01093nas a2200205 4500008004100000022001400041245008500055210006900140260008600209300001400295490000700309520034800316653002500664653001600689653001800705653001100723100003100734700002200765856010000787 2015 eng d a0039-791100aConcise synthesis of (+/-)-clopidogrel via carboxylation of benzylamine with CO20 aConcise synthesis of clopidogrel via carboxylation of benzylamin a530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USAbTAYLOR & FRANCIS INCcJUN a2099-21050 v453 a
A concise and efficient synthesis of (+/-)-clopidogrel, an antithrombotic agent, is achieved by inserting CO2 at the benzylic position as the key reaction without using any toxic transition metals. The overall yield of the synthetic process is 38% and the salient features include operationally simple process chemistry and fewer steps.
10aAntithrombatic agent10aclopidogrel10aCO2 insertion10aPlavix1 aVenkataramasubramanian, V.1 aSudalai, Arumugam uhttp://library.ncl.res.in/content/concise-synthesis-clopidogrel-carboxylation-benzylamine-co2-0