@article { ISI:000361532500003,
	title = {New butenolide cinnamate and other biological active chemical constituents from Polygonum glabrum},
	journal = {Natural Product Research},
	volume = {29},
	number = {22},
	year = {2015},
	month = {NOV},
	pages = {2080-2086},
	publisher = {TAYLOR \& FRANCIS LTD},
	address = {4 PARK SQUARE, MILTON PARK, ABINGDON OX14 4RN, OXON, ENGLAND},
	abstract = {<p>Phytochemical investigation of the methanol extract of the aerial parts of Polygonum glabrum afforded one new natural product (-)-2-methoxy-2-butenolide-3-cinnamate (1) along with six known compounds, -hydroxyfriedalanol (2), 3-hydroxy-5-methoxystilbene (3), (-) pinocembrin (4), sitosterol-(6-O-palmitoyl)-3-O{\textendash}d-glucopyranoside (5), (-) pinocembrin-5-methyl ether (6) and sitosterol-3-O{\textendash}d-glucopyranoside (7). Compound 1 showed promising in vitro anti-HIV-1 activity against primary isolates HIV-1(UG070) (X4, subtype D) and HIV-1(VB59) (R5, subtype C) assayed using TZM-bl cell line with IC50 in the range of 15.68-22.43g/mL. The extract showed TI in the range of 19.19-27.37 with IC50 in the range of 10.90-15.55g/mL. Compounds 1, 3 and 4 exhibited in vitro anti-mycobacterium activity against Mycobacterium tuberculosis H37Ra with IC50 values of 1.43, 3.33 and 1.11g/mL in dormant phase and 2.27, 3.33 and 1.21g/mL in active phase, respectively. Compound 4 was found to be the most active antiproliferative with IC50 values of 1.88-11.00g/mL against THP-1, A549, Panc-1, HeLa and MCF7 cell lines.</p>},
	keywords = {anti-HIV-1, anti-mycobacterium, antiproliferative, phytochemicals, Polygonaceae, Polygonum glabrum},
	issn = {1478-6419},
	doi = {10.1080/14786419.2015.1004674},
	author = {Said, Madhukar S. and Chinchansure, Ashish A. and Nawale, Laxman and Durge, Ankita and Wadhwani, Ashish and Kulkarni, Smita S. and Sarkar, Dhiman and Joshi, Swati P.}
}
@article {42949,
	title = {New dinor-cis-labdane diterpene and flavonoids with antimycobacterium activity from colebrookea oppositifolia},
	journal = {Planta Medica Letters},
	volume = {3},
	year = {2016},
	month = {MAR},
	pages = {e20-e24},
	abstract = {<p>The new 14,15-dinor-cis-labdane diterpene, named (+)-14,15-dinor-9α-hydroxy-cis-labd-11(E)-en-13-one (1), was isolated from the acetone extract of the aerial parts of Colebrookea oppositifolia, along with the known compounds alnustin (2), mosloflavone (3), flindulatin (4), 5,6,7-trimethoxy baicalein (5), tanetin (6), scutellarein 4'-methyl ether (7), apigenin (8), caffeic acid (9), anisofolin A (10), apigetrin (11), and forsythoside A (12). Structures of the new and known compounds were established by detailed analysis of 1D and 2D nuclear magnetic resonance studies. The isolated compounds 1{\textendash}12 were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis in both dormant and active phases. Compounds 1, 7, and 8 exhibited inhibitory activity against M. tuberculosis with IC50 values in the range of 8.1{\textendash}55.0 {\textmu}M (MIC 14.4{\textendash}119.7 {\textmu}M) in the active phase and 7.4{\textendash}43.5 {\textmu}M (MIC 11.5{\textendash}123.3 {\textmu}M) in the dormant phase. Similarly 1, 7, and 8 exhibited inhibitory activity against M. bovis with IC50 values in the range of 4.1{\textendash}98.5 {\textmu}M (MIC 13.7{\textendash}161.0 {\textmu}M) in the active phase and 4.1{\textendash}111.1 {\textmu}M (MIC 13.0{\textendash}166.4 {\textmu}M) in the dormant phase.</p>},
	doi = {10.1055/s-0042-102200},
	author = {Chinchansure, Ashish A. and Arkile, Manisha A. and Shinde, Dinesh R. and Sarkar, Dhiman and Joshi, Swati P.}
}
