01088nas a2200169 4500008004100000022001400041245015200055210006900207260007100276300001400347490000700361520035700368100001900725700002500744700002200769856012700791 2016 eng d a1523-706000aEfficient strategy for the construction of both enantiomers of the octahydropyrroloquinolinone ring system: total synthesis of (+)-aspidospermidine0 aEfficient strategy for the construction of both enantiomers of t a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcAPR a1558-15610 v183 a
An efficient and highly stereoselective intramolecular [3 + 2] cycloaddition of nonstabilized azomethine ylide generated from a designed bicyclic aminal precursor is reported for the synthesis of both (-)- and (+)-octahy-dropyrroloquinolinone. One of the enantiomers is further advanced to accomplish the total synthesis of (+)-aspidospermidine.
1 aPandey, Ganesh1 aBurugu, Shiva, Kumar1 aSingh, Pushpendra uhttp://library.ncl.res.in/content/efficient-strategy-construction-both-enantiomers-octahydropyrroloquinolinone-ring-system