@article {46380,
	title = {Crystal engineering principles: fluoroquinolone salts},
	journal = {Acta Crystallographica A-Foundation and Advances},
	volume = {70},
	year = {2014},
	month = {APR},
	pages = {C413},
	type = {Meeting Abstract},
	keywords = {ciprofloxacin, Fluoroquinolone, norfloxacin},
	issn = {2053-2733},
	author = {Dandela, Rambabu and Nangia, Ashwini}
}
@article {46006,
	title = {Mapping fusogenicity of ciprofloxacin-loaded liposomes with bacterial cells},
	journal = {AAPS Pharmscitech},
	volume = {20},
	year = {2019},
	month = {JUL},
	pages = {180},
	type = {Article},
	abstract = {<p>The process of liposome fusion with cellular membrane plays key role in delivering encapsulated drug molecule into the cell. This process becomes very important for molecules having low permeability as they fail to reach the site of action located inside the cell. Ciprofloxacin (CIP), a broad-spectrum BCS class IV antibiotic, has poor permeability. In the present work, CIP-loaded liposomes were prepared using solvent evaporation method and optimized by 3(2) factorial design approach. The optimized batch of CIP-loaded liposomes was characterized for size, entrapment efficiency, zeta potential, FTIR, and microbial susceptibility study on Staphylococcus aureus (gram-positive bacteria) and Escherichia coli (gram-negative bacteria). Confocal microscopy was used to study the fusogenicity process of CIP-loaded liposomes with bacterial cells. Additionally, the kinetics of fusogenicity process was studied using SAXS for the first time. Surprisingly, the rate of fusion of CIP-loaded liposomes with cell wall of S. aureus was twice when compared to the cell wall of E. coli. It is believed that the current work can act as a roadmap in selection of proper excipients while developing formulations which would expedite the fusogenicity and may execute pharmacological activity of poorly penetrable drug molecules at lower dose.</p>},
	keywords = {ciprofloxacin, confocal microscopy, fusion, liposomes, SAXS},
	issn = {1530-9932},
	doi = {10.1208/s12249-019-1381-4},
	author = {Patil, Runali and Torris, Arun and Bhat, Suresh and Patil, Sharvil}
}
@article {48052,
	title = {Intensified hydrodynamic cavitation using vortex flow based cavitating device for degradation of ciprofloxacin},
	journal = {Chemical Engineering Research \& Design},
	volume = {187},
	year = {2022},
	month = {NOV},
	pages = {623-632},
	type = {Article},
	abstract = {<p>
	The present work, for the first time, establishes degradation behavior of ciprofloxacin (CIP), a widely used fluoroquinolone group of antibiotics, using vortex flow based hydro-dynamic cavitation (HC) for low to high concentrations of CIP (10 and 100 mg/L). Effect of pressure on the degradation of CIP and TOC reduction was investigated on pilot plant scale (capacity 1 m3/h). Process intensifications using aeration as well as hydrogen per-oxide (H2O2) were also investigated. While aeration did not yield any significant en-hancement, process intensification using H2O2 resulted in similar to 200\% enhancement in the CIP degradation as compared to HC alone. Excellent degradations, to an extent of 79 \&amp; 95\%, were achieved corresponding to high cavitational yields of 7.2 x 10-4 mg/J and 86.8 x 10-4 mg/J for CIP concentrations of 10 and 100 mg/L respectively using the process intensified approach of HC and H2O2, not reported so far for cavitating devices without moving ele-ments. The developed methodology demonstrated 4-7 times improvement in per-pass degradation and low cost with high efficiency compared to the conventional cavitation. The results clearly highlight utility of the process intensified approach using H2O2 for the degradation of CIP even at high concentrations, specifically important for pharmaceutical industries requiring zero liquid discharge norms.(c) 2022 Institution of Chemical Engineers. Published by Elsevier Ltd. All rights reserved.</p>
},
	keywords = {Antibiotics removal, ciprofloxacin, Degradation, Oxidation, Wastewater treatment},
	issn = {0263-8762},
	doi = {10.1016/j.cherd.2022.09.027},
	author = {Patil, Pravin B. and Thanekar, Pooja and Bhandari, Vinay M.}
}
