01282nas a2200205 4500008004100000022001400041245007400055210006900129260011000198300001600308490000700324520048900331100002500820700001700845700002200862700002400884700003500908700002800943856010500971 2012 eng d a1359-734500aMultifaceted folding in a foldamer featuring highly cooperative folds0 aMultifaceted folding in a foldamer featuring highly cooperative aTHOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLANDbROYAL SOC CHEMISTRYcSEP a11205-112070 v483 a
Herein, we report on the folding pattern observed in a synthetic peptide featuring two highly mutually dependent, yet strikingly dissimilar, closed networks of hydrogen-bonded rings that work in a cumulative fashion to stabilize the entire folded architecture of the peptide. Structural studies unequivocally suggest that disruption of any one of these mutually-dependent hydrogen-bonded networks is deleterious to the stability of the fully folded conformation of the peptide.
1 aRamesh, Veera, V. E.1 aPriya, Gowri1 aKotmale, Amol, S.1 aGonnade, Rajesh, G.1 aRajamohanan, Pattuparambil, R.1 aSanjayan, Gangadhar, J. uhttp://library.ncl.res.in/content/multifaceted-folding-foldamer-featuring-highly-cooperative-folds-0