recent developments in the field will also be discussed. We strongly believe that this review will not only update but also attract the attention of researchers in dealing with the synthesis of pseudoindoxyl compounds.1 aDhote, Pawan, S.1 aPatel, Pitambar1 aVanka, Kumar1 aRamana, Chepuri, V.  uhttp://library.ncl.res.in/content/total-synthesis-pseudoindoxyl-class-natural-products