@article { ISI:000360510700002,
	title = {Chiral aziridine ring opening: facile synthesis of (R)-modletine and (R)-phenoxybenzamine hydrochloride},
	journal = {Tetrahedron Letters},
	volume = {56},
	number = {38},
	year = {2015},
	month = {SEP},
	pages = {5269-5271},
	publisher = {PERGAMON-ELSEVIER SCIENCE LTD},
	address = {THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND},
	abstract = {<p>A simple and efficient synthesis of chiral drugs (R)-mexiletine 1, an anti-arrhythmic drug and (R)-phenoxybenzamine hydrochloride 2, an anti-hypertensive drug has been described via controlled reductive ring opening of chiral aziridine as a key step. The target compounds 1 and 2 were obtained in overall yields of 34\% and 10.5\%, respectively. (C) 2015 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Aziridine, Mexiletine, Phenoxybenzamine},
	issn = {0040-4039},
	doi = {10.1016/j.tetlet.2015.07.032},
	author = {Viswanadh, N. and Velayudham, R. and Jambu, S. and Sasikumar, M. and Muthukrishnan, Murugan}
}
@article {48009,
	title = {cis-aziridine synthon based synthetic investigation for tamiflu employing horner-wadsworth-emmons reaction},
	journal = {European Journal of Organic Chemistry},
	volume = {2022},
	year = {2022},
	month = {JUL },
	pages = {e202200384},
	type = {Article},
	abstract = {<p>
	Synthetic investigations to achieve a novel intermediate of Tamiflu by using cis-aziridine as a chiral building block, which is readily synthesized from (D)-mannitol as a renewable starting material, has been presented. The present approach utilizes the intramolecular Horner-Wadsworth-Emmons reaction as the key step for the synthesis of Tamiflu. On the other hand, diene containing allylic aziridine framework is found to be inefficient to furnish the six-membered core skeleton of Tamiflu through ring-closing metathesis reaction.</p>
},
	keywords = {Aziridine, cyclization, HWE reaction, Metathesis, Tamiflu},
	issn = {1434-193X},
	doi = {10.1002/ejoc.202200384},
	author = {Chavan, Subhash P. and Kawale, Sanket A. and Gonnade, Rajesh G.}
}
