01208nas a2200181 4500008004100000022001400041245013600055210006900191260007100260300001400331490000700345520045900352100002000811700002400831700002500855700002200880856012400902 2013 eng d a0022-326300aCuCN-Mediated cascade cyclization of 4-(2-bromophenyl)-2-butenoates: a high-yield synthesis of substituted naphthalene amino esters0 aCuCNMediated cascade cyclization of 42bromophenyl2butenoates a h a1155 16TH ST, NW, WASHINGTON, DC 20036 USAbAMER CHEMICAL SOCcMAY a5045-50500 v783 a
A new method of CuCN-mediated one-pot cyclization of 4-(2-bromophenyl)-2-butenoates leading to efficient synthesis of substituted naphthalene amino esters including phenanthrene aromatic structural units is described. Deuterium labeling studies establish that this one-pot cascade cyclization proceeds through isomerization of olefin, intramolecular C-C bond cyclization, and aromatization as the key intermediates, all occurring in a single step.
1 aReddy, Santhosh1 aPrasad, Pragati, K.1 aAhuja, Brij, Bhushan1 aSudalai, Arumugam uhttp://library.ncl.res.in/content/cucn-mediated-cascade-cyclization-4-2-bromophenyl-2-butenoates-high-yield-synthesis-0