01429nas a2200217 4500008004100000022001400041245018000055210006900235260010600304300001400410490000700424520051300431653001300944653002000957653003400977653001801011653001401029100001901043700001901062856013001081 2010 eng d a0040-402000a [Cu]-Catalyzed S(N)AR reactions: direct amination of electron deficient aryl halides with sodium azide and the synthesis of arylthioethers under Cu(II)-ascorbate redox system0 aCuCatalyzed SNAR reactions direct amination of electron deficien aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcSEP a7642-76500 v663 a
A one pot [Cu]-promoted SNAr reaction of electron-deficient halobenzenes with sodium azide and the reduction of the intermediate aryl azides under the same Cu(II) ascorbate redox conditions leading to anilines has been documented. Control experiments revealed that both ascorbate and proline play important role in the reaction path way. Further, the use of this catalytic Cu(II) ascorbate redox system has been explored for the synthesis of arylthioethers. (C) 2010 Elsevier Ltd. All rights reserved.
10aAnilines10aAzide reduction10aCu(II)-ascorbate redox system10aSNAr reaction10aThioether1 aGoriya, Yogesh1 aRamana, C., V. uhttp://library.ncl.res.in/content/cu-catalyzed-snar-reactions-direct-amination-electron-deficient-aryl-halides-sodium-azide-0