02206nas a2200265   4500008004100000022001400041245010600055210006900161260000800230300001400238490000700252520132300259653002101582653001701603653002601620653001601646653002001662653001501682653001501697100002901712700001801741700001801759700003401777856012901811       2021                        eng d  a0032-388800aManipulating hydrophobicity of polyester nanofiber mats with egg albumin to enhance cell interactions0 aManipulating hydrophobicity of polyester nanofiber mats with egg  cOCT  a2496-25100 v613 aA hybrid of poly-l-lactic acid (PLA) and poly-epsilon-caprolactone (PCL) system was designed using hydrophilic generally regarded as safe (GRAS) protein, egg albumin (EA), and fabricated as nanofiber mats (NM) to facilitate improved cell interactions and functionality. Our studies include, preparation and analysis of physicochemical properties of NM. Surface morphology of NM was smooth with the diameter ranging from 250 to 400 nm. The contact angle of NM decreased from 80 to 45 degrees with the increase in EA concentration. The rate and extent of swelling was increased 3-folds with the addition of EA. Release studies of NM showed maximum amount of MTz was released with the increase in MTz concentration (>85%). The MTz interaction with EA and structure stability of EA was confirmed from fluorescence and circular dichroism studies. NM showed increase in inhibition of bacterial growth of Staphylococcus aureus and Escherichia coli with the increase in MTz concentration. Cell viability of the NM was >80% and also, the cell proliferation increased as EA content increased. NM hemolytic activity was less than 5% suggesting compatibility. Hence, results concluded that EA had regulated hydrophobicity, promoted cell interactions, and proliferation and therefore, NM is considered safe for tissue regeneration.10aBiocompatibility10aBiomaterials10adrug delivery systems10aegg albumin10aelectrospinning10ananofibers10apolyesters1 aPatel, Pratikshkumar, R.1 aPandey, Komal1 aKilli, Naresh1 aGundloori, Rathna, Venkata Na  uhttp://library.ncl.res.in/content/manipulating-hydrophobicity-polyester-nanofiber-mats-egg-albumin-enhance-cell-interactions