01048nas a2200169 4500008004100000245009600041210006900137260000800206300001600214490000700230520041600237100001700653700003300670700002900703700002200732856012400754 2012 eng d00aEfficient synthesis of gamma-keto sulfones by NHC-catalyzed intermolecular stetter reaction0 aEfficient synthesis of gammaketo sulfones by NHCcatalyzed interm cMAY a2830–28330 v143 a
The N-heterocyclic carbene-catalyzed intermolecular Stetter reaction of aldehydes with α,β-unsaturated sulfones allows the atom-economic and selective formation of γ-keto sulfones in good yields. Key to the success of this unique transition-metal-free carbon–carbon bond-forming reaction is the right choice of the NHC precursor and base. The reaction tolerates a broad range of different aldehydes.
1 aBhunia, Anup1 aYetra, Santhivardhana, Reddy1 aBhojgude, Sachin, Suresh1 aBiju, Akkattu, T. uhttp://library.ncl.res.in/content/efficient-synthesis-gamma-keto-sulfones-nhc-catalyzed-intermolecular-stetter-reaction