@article { ISI:000377822900018,
	title = {Proteomic insight reveals elevated levels of albumin in circulating immunecomplexes in diabetic plasma},
	journal = {Molecular \& Cellular Proteomics},
	volume = {15},
	number = {6},
	year = {2016},
	month = {JUN},
	pages = {2011-2020},
	publisher = {AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC},
	address = {9650 ROCKVILLE PIKE, BETHESDA, MD 20814-3996 USA},
	abstract = {<p>A Hyperglycemic condition in diabetes promotes formation of advanced glycation end products, which are known to elicit immune response and form complexes with immunoglobulins called circulating immune complexes. To investigate the involvement of advanced glycation end product (AGE)-modified proteins in the elicitation of an immune response, circulating immune complexes were isolated and proteins associated were identified and characterized. Label-free-based mass spectrometric analysis of circulating immune complexes in clinical plasma of prediabetic, newly diagnosed diabetes, and diabetic microalbuminurea revealed elevated levels of serum albumin in the circulating immune complexes, which were also observed to be AGE modified. Further, to examine the role of glycation, circulating immune complexeswere analyzed in the streptozotocin-induced diabetic mice treated with or without aminoguanidine, a prototype glycation inhibitor. Mass spectrometric analysis of circulating immune complexes showed elevated levels of serum albumin in plasma from diabetic mice over that of control animals. Aminoguanidine-treated diabetic mice displayed decreased AGE modification of plasma albumin, accompanied by a reduced level of albumin in the circulating immune complexes. In addition, elevated levels of proinflammatory cytokines such as IL-1b, IL-2, and TNF-alpha were observed in diabetes, which were reduced with aminoguanidine treatment, suggesting the involvement of glycation in the immune response.</p>},
	issn = {1535-9476},
	doi = {10.1074/mcp.M116.058008},
	author = {Bhat, Shweta and Jagadeeshaprasad, Mashanipalya G. and Patil, Yugendra R. and Shaikh, Mahemud L. and Regin, Bhaskaran S. and Mohan, Viswanathan and Giri, Ashok P. and Balasubramanyam, Muthuswamy and Boppana, Ramanamurthy and Kulkarni, Mahesh J.}
}
@article {48996,
	title = {Cerebrospinal fluid protein profiles in alzheimer{\textquoteright}s dementia patients: a bioinformatic approach},
	journal = {Annals of Indian Academy of Neurology },
	volume = {26},
	year = {2023},
	type = {Letter},
	issn = {0972-2327},
	doi = {10.4103/aian.aian_206_23},
	author = {Misra, Anamika and Chakrabarti, Sankha S. and Gambhir, Indrajeet S. and Baghel, Meghraj S. and Patil, Yugendra R.}
}
