@article {46694,
	title = {Discovery of 3-(benzofuran-2-ylmethyl)-1H-indole derivatives as potential autophagy inducers in cervical cancer cells},
	journal = {Bioorganic \& Medicinal Chemistry Letters},
	volume = {30},
	year = {2020},
	month = {OCT },
	pages = {127431},
	type = {Article},
	abstract = {<p>In this manuscript we have documented the identification of a novel anticancer scaffold 3-(benzofuran-2-yl-methyl)-1H-indole. This scaffold has been designed by tweaking the known bisindolylmethane scaffold of natural products that display a wide range of biological activities. A series of 24 new conjugates have been synthesized and among them 5 derivatives exhibited IC50 values less than 40 mu M against two cervical cancer cell lines SiHa and C33a. Further mechanistic studies of two compounds 3eb and 3ec revealed that the toxicity of these compounds was due to the effective induction of autophagy mediated cell death. The autophagy induction was confirmed by the progressive conversion of LC3I to LC3II and downregulation of p62 in cervical cancer cells.</p>
},
	keywords = {Autophagy, Benzofuran, Bisindolylmethane, Cervical cancer, Friedel-Crafts alkylation},
	issn = {0960-894X},
	doi = {10.1016/j.bmcl.2020.127431},
	author = {Siddiqui, Shaziyaparveen K. and SahayaSheela, Vinodh J. and Kolluru, Srinivas and Pandian, Ganesh N. and Santhoshkumar, Thankayyan R. and Dan, Vipin M. and Ramana, V, Chepuri}
}
@article {47601,
	title = {Implications of valosin-containing protein in promoting autophagy to prevent tau aggregation},
	journal = {Neuroscience},
	volume = {476},
	year = {2021},
	month = {NOV},
	pages = {125-134},
	type = {Review},
	abstract = {and cellular degradative mechanisms modulate Tau aggregation. During aging and neu-rodegenerative disorders, the cellular proteostasis is disturbed due to impaired protective mechanisms. This results in accumulation of aberrant Tau aggregates in the neuron that leads to microtubule destabilization and neuronal degeneration. The intricate mechanisms to prevent Tau aggregation involve chaperones, autophagy, and proteasomal system have gained main focus about concerning to therapeutic intervention. However, the thor-ough understanding of other key proteins, such as Valosin-containing protein (VCP), is limited. In various neu-rodegenerative diseases, the chaperone-like activity of VCP is involved in preventing protein aggregation and mediating the degradation of aberrant proteins by proteasome and autophagy. In the case of Tau aggregation associated with Alzheimer{\textquoteright}s disease, the importance of VCP is poorly understood. VCP is known to co-localize with Tau, and alterations in VCP cause aberrant accumulation of Tau. Nevertheless, the direct mechanism of VCP in altering Tau aggregation is not known. Hence, we speculate that VCP might be one of the key modulators in preventing Tau aggregation and can disintegrate Tau aggregates by directing its clearance by autophagy. = 2021 IBRO. Published by Elsevier Ltd. All rights reserved.},
	keywords = {Autophagy, segregase, Tau aggregates, Ubiquitin-proteasome system, valosin-containing protein},
	issn = {0306-4522},
	doi = {10.1016/j.neuroscience.2021.09.003},
	author = {Chinnathambi, Subashchandrabose and Gorantla, Nalini Vijay}
}
@article {48340,
	title = {Hyperthermia and doxorubicin release by Fol-LSMO nanoparticles induce apoptosis and autophagy in breast cancer cells},
	journal = {Nanomedicine},
	volume = {17},
	year = {2022},
	month = {OCT},
	pages = {1929-1949},
	type = {Article},
	abstract = {<p>
	Background: Studies on the anticancer effects of lanthanum strontium manganese oxide (LSMO) nanoparticles (NPs)-mediated hyperthermia at cellular and molecular levels are scarce. Materials \&amp; methods: LSMO NPs conjugated with folic acid (Fol-LSMO NPs) were synthesized, followed by doxorubicin-loading (DoxFol-LSMO NPs), and their effects on breast cancer cells were investigated. Results: Hyperthermia (45 degrees C) and combination treatments exhibited the highest (similar to 95\%) anticancer activity with increased oxidative stress. The involvement of intrinsic mitochondria-mediated apoptotic pathway and induction of autophagy was noted. Cellular and molecular evidence confirmed the crosstalk between apoptosis and autophagy, involving Beclin1, Bcl2 and Caspase-3 genes with free reactive oxygen species presence. Conclusion: The study confirmed hyperthermia and doxorubicin release by Fol-LSMO NPs induces apoptosis and autophagy in breast cancer cells.</p>
},
	keywords = {Apoptosis, Autophagy, Breast cancer, combination therapy, doxorubicin, Folic acid, hyperthermia, LSMO, MDA-MB231 cells, PEG},
	issn = {1743-5889},
	doi = {10.2217/nnm-2022-0171},
	author = {Kulkarni-Dwivedi, Neha and Patel, Pratikshkumar R. and Shravage, V. Bhupendra and Umrani, Rinku D. and Paknikar, Kishore M. and Jadhav, Sachin H.}
}
