01478nas a2200229 4500008004100000022001400041245009600055210006900151260010600220300001400326490000700340520059400347653001400941653002000955653002900975653001101004653002301015653002901038100002801067700002701095856012601122 2008 eng d a0040-403900aAmberlite-IR 120 catalyzed three-component synthesis of alpha-amino phosphonates in one-pot0 aAmberliteIR 120 catalyzed threecomponent synthesis of alphaamino aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcAPR a2598-26010 v493 a
A simple, efficient, and environmentally benign method for a three-component reaction of an amine, an aldehyde or a ketone, and diethyl phosphite catalyzed by Amberlite-IR 120 resin has been developed to afford alpha-amino phosphonates in high yields and short reaction times under solvent-free reaction conditions. The major advantages of the present method are good yields, inexpensive, ecofriendly and reusable catalyst, mild and solvent-free reaction conditions and tolerance towards various functionalities present in the substrates. (c) 2008 Elsevier Ltd. All rights reserved.
10aaldehydes10aalkyl phosphite10aalpha-amino phosphonates10aamines10aion-exchange resin10amulti-component reaction1 aBhattacharya, Asish, K.1 aRana, Kalpeshkumar, C. uhttp://library.ncl.res.in/content/amberlite-ir-120-catalyzed-three-component-synthesis-alpha-amino-phosphonates-one-pot-0