@article {47402,
	title = {Total synthesis of twelve membered resorcyclic acid lactones, (R)-penicimenolide A, (R)-resorcyclide and (R)-dihydroresorcyclide},
	journal = {Tetrahedron},
	volume = {85},
	year = {2021},
	month = {APR},
	pages = {132059},
	type = {Article},
	abstract = {<p>Resorcyclic Acid Lactones or RALs are a class of fungal secondary polyketides isolated from a variety of fungal strains like Lasiodiplodia theobromae, Penicillium sp., Syncephalastrum racemosum etc. This class of macrocyclic lactones are found to exhibit a broad spectrum of biological activities and are of significant synthetic importance. Herein, we report the first total synthesis of (R)-penicimenolide A, twelve membered RAL (RAL12) isolated from Penicillium sp. (NO. SYP-F-7919). Besides, we also report the total synthesis of two other members, namely, (R)-trans-resorcyclide and (R)-dihydroresorcyclide. In the course of synthesis, we have utilized ring closing metathesis (RCM) as the key step in constructing the core macrolactone scaffold. (C) 2021 Elsevier Ltd. All rights reserved.</p>},
	keywords = {Macrocycle, Natural product, organic synthesis, Total synthesis},
	issn = {0040-4020},
	doi = {10.1016/j.tet.2021.132059},
	author = {Das, Pronay and Reddy, D. Srinivasa}
}
@article {48045,
	title = {Studies directed toward the total synthesis of nannocystin A},
	journal = {ChemistrySelect},
	volume = {7},
	year = {2022},
	month = {NOV},
	pages = {e202203893},
	type = {Article},
	abstract = {<p>
	A full account of our efforts directed toward the stereoselective total synthesis of nannocystin A, a macrocyclic myxobacterial metabolite, is presented. In this endeavor, we have attempted two distinct synthetic routes to access polyketide fragment (C1-C11) of macrocyclic depsipeptide (21-membered) natural product from readily accessible building blocks 1,3-propanediol and benzaldehyde employing Evans aldol, CBS reduction, Heck cross-coupling, and Sharpless asymmetric epoxidation as key transformations. Ultimately, accomplished the synthesis of the complete skeleton (21-membered precursor for macrocyclic depsipeptide) of the nannocystin A possessing desired stereochemistry and functional groups.</p>
},
	keywords = {amidation, Depsipeptide, Evans aldol reaction, Macrocycle, Nannocystins},
	issn = {2365-6549},
	doi = {10.1002/slct.202203893},
	author = {Nomula, Rajesh and Pratapure, Madhukar S. and Kontham, Ravindar}
}
