01432nas a2200217 4500008004100000022001400041245010200055210006900157260007500226300001200301520059500313653001400908653002000922653002900942653001100971653003300982653002201015100002801037700001901065856013001084 2007 eng d a0936-521400aEfficient one-pot synthesis of alpha-amino phosphonates catalyzed by bismuth nitrate pentahydrate0 aEfficient onepot synthesis of alphaamino phosphonates catalyzed aRUDIGERSTR 14, D-70469 STUTTGART, GERMANYbGEORG THIEME VERLAG KGcMAR a745-7483 a
A simple, efficient, and environmentally benign method has been developed for the synthesis of alpha-amino phosphonates through a one-pot reaction of aldehydes with amines and diethyl phosphite in the presence of bismuth nitrate pentahydrate as a catalyst. Some of the major advantages of this protocol are: good yields, the involvement of a less-expensive and non-toxic catalyst, mild and solvent-free reaction conditions and also tolerance towards other functional groups present in the substrates. Eighteen examples are described, highlighting the substrate scope of the reaction.
10aaldehydes10aalkyl phosphite10aalpha-amino phosphonates10aamines10abismuth nitrate pentahydrate10asynthetic methods1 aBhattacharya, Asish, K.1 aKaur, Tanpreet uhttp://library.ncl.res.in/content/efficient-one-pot-synthesis-alpha-amino-phosphonates-catalyzed-bismuth-nitrate-pentahydrate