01746nas a2200277 4500008004100000022001400041245007400055210006900129260000800198300001000206490000600216520085000222653002801072653002901100653004101129653002301170653003201193653002201225100001901247700002101266700001701287700001701304700002201321700002401343856010101367 2016 eng d a2352-940700aFluorescent carbon nanodots for targeted in vitro cancer cell imaging0 aFluorescent carbon nanodots for targeted in vitro cancer cell im cSEP a71-770 v43 a
Carbon quantum dots (CQDs or C-dots, <= 10nm in size) are tiny carbon nanoparticles being envisaged in biosensing, bio-imaging and biomolecular/drug delivery. In the present investigation, green fluorescent carbon quantum/nano dots (GCQDs, similar to 3 nm in size) were synthesized through facile chemical slicing method. Further, folic acid (FA) functionalized GCQDs (GCQDs-FA) were obtained to enhance their targeting ability. FA is known to positively influence the binding potential and penetration into the cancer cells because of high abundance of folate receptors (FR) on various cancer cell membranes. We report high biocompatibility, photoluminescence stability and excellent in vitro cancer cell cytoplasm and nucleus targeting performance of GCQDs-FA on MCF-7 breast cancer cells. (C) 2016 Elsevier Ltd. All rights reserved.
10aCancer cell bio-imaging10aCarbon quantum/nano dots10aCell cytoplasm and nucleus targeting10aGreen fluorescence10aPhotoluminescence stability10aTargeting ability1 aAiyer, Sandhya1 aPrasad, Rajendra1 aKumar, Manoj1 aNiryikar, K.1 aJain, Bhanprakash1 aKushwaha, Omkar, S. uhttp://library.ncl.res.in/content/fluorescent-carbon-nanodots-targeted-vitro-cancer-cell-imaging