@article { ISI:000258059800003,
	title = {Capsaicin: preclinical and clinical studies},
	journal = {Plant Archives},
	volume = {8},
	number = {1},
	year = {2008},
	month = {APR},
	pages = {7-11},
	publisher = {R S YADAV},
	type = {Article},
	address = {606-2 S CIVIL LINES, MUZAFFARNAGAR, 251 001, INDIA},
	abstract = {<p>Drugs obtained from plant sources occupy important position in different pharmacopoeias. Many of the life saving drugs in the present day allopathic system are obtained from plant origin only. Extensive scientific research on capsaicin, a natural compound, pungent principle, present in the fruits of plant Capsicum anum, has been performed. In preclinical studies capsaicin shows lipid lowering by stimulating its metabolism, gastroprotection against aspirin and ethanol induced ulcers. Capsaicin in rodents shows anticancer activity against NKK induced lung and liver cancer. It also exhibits antidiabetic, antimicrobial, anti-inflammatory and antioxidant properties in rodents. In clinical studies Capsaicin shows gastroprotection in healthy volunteers. In double blind studies capsaicin proved to be useful in skin disorders against prutitic psoriasis and prurigo nodularis with randomized double blind studies. It also exhibits good analgesic activity against post-therapeutic neuralgia, osteo-arthritis, rheumatoid arthritis and diabetic neuropathy. Capsaicin is fairly safe with oral dose 0.5-1.0 mg/kg.</p>},
	keywords = {capsaicin, Capsicum anum, clinical studies, preclinical},
	issn = {0972-5210},
	author = {Qureshi, Absar A. and Qureshi, Azfar A. and Omer, Shaista and Sanghai, Dhirendra B. and Setty, S. R. and Bhajipale, N. S.}
}
@article {46949,
	title = {Phytochemicals in cancer treatment: from preclinical studies to clinical practice (vol 10, 1614, 2020)},
	journal = {Frontiers in Pharmacology},
	volume = {11},
	year = {2020},
	month = {FEB },
	pages = {175},
	type = {Correction},
	keywords = {Anticancer, clinical, medicinal plants, phytochemicals, preclinical},
	issn = {1663-9812},
	doi = {10.3389/fphar.2020.00175},
	author = {Choudhari, Amit S. and Mandave, Pallavi C. and Deshpande, Manasi and Ranjekar, Prabhakar and Prakash, Om}
}
@article {46986,
	title = {Phytochemicals in cancer treatment: from preclinical studies to clinical practice},
	journal = {Frontiers in Pharmacology},
	volume = {10},
	year = {2020},
	month = {JAN},
	pages = {1614},
	type = {Review},
	abstract = {<p>Cancer is a severe health problem that continues to be a leading cause of death worldwide. Increasing knowledge of the molecular mechanisms underlying cancer progression has led to the development of a vast number of anticancer drugs. However, the use of chemically synthesized drugs has not significantly improved the overall survival rate over the past few decades. As a result, new strategies and novel chemoprevention agents are needed to complement current cancer therapies to improve efficiency. Naturally occurring compounds from plants known as phytochemicals, serve as vital resources for novel drugs and are also sources for cancer therapy. Some typical examples include taxol analogs, vinca alkaloids such as vincristine, vinblastine, and podophyllotoxin analogs. These phytochemicals often act via regulating molecular pathways which are implicated in growth and progression of cancer. The specific mechanisms include increasing antioxidant status, carcinogen inactivation, inhibiting proliferation, induction of cell cycle arrest and apoptosis; and regulation of the immune system. The primary objective of this review is to describe what we know to date of the active compounds in the natural products, along with their pharmacologic action and molecular or specific targets. Recent trends and gaps in phytochemical based anticancer drug discovery are also explored. The authors wish to expand the phytochemical research area not only for their scientific soundness but also for their potential druggability. Hence, the emphasis is given to information about anticancer phytochemicals which are evaluated at preclinical and clinical level.</p>
},
	keywords = {Anticancer, clinical, medicinal plants, phytochemicals, preclinical},
	issn = {1663-9812},
	doi = {10.3389/fphar.2019.01614},
	author = {Choudhari, Amit S. and Mandave, Pallavi C. and Deshpande, Manasi and Ranjekar, Prabhakar and Prakash, Om}
}
