01497nas a2200289 4500008004100000022001400041245011800055210006900173260010600242300001400348490000700362520041400369653000600783653002300789653002400812653002100836653001500857653002800872653002900900100002800929700002300957700002700980700002601007700002301033700002301056856012801079 2007 eng d a0040-403900aProtecting group directed ring-closing metathesis (RCM): the first total synthesis of an anti-malarial nonenolide0 aProtecting group directed ringclosing metathesis RCM the first t aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR a2621-26250 v483 a
The first synthesis of a newly found naturally occurring anti-malarial nonenolide is described. A pivotal step in the synthesis is the ring-closing metathesis of a dienoic ester prepared by coupling an acid and alcohol that were stereoselectively synthesized from (S)-alpha-hydroxy-gamma-butyrolactone and 1,2-O-isopropylidene D-glyceraldchyde, respectively. (c) 2007 Elsevier Ltd. All rights reserved.
10a110a2-O-isopropylidene10aanti-malarial agent10aD-glyceraldehyde10aNonenolide10aRing-closing metathesis10aYamaguchi esterification1 aMohapatra, Debendra, K.1 aRamesh, Dhondi, K.1 aGiardello, Michael, A.1 aChorghade, Mukund, S.1 aGurjar, Mukund, K.1 aGrubbs, Robert, H. uhttp://library.ncl.res.in/content/protecting-group-directed-ring-closing-metathesis-rcm-first-total-synthesis-anti-malarial