01057nas a2200169 4500008004100000022001400041245010600055210006900161260011000230300001400340490000700354520033700361100002200698700002200720700002100742856012400763 2016 eng d a1359-734500aEfficient access to alkynylated quinalizinones via the gold(I)-catalyzed aminoalkynylation of alkynes0 aEfficient access to alkynylated quinalizinones via the goldIcata aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcMAY a8152-81550 v523 a
The gold-catalyzed aminoalkynylation of alkynes for the synthesis of quinalizinones is reported. For instance, the reaction of pyridinoalkynes with 1-[(triisopropylsilyl)-ethynyl]-1,2-benziodoxol-3(1H)-one (TIPS-EBX) in the presence of a catalytic amount of AuCl at 50 8C afforded alkynylated quinalizinones in 57-87% yields.
1 aShinde, Popat, S.1 aShaikh, Aslam, C.1 aPatil, Nitin, T. uhttp://library.ncl.res.in/content/efficient-access-alkynylated-quinalizinones-goldi-catalyzed-aminoalkynylation-alkynes