@article {46137,
	title = {Neural anti-inflammatory natural product periconianone A: total synthesis and biological evaluation},
	journal = {European Journal of Organic Chemistry},
	year = {2019},
	month = {APR },
	pages = {2376-2381},
	type = {Article},
	abstract = {<p>Total synthesis of periconianone A, an eremophilane-type sesquiterpenoid with impressive neural anti-inflammatory potential, has been accomplished. Diels-Alder/aldol strategy to construct tetrahydro-naphthalene-2,6-dione scaffold, allylic oxidation of dienone using DBU/O-2 and postulated biomimetic aldol reaction to construct 6/6/6 tricyclic system are the highlights of the present synthesis. Furthermore, the synthesized (+/-)-periconianone A and two close analogs were tested for their neural anti-inflammatory activity using various assays. In the course of our study we found a structurally simplified analog is superior to (+/-)-periconianone A.</p>
},
	keywords = {Aldol, Allylic oxidation, Biological evaluation, Cytotoxicity, Diels-Alder, Periconianone A},
	issn = {1434-193X},
	doi = {10.1002/ejoc.201900048},
	author = {Kalmode, Hanuman P. and Patil, Suhag S. and Handore, Kishor L. and Athawale, Paresh R. and Dandela, Rambabu and Verma, Abhishek Kumar and Basu, Anirban and Reddy, D. Srinivasa}
}
@article {48948,
	title = {Copper-mediated [3+2] oxidative cyclization of oxime acetate and its utility in the formal synthesis of fentiazac},
	journal = {Organic and biomolecular chemistry},
	volume = {22},
	year = {2024},
	month = {JAN },
	pages = {521-528},
	type = {Article},
	abstract = {<p>A new protocol for the direct synthesis of 2-aminothiazole has been developed from oxime acetate and readily available sodium thiocyanate using a copper catalyst. The present transformation has good functional group tolerance. Various thiazoles were smoothly synthesized in good to excellent yields. The applicability of the present method has been extended to the formal synthesis of the non-steroidal and anti-inflammatory drug, fentiazac via the Sandmeyer reaction and Suzuki coupling. The direct synthesis of 2-aminothiazole has been developed from oxime acetate using a copper catalyst. The applicability of the present method is used in the formal synthesis of fentiazac.</p>
},
	keywords = {Biological evaluation, C-H functionalization, Vinylazides},
	issn = {1477-0520},
	doi = {10.1039/d3ob01882b},
	author = {Jadhao, Nitin L. and Musale, Harish B. and Gajbhiye, Jayant M. and Humne, Vivek T.}
}
