01392nas a2200205 4500008004100000022001400041245014000055210006900195260000800264300001200272490000700284520064200291100001800933700001700951700002000968700001900988700002501007700002601032856012801058 2020 eng d a0022-326300aFunctionalization of alkynes and alkenes using a cascade reaction approach: synthesis of beta-keto sulfones under metal-free conditions0 aFunctionalization of alkynes and alkenes using a cascade reactio cJAN a716-7250 v853 a
Here, we are reporting a multicomponent cascade reaction approach for the synthesis of beta-keto sulfones by exploiting differential reactivity pattern of substrates under open-atmosphere and metal-free conditions. The coupling partners are aryldiazonium salts, unsaturated compounds, and DABSO. The optimized conditions worked well with both alkenes and alkynes. Moreover, the reaction also works with metabisulfite for the source of sulfone. The controlled liquid chromatography-mass spectrometry and O-18-labelled experiments suggested that air is a source of the incoming oxygen atom of the keto group of beta-keto sulfones.
1 aKumar, Mukesh1 aAhmed, Riyaz1 aSingh, Maninder1 aSharma, Shweta1 aThatikonda, Thanusha1 aSingh, Parvinder, Pal uhttp://library.ncl.res.in/content/functionalization-alkynes-and-alkenes-using-cascade-reaction-approach-synthesis-beta-keto