01166nas a2200217 4500008004100000022001400041245011500055210006900170260010600239300001200345490000700357520030800364653002900672653001600701653001800717653002000735100002400755700002300779700002300802856012300825 2015 eng d a0040-403900aFormal syntheses of (2R,3R)-3-hydroxy pipecolic acid and (2R,3S)-3-hydroxy pipecolic acid from L-ascorbic acid0 aFormal syntheses of 2R3R3hydroxy pipecolic acid and 2R3S3hydroxy aTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLANDbPERGAMON-ELSEVIER SCIENCE LTDcFEB a805-8070 v563 a
Formal syntheses of both cis and trans 3-hydroxy pipecolic acids is achieved from L-ascorbic acid. Present synthesis describes use of chiral pool approach in which epimerization, Staudinger reaction and Cyclization reactions were employed as key steps. (C) 2014 Elsevier Ltd. All rights reserved.
10a3-Hydroxy pipecolic acid10acyclization10aEpimerization10aL-Ascorbic acid1 aChavan, Subhash, P.1 aDumare, Nilesh, B.1 aPawar, Kailash, P. uhttp://library.ncl.res.in/content/formal-syntheses-2r3r-3-hydroxy-pipecolic-acid-and-2r3s-3-hydroxy-pipecolic-acid-l-0