01122nas a2200169 4500008004100000022001400041245013200055210006900187260010600256300001200362490000700374520037500381100002200756700002000778700002300798856013100821 2009 eng d a0957-416600aConcise enantioselective synthesis of 1-[(S)-3-(dimethylamino)-3,4 dihydro-6,7-dimethoxyquinolin-1(2H)-yl]propan-1-one, (S)-9030 aConcise enantioselective synthesis of 1S3dimethylamino34 dihydro aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB a335-3390 v203 a
A concise enantioselective synthesis of (S)-903, an inotropic agent, is described in nine linear steps and 95% ee based on asymmetric dihydroxylation of cinnamate ester and Co-catalyzed Multifunctional reduction of several functional groups leading to the construction of core tetrahydroquinolin-3-ol, as the key steps. (C) 2009 Elsevier Ltd. All rights reserved.
1 aJagdale, Arun, R.1 aReddy, Santhosh1 aSudalai, Arurnugam uhttp://library.ncl.res.in/content/concise-enantioselective-synthesis-1-s-3-dimethylamino-34-dihydro-67-dimethoxyquinolin-12h-0