@article { ISI:000346624500002,
	title = {Efficient synthesis of 1,5-benzodiazepines catalyzed by bismuth nitrate},
	journal = {Indian Journal of Chemistry Section B-Organic Chemistry including Medicinal Chemistry},
	volume = {53},
	number = {12},
	year = {2014},
	month = {DEC},
	pages = {1561-1567},
	publisher = {COUNCIL SCIENTIFIC \& INDUSTRIAL RES},
	address = {ANUSANDHAN BHAWAN, 2 RAFI MARG, NEW DELHI, 110001, INDIA},
	abstract = {<p>An efficient method has been developed for the synthesis of biologically active 1,5-benzodiazepines in one-pot by reacting o-phenylenediamine and ketones catalyzed by bismuth nitrate pentahydrate at room temperature or under microwave irradiation.</p>},
	keywords = {1, 5-benzodiazepines, bismuth nitrate pentahydrate, o-Phenylenediamine, synthetic methods},
	issn = {0376-4699},
	author = {Bhattacharya, Asish K. and Dange, Santoshkumar S. and Polanki, Innaiah K. and Chand, Hemender R.}
}
@article { ISI:000364803200005,
	title = {Design, synthesis, and identification of silicon incorporated oxazolidinone antibiotics with improved brain exposure},
	journal = {ACS Medicinal Chemistry Letters},
	volume = {6},
	number = {11},
	year = {2015},
	month = {NOV},
	pages = {1105-1110},
	publisher = {AMER CHEMICAL SOC},
	address = {1155 16TH ST, NW, WASHINGTON, DC 20036 USA},
	abstract = {<p>Therapeutic options for brain infections caused by pathogens with a reduced sensitivity to drugs are limited. Recent reports on the potential use of linezolid in treating brain infections prompted us to design novel compounds around this scaffold. Herein, we describe the design and synthesis of various oxazolidinone antibiotics with the incorporation of silicon. Our findings in preclinical species suggest that silicon incorporation is highly useful in improving brain exposures. Interestingly, three compounds from this series demonstrated up to a 30-fold higher brain/plasma ratio when compared to linezolid thereby indicating their therapeutic potential in brain associated disorders.</p>},
	keywords = {Antibacterial, brain exposure, linezolid, oxazolidinone, sila analogue},
	issn = {1948-5875},
	doi = {10.1021/acsmedchemlett.5b00213},
	author = {Seetharamsingh, B. and Ramesh, Remya and Dange, Santoshkumar S. and Khairnar, Pankaj V. and Singhal, Smita and Upadhyay, Dilip and Veeraraghavan, Sridhar and Viswanadha, Srikant and Vakkalanka, Swaroop and Reddy, D. Srinivasa}
}
