01834nas a2200217 4500008004100000022001400041245005600055210005600111260000800167300001000175490000700185520121100192653001201403653003101415653001201446653001201458653001801470100002601488700002001514856008201534 2018 eng d a0959-810300aInteraction of polymers with amyloidogenic peptides0 aInteraction of polymers with amyloidogenic peptides cJAN a15-240 v673 a
With this review, the aim was to gather recent representative publications which describe the interaction of polymers with amyloidogenic peptides/proteins. When functional, these take part in for instance bacterial adhesion and biofilm formation. However, several of the peptides/proteins have been identified in various diseases. One of the current approaches to discover a cure against these relies on therapeutics which either prevent or accelerate peptide/protein aggregation and/or clear readily formed aggregates. Owing to the common interest of scientists from all disciplines to identify a cure against the diseases of public health concern, there are overwhelming numbers of publications dealing with these two approaches. Since amyloid aggregation could be regarded as a nucleated polymerization, which is an established mechanism of polymer self-assembly, we recently tackled the issue of amyloid aggregation using the theories and methods established in polymer science. In this review, we hence focus on gathering relevant and recent publications which describe the role of polymers in modulating the aggregation of amyloidogenic peptides/proteins. (c) 2017 Society of Chemical Industry
10aamyloid10aneurodegenerative diseases10aPolymer10aprotein10aSelf-assembly1 aAbraham, Jancy, Nixon1 aNardin, Corinne uhttp://library.ncl.res.in/content/interaction-polymers-amyloidogenic-peptides