01451nas a2200169   4500008004100000022001400041245013100055210006900186260000900255300001200264490000700276520080400283100002201087700001901109700002201128856013101150       2022                        eng d  a1477-052000aStudies directed toward the synthesis of hedycoropyrans: total synthesis of des-hydroxy (-)-hedycoropyran B (ent-rhoiptelol B)0 aStudies directed toward the synthesis of hedycoropyrans total sy  cJAN   a444-4630 v203 aA full account of our efforts directed towards the synthesis of the diarylheptanoid-derived natural products hedycoropyrans that led to the total synthesis of ent-rhoiptelol B is described. In this endeavor, we have attempted two distinct synthetic strategies to access hedycoropyrans A and B, which led us to establish a facile synthetic route for des-hydroxy (-)-hedycoropyran B (ent-rhoiptelol B) from simple and readily accessible building blocks of 4-allylanisole and vanillin, employing Sharpless asymmetric epoxidation, CBS reduction, and an intramolecular AgOTf-catalyzed oxa-Michael reaction of suitably functionalized hydroxy-ynone as key transformations. The investigations disclosed herein will provide insights into designing novel synthetic routes for THP-DAH-derived natural products.1 aKataria, Priyanka1 aNomula, Rajesh1 aKontham, Ravindar  uhttp://library.ncl.res.in/content/studies-directed-toward-synthesis-hedycoropyrans-total-synthesis-des-hydroxy-hedycoropyran-b