01025nas a2200157 4500008004100000245005300041210005300094260000800147300001400155490000600169520054400175100002500719700001800744700002100762856008400783 2016 eng d00aEnantiospecific formal synthesis of inthomycin C0 aEnantiospecific formal synthesis of inthomycin C cMAR a495–4970 v13 a
An enantiospecific synthesis of Hatakeyama's intermediate enynol has been accomplished in both enantiomeric forms. As these intermediates can be converted to (3R)-inthomycin C and (3S)-inthomycin C through respective enynol intermediates using reported procedures, present effort may be regarded as formal synthesis of inthomycin C in both enantiomeric forms. Our synthesis highlights the use of pantolactone chiral pool and thus reconfirms the previously assigned absolute stereochemistry as 3R to the natural product inthomycin C.
1 aAthawale, Paresh, R.1 aKashinath, K.1 aReddy, Srinivasa uhttp://library.ncl.res.in/content/enantiospecific-formal-synthesis-inthomycin-c