01061nas a2200169 4500008004100000022001400041245005800055210005400113260010600167300001000273490000700283520044100290100002600731700002500757700002200782856008700804 2009 eng d a0957-416600aConcise enantioselective synthesis of (+)-febrifugine0 aConcise enantioselective synthesis of febrifugine aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcJAN a84-880 v203 a
A short enantioselective synthesis of (+)-febrifugine, a potent antimalarial alkaloid, has been described based on the regioselective asymmetric dihydroxylation of a 1,4-dienic ester as the key step. The strategy also involves chemoselective [3,3]-sigmatropic rearrangement of 1,5-hexadiene-3-ol and intramolecular lactamization of azidolactone for the construction of piperidine core. (C) 2008 Elsevier Ltd. All rights reserved.
1 aEmmanuvel, Lourdusamy1 aKamble, Dayanand, A.1 aSudalai, Arumugam uhttp://library.ncl.res.in/content/concise-enantioselective-synthesis-febrifugine-0